Affiliation: Sahlgrenska University Hospital
Ohlsson C, SjÃ¶gren K. Effects of the gut microbiota on bone mass. Trends Endocrinol Metab. 2015;26:69-74 pubmed publisher
..Here we review current knowledge on the possible role for the GM in the regulation of bone metabolism and propose that the GM might be a novel therapeutic target for osteoporosis and fracture prevention. ..
Sjögren K, Engdahl C, Henning P, Lerner U, Tremaroli V, Lagerquist M, et al
. The gut microbiota regulates bone mass in mice. J Bone Miner Res. 2012;27:1357-67 pubmed publisher
..Further studies are required to evaluate the gut microbiota as a novel therapeutic target for osteoporosis. ..
Ohlsson C, Nigro G, Boneca I, Backhed F, Sansonetti P, Sjögren K. Regulation of bone mass by the gut microbiota is dependent on NOD1 and NOD2 signaling. Cell Immunol. 2017;317:55-58 pubmed publisher
Ohlsson C, Hammarstedt A, Vandenput L, Saarinen N, Ryberg H, Windahl S, et al
. Increased adipose tissue aromatase activity improves insulin sensitivity and reduces adipose tissue inflammation in male mice. Am J Physiol Endocrinol Metab. 2017;313:E450-E462 pubmed publisher
..We propose that estrogen increases insulin sensitivity via a local effect in WAT on adiponectin expression, adipose tissue inflammation, and adipogenesis. ..
Ohlsson C, Sjögren K. Osteomicrobiology: A New Cross-Disciplinary Research Field. Calcif Tissue Int. 2018;102:426-432 pubmed publisher
..Future studies will determine if the GM is a novel therapeutic target for osteoporosis and if the GM composition might be used as a biomarker for fracture prediction. ..