Magnus Sjogren

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. ncbi Cytoskeleton proteins in CSF distinguish frontotemporal dementia from AD
    M Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Sweden
    Neurology 54:1960-4. 2000
  2. ncbi Advances in the detection of Alzheimer's disease-use of cerebrospinal fluid biomarkers
    Magnus Sjogren
    Institute of Clinical Neuroscience, Goteborg University, SE 431 80, Goteborg, Sweden
    Clin Chim Acta 332:1-10. 2003
  3. ncbi Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- and beta-cleaved amyloid precursor protein
    Magnus Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital Molndal, SE 431 80 Molndal, Sweden
    Dement Geriatr Cogn Disord 16:25-30. 2003
  4. ncbi Cognition-enhancing effect of vagus nerve stimulation in patients with Alzheimer's disease: a pilot study
    Magnus J C Sjögren
    Institute of Clinical Neuroscience, Goteborg University, Molndal, Sweden
    J Clin Psychiatry 63:972-80. 2002
  5. ncbi Biological correlates of clinical subgroups of Alzheimer's disease
    Magnus Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Goteborg, Sweden
    Dement Geriatr Cogn Disord 14:191-7. 2002
  6. ncbi [A new putative principle for diagnosis of Creutzfeldt-Jakob disease]
    Magnus Sjogren
    Sahlgrenska Universitetssjukhuset Mölndal
    Lakartidningen 99:2382-4. 2002
  7. ncbi Neurofilament protein in cerebrospinal fluid: a marker of white matter changes
    M Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Goteborg, Sweden
    J Neurosci Res 66:510-6. 2001
  8. ncbi Low cerebrospinal fluid beta-amyloid 42 in patients with acute bacterial meningitis and normalization after treatment
    M Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital, Molndal, SE 431 80 Molndal, Sweden
    Neurosci Lett 314:33-6. 2001
  9. ncbi Frontotemporal dementia can be distinguished from Alzheimer's disease and subcortical white matter dementia by an anterior-to-posterior rCBF-SPET ratio
    M Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Goteborg, Sweden
    Dement Geriatr Cogn Disord 11:275-85. 2000
  10. ncbi CSF levels of tau, beta-amyloid(1-42) and GAP-43 in frontotemporal dementia, other types of dementia and normal aging
    M Sjogren
    Institute of Clinical Neuroscience, Göbteborg University, Sahlgrenska University Hospital, Molndal, Sweden
    J Neural Transm 107:563-79. 2000

Detail Information

Publications26

  1. ncbi Cytoskeleton proteins in CSF distinguish frontotemporal dementia from AD
    M Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Sweden
    Neurology 54:1960-4. 2000
    ..Both proteins have been implicated in the pathophysiology of FTD...
  2. ncbi Advances in the detection of Alzheimer's disease-use of cerebrospinal fluid biomarkers
    Magnus Sjogren
    Institute of Clinical Neuroscience, Goteborg University, SE 431 80, Goteborg, Sweden
    Clin Chim Acta 332:1-10. 2003
    ..It increases if P-tau is added. An increasing number of studies suggest that supplementary use of these CSF markers, preferably in combination, adds to the accuracy of an AD diagnosis...
  3. ncbi Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- and beta-cleaved amyloid precursor protein
    Magnus Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital Molndal, SE 431 80 Molndal, Sweden
    Dement Geriatr Cogn Disord 16:25-30. 2003
    ..The ADAS-cog score was slightly increased (p < 0.05). The results suggest that simvastatin acts directly on the processing of APP by inhibiting both the alpha- and the beta-secretase pathways...
  4. ncbi Cognition-enhancing effect of vagus nerve stimulation in patients with Alzheimer's disease: a pilot study
    Magnus J C Sjögren
    Institute of Clinical Neuroscience, Goteborg University, Molndal, Sweden
    J Clin Psychiatry 63:972-80. 2002
    ..The purpose of the present pilot study was to investigate the effect of VNS on cognition in patients with Alzheimer's disease...
  5. ncbi Biological correlates of clinical subgroups of Alzheimer's disease
    Magnus Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Goteborg, Sweden
    Dement Geriatr Cogn Disord 14:191-7. 2002
    ..For instance, a decreased CSF level of HVA (p < 0.001) was specific to AD type I and decreased rCBF (p < 0.05 to <0.001) in three particular regions was specific to AD type II...
  6. ncbi [A new putative principle for diagnosis of Creutzfeldt-Jakob disease]
    Magnus Sjogren
    Sahlgrenska Universitetssjukhuset Mölndal
    Lakartidningen 99:2382-4. 2002
    ..This change is detectable early in the course of the disease also in tissues outside the central nervous system, for instance blood...
  7. ncbi Neurofilament protein in cerebrospinal fluid: a marker of white matter changes
    M Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Goteborg, Sweden
    J Neurosci Res 66:510-6. 2001
    ..Because NFL is located mainly in large myelinated axons, increased CSF NFL in individuals with WMC probably reflects axonal degeneration...
  8. ncbi Low cerebrospinal fluid beta-amyloid 42 in patients with acute bacterial meningitis and normalization after treatment
    M Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital, Molndal, SE 431 80 Molndal, Sweden
    Neurosci Lett 314:33-6. 2001
    ..Our findings suggest that the reduction in CSF-A beta 42 found in bacterial meningitis is not a direct consequence of the inflammatory process. The cause may be disturbance of the clearance of A beta 42 from the brain...
  9. ncbi Frontotemporal dementia can be distinguished from Alzheimer's disease and subcortical white matter dementia by an anterior-to-posterior rCBF-SPET ratio
    M Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Goteborg, Sweden
    Dement Geriatr Cogn Disord 11:275-85. 2000
    ..6%. CT/MRI was found to be helpful in the differential diagnosis between FTD and SWD. In FTD patients, the mesial superior frontal gyrus, near the polus frontalis, was found to be the region with the most reduced rCBF values...
  10. ncbi CSF levels of tau, beta-amyloid(1-42) and GAP-43 in frontotemporal dementia, other types of dementia and normal aging
    M Sjogren
    Institute of Clinical Neuroscience, Göbteborg University, Sahlgrenska University Hospital, Molndal, Sweden
    J Neural Transm 107:563-79. 2000
    ..In SWD, decreased levels of CSF-beta-amyloid(1-42) suggest concomitant involvement of vascular and amyloid protein mechanisms...
  11. pmc Both total and phosphorylated tau are increased in Alzheimer's disease
    M Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital SE 431 80 Mölndal, Sweden
    J Neurol Neurosurg Psychiatry 70:624-30. 2001
    ..As CSF tau protein is increased after stroke, tau may also be implicated in the pathophysiology of vascular dementia, of which subcortical arteriosclerotic encephalopathy (SAE) is a putative subtype...
  12. ncbi Tacrine and rate of progression in Alzheimer's disease--relation to ApoE allele genotype
    M Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital Molndal, Sweden
    J Neural Transm 108:451-8. 2001
    ..The results primarily suggest a faster rate of decline in the ApoE4 AD compared to the ApoE2-3, but may also reflect that ApoE epsilon4 genotype inheritance is a negative predictor of treatment effect of tacrine in AD patients...
  13. ncbi Tau and Abeta42 in cerebrospinal fluid from healthy adults 21-93 years of age: establishment of reference values
    M Sjogren
    Institute of Clinical Neuroscience, Psychiatry Section, Goteborg University, SE 431 80 Molndal, Sweden
    Clin Chem 47:1776-81. 2001
    ..For the introduction of these assays in clinical practice, adequate reference values are of importance...
  14. ncbi Decreased CSF-beta-amyloid 42 in Alzheimer's disease and amyotrophic lateral sclerosis may reflect mismetabolism of beta-amyloid induced by disparate mechanisms
    Magnus Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital, Molndal, Sweden
    Dement Geriatr Cogn Disord 13:112-8. 2002
    ..Furthermore, decreased CSF-Abeta42 levels may be common in neurodegenerative disorders possibly reflecting changes in the metabolism of beta-amyloid or axonal degeneration...
  15. ncbi Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients
    Annika Olsson
    Institute of Clinical Neuroscience, Experimental Neuroscience Section, Goteborg University, Sahlgrenska University Hospital, Molndal, Sweden
    Exp Neurol 183:74-80. 2003
    ..Neither the levels of CSF-beta-sAPP nor CSF-Abeta(42) differed when comparing ApoE4 allele-positive with allele-negative individuals...
  16. ncbi Depressive symptoms and white matter changes in patients with dementia
    Karin Lind
    Institute of Clinical Neuroscience, Goteborg University, Sweden
    Int J Geriatr Psychiatry 21:119-25. 2006
    ..The aim of the present study was to investigate if depressive symptoms in demented patients are associated with white matter changes (WMCs) in the brain...
  17. ncbi Proteome analysis of cerebrospinal fluid proteins in Alzheimer patients
    Pia Davidsson
    Department of Clinical Neuroscience, Experimental Neuroscience Section, Goteborg University, Sahlgrenska University Hospital Molndal, SE 431 80, Sweden
    Neuroreport 13:611-5. 2002
    ..The most prominently altered proteins were the apolipoproteins, especially proapolipoprotein...
  18. ncbi Decreased cerebrospinal fluid acetylcholinesterase in patients with subcortical ischemic vascular dementia
    Anders Wallin
    Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Molndal, Sweden
    Dement Geriatr Cogn Disord 16:200-7. 2003
    ..01) and FTD groups (p < 0.05). No influence of ApoE epsilon4 allele possession on CSF-AChE activity was found. It is suggested that abnormal CSF-AChE activity in patients with SVD reflects a disturbance in the cholinergic system...
  19. doi The pattern of cognitive symptoms predicts time to dementia onset
    Simona Sacuiu
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Alzheimers Dement 5:199-206. 2009
    ..Our objective was to investigate whether different patterns of cognitive symptoms at ages 70, 75, and 79 years predict short-term (< or =5 years) and long-term (>5 years) dementia onset...
  20. ncbi Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia
    Elisabeth Tarkowski
    Department of Rheumatology, University of Goteborg, Goteborg, Sweden
    Neurobiol Aging 23:237-43. 2002
    ..In addition, we show in AD and VAD an intrathecal production of TGF-beta, a cytokine exerting on one hand anti-inflammatory and angiogenic properties, but on the other promoting amyloidogenesis...
  21. ncbi The use of proteomics in biomarker discovery in neurodegenerative diseases
    Pia Davidsson
    Discovery Medicine Molecular Sciences, AstraZeneca R and D, Molndal, Sweden
    Dis Markers 21:81-92. 2005
    ....
  22. ncbi Proteome studies of CSF in AD patients
    Pia Davidsson
    Discovery Medicine Molecular Pharmacology, AstraZeneca R and D, Molndal, SE 431 83 Molndal, Sweden
    Mech Ageing Dev 127:133-7. 2006
    ..Several studies show that the use of a panel of biomarkers derived from proteomic analysis is an advantageous way to distinguish AD from normal, and other dementia subjects...
  23. ncbi Negative neurofilament light and tau immunostaining in frontotemporal dementia
    Magnus Sjogren
    Department of Neuropsychiatry, Sahlgrenska University Hospital, Molndal, Sweden
    Dement Geriatr Cogn Disord 17:346-9. 2004
    ..These findings regarding NFL and tau staining may be useful in the differential diagnosis of FLD and AD...
  24. ncbi Objective measurement of the alertness level in dementia
    Ake Edman
    Institute of Clinical Neuroscience, Section of Psychiatry, Goteborg University, Sahlgrenska University Hospital, Molndal, Sweden
    Dement Geriatr Cogn Disord 15:212-7. 2003
    ..The intensity of this decrease was proportional to the degree of the dementia. The alertness disturbance was found to be particularly associated with the parietal brain syndrome...
  25. ncbi Studies of the pathophysiological mechanisms in frontotemporal dementia by proteome analysis of CSF proteins
    Pia Davidsson
    Department of Clinical Neuroscience, Experimental Neuroscience Section, Goteborg University, Sahlgrenska University Hospital, Molndal, Sweden
    Brain Res Mol Brain Res 109:128-33. 2002
    ....
  26. ncbi Classification and subtypes of vascular dementia
    Anders Wallin
    Goteborg University, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Molndal, Sweden
    Int Psychogeriatr 15:27-37. 2003
    ..Subcortical VaD has a relatively homogeneous clinical picture for which detailed criteria are suggested. AD + VaD is more difficult to identify but is possible, sometimes with the aid of neuroimaging and/or biological markers...