Yvonne Wettergren

Summary

Affiliation: Sahlgrenska University Hospital/Ostra
Country: Sweden

Publications

  1. doi request reprint Pretherapeutic uracil and dihydrouracil levels of colorectal cancer patients are associated with sex and toxic side effects during adjuvant 5-fluorouracil-based chemotherapy
    Yvonne Wettergren
    Surgical Oncology Laboratory, Department of Surgery, Institute of Clinical Sciences, Sahlgrenska University Hospital Ostra, the Sahlgrenska Academy at University of Gothenburg, Goteborg, Sweden
    Cancer 118:2935-43. 2012
  2. ncbi request reprint Low expression of reduced folate carrier-1 and folylpolyglutamate synthase correlates with lack of a deleted in colorectal carcinoma mRNA splice variant in normal-appearing mucosa of colorectal carcinoma patients
    Yvonne Wettergren
    Department of General Surgery, Sahlgrenska University Hospital Ostra, Goteborg University, S 416 85 Goteborg, Sweden
    Cancer Detect Prev 29:348-55. 2005
  3. pmc MTHFR, MTR, and MTRR polymorphisms in relation to p16INK4A hypermethylation in mucosa of patients with colorectal cancer
    Yvonne Wettergren
    Department of General Surgery, University of Gothenburg, Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
    Mol Med 16:425-32. 2010
  4. pmc p16INK4a gene promoter hypermethylation in mucosa as a prognostic factor for patients with colorectal cancer
    Yvonne Wettergren
    Department of General Surgery, Goteborg University, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Mol Med 14:412-21. 2008
  5. ncbi request reprint Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients
    Elisabeth Odin
    Department of General Surgery, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Clin Cancer Res 9:6012-9. 2003
  6. doi request reprint A study of the MTHFR gene polymorphism C677T in colorectal cancer
    Kristoffer Derwinger
    Department of Surgery, Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
    Clin Colorectal Cancer 8:43-8. 2009
  7. ncbi request reprint Expression and clinical significance of methylenetetrahydrofolate reductase in patients with colorectal cancer
    Elisabeth Odin
    Department of General Surgery, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Clin Colorectal Cancer 5:344-9. 2006
  8. doi request reprint Determination of reduced folates in tumor and adjacent mucosa of colorectal cancer patients using LC-MS/MS
    Elisabeth Odin
    Department of Surgery, Sahlgrenska Academy at University of Gothenburg, Goteborg, Sweden
    Biomed Chromatogr 27:487-95. 2013
  9. ncbi request reprint Colorectal carcinomas with microsatellite instability display increased thymidylate synthase gene expression levels
    Elisabeth Odin
    Department of General Surgery, Goteborg University, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Clin Colorectal Cancer 6:720-7. 2007
  10. doi request reprint Molecular determinants of efficacy for 5-FU-based treatments in advanced colorectal cancer: mRNA expression for 18 chemotherapy-related genes
    Bengt Gustavsson
    Department of General Surgery, Goteborg University, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Int J Cancer 124:1220-6. 2009

Detail Information

Publications13

  1. doi request reprint Pretherapeutic uracil and dihydrouracil levels of colorectal cancer patients are associated with sex and toxic side effects during adjuvant 5-fluorouracil-based chemotherapy
    Yvonne Wettergren
    Surgical Oncology Laboratory, Department of Surgery, Institute of Clinical Sciences, Sahlgrenska University Hospital Ostra, the Sahlgrenska Academy at University of Gothenburg, Goteborg, Sweden
    Cancer 118:2935-43. 2012
    ..Pretherapeutic detection of DPD deficiency could prevent severe toxicity otherwise limiting drug administration. Assays showing that DPD deficiency impairs breakdown of Ura to dihydrouracil (UH(2)) seem promising for clinical use...
  2. ncbi request reprint Low expression of reduced folate carrier-1 and folylpolyglutamate synthase correlates with lack of a deleted in colorectal carcinoma mRNA splice variant in normal-appearing mucosa of colorectal carcinoma patients
    Yvonne Wettergren
    Department of General Surgery, Sahlgrenska University Hospital Ostra, Goteborg University, S 416 85 Goteborg, Sweden
    Cancer Detect Prev 29:348-55. 2005
    ..The purpose of this study was to analyze if the folate level and the gene expression levels of reduced folate carrier (RFC-1) and folylpolyglutamate synthase (FPGS) had impact on the expression of DCC splice variants...
  3. pmc MTHFR, MTR, and MTRR polymorphisms in relation to p16INK4A hypermethylation in mucosa of patients with colorectal cancer
    Yvonne Wettergren
    Department of General Surgery, University of Gothenburg, Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
    Mol Med 16:425-32. 2010
    ..These results indicate a relationship between genetic germ-line variants of the MTRR gene and p16 hypermethylation in mucosa, which may affect the clinical outcome of patients with colorectal cancer...
  4. pmc p16INK4a gene promoter hypermethylation in mucosa as a prognostic factor for patients with colorectal cancer
    Yvonne Wettergren
    Department of General Surgery, Goteborg University, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Mol Med 14:412-21. 2008
    ..The results suggest that there might be a connection between folate-associated gene expression and p16 methylation status...
  5. ncbi request reprint Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients
    Elisabeth Odin
    Department of General Surgery, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Clin Cancer Res 9:6012-9. 2003
    ..The purpose of this study was to analyze whether gene expression levels of folate enzymes in adjacent mucosa were associated with outcome of colorectal cancer patients...
  6. doi request reprint A study of the MTHFR gene polymorphism C677T in colorectal cancer
    Kristoffer Derwinger
    Department of Surgery, Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
    Clin Colorectal Cancer 8:43-8. 2009
    ..The hypothesis was that the genotype could affect the risk of cancer development and the results of cancer treatment...
  7. ncbi request reprint Expression and clinical significance of methylenetetrahydrofolate reductase in patients with colorectal cancer
    Elisabeth Odin
    Department of General Surgery, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Clin Colorectal Cancer 5:344-9. 2006
    ....
  8. doi request reprint Determination of reduced folates in tumor and adjacent mucosa of colorectal cancer patients using LC-MS/MS
    Elisabeth Odin
    Department of Surgery, Sahlgrenska Academy at University of Gothenburg, Goteborg, Sweden
    Biomed Chromatogr 27:487-95. 2013
    ..The correlation between folate levels and tumor site further strengthens the fact that development of right- and left-sided tumors follows different pathways...
  9. ncbi request reprint Colorectal carcinomas with microsatellite instability display increased thymidylate synthase gene expression levels
    Elisabeth Odin
    Department of General Surgery, Goteborg University, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Clin Colorectal Cancer 6:720-7. 2007
    ..Furthermore, the influence of TS polymorphisms on TS gene expression levels and MSI-H was studied...
  10. doi request reprint Molecular determinants of efficacy for 5-FU-based treatments in advanced colorectal cancer: mRNA expression for 18 chemotherapy-related genes
    Bengt Gustavsson
    Department of General Surgery, Goteborg University, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Int J Cancer 124:1220-6. 2009
    ..Further analysis of the prognostic or predictive value of these genes in prospective trials in CRC patients seems warranted...
  11. ncbi request reprint Gene polymorphisms MTHFRC677T and MTRA2756G as predictive factors in adjuvant chemotherapy for stage III colorectal cancer
    Helena Taflin
    Department of Surgery, Sahlgrenska University Hospital Ostra, 41685 Gothenburg, Sweden
    Anticancer Res 31:3057-62. 2011
    ..A secondary aim was to investigate any possible interdependency between the two genes...
  12. ncbi request reprint Changes in thymidine phosphorylase gene expression related to treatment of rectal cancer
    Kristoffer Derwinger
    Department of Surgery at the Institute of Clinical Sciences, the Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
    Anticancer Res 33:2447-51. 2013
    ..The enzyme thymidine phosphorylase (TYMP) has tumor-promoting functions and its expression is often elevated in tumors...
  13. pmc Thymidine Phosphorylase Gene Expression in Stage III Colorectal Cancer
    Elinor B Lindskog
    Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
    Clin Med Insights Oncol 6:347-53. 2012
    ..The aim of this study was to explore TP gene expression in relation to clinical and histopathological data obtained from patients with stage III colorectal cancer...