Lars Sjöström

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. ncbi request reprint Effects of bariatric surgery on mortality in Swedish obese subjects
    Lars Sjöström
    Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
    N Engl J Med 357:741-52. 2007
  2. ncbi request reprint Surgical intervention as a strategy for treatment of obesity
    L Sjostrom
    The SOS, Secretariat, Sahlgrenska University Hospital, Goteborg, Sweden
    Endocrine 13:213-30. 2000
  3. doi request reprint Bariatric surgery and reduction in morbidity and mortality: experiences from the SOS study
    L Sjostrom
    Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    Int J Obes (Lond) 32:S93-7. 2008
  4. ncbi request reprint Body composition in the SOS (Swedish Obese Subjects) reference study
    I Larsson
    Department of Body Composition and Metabolism, Sahlgrenska Academy at Goteborg University, SE 41345 Goteborg, Sweden
    Int J Obes Relat Metab Disord 28:1317-24. 2004
  5. ncbi request reprint Optimized predictions of absolute and relative amounts of body fat from weight, height, other anthropometric predictors, and age 1
    Ingrid Larsson
    Sahlgrenska Academy at Goteborg University, Department of Body Composition and Metabolism, Goteborg, Sweden
    Am J Clin Nutr 83:252-9. 2006
  6. ncbi request reprint Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery
    Lars Sjöström
    Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    N Engl J Med 351:2683-93. 2004
  7. ncbi request reprint High expression of complement components in omental adipose tissue in obese men
    Britt G Gabrielsson
    Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Obes Res 11:699-708. 2003
  8. ncbi request reprint Alcohol consumption and alcohol problems after bariatric surgery in the Swedish obese subjects study
    Per Arne Svensson
    Department of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at Gothenburg University, SE 41345 Gothenburg, Sweden
    Obesity (Silver Spring) 21:2444-51. 2013
  9. ncbi request reprint Depot-specific expression of fibroblast growth factors in human adipose tissue
    Britt G Gabrielsson
    Research Centre for Endocrinology and Metabolism and Division for Body Composition and Metabolism, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Obes Res 10:608-16. 2002
  10. ncbi request reprint Bariatric surgery and prevention of type 2 diabetes in Swedish obese subjects
    Lena M S Carlsson
    Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    N Engl J Med 367:695-704. 2012

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Effects of bariatric surgery on mortality in Swedish obese subjects
    Lars Sjöström
    Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
    N Engl J Med 357:741-52. 2007
    ..In fact, many observational studies suggest that weight reduction is associated with increased mortality...
  2. ncbi request reprint Surgical intervention as a strategy for treatment of obesity
    L Sjostrom
    The SOS, Secretariat, Sahlgrenska University Hospital, Goteborg, Sweden
    Endocrine 13:213-30. 2000
    ..No non-surgical treatment available today can achieve such results, not even over 2 years. Surgical treatment for obesity needs to become much more common, particularly in obese patients with metabolic disturbances...
  3. doi request reprint Bariatric surgery and reduction in morbidity and mortality: experiences from the SOS study
    L Sjostrom
    Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    Int J Obes (Lond) 32:S93-7. 2008
    ..Bariatric surgery for severe obesity is associated with long-term weight loss, improved risk factors and decreased overall mortality...
  4. ncbi request reprint Body composition in the SOS (Swedish Obese Subjects) reference study
    I Larsson
    Department of Body Composition and Metabolism, Sahlgrenska Academy at Goteborg University, SE 41345 Goteborg, Sweden
    Int J Obes Relat Metab Disord 28:1317-24. 2004
    ..Another objective was to examine if secular changes in adipose tissue distribution occurred during the sampling period, 1994-1999...
  5. ncbi request reprint Optimized predictions of absolute and relative amounts of body fat from weight, height, other anthropometric predictors, and age 1
    Ingrid Larsson
    Sahlgrenska Academy at Goteborg University, Department of Body Composition and Metabolism, Goteborg, Sweden
    Am J Clin Nutr 83:252-9. 2006
    ..Body mass index (BMI) is the dominating weight-for-height index, but its validity as a body fat (BF) index has not been properly examined...
  6. ncbi request reprint Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery
    Lars Sjöström
    Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    N Engl J Med 351:2683-93. 2004
    ..Weight loss is associated with short-term amelioration and prevention of metabolic and cardiovascular risk, but whether these benefits persist over time is unknown...
  7. ncbi request reprint High expression of complement components in omental adipose tissue in obese men
    Britt G Gabrielsson
    Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Obes Res 11:699-708. 2003
    ..Accumulation of visceral fat is recognized as a predictor of obesity-related metabolic disturbances. Factors that are predominantly expressed in this depot could mediate the link between visceral obesity and associated diseases...
  8. ncbi request reprint Alcohol consumption and alcohol problems after bariatric surgery in the Swedish obese subjects study
    Per Arne Svensson
    Department of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at Gothenburg University, SE 41345 Gothenburg, Sweden
    Obesity (Silver Spring) 21:2444-51. 2013
    ..Increased sensitivity to alcohol after gastric bypass has been described. The aim of this study was to investigate whether bariatric surgery is associated with alcohol problems...
  9. ncbi request reprint Depot-specific expression of fibroblast growth factors in human adipose tissue
    Britt G Gabrielsson
    Research Centre for Endocrinology and Metabolism and Division for Body Composition and Metabolism, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Obes Res 10:608-16. 2002
    ..We have investigated the expression of several fibroblast growth factors (FGFs) and FGF-receptors (FGFRs) in human adipose tissue and adipose-tissue cell fractions obtained from both subcutaneous (sc) and omental (om) depots...
  10. ncbi request reprint Bariatric surgery and prevention of type 2 diabetes in Swedish obese subjects
    Lena M S Carlsson
    Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    N Engl J Med 367:695-704. 2012
    ..In an analysis of data from a nonrandomized, prospective, controlled study, we examined the effects of bariatric surgery on the prevention of type 2 diabetes...
  11. ncbi request reprint Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial
    Lars Sjöström
    The Institutes of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Lancet Oncol 10:653-62. 2009
    ..To our knowledge, the Swedish Obese Subjects (SOS) study is the first intervention trial in the obese population to provide prospective, controlled cancer-incidence data...
  12. ncbi request reprint Potassium per kilogram fat-free mass and total body potassium: predictions from sex, age, and anthropometry
    Ingrid Larsson
    Department of Body Composition and Metabolism, The Sahlgrenska Academy at Goteborg University, SE 41345 Goteborg, Sweden
    Am J Physiol Endocrinol Metab 284:E416-23. 2003
    ..8%, respectively. By adding FFM(DEXA) as a fourth predictor, the error of the TBK prediction decreased by approximately two percentage units. In conclusion, TBK and TBK/FFM can be meaningfully estimated from sex, age, weight, and height...
  13. pmc Cardiovascular events after bariatric surgery in obese subjects with type 2 diabetes
    Stefano Romeo
    Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Diabetes Care 35:2613-7. 2012
    ..The aim of the present study was to examine the effect of bariatric surgery on cardiovascular events in the SOS study participants with type 2 diabetes...
  14. ncbi request reprint CCAAT/enhancer binding protein alpha (C/EBPalpha) in adipose tissue regulates genes in lipid and glucose metabolism and a genetic variation in C/EBPalpha is associated with serum levels of triglycerides
    Louise E Olofsson
    Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, Vita stråket 15, 413 45 Gothenburg, Sweden
    J Clin Endocrinol Metab 93:4880-6. 2008
    ..CCAAT/enhancer binding protein alpha (C/EBPalpha) is a transcription factor involved in adipogenesis and hepatic glucose and lipid metabolism...
  15. ncbi request reprint Association of bariatric surgery with long-term remission of type 2 diabetes and with microvascular and macrovascular complications
    Lars Sjöström
    Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
    JAMA 311:2297-304. 2014
    ..Short-term studies show that bariatric surgery causes remission of diabetes. The long-term outcomes for remission and diabetes-related complications are not known...
  16. pmc Long-term effect of bariatric surgery on liver enzymes in the Swedish Obese Subjects (SOS) study
    Maria Antonella Burza
    Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 8:e60495. 2013
    ..Bariatric surgery is effective in obtaining and maintaining weight loss. Aim of the present study was to examine the long-term effects of bariatric surgery on transaminase levels in obese individuals...
  17. ncbi request reprint XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients
    Jarl S Torgerson
    Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    Diabetes Care 27:155-61. 2004
    ..We hypothesized that adding a weight-reducing agent to lifestyle changes may lead to an even greater decrease in body weight, and thus the incidence of type 2 diabetes, in obese patients...
  18. ncbi request reprint The IRS1 rs2943641 variant and risk of future cancer among morbidly obese individuals
    Cristina Maglio
    Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, The Sahlgrenska Academy, University of Gothenburg, S 413 45 Gothenburg, Sweden
    J Clin Endocrinol Metab 98:E785-9. 2013
    ..Obesity and insulin resistance are risk factors for cancer development. The IRS1 rs2943641 genetic variant has been widely associated with insulin resistance...
  19. doi request reprint ITIH-5 expression in human adipose tissue is increased in obesity
    Åsa Anveden
    Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Obesity (Silver Spring) 20:708-14. 2012
    ..Together, this indicates that ITIH-5 merits further investigation as a regulator of human metabolism...
  20. ncbi request reprint Effort-related calf pain in the obese and long-term changes after surgical obesity treatment
    Kristjan Karason
    Department of Cardiology, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Obes Res 13:137-45. 2005
    ..To compare the prevalence of effort-related calf pain in an obese and a general population and to analyze the incidence of and recovery from such pain after surgical and conventional obesity treatment...
  21. doi request reprint Bariatric surgery and long-term cardiovascular events
    Lars Sjöström
    Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    JAMA 307:56-65. 2012
    ..Obesity is a risk factor for cardiovascular events. Weight loss might protect against cardiovascular events, but solid evidence is lacking...
  22. pmc Evaluation of current eligibility criteria for bariatric surgery: diabetes prevention and risk factor changes in the Swedish obese subjects (SOS) study
    Kajsa Sjöholm
    University of Gothenburg, Gothenburg, Sweden
    Diabetes Care 36:1335-40. 2013
    ..We used Swedish obese subjects (SOS) to explore long-term outcomes in noneligible versus eligible patients...
  23. ncbi request reprint Evidence for gender-specific associations between leptin and olfaction
    A Cecilia Karlsson
    Department of Body Composition and Metabolism, Vita stråket 15, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    J Gend Specif Med 5:25-32. 2002
    ..The long leptin receptor is also expressed in the piriform cortex, an area involved in the relay of olfactory cues. In rodents, both olfaction and leptin influence food seeking...
  24. ncbi request reprint Relations of adipose tissue CIDEA gene expression to basal metabolic rate, energy restriction, and obesity: population-based and dietary intervention studies
    Anders Gummesson
    Department of Molecular and Clinical Medicine and Wallenberg Laboratory for Cardiovascular Research, Institute of Medicine, The Sahlgrenska Academy, Goteborg University, SE 413 45 Goteborg, Sweden
    J Clin Endocrinol Metab 92:4759-65. 2007
    ....
  25. doi request reprint Impact of body composition, fat distribution and sustained weight loss on cardiac function in obesity
    Dimitris Kardassis
    Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden
    Int J Cardiol 159:128-33. 2012
    ..In a case-control study we examined how sustained weight losses affect cardiac function and report on how body composition and fat distribution relate to the left ventricular performance...
  26. pmc Adipose tissue resting energy expenditure and expression of genes involved in mitochondrial function are higher in women than in men
    Intawat Nookaew
    Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg 41296, Sweden
    J Clin Endocrinol Metab 98:E370-8. 2013
    ..Men and women differ in body fat distribution and adipose tissue metabolism as well as in obesity comorbidities and their response to obesity treatment...
  27. pmc Regulation of carboxylesterase 1 (CES1) in human adipose tissue
    Margareta Jernas
    Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, The Sahlgrenska Academy, Goteborg, Sweden
    Biochem Biophys Res Commun 383:63-7. 2009
    ..1x10(-6)). Basal and stimulated lipolysis was not different in individuals with high, intermediate, and low expression of CES1. Thus, CES1 expression was linked to body fat and adipocyte fat content but not to lipolytic activity...
  28. pmc Gastric bypass surgery is followed by lowered blood pressure and increased diuresis - long term results from the Swedish Obese Subjects (SOS) study
    Peter Hallersund
    Department of Gastrosurgical Research and Education, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 7:e49696. 2012
    ..To compare two bariatric surgical principles with regard to effects on blood pressure and salt intake...
  29. doi request reprint The influence of body composition, fat distribution, and sustained weight loss on left ventricular mass and geometry in obesity
    Dimitris Kardassis
    Department of Cardiology, Sahlgrenska University Hospital and Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Obesity (Silver Spring) 20:605-11. 2012
    ..Obesity is associated with concentric left ventricular remodeling and sustained 10-year weight loss results in lower cavity size, wall thickness and mass...
  30. ncbi request reprint Molecular characterization of a local sulfonylurea system in human adipose tissue
    Britt G Gabrielsson
    Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Mol Cell Biochem 258:65-71. 2004
    ..1. The expression of SUR2B was higher in subcutaneous compared with omental adipose tissue and was not affected by weight loss...
  31. ncbi request reprint Pharmaceutical costs in obese individuals: comparison with a randomly selected population sample and long-term changes after conventional and surgical treatment: the SOS intervention study
    Kristina Narbro
    SOS Secretariat, Department of Internal Medicine, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Arch Intern Med 162:2061-9. 2002
    ..Obesity is associated with increased morbidity rates and pharmaceutical costs. To what extent various medication costs are affected by intentional weight loss is unknown...
  32. pmc Body composition, dietary intake, and energy expenditure after laparoscopic Roux-en-Y gastric bypass and laparoscopic vertical banded gastroplasty: a randomized clinical trial
    Torsten Olbers
    Department of Surgery and Gastro Research, Sahlgrenska University Hospital, Goteborg, Sweden
    Ann Surg 244:715-22. 2006
    ..To assess body composition, eating pattern, and basal metabolic rate in patients undergoing obesity surgery in a randomized trial...
  33. pmc ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease
    Lena M S Carlsson
    Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, The Sahlgrenska Academy, Goteborg, Sweden
    Biochem Biophys Res Commun 382:309-14. 2009
    ..We conclude that activin B may have local effects in adipose tissue and thereby influence obesity and its comorbidities...
  34. doi request reprint Sleep apnea modifies the long-term impact of surgically induced weight loss on cardiac function and inflammation
    Dimitris Kardassis
    Department of Cardiology, Sahlgrenska University Hospital and Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Obesity (Silver Spring) 21:698-704. 2013
    ..We used a nested cohort study design to evaluate the long-term impact of bariatric surgery on OSA and how weight loss and OSA relate to inflammation and cardiac performance...
  35. doi request reprint PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals
    Maria Antonella Burza
    Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Dig Liver Dis 44:1037-41. 2012
    ..In the present study we examined the association between the PNPLA3 I148M genetic variant and hepatocellular carcinoma in obese individuals from the Swedish Obese Subjects cohort (n = 4047)...
  36. ncbi request reprint Health care use during 20 years following bariatric surgery
    Martin Neovius
    Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    JAMA 308:1132-41. 2012
    ..Bariatric surgery results in sustained weight loss; reduced incidence of diabetes, cardiovascular events, and cancer; and improved survival. The long-term effect on health care use is unknown...
  37. pmc Two year reduction in sleep apnea symptoms and associated diabetes incidence after weight loss in severe obesity
    Ronald R Grunstein
    Department of Puhnlmonary and Sleep Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Sleep 30:703-10. 2007
    ..To evaluate the effect of bariatric surgery on sleep apnea symptoms and obesity-associated morbidity in patients with severe obesity...
  38. ncbi request reprint Impact of blood pressure and insulin on the relationship between body fat and left ventricular structure
    Kristjan Karason
    Sahlgrenska University Hospital, Cardiovascular Institute, 413 45 Gothenburg, Sweden
    Eur Heart J 24:1500-5. 2003
    ..However, the underlying mechanisms behind these relationships are not clear. The aim of this study was to investigate how body composition, blood pressure and metabolic factors relate to left ventricular mass and geometry...
  39. ncbi request reprint Spouse resemblance in body mass index: effects on adult obesity prevalence in the offspring generation
    Peter Jacobson
    Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    Am J Epidemiol 165:101-8. 2007
    ..Parental obesity concordance is a strong, easily identifiable genetic risk factor that should be considered in the complex network of risk factors for obesity in designing primary prevention programs...
  40. ncbi request reprint Analysis of the XENDOS study (Xenical in the Prevention of Diabetes in Obese Subjects)
    Lars Sjöström
    Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    Endocr Pract 12:31-3. 2006
    ..To present an overview and analysis of the previously published XENDOS (Xenical in the Prevention of Diabetes in Obese Subjects) study...
  41. ncbi request reprint Computerized determination of adipocyte size
    Tom Björnheden
    Department of Internal Medicine, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
    Obes Res 12:95-105. 2004
    ..The aim of this study was to develop a new, computerized method for rapid and accurate determination of adipocyte size in a cell suspension obtained by incubating human or rat adipose tissue biopsies with collagenase...
  42. ncbi request reprint Ten-year trends in health-related quality of life after surgical and conventional treatment for severe obesity: the SOS intervention study
    J Karlsson
    Health Care Research Unit, Institute of Medicine, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Int J Obes (Lond) 31:1248-61. 2007
    ..To examine trends and effects of weight loss treatment on health-related quality of life (HRQL) in the severely obese over 10 years...
  43. ncbi request reprint Topiramate in the treatment of obese subjects with drug-naive type 2 diabetes
    K Stenlof
    Sahlgrenska University Hospital, Goteborg, Sweden
    Diabetes Obes Metab 9:360-8. 2007
    ..The aim of this study was to examine the efficacy and safety of topiramate as an adjunct to diet and exercise in drug-naive, obese subjects with type 2 diabetes...
  44. doi request reprint Body composition in a cohort of Swedish adolescents aged 15, 17 and 20.5 years
    H Lantz
    Department of Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Acta Paediatr 97:1691-7. 2008
    ..To assess variables of body composition and identify their correlates in a group of individuals studied from adolescence to early adulthood...