Research Topics
Genomes and Genes
| Henrik ZetterbergSummaryAffiliation: Sahlgrenska University Hospital Country: Sweden Publications
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Detail Information
Publications
Neurochemical aftermath of amateur boxingHenrik Zetterberg
Department of Experimental Neuroscience, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Arch Neurol 63:1277-80. 2006..Little solid information is available on the possible risks for neuronal injury in amateur boxing...- Kinesin gene variability may affect tau phosphorylation in early Alzheimer's diseaseMalin E Andersson
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Int J Mol Med 20:233-9. 2007..018). These findings support earlier indications that genetic variability in the KNS2 gene may play a role during early stages of AD pathogenesis... - Cerebrospinal fluid neurofilament light levels in amyotrophic lateral sclerosis: impact of SOD1 genotypeH Zetterberg
Department of Neurochemistry and Psychiatry, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
Eur J Neurol 14:1329-33. 2007..518, P = 0.001). NF-L levels were lower in SOD1 mutation-associated ALS compared with SOD1 wild-type (wt) ALS (P = 0.03). In conclusion, CSF NF-L levels may provide both diagnostic and prognostic information, particularly in SOD1 wt ALS... 
Characterization of tau in cerebrospinal fluid using mass spectrometryErik Portelius
Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, S 431 80 Molndal, Sweden
J Proteome Res 7:2114-20. 2008..Nineteen tryptic fragments of tau were detected, of which 16 are found in all tau isoforms while 3 represented unique tau isoforms. These results pave the way for clinical CSF studies on the tauopathies...- Subcortical vascular dementia biomarker pattern in mild cognitive impairmentMaria Bjerke
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
Dement Geriatr Cogn Disord 28:348-56. 2009..Mild cognitive impairment (MCI) is an etiologically unclear disorder. Cerebrospinal fluid (CSF) biomarkers are potentially useful for the differentiation between various MCI etiologies... 
The cerebrospinal fluid proteome in HIV infection: change associated with disease severityThomas E Angel
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA
Clin Proteomics 9:3. 2012..abstract:..- Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humansHenrik Zetterberg
Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
PLoS ONE 6:e28263. 2011..These data provide the first direct evidence in living humans that ischemia acutely increases Aβ levels in blood. The results point to the possibility that hypoxia may play a role in the amyloidogenic process of AD... - BACE1 gene variants do not influence BACE1 activity, levels of APP or Aβ isoforms in CSF in Alzheimer's diseaseAnnica Sjölander
Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, Sahlgrenska University Hospital, University of Gothenburg, Sweden
Mol Neurodegener 5:37. 2010..e., total-tau and phospho-tau181. Gene variants of BACE1 were neither associated with amyloid-related biomarkers, nor with markers for axonal degeneration in AD... - Effects of cerebrovascular disease on amyloid precursor protein metabolites in cerebrospinal fluidPer Selnes
Department of Neurology, Akershus University Hospital, Norway
Cerebrospinal Fluid Res 7:10. 2010..Through measurements of CSF APP metabolite levels in patients with a wide range of WML volumes, this study aimed to determine how SVD influences APP metabolism... - Neuroinflammation in Lyme neuroborreliosis affects amyloid metabolismNiklas Mattsson
Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
BMC Neurol 10:51. 2010..We have previously found altered cerebral amyloid metabolism in other neuroinflammatory conditions. To further elucidate this, we investigated amyloid metabolism in patients with Lyme neuroborreliosis (LNB)... - Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's diseaseMalin von Otter
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Bla Straket 15, 413 45 Gothenburg, Sweden
BMC Med Genet 11:36. 2010..Here, we hypothesize that variation in NFE2L2 and KEAP1, the genes encoding the two major regulators of the phase II response, may affect the risk of Parkinson's disease... - A novel Abeta isoform pattern in CSF reflects gamma-secretase inhibition in Alzheimer diseaseErik Portelius
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, SE 431 80, Sweden
Alzheimers Res Ther 2:7. 2010..These Abeta isoforms may be novel sensitive biomarkers to monitor the biochemical effect in clinical trials. TRIAL REGISTRATION : Clinical Trials.gov NCT00244322... - [New investigations in suspected Creutzfeldt-Jakob disease. Analysis of 14-3-3 protein and T-tau in cerebrospinal fluid for safer diagnosis]Henrik Zetterberg
Institutionen för klinisk neurovetenskap, Göteborgs Universitet, Sweden
Lakartidningen 102:956-8, 960-1. 2005..Here, we review how CSF T-tau and P-tau may aid in the diagnosis of CJD and illustrate this by presenting cases from routine clinical practice... - No neurochemical evidence for brain injury caused by heading in soccerHenrik Zetterberg
Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Br J Sports Med 41:574-7. 2007..The possible injurious effect to the brain of heading in soccer is a matter of discussion... - Increased frequency of combined methylenetetrahydrofolate reductase C677T and A1298C mutated alleles in spontaneously aborted embryosHenrik Zetterberg
Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, Sweden
Eur J Hum Genet 10:113-8. 2002..The present finding of high prevalence of mutated MTHFR genotypes in spontaneously aborted embryos emphasises the potential protective role of periconceptional folic acid supplementation... - The szilard hypothesis on the nature of aging revisitedHenrik Zetterberg
Department of Clinical Chemistry and Transfusion Medicine, University of Gothenburg, S 413 45 Gothenburg, Sweden
Genetics 182:3-9. 2009..Here, we review Szilard's assumptions in the light of current knowledge on aging and reassess his mathematical model in an attempt to reach a conclusion on the relevance of Szilard's aging hypothesis today... - Association of APOE with age at onset of sporadic amyotrophic lateral sclerosisHenrik Zetterberg
Department of Neurochemistry and Psychiatry, Sahlgrenska University Hospital, Goteborg University, Sweden
J Neurol Sci 273:67-9. 2008..027). These data support APOE epsilon4 as a subordinate contributing factor in ALS... - Clinical proteomics in neurodegenerative disordersH Zetterberg
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Sweden
Acta Neurol Scand 118:1-11. 2008.... - Intra-individual stability of CSF biomarkers for Alzheimer's disease over two yearsHenrik Zetterberg
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
J Alzheimers Dis 12:255-60. 2007..Thus, even minor biochemical changes induced by treatment against AD should be detectable using these biomarkers, which bodes well for their usefulness as surrogate markers for drug efficacy in clinical trials... - Aspects of beta-amyloid as a biomarker for Alzheimer's diseaseUlf Andreasson
, , S 431 80, , , Sweden
Biomark Med 1:59-78. 2007.... - Increased cerebrospinal fluid levels of transforming growth factor-beta1 in Alzheimer's diseaseHenrik Zetterberg
Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, S 413 45 Gothenburg, Sweden
Neurosci Lett 367:194-6. 2004..35; P = 0.020), although this correlation failed to reach significance in the AD group alone (r = -0.38; P = 0.099). Taken together, the data indicate that TGF-beta1 plays a role in the processes that affect amyloid metabolism in AD... - Multiple EBNA1-binding sites within oriPI are required for EBNA1-dependent transactivation of the Epstein-Barr virus C promoterHenrik Zetterberg
Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, S 413 45 Goteborg, Sweden
Int J Oncol 25:693-6. 2004.... - Influence of the apolipoprotein E epsilon4 allele on human embryonic developmentHenrik Zetterberg
Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, 41345 Gothenburg, Sweden
Neurosci Lett 324:189-92. 2002..005), suggesting that epsilon4 may have protective effects during embryogenesis. These protective effects might counterbalance the deleterious age-related effects of the epsilon4 allele in natural selection... - The transcobalamin codon 259 polymorphism influences the risk of human spontaneous abortionH Zetterberg
Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, S 413 45 Gothenburg, Sweden
Hum Reprod 17:3033-6. 2002..Transcobalamin (TC) transports vitamin B(12) to the tissues. The objective of the present investigation was to explore the putative association between the major TC genetic polymorphism (Pro259Arg) and human spontaneous abortion... - No association between the MTHFR A1298C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic diseaseHenrik Zetterberg
Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, , Sweden
Thromb Res 108:127-31. 2002 - Methylenetetrahydrofolate reductase and transcobalamin genetic polymorphisms in human spontaneous abortion: biological and clinical implicationsHenrik Zetterberg
Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, S 413 45 Goteborg, Sweden
Reprod Biol Endocrinol 2:7. 2004.... - Gene-gene interaction between fetal MTHFR 677C>T and transcobalamin 776C>G polymorphisms in human spontaneous abortionHenrik Zetterberg
Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, S 413 45 Goteborg, Sweden
Hum Reprod 18:1948-50. 2003..It was hypothesized that there may be a significant interaction between MTHFR and TC genotypes which affects the pathogenesis of spontaneous abortion... - Association of the RAGE G82S polymorphism with Alzheimer's diseaseJonny Daborg
Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 432, 405 30, Gothenburg, Sweden
J Neural Transm 117:861-7. 2010..4), and none of the AGER SNPs showed association with Abeta(42), T-tau, P-tau(181) or mini-mental state examination scores. The data speak for a weak, but significant effect of AGER on risk of AD... - Association of complement factor H Y402H gene polymorphism with Alzheimer's diseaseMadeleine Zetterberg
Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Section of Ophthalmology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
Am J Med Genet B Neuropsychiatr Genet 147:720-6. 2008..The CFH 1277C allele may predispose patients for co-morbidity in AD and AMD... - Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataractMalin von Otter
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Bla Straket 15, the Sahlgrenska Academy at University of Gothenburg, S 413 45 Gothenburg, Sweden
Mech Ageing Dev 131:105-10. 2010..009). Our findings do not support NFE2L2 or KEAP1 as susceptibility genes for AD or cataract. However, common variants of the NFE2L2 gene may affect disease progression, potentially altering clinically recognized disease onset... - The PPAR-alpha gene in Alzheimer's disease: lack of replication of earlier associationAnnica Sjölander
Department of Clinical Neuroscience, Unit of Neurochemistry, The Sahlgrenska Academy at Goteborg University, Sweden
Neurobiol Aging 30:666-8. 2009..We found no significant differences in genotype or allele distributions between AD patients and controls. None of the PPAR-alpha gene variants influenced markers for AD... - Variability in the kinesin light chain 1 gene may influence risk of age-related cataractMalin E Andersson
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Mol Vis 13:993-6. 2007..Here, we test the hypothesis that the rs8702 polymorphism in the kinesin light chain 1 gene (KLC1), previously linked to Alzheimer disease (AD), may play a role in cataractogenesis... - A novel ARC gene polymorphism is associated with reduced risk of Alzheimer's diseaseSara Landgren
Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
J Neural Transm 119:833-42. 2012..However, further investigation of the importance of this SNP for ARC function, ARC processing and the pathology of AD is needed... - Do alcohol-dependent individuals with DRD2 A1 allele have an increased risk of relapse? A pilot studyAngelica Dahlgren
Department of Psychology, University of Gothenburg, PO Box 500, SE 405 30 Goteborg, Sweden
Alcohol Alcohol 46:509-13. 2011..On average, 1½ year after the end of the treatment program, subjects were re-interviewed by using the alcohol-related items from the Addiction Severity Index follow-up version... - Kinesin light chain 1 gene haplotypes in three conformational diseasesMalin von Otter
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Neuromolecular Med 12:229-36. 2010..Altogether, these results do not convincingly support KLC1 as a major susceptibility gene in any of the studied diseases, although there is a small effect of KLC1 in relation to cataract... - Reward-related genes and personality traits in alcohol-dependent individuals: a pilot case control studySara Landgren
Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Neuropsychobiology 64:38-46. 2011..In conclusion, this pilot study suggests that reward-related genes are associated with altered personality scores in type 1 alcohol dependence, which warrants future studies of these associations in larger study samples... - TAU haplotype and the Saitohin Q7R gene polymorphism do not influence CSF Tau in Alzheimer's disease and are not associated with frontotemporal dementia or Parkinson's diseaseAnnica Johansson
Department of Clinical Neuroscience, Unit of Neurochemistry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Neurodegener Dis 2:28-35. 2005..A single nucleotide polymorphism in the STH gene has been suggested to be involved in sporadic AD and is in complete linkage disequilibrium with the TAU haplotype H1... - Low cerebrospinal fluid sulfatide predicts progression of white matter lesions: The LADIS studyMichael Jonsson
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Sweden
Dement Geriatr Cogn Disord 34:61-7. 2012..The neurochemistry of ongoing WML is only partially known. We explored cerebrospinal fluid (CSF) substances as markers of brain tissue damage in relation to progression of WML rated on magnetic resonance imaging... - Leukocyte telomere length (LTL) is reduced in stable mild cognitive impairment but low LTL is not associated with conversion to Alzheimer's disease: a pilot studySofia Movérare-Skrtic
Institute of Medicine, Department of Internal Medicine, The Sahlgrenska Academy, University of Gothenburg, S 41345 Gothenburg, Sweden
Exp Gerontol 47:179-82. 2012..Patients with stable MCI that did not progress to dementia had reduced LTL compared to controls, which might suggest a more marked biological aging as a cause of the cognitive symptoms in this group... - Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and womenJaana Gustavsson
Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden
Atherosclerosis 220:486-92. 2012..However, these associations may be modified by lifestyle factors. Therefore, we studied whether smoking, physical inactivity or overweight interact with APOE on cholesterol levels and CHD risk... - Association of nAChR gene haplotypes with heavy alcohol use and body massSara Landgren
Institute of Neuroscience and Physiology, Department of Pharmacology, University of Gothenburg, Sweden
Brain Res 1305:S72-9. 2009.... - Ubiquitin carboxyl-terminal esterase L1 (UCHL1) S18Y polymorphism in patients with cataractsThiemo Rudolph
Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Section of Ophthalmology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
Ophthalmic Genet 32:75-9. 2011..A protective role of the p.S18Y polymorphism of the UCHL1 gene has been shown in Parkinson`s disease. The current study aimed to examine possible effects on cataract formation... - No association of VEGF polymorphims with Alzheimer's diseaseSara Landgren
Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Medicinaregatan 13A, Gothenburg, Sweden
Neuromolecular Med 12:224-8. 2010..No significant associations with risk for AD or any of the studied biomarkers could be found in this study, thus not supporting VEGF as being a major risk gene for AD... - Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal fluidErik Portelius
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, S 431 80 Molndal, Sweden
Exp Neurol 223:351-8. 2010.... - Genetic variation of the ghrelin signaling system in females with severe alcohol dependenceSara Landgren
Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Alcohol Clin Exp Res 34:1519-24. 2010.... - Extreme stability of chitotriosidase in cerebrospinal fluid makes it a suitable marker for microglial activation in clinical trialsBob Olsson
Department of Psychiatry and Neurochemistry, University of Gothenburg, Molndal, Sweden
J Alzheimers Dis 32:273-6. 2012..Thus, chitotriosidase may be useful in clinical trials where microglia is targeted or as a safety biomarker in other trials where the brain is a bystander organ... - Cerebrospinal fluid matrix metalloproteinases and tissue inhibitor of metalloproteinases in combination with subcortical and cortical biomarkers in vascular dementia and Alzheimer's diseaseMaria Bjerke
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
J Alzheimers Dis 27:665-76. 2011..The CSF biomarkers reflecting AD pathology (T-tau, P-tau(181), and Aβ(1-42)), white matter lesions (NF-L and MBP) and matrix remodeling (MMP-9 and TIMP-1) perform well in differentiating between SVD and AD patients... - An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid β and amyloid precursor protein in human and cat cerebrospinal fluidGunnar Brinkmalm
Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
J Mass Spectrom 47:591-603. 2012..We here describe a detailed characterization of endogenous APP/Aβ peptide species in CSF by using an online top-down MS-based method... - High education may offer protection against tauopathy in patients with mild cognitive impairmentSindre Rolstad
Institute of Neuroscience and Physiology, Section for Neurochemistry and Psychiatry, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
J Alzheimers Dis 21:221-8. 2010..Also, educational level predicted a significant proportion of the total variance in t-tau concentrations. Our results suggest that higher education may offer protection against tauopathy... - Proteomic profiling of cerebrospinal fluid in parkinsonian disordersRadu Constantinescu
Institute of Neuroscience and Physiology, Department of Neurology, The Sahlgrenska Academy at the University of Gothenburg, 413 45 Goteborg, Sweden
Parkinsonism Relat Disord 16:545-9. 2010..However, they could not differentiate PD patients from controls. As none of these changes were APD subgroup-specific, they most likely reflect the intensity and/or extent of the neurodegenerative process in general... - Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?Annika Ohrfelt
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
Neurosci Lett 450:332-5. 2009..The lower alpha-syn levels in AD, as well as the association of alpha-syn reduction with AD severity, approximated by MMSE, suggests that it may be a general marker of synapse loss, a hypothesis that warrants further investigation... - Converging pathways of chromogranin and amyloid metabolism in the brainNiklas Mattsson
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Gothenburg and Mölndal, Sweden
J Alzheimers Dis 20:1039-49. 2010..Cell medium from BACE1-inhibited cells had decreased CgB levels. These results suggest that a large part of AbetaPP in the human central nervous system is processed in the regulated secretory pathway of neurons... - Apolipoprotein E polymorphisms in patients with primary open-angle glaucomaMadeleine Zetterberg
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
Am J Ophthalmol 143:1059-60. 2007..To investigate apolipoprotein E (APOE) polymorphisms, which are known to influence the risk of Alzheimer disease (AD), in patients with primary open-angle glaucoma (POAG)... - Proteomics/peptidomics tools to find CSF biomarkers for neurodegenerative diseasesAnn Westman-Brinkmalm
Institute of Neuroscience and Physiology, Department of Psychiatry and Neuochemistry, The Sahlgrenska Academy at Goteborg University, Sweden
Front Biosci 14:1793-806. 2009..In this review we discuss our experience in the field of neuroproteomics/peptidomics, with special focus on biomarker discovery studies that have been performed on CSF samples from well-defined patient and control populations... - Cerebrospinal fluid levels of complement proteins C3, C4 and CR1 in Alzheimer's diseaseJonny Daborg
Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 405 30, Gothenburg, Sweden
J Neural Transm 119:789-97. 2012..These results provide support for aberrant complement regulation as a part in the AD process, but the changes are not diagnostically useful... - Evaluation of the performance of novel Aβ isoforms as theragnostic markers in Alzheimer's disease: from the cell to the patientErik Portelius
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
Neurodegener Dis 10:138-40. 2012.... - Cerebrospinal fluid profiles of amyloid β-related biomarkers in Alzheimer's diseaseChristoffer Rosén
Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
Neuromolecular Med 14:65-73. 2012.... - Cerebrospinal fluid microglial markers in Alzheimer's disease: elevated chitotriosidase activity but lack of diagnostic utilityNiklas Mattsson
Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, S 431 80 Molndal, Sweden
Neuromolecular Med 13:151-9. 2011..Microglial markers are unlikely to be useful for AD diagnosis, but might be useful for identification of distinct subgroups of patients, and for the development and implementation of drugs targeting microglial pathology... - Reduced levels of amyloid-beta-binding proteins in cerebrospinal fluid from Alzheimer's disease patientsSara F Hansson
Neurochemical Laboratory, Department of Neuroscience and Physiology, Section of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital Molndal, Molndal, Sweden
J Alzheimers Dis 16:389-97. 2009..015). Positive correlations between Abeta(1-42) and beta-trace, CysC and TTR, respectively, were seen only in the AD group, suggesting that deficient Abeta-binding capacity in CSF may contribute to the amyloidogenic process in AD... - Methylenetetrahydrofolate reductase genetic polymorphisms in patients with cataractMadeleine Zetterberg
Institute of Clinical Neuroscience, Section of Ophthalmology, Sahlgrenska University Hospital, Goteborg University, Molndal, Sweden
Am J Ophthalmol 140:932-4. 2005..The level of homocysteine can be lowered by dietary intake of folate. A protective effect of folate supplementation has been reported against cataract. Here we investigate MTHFR polymorphisms in human cataract... - Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucomaMadeleine Zetterberg
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
Ophthalmic Genet 28:47-50. 2007..The purpose of the present study was to determine if hyperhomocysteinemia-associated polymorphisms of the methylenetetrahydrofolate reductase gene (MTHFR) are overrepresented in primary open-angle glaucoma... - Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's diseaseAnnika Thorsell
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
Brain Res 1362:13-22. 2010..These results together suggest that cerebrospinal fluid neurogranin might be valuable together with the established AD biomarkers in the early diagnosis of AD and warrants further studies to determine the diagnostic value of neurogranin... - Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer's diseaseAnnica Johansson
Department of Clinical Neuroscience, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
Hum Genet 114:581-7. 2004..Our results provide an important independent replication of previous findings, supporting the existence of CYP46A1 sequence variants that contribute to variability in beta-amyloid metabolism... - Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid β42Niklas Mattsson
Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Molndal, Sweden
Biomark Med 6:409-17. 2012..We describe possible technical approaches, focusing on a selected reaction monitoring mass spectrometry assay as a candidate reference method for quantification of CSF amyloid β42... - BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous systemNiklas Mattsson
Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
PLoS ONE 7:e31084. 2012..The described CSF Aβ pattern may be used as a pharmacodynamic fingerprint to detect biochemical effects of BACE1-therapies in clinical trials, which might accelerate development of novel therapies... - No association of LOXL1 gene polymorphisms with Alzheimer's diseaseAlexandra Abramsson
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Neuromolecular Med 13:160-6. 2011..No evidence for associations of these polymorphisms with risk for AD or any of the studied CSF biomarkers measured was found. These results do not support LOXL1 as being a major risk gene for AD... - SILAC zebrafish for quantitative analysis of protein turnover and tissue regenerationAnn Westman-Brinkmalm
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Sweden
J Proteomics 75:425-34. 2011..This newly developed SILAC zebrafish model constitutes a novel tool to analyze tissue regeneration in an animal model amenable to genetic and pharmacologic manipulation... - Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's diseaseMadeleine Zetterberg
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
Mol Neurodegener 5:11. 2010..82 ([95% CI 0.55-1.24], P = 0.35) was obtained for a positive UCHL1 allele A carrier status. The present study thus do not support a protective effect of the UCHL1 S18Y polymorphism against AD... - Amyloid and tau cerebrospinal fluid biomarkers in HIV infectionMagnus Gisslen
Department of Infectious Diseases, University of Gothenburg, Sahlgrenska University Hospital, SE 416 85 Gothenburg, Sweden
BMC Neurol 9:63. 2009..Because of the emerging intersections of HIV infection and Alzheimer's disease, we examined cerebrospinal fluid (CSF) biomarkers related of amyloid and tau metabolism in HIV-infected patients... - Characterization of amyloid beta peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometryErik Portelius
Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, S 431 80 Molndal, Sweden
J Proteome Res 6:4433-9. 2007..Finally, we report the finding of two novel Abeta peptides (Abeta2-17 and Abeta3-17)... - A novel pathway for amyloid precursor protein processingErik Portelius
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, S 431 80 Molndal, Sweden
Neurobiol Aging 32:1090-8. 2011.... - CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairmentNiklas Mattsson
Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
JAMA 302:385-93. 2009.... - Converging molecular pathways in human neural development and degenerationNiklas Mattsson
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at University of Gothenburg, Göteborg Mölndal, Sweden
Neurosci Res 66:330-2. 2010..Tau phosphorylation in Alzheimer's disease may be a physiological response to Alzheimer-associated synaptotoxicity... - Longitudinal stability of CSF biomarkers in Alzheimer's diseaseKaj Blennow
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, Sweden
Neurosci Lett 419:18-22. 2007.... - Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's diseaseErik Portelius
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, SE 431 80 Molndal, Sweden
Neurodegener Dis 6:258-62. 2009..g. Abeta1-15 and Abeta1-16), and that the levels of these shorter isoforms are elevated in media from cells that have been treated with gamma-secretase inhibitors... - Identification of novel α-synuclein isoforms in human brain tissue by using an online nanoLC-ESI-FTICR-MS methodAnnika Ohrfelt
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, S 43180 Mölndal, Sweden
Neurochem Res 36:2029-42. 2011..Quantification of α-syn in each brain tissue fraction was performed using a novel enzyme-linked immunosorbent assay (ELISA)... - Identification of novel APP/Abeta isoforms in human cerebrospinal fluidErik Portelius
Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, Molndal, Sweden
Neurodegener Dis 6:87-94. 2009..A lot of research has focused on Abeta production and the neurotoxic 42-amino-acid form of Abeta (Abeta1-42), while less is known about the nonamyloidogenic pathway and how Abeta is degraded... - Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's diseaseErik Portelius
Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
Acta Neuropathol 120:185-93. 2010..No prominent differences in Abeta isoform patterns between FAD and SAD patients were seen, underscoring the similarity in the amyloid pathology of these two disease entities... - The N-terminal domain of α-dystroglycan, released as a 38 kDa protein, is increased in cerebrospinal fluid in patients with Lyme neuroborreliosisCamilla Hesse
Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine, The Sahlgrenska Academy, University of Gothenburg, Sweden
Biochem Biophys Res Commun 412:494-9. 2011..In untreated acute phase LNB patients, 67% showed a significant increase of CSF α-DG-N compared to healthy controls. After treatment with antibiotics the CSF α-DG-N levels were normalized in the LNB patients... - An Alzheimer's disease-specific beta-amyloid fragment signature in cerebrospinal fluidErik Portelius
Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, Molndal, Sweden
Neurosci Lett 409:215-9. 2006..Here, we provide direct evidence that an Abeta fragment signature consisting of Abeta1-16, Abeta1-33, Abeta1-39, and Abeta1-42 in CSF distinguishes sporadic AD patients from non-demented controls with an overall accuracy of 86%... - Cerebrospinal fluid beta-amyloid 1-42 concentration may predict cognitive decline in older womenDeborah R Gustafson
The Institute of Neuroscience and Physiology, Section for Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
J Neurol Neurosurg Psychiatry 78:461-4. 2007..It is not known, however, whether these biomarkers may be risk indicators for cognitive decline in otherwise healthy older people... - Cerebrospinal fluid markers for prediction of Alzheimer's diseaseHenrik Zetterberg
Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, S 413 45 Gothenburg, Sweden
Neurosci Lett 352:67-9. 2003..The usefulness of these markers is further emphasized by the finding of a positive predictive value of 94% and a negative predictive value of 81%... - Genetic association of CDC2 with cerebrospinal fluid tau in Alzheimer's diseaseAnnica Johansson
Department of Clinical Neuroscience, Unit of Neurochemistry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Dement Geriatr Cogn Disord 20:367-74. 2005..006, OR = 1.57, 95% CI 1.13-2.17). Our results provide further evidence for an involvement of cdc2 in the pathogenesis of AD... - Amyloid-β₄₂ is associated with cognitive impairment in healthy elderly and subjective cognitive impairmentSindre Rolstad
Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
J Alzheimers Dis 26:135-42. 2011..Aβ₄₂ is associated with cognitive functions from a potentially early to a later disease phase, and T-tau is more indicative of performance in a later disease phase... - Is there a CSF biomarker profile related to depression in elderly women?Pia Gudmundsson
Institute of Neuroscience and Physiology, Section for Psychiatry and Neurochemistry, Sahlgrenska Academy at University of Gothenburg, Sweden
Psychiatry Res 176:174-8. 2010..This contrasts with the well-characterized pattern of low Abeta42, higher CSF/serum albumin ratio, and higher NFL in Alzheimer's disease... - Memory in individuals with mild cognitive impairment in relation to APOE and CSF Abeta42Valgeir Thorvaldsson
Department of Psychology, University of Gothenburg, SE 405 30 Gothenburg, Sweden
Int Psychogeriatr 22:598-606. 2010..In this study we examine the interaction of these markers with episodic memory in a sample identified as having mild cognitive impairment (MCI)... - [There is a strong evidence that professional boxing results in chronic brain damage. The more head punches during a boxer's career, the bigger is the risk]Kaj Blennow
Institutionen för klinisk neurovetenskap, Sahlgrenska Universitetssjukhuset Mölndal, Sweden
Lakartidningen 102:2468-70, 2472-5. 2005..Focus is also set on the interesting similarities in neurochemical changes and pathogenic mechanisms between CTBI-B, acute traumatic brain injury (e.g. road traffic accidents) and Alzheimer's disease... - Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer diseaseHenrik Zetterberg
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at Goteborg University, Molndal, Sweden
Arch Neurol 65:1102-7. 2008.... - Low incidence of post-lumbar puncture headache in 1,089 consecutive memory clinic patientsHenrik Zetterberg
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
Eur Neurol 63:326-30. 2010..To examine the incidence of post-lumbar puncture headache (PLPH) in patients admitted for cognitive disturbances... - The transcobalamin (TC) codon 259 genetic polymorphism influences holo-TC concentration in cerebrospinal fluid from patients with Alzheimer diseaseHenrik Zetterberg
Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, , S-413 45 Gothenburg, Sweden
Clin Chem 49:1195-8. 2003 - The taqI DRD2 A1 allele is associated with alcohol-dependence although its effect size is smallUlf Berggren
From the Institute of Clinical Neuroscience, Section of Psychiatry, The Sahlgrenska Academy at Goteborg University, Sweden
Alcohol Alcohol 41:479-85. 2006.... - Biochemical markers in Alzheimer's disease clinical trialsHenrik Zetterberg
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
Biomark Med 4:91-8. 2010.... - Cerebrospinal fluid biomarkers for Alzheimer's diseaseKaj Blennow
Clinical Neurochemistry Laboratory, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
J Alzheimers Dis 18:413-7. 2009..This paper reviews recent research advances on these CSF biomarkers for use in clinical diagnosis and in clinical trials in AD... - Consecutive analyses of cerebrospinal fluid axonal and glial markers in Parkinson's disease and atypical Parkinsonian disordersRadu Constantinescu
Department of Neurology, Sahlgrenska University Hospital, 413 45 Goteborg, Sweden
Parkinsonism Relat Disord 16:142-5. 2010..Our results suggest that measurements of CSF NFL but not GFAP can be useful in the differential diagnosis of PD versus atypical parkinsonian disorders (APD). However they do not help differentiate between the different APD... - Sustained release of neuron-specific enolase to serum in amateur boxersHenrik Zetterberg
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
Brain Inj 23:723-6. 2009..We assess the potential of a panel of serum biomarkers to identify chronic neuronal injury in amateur boxers as compared to healthy controls without any history of head trauma... - Cerebrospinal fluid and plasma biomarkers in Alzheimer diseaseKaj Blennow
Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, SE 431 80 Molndal, Sweden
Nat Rev Neurol 6:131-44. 2010..Furthermore, we outline the roles of CSF biomarkers in drug discovery and clinical trials, and provide perspectives on AD biomarker discovery and the validation of such markers for use in the clinic... - Identification of CSF biomarkers for frontotemporal dementia using SELDI-TOFUlla Ruetschi
Institute of Laboratory Medicine, Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, Sweden
Exp Neurol 196:273-81. 2005..With use of these potential biomarkers, FTD can be distinguished from control subjects with high accuracy in this pilot study... - Is plasma amyloid-beta a reliable biomarker for Alzheimer's disease?Henrik Zetterberg
Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, The Sahlgrenska Academy at Gothenburg University, Sahlgrenska University Hospital Molndal, S 431 80 Molndal, Sweden
Recent Pat CNS Drug Discov 3:109-11. 2008..This review provides an update on the current status of research on plasma Abeta as a biomarker for AD in the context of recent patents in the field... - Increased frequency of a new polymorphism in the cell division cycle 2 (cdc2) gene in patients with Alzheimer's disease and frontotemporal dementiaA Johansson
Department of Clinical Neuroscience, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Neurosci Lett 340:69-73. 2003..In the combined tauopathy (AD and FTD) group the odds ratio (OR) was 1.77 (95% CI 1.19-2.63) for the Ex6+7II genotype. Our findings suggest that the Ex6+7I allele is associated with tauopathies, both AD and FTD... - Inter-laboratory variation in cerebrospinal fluid biomarkers for Alzheimer's disease: united we stand, divided we fallNiklas Mattsson
Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Institute of Neuroscience and Physiology, Göteborg and Mölndal, Sweden
Clin Chem Lab Med 48:603-7. 2010..Here, we discuss the causes of these variations, and present a global quality control program to overcome them... - Diagnostic value of 14-3-3beta immunoblot and T-tau/P-tau ratio in clinically suspected Creutzfeldt-Jakob diseaseKaj Blennow
Institute of Clinical Neuroscience, Department of Experimental Neuroscience, Sahlgrenska University Hospital, , , Sweden
Int J Mol Med 16:1147-9. 2005..023). The high predictive values achieved by the combined tau test suggest that it could be used in conjunction with other diagnostic methods for accurate intra vitam diagnosis of CJD...