Henrik Zetterberg

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. ncbi request reprint Neurochemical aftermath of amateur boxing
    Henrik Zetterberg
    Department of Experimental Neuroscience, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Arch Neurol 63:1277-80. 2006
  2. ncbi request reprint Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease
    Malin E Andersson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Int J Mol Med 20:233-9. 2007
  3. ncbi request reprint Cerebrospinal fluid neurofilament light levels in amyotrophic lateral sclerosis: impact of SOD1 genotype
    H Zetterberg
    Department of Neurochemistry and Psychiatry, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Eur J Neurol 14:1329-33. 2007
  4. doi request reprint Characterization of tau in cerebrospinal fluid using mass spectrometry
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, S 431 80 Molndal, Sweden
    J Proteome Res 7:2114-20. 2008
  5. doi request reprint Subcortical vascular dementia biomarker pattern in mild cognitive impairment
    Maria Bjerke
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Dement Geriatr Cogn Disord 28:348-56. 2009
  6. pmc Variability in the kinesin light chain 1 gene may influence risk of age-related cataract
    Malin E Andersson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Mol Vis 13:993-6. 2007
  7. pmc Fluid biomarkers in Alzheimer's disease - current concepts
    Christoffer Rosén
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg Mölndal, S 431 80, Molndal, Sweden
    Mol Neurodegener 8:20. 2013
  8. pmc Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice
    Kathryn Rogers
    EnVivo Pharmaceuticals, Inc, 500 Arsenal Street, Watertown, MA 02472, USA
    Mol Neurodegener 7:61. 2012
  9. pmc Changes in serum and cerebrospinal fluid cytokines in response to non-neurological surgery: an observational study
    Sara Bromander
    Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    J Neuroinflammation 9:242. 2012
  10. pmc Cerebrospinal fluid neurofilament light chain protein levels in subtypes of frontotemporal dementia
    Maria Landqvist Waldö
    Section of Geriatric Psychiatry, Department of Clinical Sciences, Lund University Hospital, Klinikgatan 22, Lund SE 221 85, Sweden
    BMC Neurol 13:54. 2013

Detail Information

Publications161 found, 100 shown here

  1. ncbi request reprint Neurochemical aftermath of amateur boxing
    Henrik Zetterberg
    Department of Experimental Neuroscience, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Arch Neurol 63:1277-80. 2006
    ..Little solid information is available on the possible risks for neuronal injury in amateur boxing...
  2. ncbi request reprint Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease
    Malin E Andersson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Int J Mol Med 20:233-9. 2007
    ..018). These findings support earlier indications that genetic variability in the KNS2 gene may play a role during early stages of AD pathogenesis...
  3. ncbi request reprint Cerebrospinal fluid neurofilament light levels in amyotrophic lateral sclerosis: impact of SOD1 genotype
    H Zetterberg
    Department of Neurochemistry and Psychiatry, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Eur J Neurol 14:1329-33. 2007
    ..518, P = 0.001). NF-L levels were lower in SOD1 mutation-associated ALS compared with SOD1 wild-type (wt) ALS (P = 0.03). In conclusion, CSF NF-L levels may provide both diagnostic and prognostic information, particularly in SOD1 wt ALS...
  4. doi request reprint Characterization of tau in cerebrospinal fluid using mass spectrometry
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, S 431 80 Molndal, Sweden
    J Proteome Res 7:2114-20. 2008
    ..Nineteen tryptic fragments of tau were detected, of which 16 are found in all tau isoforms while 3 represented unique tau isoforms. These results pave the way for clinical CSF studies on the tauopathies...
  5. doi request reprint Subcortical vascular dementia biomarker pattern in mild cognitive impairment
    Maria Bjerke
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Dement Geriatr Cogn Disord 28:348-56. 2009
    ..Mild cognitive impairment (MCI) is an etiologically unclear disorder. Cerebrospinal fluid (CSF) biomarkers are potentially useful for the differentiation between various MCI etiologies...
  6. pmc Variability in the kinesin light chain 1 gene may influence risk of age-related cataract
    Malin E Andersson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Mol Vis 13:993-6. 2007
    ..Here, we test the hypothesis that the rs8702 polymorphism in the kinesin light chain 1 gene (KLC1), previously linked to Alzheimer disease (AD), may play a role in cataractogenesis...
  7. pmc Fluid biomarkers in Alzheimer's disease - current concepts
    Christoffer Rosén
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg Mölndal, S 431 80, Molndal, Sweden
    Mol Neurodegener 8:20. 2013
    ..But before drawing any major conclusions, these results need to be verified in independent studies. ..
  8. pmc Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice
    Kathryn Rogers
    EnVivo Pharmaceuticals, Inc, 500 Arsenal Street, Watertown, MA 02472, USA
    Mol Neurodegener 7:61. 2012
    ..This approach, frequently called γ-secretase modulation, appears more promising and has lead to the development of new therapeutic candidates for disease modification in Alzheimer's disease...
  9. pmc Changes in serum and cerebrospinal fluid cytokines in response to non-neurological surgery: an observational study
    Sara Bromander
    Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    J Neuroinflammation 9:242. 2012
    ..Our aim was to compare inflammatory markers in serum and cerebrospinal fluid (CSF) before and after surgery and evaluate their association with measures of blood-brain barrier (BBB) integrity...
  10. pmc Cerebrospinal fluid neurofilament light chain protein levels in subtypes of frontotemporal dementia
    Maria Landqvist Waldö
    Section of Geriatric Psychiatry, Department of Clinical Sciences, Lund University Hospital, Klinikgatan 22, Lund SE 221 85, Sweden
    BMC Neurol 13:54. 2013
    ..NFL has been shown to be elevated in CSF in patients with FTD compared with AD and controls. Our hypothesis was that the levels of NFL also differ between the subtypes of FTD and may indicate the underlying pathological subtype...
  11. pmc Cerebrospinal fluid CXCL13 in Lyme neuroborreliosis and asymptomatic HIV infection
    Daniel Bremell
    Department of Infectious Medicine, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    BMC Neurol 13:2. 2013
    ..Like Borrelia burgdorferi, HIV also has neurotropic properties. Elevated serum CXCL13 concentrations have been reported in HIV patients, but data on CSF levels are limited...
  12. pmc The cerebrospinal fluid proteome in HIV infection: change associated with disease severity
    Thomas E Angel
    Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA
    Clin Proteomics 9:3. 2012
    ..abstract:..
  13. pmc Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans
    Henrik Zetterberg
    Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    PLoS ONE 6:e28263. 2011
    ..These data provide the first direct evidence in living humans that ischemia acutely increases Aβ levels in blood. The results point to the possibility that hypoxia may play a role in the amyloidogenic process of AD...
  14. pmc BACE1 gene variants do not influence BACE1 activity, levels of APP or Aβ isoforms in CSF in Alzheimer's disease
    Annica Sjölander
    Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, Sahlgrenska University Hospital, University of Gothenburg, Sweden
    Mol Neurodegener 5:37. 2010
    ..e., total-tau and phospho-tau181. Gene variants of BACE1 were neither associated with amyloid-related biomarkers, nor with markers for axonal degeneration in AD...
  15. pmc Effects of cerebrovascular disease on amyloid precursor protein metabolites in cerebrospinal fluid
    Per Selnes
    Department of Neurology, Akershus University Hospital, Norway
    Cerebrospinal Fluid Res 7:10. 2010
    ..Through measurements of CSF APP metabolite levels in patients with a wide range of WML volumes, this study aimed to determine how SVD influences APP metabolism...
  16. pmc Neuroinflammation in Lyme neuroborreliosis affects amyloid metabolism
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    BMC Neurol 10:51. 2010
    ..We have previously found altered cerebral amyloid metabolism in other neuroinflammatory conditions. To further elucidate this, we investigated amyloid metabolism in patients with Lyme neuroborreliosis (LNB)...
  17. pmc Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease
    Malin von Otter
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Bla Straket 15, 413 45 Gothenburg, Sweden
    BMC Med Genet 11:36. 2010
    ..Here, we hypothesize that variation in NFE2L2 and KEAP1, the genes encoding the two major regulators of the phase II response, may affect the risk of Parkinson's disease...
  18. pmc A novel Abeta isoform pattern in CSF reflects gamma-secretase inhibition in Alzheimer disease
    Erik Portelius
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, SE 431 80, Sweden
    Alzheimers Res Ther 2:7. 2010
    ..These Abeta isoforms may be novel sensitive biomarkers to monitor the biochemical effect in clinical trials. TRIAL REGISTRATION : Clinical Trials.gov NCT00244322...
  19. ncbi request reprint Intra-individual stability of CSF biomarkers for Alzheimer's disease over two years
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    J Alzheimers Dis 12:255-60. 2007
    ..Thus, even minor biochemical changes induced by treatment against AD should be detectable using these biomarkers, which bodes well for their usefulness as surrogate markers for drug efficacy in clinical trials...
  20. doi request reprint Association of APOE with age at onset of sporadic amyotrophic lateral sclerosis
    Henrik Zetterberg
    Department of Neurochemistry and Psychiatry, Sahlgrenska University Hospital, Goteborg University, Sweden
    J Neurol Sci 273:67-9. 2008
    ..027). These data support APOE epsilon4 as a subordinate contributing factor in ALS...
  21. doi request reprint Clinical proteomics in neurodegenerative disorders
    H Zetterberg
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Sweden
    Acta Neurol Scand 118:1-11. 2008
    ....
  22. pmc The szilard hypothesis on the nature of aging revisited
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, University of Gothenburg, S 413 45 Gothenburg, Sweden
    Genetics 182:3-9. 2009
    ..Here, we review Szilard's assumptions in the light of current knowledge on aging and reassess his mathematical model in an attempt to reach a conclusion on the relevance of Szilard's aging hypothesis today...
  23. pmc No neurochemical evidence for brain injury caused by heading in soccer
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Br J Sports Med 41:574-7. 2007
    ..The possible injurious effect to the brain of heading in soccer is a matter of discussion...
  24. ncbi request reprint Aspects of beta-amyloid as a biomarker for Alzheimer's disease
    Ulf Andreasson
    , , S 431 80, , , Sweden
    Biomark Med 1:59-78. 2007
    ....
  25. ncbi request reprint Increased frequency of combined methylenetetrahydrofolate reductase C677T and A1298C mutated alleles in spontaneously aborted embryos
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, Sweden
    Eur J Hum Genet 10:113-8. 2002
    ..The present finding of high prevalence of mutated MTHFR genotypes in spontaneously aborted embryos emphasises the potential protective role of periconceptional folic acid supplementation...
  26. pmc Methylenetetrahydrofolate reductase and transcobalamin genetic polymorphisms in human spontaneous abortion: biological and clinical implications
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, S 413 45 Goteborg, Sweden
    Reprod Biol Endocrinol 2:7. 2004
    ....
  27. ncbi request reprint Multiple EBNA1-binding sites within oriPI are required for EBNA1-dependent transactivation of the Epstein-Barr virus C promoter
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, S 413 45 Goteborg, Sweden
    Int J Oncol 25:693-6. 2004
    ....
  28. ncbi request reprint Increased cerebrospinal fluid levels of transforming growth factor-beta1 in Alzheimer's disease
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, S 413 45 Gothenburg, Sweden
    Neurosci Lett 367:194-6. 2004
    ..35; P = 0.020), although this correlation failed to reach significance in the AD group alone (r = -0.38; P = 0.099). Taken together, the data indicate that TGF-beta1 plays a role in the processes that affect amyloid metabolism in AD...
  29. ncbi request reprint [New investigations in suspected Creutzfeldt-Jakob disease. Analysis of 14-3-3 protein and T-tau in cerebrospinal fluid for safer diagnosis]
    Henrik Zetterberg
    Institutionen för klinisk neurovetenskap, Göteborgs Universitet, Sweden
    Lakartidningen 102:956-8, 960-1. 2005
    ..Here, we review how CSF T-tau and P-tau may aid in the diagnosis of CJD and illustrate this by presenting cases from routine clinical practice...
  30. ncbi request reprint Gene-gene interaction between fetal MTHFR 677C>T and transcobalamin 776C>G polymorphisms in human spontaneous abortion
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, S 413 45 Goteborg, Sweden
    Hum Reprod 18:1948-50. 2003
    ..It was hypothesized that there may be a significant interaction between MTHFR and TC genotypes which affects the pathogenesis of spontaneous abortion...
  31. ncbi request reprint The transcobalamin codon 259 polymorphism influences the risk of human spontaneous abortion
    H Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, S 413 45 Gothenburg, Sweden
    Hum Reprod 17:3033-6. 2002
    ..Transcobalamin (TC) transports vitamin B(12) to the tissues. The objective of the present investigation was to explore the putative association between the major TC genetic polymorphism (Pro259Arg) and human spontaneous abortion...
  32. ncbi request reprint Influence of the apolipoprotein E epsilon4 allele on human embryonic development
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, 41345 Gothenburg, Sweden
    Neurosci Lett 324:189-92. 2002
    ..005), suggesting that epsilon4 may have protective effects during embryogenesis. These protective effects might counterbalance the deleterious age-related effects of the epsilon4 allele in natural selection...
  33. ncbi request reprint No association between the MTHFR A1298C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic disease
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, Sweden
    Thromb Res 108:127-31. 2002
  34. doi request reprint Association of complement factor H Y402H gene polymorphism with Alzheimer's disease
    Madeleine Zetterberg
    Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Section of Ophthalmology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Am J Med Genet B Neuropsychiatr Genet 147:720-6. 2008
    ..The CFH 1277C allele may predispose patients for co-morbidity in AD and AMD...
  35. pmc Association of the RAGE G82S polymorphism with Alzheimer's disease
    Jonny Daborg
    Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 432, 405 30, Gothenburg, Sweden
    J Neural Transm 117:861-7. 2010
    ..4), and none of the AGER SNPs showed association with Abeta(42), T-tau, P-tau(181) or mini-mental state examination scores. The data speak for a weak, but significant effect of AGER on risk of AD...
  36. doi request reprint Evaluation of the cerebrospinal fluid amyloid-β1-42/amyloid-β1-40 ratio measured by alpha-LISA to distinguish Alzheimer's disease from other dementia disorders
    Magdalena Nutu
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Dement Geriatr Cogn Disord 36:99-110. 2013
    ..This study aimed to evaluate whether the cerebrospinal fluid (CSF) amyloid-β (Aβ)1-42/Aβ1-40 ratio, measured by a novel method, could improve the differential diagnosis of AD, DLB and PDD...
  37. doi request reprint Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract
    Malin von Otter
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Bla Straket 15, the Sahlgrenska Academy at University of Gothenburg, S 413 45 Gothenburg, Sweden
    Mech Ageing Dev 131:105-10. 2010
    ..009). Our findings do not support NFE2L2 or KEAP1 as susceptibility genes for AD or cataract. However, common variants of the NFE2L2 gene may affect disease progression, potentially altering clinically recognized disease onset...
  38. ncbi request reprint The PPAR-alpha gene in Alzheimer's disease: lack of replication of earlier association
    Annica Sjölander
    Department of Clinical Neuroscience, Unit of Neurochemistry, The Sahlgrenska Academy at Goteborg University, Sweden
    Neurobiol Aging 30:666-8. 2009
    ..We found no significant differences in genotype or allele distributions between AD patients and controls. None of the PPAR-alpha gene variants influenced markers for AD...
  39. ncbi request reprint Methylenetetrahydrofolate reductase genetic polymorphisms in patients with cataract
    Madeleine Zetterberg
    Institute of Clinical Neuroscience, Section of Ophthalmology, Sahlgrenska University Hospital, Goteborg University, Molndal, Sweden
    Am J Ophthalmol 140:932-4. 2005
    ..The level of homocysteine can be lowered by dietary intake of folate. A protective effect of folate supplementation has been reported against cataract. Here we investigate MTHFR polymorphisms in human cataract...
  40. doi request reprint Cerebrospinal fluid biomarkers of β-amyloid metabolism in multiple sclerosis
    Kristin Augutis
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Mult Scler 19:543-52. 2013
    ....
  41. doi request reprint A novel ARC gene polymorphism is associated with reduced risk of Alzheimer's disease
    Sara Landgren
    Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    J Neural Transm 119:833-42. 2012
    ..However, further investigation of the importance of this SNP for ARC function, ARC processing and the pathology of AD is needed...
  42. ncbi request reprint Do alcohol-dependent individuals with DRD2 A1 allele have an increased risk of relapse? A pilot study
    Angelica Dahlgren
    Department of Psychology, University of Gothenburg, PO Box 500, SE 405 30 Goteborg, Sweden
    Alcohol Alcohol 46:509-13. 2011
    ..On average, 1½ year after the end of the treatment program, subjects were re-interviewed by using the alcohol-related items from the Addiction Severity Index follow-up version...
  43. ncbi request reprint TAU haplotype and the Saitohin Q7R gene polymorphism do not influence CSF Tau in Alzheimer's disease and are not associated with frontotemporal dementia or Parkinson's disease
    Annica Johansson
    Department of Clinical Neuroscience, Unit of Neurochemistry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Neurodegener Dis 2:28-35. 2005
    ..A single nucleotide polymorphism in the STH gene has been suggested to be involved in sporadic AD and is in complete linkage disequilibrium with the TAU haplotype H1...
  44. doi request reprint Reward-related genes and personality traits in alcohol-dependent individuals: a pilot case control study
    Sara Landgren
    Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Neuropsychobiology 64:38-46. 2011
    ..In conclusion, this pilot study suggests that reward-related genes are associated with altered personality scores in type 1 alcohol dependence, which warrants future studies of these associations in larger study samples...
  45. doi request reprint Kinesin light chain 1 gene haplotypes in three conformational diseases
    Malin von Otter
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Neuromolecular Med 12:229-36. 2010
    ..Altogether, these results do not convincingly support KLC1 as a major susceptibility gene in any of the studied diseases, although there is a small effect of KLC1 in relation to cataract...
  46. doi request reprint Low cerebrospinal fluid sulfatide predicts progression of white matter lesions: The LADIS study
    Michael Jonsson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Sweden
    Dement Geriatr Cogn Disord 34:61-7. 2012
    ..The neurochemistry of ongoing WML is only partially known. We explored cerebrospinal fluid (CSF) substances as markers of brain tissue damage in relation to progression of WML rated on magnetic resonance imaging...
  47. doi request reprint Leukocyte telomere length (LTL) is reduced in stable mild cognitive impairment but low LTL is not associated with conversion to Alzheimer's disease: a pilot study
    Sofia Movérare-Skrtic
    Institute of Medicine, Department of Internal Medicine, The Sahlgrenska Academy, University of Gothenburg, S 41345 Gothenburg, Sweden
    Exp Gerontol 47:179-82. 2012
    ..Patients with stable MCI that did not progress to dementia had reduced LTL compared to controls, which might suggest a more marked biological aging as a cause of the cognitive symptoms in this group...
  48. pmc Increased CSF levels of phosphorylated neurofilament heavy protein following bout in amateur boxers
    Sanna Neselius
    Department of Orthopaedics, Sahlgrenska University Hospital, Gothenburg, Sweden Institution for Clinical Sciences, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 8:e81249. 2013
    ..The aims of this study were to find other biomarkers of mild TBI, which may help clinicians diagnose and monitor mild TBI, and to calculate the role of APOE ε4 allele genotype which has been associated with poor outcome after TBI...
  49. doi request reprint Cerebrospinal fluid brain injury biomarkers in children: a multicenter study
    Pashtun Shahim
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Neurochemistry, Sahlgrenska University Hospital Molndal, Sweden
    Pediatr Neurol 49:31-39.e2. 2013
    ....
  50. doi request reprint Olympic boxing is associated with elevated levels of the neuronal protein tau in plasma
    Sanna Neselius
    Department of Orthopaedics, Sahlgrenska University Hospital, Gothenburg, Sweden
    Brain Inj 27:425-33. 2013
    ..The aim of this study was to investigate if olympic (amateur) boxing is associated with elevation of brain injury biomarkers in peripheral blood compared to controls...
  51. doi request reprint Soluble amyloid precursor protein α and β in CSF in Alzheimer's disease
    Gunnar Brinkmalm
    Department of Psychiatry and Neurochemistry, Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Brain Res 1513:117-26. 2013
    ..Conclusion: Using high resolution MS, we show here for the first time that sAPPα in CSF ends at Q686 and K687. The findings also support the conclusion from several previous studies that sAPPα and sAPPβ levels are unaltered in AD...
  52. doi request reprint Mass spectrometric characterization of amyloid-β species in the 7PA2 cell model of Alzheimer's disease
    Erik Portelius
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 33:85-93. 2013
    ..The formation of these AβPP/Aβ peptides may have implications for the use of the 7PA2 cell line as a model for Aβ pathology. The enzyme(s) responsible for this particular BACE1-independent AβPP-processing remains to be identified...
  53. doi request reprint Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women
    Jaana Gustavsson
    Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden
    Atherosclerosis 220:486-92. 2012
    ..However, these associations may be modified by lifestyle factors. Therefore, we studied whether smoking, physical inactivity or overweight interact with APOE on cholesterol levels and CHD risk...
  54. doi request reprint Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal fluid
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, S 431 80 Molndal, Sweden
    Exp Neurol 223:351-8. 2010
    ....
  55. doi request reprint Association of nAChR gene haplotypes with heavy alcohol use and body mass
    Sara Landgren
    Institute of Neuroscience and Physiology, Department of Pharmacology, University of Gothenburg, Sweden
    Brain Res 1305:S72-9. 2009
    ....
  56. doi request reprint Genetic variation of the ghrelin signaling system in females with severe alcohol dependence
    Sara Landgren
    Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Alcohol Clin Exp Res 34:1519-24. 2010
    ....
  57. pmc Ubiquitin carboxyl-terminal esterase L1 (UCHL1) S18Y polymorphism in patients with cataracts
    Thiemo Rudolph
    Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Section of Ophthalmology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Ophthalmic Genet 32:75-9. 2011
    ..A protective role of the p.S18Y polymorphism of the UCHL1 gene has been shown in Parkinson`s disease. The current study aimed to examine possible effects on cataract formation...
  58. doi request reprint No association of VEGF polymorphims with Alzheimer's disease
    Sara Landgren
    Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Medicinaregatan 13A, Gothenburg, Sweden
    Neuromolecular Med 12:224-8. 2010
    ..No significant associations with risk for AD or any of the studied biomarkers could be found in this study, thus not supporting VEGF as being a major risk gene for AD...
  59. ncbi request reprint Serum but not cerebrospinal fluid levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) are increased in Alzheimer's disease
    Per Johansson
    Department of Neuropsychiatry, Skaraborg Hospital, SE 521 85 Falköping, Sweden Department of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, SE 413 45 Gothenburg, Sweden
    Psychoneuroendocrinology 38:1729-37. 2013
    ..Although insulin-like growth factor-I (IGF-I) is of importance for the adult function of the central nervous system (CNS), little is known of the significance of IGF-I in cerebrospinal fluid (CSF) in relation to Alzheimer's disease (AD)...
  60. doi request reprint Superoxide dismutase gene polymorphisms in patients with age-related cataract
    Dragana Celojevic
    Department of Clinical Neuroscience and Rehabilitation Ophthalmology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Ophthalmic Genet 34:140-5. 2013
    ..In this study, we investigated a number of disease-associated single nucleotide polymorphisms (SNPs) of SOD1, SOD2 and SOD3, in patients with age-related cataract...
  61. ncbi request reprint Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucoma
    Madeleine Zetterberg
    Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Ophthalmic Genet 28:47-50. 2007
    ..The purpose of the present study was to determine if hyperhomocysteinemia-associated polymorphisms of the methylenetetrahydrofolate reductase gene (MTHFR) are overrepresented in primary open-angle glaucoma...
  62. ncbi request reprint Cerebrospinal fluid biomarkers mirror rate of cognitive decline
    Sindre Rolstad
    Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Gothenburg University, Molndal, Sweden
    J Alzheimers Dis 34:949-56. 2013
    ..CSF predicted subsequent decline in more cognitive domains among MCI cases, but the impact was most pronounced in patients with dementia...
  63. doi request reprint Longitudinal cerebrospinal fluid biomarkers over four years in mild cognitive impairment
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 30:767-78. 2012
    ..Knowledge on these biomarkers and their trajectories may facilitate early diagnosis of AD and be useful in future clinical trials to track effects of disease modifying drugs...
  64. doi request reprint Extreme stability of chitotriosidase in cerebrospinal fluid makes it a suitable marker for microglial activation in clinical trials
    Bob Olsson
    Department of Psychiatry and Neurochemistry, University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 32:273-6. 2012
    ..Thus, chitotriosidase may be useful in clinical trials where microglia is targeted or as a safety biomarker in other trials where the brain is a bystander organ...
  65. doi request reprint Cerebrospinal fluid matrix metalloproteinases and tissue inhibitor of metalloproteinases in combination with subcortical and cortical biomarkers in vascular dementia and Alzheimer's disease
    Maria Bjerke
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 27:665-76. 2011
    ..The CSF biomarkers reflecting AD pathology (T-tau, P-tau(181), and Aβ(1-42)), white matter lesions (NF-L and MBP) and matrix remodeling (MMP-9 and TIMP-1) perform well in differentiating between SVD and AD patients...
  66. doi request reprint An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid β and amyloid precursor protein in human and cat cerebrospinal fluid
    Gunnar Brinkmalm
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    J Mass Spectrom 47:591-603. 2012
    ..We here describe a detailed characterization of endogenous APP/Aβ peptide species in CSF by using an online top-down MS-based method...
  67. doi request reprint Proteomic profiling of cerebrospinal fluid in parkinsonian disorders
    Radu Constantinescu
    Institute of Neuroscience and Physiology, Department of Neurology, The Sahlgrenska Academy at the University of Gothenburg, 413 45 Goteborg, Sweden
    Parkinsonism Relat Disord 16:545-9. 2010
    ..However, they could not differentiate PD patients from controls. As none of these changes were APD subgroup-specific, they most likely reflect the intensity and/or extent of the neurodegenerative process in general...
  68. ncbi request reprint High education may offer protection against tauopathy in patients with mild cognitive impairment
    Sindre Rolstad
    Institute of Neuroscience and Physiology, Section for Neurochemistry and Psychiatry, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    J Alzheimers Dis 21:221-8. 2010
    ..Also, educational level predicted a significant proportion of the total variance in t-tau concentrations. Our results suggest that higher education may offer protection against tauopathy...
  69. doi request reprint Converging pathways of chromogranin and amyloid metabolism in the brain
    Niklas Mattsson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Gothenburg and Mölndal, Sweden
    J Alzheimers Dis 20:1039-49. 2010
    ..Cell medium from BACE1-inhibited cells had decreased CgB levels. These results suggest that a large part of AbetaPP in the human central nervous system is processed in the regulated secretory pathway of neurons...
  70. doi request reprint Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?
    Annika Ohrfelt
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Neurosci Lett 450:332-5. 2009
    ..The lower alpha-syn levels in AD, as well as the association of alpha-syn reduction with AD severity, approximated by MMSE, suggests that it may be a general marker of synapse loss, a hypothesis that warrants further investigation...
  71. ncbi request reprint Apolipoprotein E polymorphisms in patients with primary open-angle glaucoma
    Madeleine Zetterberg
    Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Am J Ophthalmol 143:1059-60. 2007
    ..To investigate apolipoprotein E (APOE) polymorphisms, which are known to influence the risk of Alzheimer disease (AD), in patients with primary open-angle glaucoma (POAG)...
  72. pmc Evaluating amyloid-β oligomers in cerebrospinal fluid as a biomarker for Alzheimer's disease
    Mikko Hölttä
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    PLoS ONE 8:e66381. 2013
    ..These results indicate that presence of high or measurable Aβo levels in CSF is clearly associated with AD, but the overlap is too large for the test to have any diagnostic potential on its own. ..
  73. ncbi request reprint Complement gene single nucleotide polymorphisms and biomarker endophenotypes of Alzheimer's disease
    Jonny Daborg
    Institute of Neuroscience and Physiology, Department of Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    J Alzheimers Dis 35:51-7. 2013
    ..023) and Mini-Mental State Examination scores (p = 0.012), both of which may be considered markers of disease intensity/severity...
  74. doi request reprint Cerebrospinal fluid levels of heart fatty acid binding protein are elevated prodromally in Alzheimer's disease and vascular dementia
    Bob Olsson
    Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 34:673-9. 2013
    ..In conclusion, HFABP seems to be a stable CSF biomarker that reflects neuronal cell death in several neurodegenerative disorders, including early stages of AD and VaD...
  75. doi request reprint Aβ1-15/16 as a potential diagnostic marker in neurodegenerative diseases
    Magdalena Nutu
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital Molndal, S 431 80, Molndal, Sweden
    Neuromolecular Med 15:169-79. 2013
    ..We found reduced levels of Aβ1-15 in parkinsonian disease groups. The molecular mechanism behind this reduction is at present unknown...
  76. pmc Amyloid-β(1-15/16) as a marker for γ-secretase inhibition in Alzheimer's disease
    Erik Portelius
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 31:335-41. 2012
    ..Our data shows that CSF levels of Aβ(1-15/16) increase during treatment with semagacestat supporting its feasibility as a pharmacodynamic biomarker for drug candidates aimed at inhibiting γ-secretase-mediated AβPP-processing...
  77. doi request reprint The application of cerebrospinal fluid biomarkers in early diagnosis of Alzheimer disease
    Kaj Blennow
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Mölndal Campus, Molndal, Sweden
    Med Clin North Am 97:369-76. 2013
    ..Recent findings in sporadic and genetic preclinical AD are also discussed and, more specifically, what the biomarkers have taught us on the sequence of events in the pathogenic process underlying AD...
  78. ncbi request reprint Proteomics/peptidomics tools to find CSF biomarkers for neurodegenerative diseases
    Ann Westman-Brinkmalm
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neuochemistry, The Sahlgrenska Academy at Goteborg University, Sweden
    Front Biosci (Landmark Ed) 14:1793-806. 2009
    ..In this review we discuss our experience in the field of neuroproteomics/peptidomics, with special focus on biomarker discovery studies that have been performed on CSF samples from well-defined patient and control populations...
  79. doi request reprint Cerebrospinal fluid levels of complement proteins C3, C4 and CR1 in Alzheimer's disease
    Jonny Daborg
    Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 405 30, Gothenburg, Sweden
    J Neural Transm 119:789-97. 2012
    ..These results provide support for aberrant complement regulation as a part in the AD process, but the changes are not diagnostically useful...
  80. doi request reprint Evaluation of the performance of novel Aβ isoforms as theragnostic markers in Alzheimer's disease: from the cell to the patient
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Neurodegener Dis 10:138-40. 2012
    ....
  81. doi request reprint Cerebrospinal fluid profiles of amyloid β-related biomarkers in Alzheimer's disease
    Christoffer Rosén
    Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Neuromolecular Med 14:65-73. 2012
    ....
  82. doi request reprint Cerebrospinal fluid microglial markers in Alzheimer's disease: elevated chitotriosidase activity but lack of diagnostic utility
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, S 431 80 Molndal, Sweden
    Neuromolecular Med 13:151-9. 2011
    ..Microglial markers are unlikely to be useful for AD diagnosis, but might be useful for identification of distinct subgroups of patients, and for the development and implementation of drugs targeting microglial pathology...
  83. ncbi request reprint Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer's disease
    Annica Johansson
    Department of Clinical Neuroscience, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Hum Genet 114:581-7. 2004
    ..Our results provide an important independent replication of previous findings, supporting the existence of CYP46A1 sequence variants that contribute to variability in beta-amyloid metabolism...
  84. doi request reprint Reduced levels of amyloid-beta-binding proteins in cerebrospinal fluid from Alzheimer's disease patients
    Sara F Hansson
    Neurochemical Laboratory, Department of Neuroscience and Physiology, Section of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital Molndal, Molndal, Sweden
    J Alzheimers Dis 16:389-97. 2009
    ..015). Positive correlations between Abeta(1-42) and beta-trace, CysC and TTR, respectively, were seen only in the AD group, suggesting that deficient Abeta-binding capacity in CSF may contribute to the amyloidogenic process in AD...
  85. doi request reprint Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's disease
    Annika Thorsell
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Brain Res 1362:13-22. 2010
    ..These results together suggest that cerebrospinal fluid neurogranin might be valuable together with the established AD biomarkers in the early diagnosis of AD and warrants further studies to determine the diagnostic value of neurogranin...
  86. doi request reprint Amyloid-β metabolism in Niemann-Pick C disease models and patients
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Gothenburg, Sweden
    Metab Brain Dis 27:573-85. 2012
    ..The preliminary findings from NPC cats suggest that treatment with cyclodextrin may have an impact on APP processing pathways. CSF Aβ, sAPP and tau biomarkers were dynamically altered over time in human NPC patients...
  87. doi request reprint Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid β42
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Molndal, Sweden
    Biomark Med 6:409-17. 2012
    ..We describe possible technical approaches, focusing on a selected reaction monitoring mass spectrometry assay as a candidate reference method for quantification of CSF amyloid β42...
  88. pmc BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    PLoS ONE 7:e31084. 2012
    ..The described CSF Aβ pattern may be used as a pharmacodynamic fingerprint to detect biochemical effects of BACE1-therapies in clinical trials, which might accelerate development of novel therapies...
  89. doi request reprint No association of LOXL1 gene polymorphisms with Alzheimer's disease
    Alexandra Abramsson
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Neuromolecular Med 13:160-6. 2011
    ..No evidence for associations of these polymorphisms with risk for AD or any of the studied CSF biomarkers measured was found. These results do not support LOXL1 as being a major risk gene for AD...
  90. doi request reprint SILAC zebrafish for quantitative analysis of protein turnover and tissue regeneration
    Ann Westman-Brinkmalm
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Sweden
    J Proteomics 75:425-34. 2011
    ..This newly developed SILAC zebrafish model constitutes a novel tool to analyze tissue regeneration in an animal model amenable to genetic and pharmacologic manipulation...
  91. pmc Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease
    Madeleine Zetterberg
    Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Mol Neurodegener 5:11. 2010
    ..82 ([95% CI 0.55-1.24], P = 0.35) was obtained for a positive UCHL1 allele A carrier status. The present study thus do not support a protective effect of the UCHL1 S18Y polymorphism against AD...
  92. pmc Amyloid and tau cerebrospinal fluid biomarkers in HIV infection
    Magnus Gisslen
    Department of Infectious Diseases, University of Gothenburg, Sahlgrenska University Hospital, SE 416 85 Gothenburg, Sweden
    BMC Neurol 9:63. 2009
    ..Because of the emerging intersections of HIV infection and Alzheimer's disease, we examined cerebrospinal fluid (CSF) biomarkers related of amyloid and tau metabolism in HIV-infected patients...
  93. ncbi request reprint Longitudinal stability of CSF biomarkers in Alzheimer's disease
    Kaj Blennow
    Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, Sweden
    Neurosci Lett 419:18-22. 2007
    ....
  94. doi request reprint Converging molecular pathways in human neural development and degeneration
    Niklas Mattsson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at University of Gothenburg, Göteborg Mölndal, Sweden
    Neurosci Res 66:330-2. 2010
    ..Tau phosphorylation in Alzheimer's disease may be a physiological response to Alzheimer-associated synaptotoxicity...
  95. pmc Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, SE 431 80 Molndal, Sweden
    Neurodegener Dis 6:258-62. 2009
    ..g. Abeta1-15 and Abeta1-16), and that the levels of these shorter isoforms are elevated in media from cells that have been treated with gamma-secretase inhibitors...
  96. doi request reprint A novel pathway for amyloid precursor protein processing
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, S 431 80 Molndal, Sweden
    Neurobiol Aging 32:1090-8. 2011
    ....
  97. ncbi request reprint Characterization of amyloid beta peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, S 431 80 Molndal, Sweden
    J Proteome Res 6:4433-9. 2007
    ..Finally, we report the finding of two novel Abeta peptides (Abeta2-17 and Abeta3-17)...
  98. doi request reprint CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment
    Niklas Mattsson
    Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    JAMA 302:385-93. 2009
    ....
  99. pmc Identification of novel α-synuclein isoforms in human brain tissue by using an online nanoLC-ESI-FTICR-MS method
    Annika Ohrfelt
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, S 43180 Mölndal, Sweden
    Neurochem Res 36:2029-42. 2011
    ..Quantification of α-syn in each brain tissue fraction was performed using a novel enzyme-linked immunosorbent assay (ELISA)...
  100. pmc Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease
    Erik Portelius
    Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Acta Neuropathol 120:185-93. 2010
    ..No prominent differences in Abeta isoform patterns between FAD and SAD patients were seen, underscoring the similarity in the amyloid pathology of these two disease entities...
  101. doi request reprint Identification of novel APP/Abeta isoforms in human cerebrospinal fluid
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, Molndal, Sweden
    Neurodegener Dis 6:87-94. 2009
    ..A lot of research has focused on Abeta production and the neurotoxic 42-amino-acid form of Abeta (Abeta1-42), while less is known about the nonamyloidogenic pathway and how Abeta is degraded...