Research Topics
Genomes and GenesSpecies | Lars SjöströmSummaryAffiliation: Sahlgrenska University Hospital Country: Sweden Publications
| Collaborators
|
Detail Information
Publications
Evaluation of Current Eligibility Criteria for Bariatric Surgery: Diabetes prevention and risk factor changes in the Swedish Obese Subjects (SOS) studyKajsa Sjöholm
Corresponding author Lars Sjöström
Diabetes Care 36:1335-40. 2013..Our results show that strict BMI cutoffs are of limited use for bariatric surgery prioritization if the aim is to prevent diabetes and improve cardiovascular risk factors...
Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgeryL Sjostrom
Department of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy, The University of Gothenburg, Gothenburg, Sweden
J Intern Med 273:219-34. 2013..45; P < 0.001). Whereas high insulin and/or high glucose at baseline predicted favourable treatment effects, high baseline BMI did not, indicating that current selection criteria for bariatric surgery need to be revised...- Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trialLars Sjöström
The Institutes of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Lancet Oncol 10:653-62. 2009..To our knowledge, the Swedish Obese Subjects (SOS) study is the first intervention trial in the obese population to provide prospective, controlled cancer-incidence data... - Bariatric surgery and long-term cardiovascular eventsLars Sjöström
Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
JAMA 307:56-65. 2012..Obesity is a risk factor for cardiovascular events. Weight loss might protect against cardiovascular events, but solid evidence is lacking... - Cardiovascular events after bariatric surgery in obese subjects with type 2 diabetesStefano Romeo
Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Diabetes Care 35:2613-7. 2012..The aim of the present study was to examine the effect of bariatric surgery on cardiovascular events in the SOS study participants with type 2 diabetes... - Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight lossAtsuhito Saiki
Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at Gothenburg University, 413 45 Gothenburg, Sweden
J Clin Endocrinol Metab 94:3987-94. 2009..Global gene expression scans show that the TNMD gene also is expressed in human adipose tissue and that its expression is regulated in response to weight reduction; however, more detailed information is lacking... - CCAAT/enhancer binding protein alpha (C/EBPalpha) in adipose tissue regulates genes in lipid and glucose metabolism and a genetic variation in C/EBPalpha is associated with serum levels of triglyceridesLouise E Olofsson
Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, Vita stråket 15, 413 45 Gothenburg, Sweden
J Clin Endocrinol Metab 93:4880-6. 2008..CCAAT/enhancer binding protein alpha (C/EBPalpha) is a transcription factor involved in adipogenesis and hepatic glucose and lipid metabolism... - Bariatric surgery and prevention of type 2 diabetes in Swedish obese subjectsLena M S Carlsson
Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
N Engl J Med 367:695-704. 2012..In an analysis of data from a nonrandomized, prospective, controlled study, we examined the effects of bariatric surgery on the prevention of type 2 diabetes... - ITIH-5 expression in human adipose tissue is increased in obesityÅsa Anveden
Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Obesity (Silver Spring) 20:708-14. 2012..Together, this indicates that ITIH-5 merits further investigation as a regulator of human metabolism... 
Effects of bariatric surgery on mortality in Swedish obese subjectsLars Sjöström
Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
N Engl J Med 357:741-52. 2007..In fact, many observational studies suggest that weight reduction is associated with increased mortality...- Regulation of carboxylesterase 1 (CES1) in human adipose tissueMargareta Jernas
Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, The Sahlgrenska Academy, Goteborg, Sweden
Biochem Biophys Res Commun 383:63-7. 2009..1x10(-6)). Basal and stimulated lipolysis was not different in individuals with high, intermediate, and low expression of CES1. Thus, CES1 expression was linked to body fat and adipocyte fat content but not to lipolytic activity... - Adipose tissue resting energy expenditure and expression of genes involved in mitochondrial function are higher in women than in menIntawat Nookaew
Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg 41296, Sweden
J Clin Endocrinol Metab 98:E370-8. 2013..Men and women differ in body fat distribution and adipose tissue metabolism as well as in obesity comorbidities and their response to obesity treatment... - PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individualsMaria Antonella Burza
Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Dig Liver Dis 44:1037-41. 2012..In the present study we examined the association between the PNPLA3 I148M genetic variant and hepatocellular carcinoma in obese individuals from the Swedish Obese Subjects cohort (n = 4047)... - ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic diseaseLena M S Carlsson
Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, The Sahlgrenska Academy, Goteborg, Sweden
Biochem Biophys Res Commun 382:309-14. 2009..We conclude that activin B may have local effects in adipose tissue and thereby influence obesity and its comorbidities... - Long-Term Effect of Bariatric Surgery on Liver Enzymes in the Swedish Obese Subjects (SOS) StudyMaria Antonella Burza
Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
PLoS ONE 8:e60495. 2013..Bariatric surgery is effective in obtaining and maintaining weight loss. Aim of the present study was to examine the long-term effects of bariatric surgery on transaminase levels in obese individuals... - Preliminary report: Zn-alpha2-glycoprotein genotype and serum levels are associated with serum lipidsLouise E Olofsson
The Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden
Metabolism 59:1316-8. 2010..014) and low-density lipoprotein cholesterol (P = .026) in healthy subjects, and the associations were replicated in an additional cohort (P = .0017 and P = .060, respectively). Our data indicate that ZAG plays a role in lipid metabolism... - The influence of body composition, fat distribution, and sustained weight loss on left ventricular mass and geometry in obesityDimitris Kardassis
Department of Cardiology, Sahlgrenska University Hospital and Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Obesity (Silver Spring) 20:605-11. 2012..Obesity is associated with concentric left ventricular remodeling and sustained 10-year weight loss results in lower cavity size, wall thickness and mass... - Health care use during 20 years following bariatric surgeryMartin Neovius
Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
JAMA 308:1132-41. 2012..Bariatric surgery results in sustained weight loss; reduced incidence of diabetes, cardiovascular events, and cancer; and improved survival. The long-term effect on health care use is unknown... - Impact of body composition, fat distribution and sustained weight loss on cardiac function in obesityDimitris Kardassis
Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden
Int J Cardiol 159:128-33. 2012..In a case-control study we examined how sustained weight losses affect cardiac function and report on how body composition and fat distribution relate to the left ventricular performance... - Optimized predictions of absolute and relative amounts of body fat from weight, height, other anthropometric predictors, and age 1Ingrid Larsson
Sahlgrenska Academy at Goteborg University, Department of Body Composition and Metabolism, Goteborg, Sweden
Am J Clin Nutr 83:252-9. 2006..Body mass index (BMI) is the dominating weight-for-height index, but its validity as a body fat (BF) index has not been properly examined... - Effort-related calf pain in the obese and long-term changes after surgical obesity treatmentKristjan Karason
Department of Cardiology, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
Obes Res 13:137-45. 2005..To compare the prevalence of effort-related calf pain in an obese and a general population and to analyze the incidence of and recovery from such pain after surgical and conventional obesity treatment... - Impact of blood pressure and insulin on the relationship between body fat and left ventricular structureKristjan Karason
Sahlgrenska University Hospital, Cardiovascular Institute, 413 45 Gothenburg, Sweden
Eur Heart J 24:1500-5. 2003..However, the underlying mechanisms behind these relationships are not clear. The aim of this study was to investigate how body composition, blood pressure and metabolic factors relate to left ventricular mass and geometry... - Pharmaceutical costs in obese individuals: comparison with a randomly selected population sample and long-term changes after conventional and surgical treatment: the SOS intervention studyKristina Narbro
SOS Secretariat, Department of Internal Medicine, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
Arch Intern Med 162:2061-9. 2002..Obesity is associated with increased morbidity rates and pharmaceutical costs. To what extent various medication costs are affected by intentional weight loss is unknown... - Relations of adipose tissue CIDEA gene expression to basal metabolic rate, energy restriction, and obesity: population-based and dietary intervention studiesAnders Gummesson
Department of Molecular and Clinical Medicine and Wallenberg Laboratory for Cardiovascular Research, Institute of Medicine, The Sahlgrenska Academy, Goteborg University, SE 413 45 Goteborg, Sweden
J Clin Endocrinol Metab 92:4759-65. 2007.... - Gastric bypass surgery is followed by lowered blood pressure and increased diuresis - long term results from the Swedish Obese Subjects (SOS) studyPeter Hallersund
Department of Gastrosurgical Research and Education, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
PLoS ONE 7:e49696. 2012..To compare two bariatric surgical principles with regard to effects on blood pressure and salt intake...