Ruijin Shao

Summary

Country: Sweden

Publications

  1. pmc Direct effects of metformin in the endometrium: a hypothetical mechanism for the treatment of women with PCOS and endometrial carcinoma
    Ruijin Shao
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden
    J Exp Clin Cancer Res 33:41. 2014
  2. pmc Understanding the mechanisms of human tubal ectopic pregnancies: new evidence from knockout mouse models
    Ruijin Shao
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Hum Reprod 25:584-7. 2010
  3. pmc Endometrial progesterone resistance and PCOS
    Xin Li
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden
    J Biomed Sci 21:2. 2014
  4. pmc Aberrant alteration of vascular endothelial growth factor-family signaling in human tubal ectopic pregnancy: what is known and unknown?
    Ruijin Shao
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden
    Int J Clin Exp Pathol 6:810-5. 2013
  5. pmc Comparison of the diagnostic values of circulating steroid hormones, VEGF-A, PIGF, and ADAM12 in women with ectopic pregnancy
    Shien Zou
    Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China
    J Transl Med 11:44. 2013
  6. doi request reprint From mice to women and back again: causalities and clues for Chlamydia-induced tubal ectopic pregnancy
    Ruijin Shao
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Fertil Steril 98:1175-85. 2012
  7. doi request reprint Coordinate regulation of heterogeneous nuclear ribonucleoprotein dynamics by steroid hormones in the human fallopian tube and endometrium in vivo and in vitro
    Ruijin Shao
    Dept of Physiology Endocrinology, Sahlgrenska Academy, Univ of Gothenburg, Box 434, Gothenburg, Sweden
    Am J Physiol Endocrinol Metab 302:E1269-82. 2012
  8. doi request reprint Revealing the hidden mechanisms of smoke-induced fallopian tubal implantation
    Ruijin Shao
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Biol Reprod 86:131. 2012
  9. ncbi request reprint Downregulation of cilia-localized Il-6R alpha by 17beta-estradiol in mouse and human fallopian tubes
    Ruijin Shao
    Dept of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Univ of Gothenburg, Medicinareg 11, PO Box 434, Gothenburg 40530, Sweden
    Am J Physiol Cell Physiol 297:C140-51. 2009
  10. pmc Nitric oxide synthases and tubal ectopic pregnancies induced by Chlamydia infection: basic and clinical insights
    Ruijin Shao
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Mol Hum Reprod 16:907-15. 2010

Collaborators

Detail Information

Publications40

  1. pmc Direct effects of metformin in the endometrium: a hypothetical mechanism for the treatment of women with PCOS and endometrial carcinoma
    Ruijin Shao
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden
    J Exp Clin Cancer Res 33:41. 2014
    ....
  2. pmc Understanding the mechanisms of human tubal ectopic pregnancies: new evidence from knockout mouse models
    Ruijin Shao
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Hum Reprod 25:584-7. 2010
    ..Our understanding of the mechanisms which contribute to tubal ectopic pregnancy in humans may be enhanced through further study of these KO mouse models...
  3. pmc Endometrial progesterone resistance and PCOS
    Xin Li
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden
    J Biomed Sci 21:2. 2014
    ....
  4. pmc Aberrant alteration of vascular endothelial growth factor-family signaling in human tubal ectopic pregnancy: what is known and unknown?
    Ruijin Shao
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden
    Int J Clin Exp Pathol 6:810-5. 2013
    ..Our hypothesis may also lead to a new therapeutic strategy for women with tubal ectopic pregnancy...
  5. pmc Comparison of the diagnostic values of circulating steroid hormones, VEGF-A, PIGF, and ADAM12 in women with ectopic pregnancy
    Shien Zou
    Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China
    J Transl Med 11:44. 2013
    ..We investigated the presence and the possible changes in circulating molecules that distinguish between normal intrauterine pregnancy (IUP) and tubal ectopic pregnancy...
  6. doi request reprint From mice to women and back again: causalities and clues for Chlamydia-induced tubal ectopic pregnancy
    Ruijin Shao
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Fertil Steril 98:1175-85. 2012
    ....
  7. doi request reprint Coordinate regulation of heterogeneous nuclear ribonucleoprotein dynamics by steroid hormones in the human fallopian tube and endometrium in vivo and in vitro
    Ruijin Shao
    Dept of Physiology Endocrinology, Sahlgrenska Academy, Univ of Gothenburg, Box 434, Gothenburg, Sweden
    Am J Physiol Endocrinol Metab 302:E1269-82. 2012
    ..Both actions may contribute to regulation of gene transcription...
  8. doi request reprint Revealing the hidden mechanisms of smoke-induced fallopian tubal implantation
    Ruijin Shao
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Biol Reprod 86:131. 2012
    ..Because cigarette/tobacco smoke adversely affects the success of intrauterine implantation, there is a great need to determine how embryo implantation occurs in the fallopian tube in female smokers of reproductive age...
  9. ncbi request reprint Downregulation of cilia-localized Il-6R alpha by 17beta-estradiol in mouse and human fallopian tubes
    Ruijin Shao
    Dept of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Univ of Gothenburg, Medicinareg 11, PO Box 434, Gothenburg 40530, Sweden
    Am J Physiol Cell Physiol 297:C140-51. 2009
    ..Our findings open the possibility that cilia-specific IL-6R alpha may play a role in the regulation of OCC transport and suggest an estrogen-regulatory pathway of IL-6R alpha in the fallopian tube...
  10. pmc Nitric oxide synthases and tubal ectopic pregnancies induced by Chlamydia infection: basic and clinical insights
    Ruijin Shao
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Mol Hum Reprod 16:907-15. 2010
    ..Therefore, tissue-specific therapeutic approaches to suppress iNOS expression may help to prevent ectopic implantation in patients with prior C. trachomatis infection of the Fallopian tube...
  11. doi request reprint Distinct expression pattern of Dicer1 correlates with ovarian-derived steroid hormone receptor expression in human Fallopian tubes during ovulation and the midsecretory phase
    Ruijin Shao
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, 40530 Gothenburg, Sweden
    J Clin Endocrinol Metab 96:E869-77. 2011
    ..Tissue-specific dicer1 knockout mice display severe, irreversible Fallopian tube damage and disrupted tubal transport. It is not known how Dicer1 affects human Fallopian tube function...
  12. doi request reprint Clomiphene citrate causes aberrant tubal apoptosis and estrogen receptor activation in rat fallopian tube: implications for tubal ectopic pregnancy
    Ruijin Shao
    Department of Physiology Endocrinology, Core Facilities, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
    Biol Reprod 80:1262-71. 2009
    ....
  13. ncbi request reprint Nuclear progesterone receptor A and B isoforms in mouse fallopian tube and uterus: implications for expression, regulation, and cellular function
    Ruijin Shao
    Section of Endocrinology, Dept of Physiology and Pharmacology, Sahlgrenska Academy, Goteborg University, SE 40530, Gothenburg, Sweden
    Am J Physiol Endocrinol Metab 291:E59-72. 2006
    ....
  14. ncbi request reprint Developmental and hormonal regulation of progesterone receptor A-form expression in female mouse lung in vivo: interaction with glucocorticoid receptors
    Ruijin Shao
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Goteborg University, SE 40530 Goteborg, Sweden
    J Endocrinol 190:857-70. 2006
    ....
  15. ncbi request reprint Induction of apoptosis increases SUMO-1 protein expression and conjugation in mouse periovulatory granulosa cells in vitro
    Ruijin Shao
    Department of Physiology, Section of Endocrinology, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Mol Reprod Dev 73:50-60. 2006
    ..Taken together, our observations suggest that SUMO-1 via sumoylation has an important role in the regulation of granulosa cell apoptosis during granulosa cell differentiation in the mouse ovary...
  16. ncbi request reprint Estrogen-induced upregulation of AR expression and enhancement of AR nuclear translocation in mouse fallopian tubes in vivo
    Ruijin Shao
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Goteborg University, SE 40530 Gothenburg, Sweden
    Am J Physiol Endocrinol Metab 292:E604-14. 2007
    ..To our knowledge, this study provides the first demonstration to illustrate that estrogen as a principal regulator may contribute to regulate and activate AR in the fallopian tubes in vivo...
  17. ncbi request reprint Ciliated epithelial-specific and regional-specific expression and regulation of the estrogen receptor-beta2 in the fallopian tubes of immature rats: a possible mechanism for estrogen-mediated transport process in vivo
    Ruijin Shao
    Instiute of Neuroscience and Physiology, The Sahlgrenska Academy at Gothenburg University, SE 41390 Gothenburg, Sweden
    Am J Physiol Endocrinol Metab 293:E147-58. 2007
    ..We show for the first time that a previously unrecognized localization of ERbeta isoform in rat fallopian tubes can combine with estrogen to individually control the expression of ER beta-isoforms in normal target tissues...
  18. ncbi request reprint Dynamic regulation of estrogen receptor-alpha isoform expression in the mouse fallopian tube: mechanistic insight into estrogen-dependent production and secretion of insulin-like growth factors
    Ruijin Shao
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Gothenburg University, SE 41390, Gothenburg, Sweden
    Am J Physiol Endocrinol Metab 293:E1430-42. 2007
    ....
  19. doi request reprint Differences in prolactin receptor (PRLR) in mouse and human fallopian tubes: evidence for multiple regulatory mechanisms controlling PRLR isoform expression in mice
    Ruijin Shao
    Department of Physiology, The Sahlgrenska Academy at Gothenburg University, SE 41390 Gothenburg, Sweden
    Biol Reprod 79:748-57. 2008
    ..These findings may contribute to our understanding of the mechanisms controlling PRLR isoform expression in the fallopian tube (in addition to ovary and uterus), with implications for female reproduction...
  20. pmc Reduced bone mass and muscle strength in male 5α-reductase type 1 inactivated mice
    Sara H Windahl
    Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 6:e21402. 2011
    ..In contrast, the increased cortical bone mass in female Srd5a1⁻/⁻ mice, is an indirect effect mediated by elevated circulating androgen levels...
  21. ncbi request reprint Expression of progesterone receptor (PR) A and B isoforms in mouse granulosa cells: stage-dependent PR-mediated regulation of apoptosis and cell proliferation
    Ruijin Shao
    Department of Physiology and Pharmacology, Goteborg University, SE 40530 Goteborg, Sweden
    Biol Reprod 68:914-21. 2003
    ..These results indicate that PR and its isoforms participate in regulation of ovulation, along with suppression of granulosa cell apoptosis and promotion of cell survival in the mouse ovary...
  22. doi request reprint Effects of androgen and leptin on behavioral and cellular responses in female rats
    Yi Feng
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Horm Behav 60:427-38. 2011
    ..Elucidating mechanisms by which androgens modulate female anxiety-like behavior may uncover useful approaches for treating women with PCOS who have symptoms of anxiety...
  23. ncbi request reprint Progesterone-receptor antagonists and statins decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells in vitro
    Emilia Rung
    Department of Physiology and Pharmacology, Goteborg, Sweden
    Biol Reprod 72:538-45. 2005
    ..These results show that PR antagonists reduce cholesterol synthesis in periovulatory granulosa cells and that cholesterol synthesis is important for granulosa cell survival...
  24. ncbi request reprint Inhibition of small ubiquitin-related modifier-1 expression by luteinizing hormone receptor stimulation is linked to induction of progesterone receptor during ovulation in mouse granulosa cells
    Ruijin Shao
    Division of Endocrinology, Department of Physiology and Pharmacology, Goteborg University, SE 40530 Goteborg, Sweden
    Endocrinology 145:384-92. 2004
    ..These results suggest that a functional link between SUMO-1 and PR is of physiological importance for the local modulation of PR-mediated events in the ovary...
  25. doi request reprint Stromal cell-specific apoptotic and antiestrogenic mechanisms may explain uterine defects in humans after clomiphene citrate therapy
    Magdalena Nutu
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Am J Obstet Gynecol 203:65.e1-65.e10. 2010
    ..The purpose of this study was to investigate clomiphene citrate (CC)-induced modulation of uterine cell function in vivo...
  26. doi request reprint Electrical and manual acupuncture stimulation affect oestrous cyclicity and neuroendocrine function in an 5α-dihydrotestosterone-induced rat polycystic ovary syndrome model
    Yi Feng
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden
    Exp Physiol 97:651-62. 2012
    ..The effects of low-frequency EA may be mediated by central opioid receptors, while manual stimulation may involve regulation of steroid hormone/peptide receptors...
  27. doi request reprint Spatiotemporal expression of androgen receptors in the female rat brain during the oestrous cycle and the impact of exogenous androgen administration: a comparison with gonadally intact males
    Yi Feng
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Mol Cell Endocrinol 321:161-74. 2010
    ..As a whole, the present study provides the first step toward understanding the dynamics of AR expression and regulation in the brain during normal physiological conditions and for differences in neuronal androgen effects based on sex...
  28. doi request reprint Liver-derived IGF1 enhances the androgenic response in prostate
    Johan Svensson
    Division of Endocrinology, Department of Internal Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, Goteborg University, Grona Straket 8, SE 413 45 Goteborg, Sweden
    J Endocrinol 199:489-97. 2008
    ..These findings may explain, at least in part, the well-known clinical association between serum IGF1 levels and conditions with abnormal prostate growth...
  29. pmc Electrical vs manual acupuncture stimulation in a rat model of polycystic ovary syndrome: different effects on muscle and fat tissue insulin signaling
    Julia Johansson
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 8:e54357. 2013
    ..The underlying mechanism of the differential effects of the intermittent manual and the continuous electrical stimulation remains to be elucidated...
  30. doi request reprint Intense electroacupuncture normalizes insulin sensitivity, increases muscle GLUT4 content, and improves lipid profile in a rat model of polycystic ovary syndrome
    Julia Johansson
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Am J Physiol Endocrinol Metab 299:E551-9. 2010
    ..Thus, in rats with DHT-induced PCOS, low-frequency EA has systemic and local effects involving intracellular signaling pathways in muscle that may, at least in part, account for the marked improved insulin sensitivity...
  31. ncbi request reprint The role of estrogen receptor α in growth plate cartilage for longitudinal bone growth
    Anna E Börjesson
    Centre for Bone and Arthritis Research, Institute of Medicine, University of Gothenburg, Sahlgrenska Academy, Goteborg, Sweden
    J Bone Miner Res 25:2690-700. 2010
    ..In contrast, it is essential for high-dose estradiol to reduce the growth plate height in adult mice and for reduction of longitudinal bone growth in elderly mice...
  32. ncbi request reprint Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo
    Ruijin Shao
    Division of Endocrinology, Department of Physiology and Pharmacology, Goteborg University, SE 40530 Goteborg, Sweden
    FEBS Lett 569:293-300. 2004
    ..These results indicate that the increased levels of SUMO-1 participate in the modulation of HIF-1alpha function through sumoylation in brain and heart...
  33. doi request reprint Maternal androgen excess reduces placental and fetal weights, increases placental steroidogenesis, and leads to long-term health effects in their female offspring
    Miao Sun
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Am J Physiol Endocrinol Metab 303:E1373-85. 2012
    ..We demonstrate for the first time that prenatal testosterone exposure alters placental steroidogenesis and leads to dysregulation of lipid metabolism in their adult female offspring...
  34. pmc The onset of human ectopic pregnancy demonstrates a differential expression of miRNAs and their cognate targets in the Fallopian tube
    Yi Feng
    Department of Integrative Medicine and Neurobiology, State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University Shanghai 200032, China Institute of Acupuncture Research WHO Collaborating Center for Traditional Medicine, Fudan University Shanghai 200032, China Institutes of Brain Science, Fudan University Shanghai 200032, China Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg Gothenburg 40530, Sweden
    Int J Clin Exp Pathol 7:64-79. 2013
    ..Our study suggests that changes in miRNA levels by the DICER-mediated miRNA-processing machinery result in aberrant expression of cell type-specific proteins that are potentially involved in the onset of tubal EP. ..
  35. pmc Hypothalamic neuroendocrine functions in rats with dihydrotestosterone-induced polycystic ovary syndrome: effects of low-frequency electro-acupuncture
    Yi Feng
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 4:e6638. 2009
    ..Repeated low-frequency EA normalized estrous cyclicity and restored GnRH and AR protein expression. These results may help explain the beneficial neuroendocrine effects of low-frequency EA in women with PCOS...
  36. ncbi request reprint Survival factors regulating ovarian apoptosis -- dependence on follicle differentiation
    Emilia Markström
    Department of Physiology, Goteborg University, PO Box 434, SE 405 30 Goteborg, Sweden
    Reproduction 123:23-30. 2002
    ..Relatively little is known about the period between the LH surge and ovulation; however, it has been suggested that at this stage progesterone acts as a survival factor...
  37. ncbi request reprint Gene expression analysis of prostate hyperplasia in mice overexpressing the prolactin gene specifically in the prostate
    Karin Dillner
    Department of Pharmacology and Physiology, Goteborg University, 405 30, Sweden
    Endocrinology 144:4955-66. 2003
    ....
  38. pmc Genetic modeling of ovarian phenotypes in mice for the study of human polycystic ovary syndrome
    Yi Feng
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg Gothenburg, Sweden Department of Integrative Medicine and Neurobiology, State Key Laboratory of Medical Neurobiology, Shanghai Medical College Institute of Acupuncture Research WHO Collaborating Center for Traditional Medicine Institutes of Brain Science, Fudan University Shanghai, China
    Am J Transl Res 5:15-20. 2013
    ....
  39. pmc Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6
    Rozita Shirazi
    Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, SE 405 30 Gothenburg, Sweden
    Proc Natl Acad Sci U S A 110:16199-204. 2013
    ..These data outline a previously unidentified role of the central IL-1 and IL-6 in mediating the anorexic and body weight loss effects of GLP-1 receptor activation. ..