Research Topics
Genomes and GenesSpecies | Lars SjöströmSummaryAffiliation: Sahlgrenska University Hospital Country: Sweden Publications
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Detail Information
Publications
Effects of bariatric surgery on mortality in Swedish obese subjectsLars Sjöström
Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
N Engl J Med 357:741-52. 2007..In fact, many observational studies suggest that weight reduction is associated with increased mortality...- Surgical intervention as a strategy for treatment of obesityL Sjostrom
The SOS, Secretariat, Sahlgrenska University Hospital, Goteborg, Sweden
Endocrine 13:213-30. 2000..No non-surgical treatment available today can achieve such results, not even over 2 years. Surgical treatment for obesity needs to become much more common, particularly in obese patients with metabolic disturbances... 
Bariatric surgery and reduction in morbidity and mortality: experiences from the SOS studyL Sjostrom
Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
Int J Obes (Lond) 32:S93-7. 2008..Bariatric surgery for severe obesity is associated with long-term weight loss, improved risk factors and decreased overall mortality...- Optimized predictions of absolute and relative amounts of body fat from weight, height, other anthropometric predictors, and age 1Ingrid Larsson
Sahlgrenska Academy at Goteborg University, Department of Body Composition and Metabolism, Goteborg, Sweden
Am J Clin Nutr 83:252-9. 2006..Body mass index (BMI) is the dominating weight-for-height index, but its validity as a body fat (BF) index has not been properly examined... - Body composition in the SOS (Swedish Obese Subjects) reference studyI Larsson
Department of Body Composition and Metabolism, Sahlgrenska Academy at Goteborg University, SE 41345 Goteborg, Sweden
Int J Obes Relat Metab Disord 28:1317-24. 2004..Another objective was to examine if secular changes in adipose tissue distribution occurred during the sampling period, 1994-1999... - Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgeryLars Sjöström
Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
N Engl J Med 351:2683-93. 2004..Weight loss is associated with short-term amelioration and prevention of metabolic and cardiovascular risk, but whether these benefits persist over time is unknown... - Bariatric surgery and prevention of type 2 diabetes in Swedish obese subjectsLena M S Carlsson
Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
N Engl J Med 367:695-704. 2012..In an analysis of data from a nonrandomized, prospective, controlled study, we examined the effects of bariatric surgery on the prevention of type 2 diabetes... - Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trialLars Sjöström
The Institutes of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Lancet Oncol 10:653-62. 2009..To our knowledge, the Swedish Obese Subjects (SOS) study is the first intervention trial in the obese population to provide prospective, controlled cancer-incidence data... - CCAAT/enhancer binding protein alpha (C/EBPalpha) in adipose tissue regulates genes in lipid and glucose metabolism and a genetic variation in C/EBPalpha is associated with serum levels of triglyceridesLouise E Olofsson
Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, Vita stråket 15, 413 45 Gothenburg, Sweden
J Clin Endocrinol Metab 93:4880-6. 2008..CCAAT/enhancer binding protein alpha (C/EBPalpha) is a transcription factor involved in adipogenesis and hepatic glucose and lipid metabolism... - ITIH-5 expression in human adipose tissue is increased in obesityÅsa Anveden
Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Obesity (Silver Spring) 20:708-14. 2012..Together, this indicates that ITIH-5 merits further investigation as a regulator of human metabolism... - Effort-related calf pain in the obese and long-term changes after surgical obesity treatmentKristjan Karason
Department of Cardiology, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
Obes Res 13:137-45. 2005..To compare the prevalence of effort-related calf pain in an obese and a general population and to analyze the incidence of and recovery from such pain after surgical and conventional obesity treatment... - Bariatric surgery and long-term cardiovascular eventsLars Sjöström
Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
JAMA 307:56-65. 2012..Obesity is a risk factor for cardiovascular events. Weight loss might protect against cardiovascular events, but solid evidence is lacking... 
Regulation of carboxylesterase 1 (CES1) in human adipose tissueMargareta Jernas
Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, The Sahlgrenska Academy, Goteborg, Sweden
Biochem Biophys Res Commun 383:63-7. 2009..1x10(-6)). Basal and stimulated lipolysis was not different in individuals with high, intermediate, and low expression of CES1. Thus, CES1 expression was linked to body fat and adipocyte fat content but not to lipolytic activity...- Cardiovascular events after bariatric surgery in obese subjects with type 2 diabetesStefano Romeo
Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Diabetes Care 35:2613-7. 2012..The aim of the present study was to examine the effect of bariatric surgery on cardiovascular events in the SOS study participants with type 2 diabetes... - Relations of adipose tissue CIDEA gene expression to basal metabolic rate, energy restriction, and obesity: population-based and dietary intervention studiesAnders Gummesson
Department of Molecular and Clinical Medicine and Wallenberg Laboratory for Cardiovascular Research, Institute of Medicine, The Sahlgrenska Academy, Goteborg University, SE 413 45 Goteborg, Sweden
J Clin Endocrinol Metab 92:4759-65. 2007.... - Evidence for gender-specific associations between leptin and olfactionA Cecilia Karlsson
Department of Body Composition and Metabolism, Vita stråket 15, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
J Gend Specif Med 5:25-32. 2002..The long leptin receptor is also expressed in the piriform cortex, an area involved in the relay of olfactory cues. In rodents, both olfaction and leptin influence food seeking... - The influence of body composition, fat distribution, and sustained weight loss on left ventricular mass and geometry in obesityDimitris Kardassis
Department of Cardiology, Sahlgrenska University Hospital and Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Obesity (Silver Spring) 20:605-11. 2012..Obesity is associated with concentric left ventricular remodeling and sustained 10-year weight loss results in lower cavity size, wall thickness and mass... - Pharmaceutical costs in obese individuals: comparison with a randomly selected population sample and long-term changes after conventional and surgical treatment: the SOS intervention studyKristina Narbro
SOS Secretariat, Department of Internal Medicine, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
Arch Intern Med 162:2061-9. 2002..Obesity is associated with increased morbidity rates and pharmaceutical costs. To what extent various medication costs are affected by intentional weight loss is unknown... - Body composition, dietary intake, and energy expenditure after laparoscopic Roux-en-Y gastric bypass and laparoscopic vertical banded gastroplasty: a randomized clinical trialTorsten Olbers
Department of Surgery and Gastro Research, Sahlgrenska University Hospital, Goteborg, Sweden
Ann Surg 244:715-22. 2006..To assess body composition, eating pattern, and basal metabolic rate in patients undergoing obesity surgery in a randomized trial... - ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic diseaseLena M S Carlsson
Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, The Sahlgrenska Academy, Goteborg, Sweden
Biochem Biophys Res Commun 382:309-14. 2009..We conclude that activin B may have local effects in adipose tissue and thereby influence obesity and its comorbidities... - Molecular characterization of a local sulfonylurea system in human adipose tissueBritt G Gabrielsson
Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Mol Cell Biochem 258:65-71. 2004..1. The expression of SUR2B was higher in subcutaneous compared with omental adipose tissue and was not affected by weight loss... - Adipose tissue resting energy expenditure and expression of genes involved in mitochondrial function are higher in women than in menIntawat Nookaew
Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg 41296, Sweden
J Clin Endocrinol Metab 98:E370-8. 2013..Men and women differ in body fat distribution and adipose tissue metabolism as well as in obesity comorbidities and their response to obesity treatment... - Health care use during 20 years following bariatric surgeryMartin Neovius
Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
JAMA 308:1132-41. 2012..Bariatric surgery results in sustained weight loss; reduced incidence of diabetes, cardiovascular events, and cancer; and improved survival. The long-term effect on health care use is unknown... - Two year reduction in sleep apnea symptoms and associated diabetes incidence after weight loss in severe obesityRonald R Grunstein
Department of Puhnlmonary and Sleep Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
Sleep 30:703-10. 2007..To evaluate the effect of bariatric surgery on sleep apnea symptoms and obesity-associated morbidity in patients with severe obesity... - Analysis of the XENDOS study (Xenical in the Prevention of Diabetes in Obese Subjects)Lars Sjöström
Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
Endocr Pract 12:31-3. 2006..To present an overview and analysis of the previously published XENDOS (Xenical in the Prevention of Diabetes in Obese Subjects) study... - Spouse resemblance in body mass index: effects on adult obesity prevalence in the offspring generationPeter Jacobson
Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
Am J Epidemiol 165:101-8. 2007..Parental obesity concordance is a strong, easily identifiable genetic risk factor that should be considered in the complex network of risk factors for obesity in designing primary prevention programs... - Impact of blood pressure and insulin on the relationship between body fat and left ventricular structureKristjan Karason
Sahlgrenska University Hospital, Cardiovascular Institute, 413 45 Gothenburg, Sweden
Eur Heart J 24:1500-5. 2003..However, the underlying mechanisms behind these relationships are not clear. The aim of this study was to investigate how body composition, blood pressure and metabolic factors relate to left ventricular mass and geometry... - Gastric bypass surgery is followed by lowered blood pressure and increased diuresis - long term results from the Swedish Obese Subjects (SOS) studyPeter Hallersund
Department of Gastrosurgical Research and Education, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
PLoS ONE 7:e49696. 2012..To compare two bariatric surgical principles with regard to effects on blood pressure and salt intake... - Impact of body composition, fat distribution and sustained weight loss on cardiac function in obesityDimitris Kardassis
Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden
Int J Cardiol 159:128-33. 2012..In a case-control study we examined how sustained weight losses affect cardiac function and report on how body composition and fat distribution relate to the left ventricular performance... - PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individualsMaria Antonella Burza
Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Dig Liver Dis 44:1037-41. 2012..In the present study we examined the association between the PNPLA3 I148M genetic variant and hepatocellular carcinoma in obese individuals from the Swedish Obese Subjects cohort (n = 4047)... - Ten-year trends in health-related quality of life after surgical and conventional treatment for severe obesity: the SOS intervention studyJ Karlsson
Health Care Research Unit, Institute of Medicine, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Int J Obes (Lond) 31:1248-61. 2007..To examine trends and effects of weight loss treatment on health-related quality of life (HRQL) in the severely obese over 10 years... - Computerized determination of adipocyte sizeTom Björnheden
Department of Internal Medicine, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
Obes Res 12:95-105. 2004..The aim of this study was to develop a new, computerized method for rapid and accurate determination of adipocyte size in a cell suspension obtained by incubating human or rat adipose tissue biopsies with collagenase... - Topiramate in the treatment of obese subjects with drug-naive type 2 diabetesK Stenlof
Sahlgrenska University Hospital, Goteborg, Sweden
Diabetes Obes Metab 9:360-8. 2007..The aim of this study was to examine the efficacy and safety of topiramate as an adjunct to diet and exercise in drug-naive, obese subjects with type 2 diabetes... - Body composition in a cohort of Swedish adolescents aged 15, 17 and 20.5 yearsH Lantz
Department of Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
Acta Paediatr 97:1691-7. 2008..To assess variables of body composition and identify their correlates in a group of individuals studied from adolescence to early adulthood...