M Simren

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. pmc Intestinal microbiota in functional bowel disorders: a Rome foundation report
    Magnus Simren
    Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg S 41345, Sweden
    Gut 62:159-76. 2013
  2. pmc Polymorphism in the oxytocin promoter region in patients with lactase non-persistence is not related to symptoms
    Mikael Truedsson
    Department of Clinical Sciences, Division of Gastroenterology and Hepatology, Malmo University Hospital, Lund University, Lund, Sweden
    BMC Gastroenterol 9:90. 2009
  3. pmc Development of an educational intervention for patients with Irritable Bowel Syndrome (IBS): a pilot study
    Gisela Ringström
    Dept of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    BMC Gastroenterol 9:10. 2009
  4. pmc An exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndrome
    M Simren
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Gut 48:20-7. 2001
  5. ncbi request reprint High interdigestive and postprandial motilin levels in patients with the irritable bowel syndrome
    M Simren
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Neurogastroenterol Motil 17:51-7. 2005
  6. ncbi request reprint Hypnosis for irritable bowel syndrome: the quest for the mechanism of action
    Magnus Simren
    Dept of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Int J Clin Exp Hypn 54:65-84. 2006
  7. ncbi request reprint Health-related quality of life in patients attending a gastroenterology outpatient clinic: functional disorders versus organic diseases
    Magnus Simren
    Department of Internal Medicine, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, S 41345 Goteborg, Sweden
    Clin Gastroenterol Hepatol 4:187-95. 2006
  8. pmc Use and abuse of hydrogen breath tests
    M Simren
    Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, S 41345 Goteborg, Sweden
    Gut 55:297-303. 2006
  9. ncbi request reprint Predictors of subjective fatigue in chronic gastrointestinal disease
    M Simren
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Aliment Pharmacol Ther 28:638-47. 2008
  10. ncbi request reprint Lipid-induced colonic hypersensitivity in the irritable bowel syndrome: the role of bowel habit, sex, and psychologic factors
    Magnus Simren
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Clin Gastroenterol Hepatol 5:201-8. 2007

Detail Information

Publications44

  1. pmc Intestinal microbiota in functional bowel disorders: a Rome foundation report
    Magnus Simren
    Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg S 41345, Sweden
    Gut 62:159-76. 2013
    ..The authors also provide clinical guidance on modulation of gut microbiota in IBS...
  2. pmc Polymorphism in the oxytocin promoter region in patients with lactase non-persistence is not related to symptoms
    Mikael Truedsson
    Department of Clinical Sciences, Division of Gastroenterology and Hepatology, Malmo University Hospital, Lund University, Lund, Sweden
    BMC Gastroenterol 9:90. 2009
    ..The aim of this study was to examine genetic variations or polymorphism of oxytocin (OXT) and its receptor (OXTR) genes in patients with GI complaints without visible organic abnormalities...
  3. pmc Development of an educational intervention for patients with Irritable Bowel Syndrome (IBS): a pilot study
    Gisela Ringström
    Dept of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    BMC Gastroenterol 9:10. 2009
    ..We aimed to develop a structured patient education, an 'IBS school', and investigate if the efficacy could be evaluated in terms of improved knowledge, symptom severity and health related quality of life (HRQOL)...
  4. pmc An exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndrome
    M Simren
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Gut 48:20-7. 2001
    ..Visceral hypersensitivity is a feature of the irritable bowel syndrome (IBS). Postprandial symptoms are common in these patients. The effects of nutrients on colonic perception in IBS are incompletely understood...
  5. ncbi request reprint High interdigestive and postprandial motilin levels in patients with the irritable bowel syndrome
    M Simren
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Neurogastroenterol Motil 17:51-7. 2005
    ..These findings may bear some pathophysiological importance in IBS and relate to the gastrointestinal dysmotility often seen in these patients...
  6. ncbi request reprint Hypnosis for irritable bowel syndrome: the quest for the mechanism of action
    Magnus Simren
    Dept of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Int J Clin Exp Hypn 54:65-84. 2006
    ..Hypnosis may affect IBS partly through changes in colorectal sensitivity and improvement in psychological factors. The effects on GI motility and the autonomic nervous system are less clear and need further evaluation...
  7. ncbi request reprint Health-related quality of life in patients attending a gastroenterology outpatient clinic: functional disorders versus organic diseases
    Magnus Simren
    Department of Internal Medicine, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, S 41345 Goteborg, Sweden
    Clin Gastroenterol Hepatol 4:187-95. 2006
    ..This study aimed to compare HRQOL between these 2 groups and to assess factors of importance for HRQOL...
  8. pmc Use and abuse of hydrogen breath tests
    M Simren
    Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, S 41345 Goteborg, Sweden
    Gut 55:297-303. 2006
    ..The limitations and pitfalls of these tests will be reviewed in this article, and hopefully the occasional abuse of these tests can be turned into proper clinical and scientific use instead in the future...
  9. ncbi request reprint Predictors of subjective fatigue in chronic gastrointestinal disease
    M Simren
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Aliment Pharmacol Ther 28:638-47. 2008
    ..Fatigue is a common, but poorly understood symptom in patients with chronic gastrointestinal (GI) diseases...
  10. ncbi request reprint Lipid-induced colonic hypersensitivity in the irritable bowel syndrome: the role of bowel habit, sex, and psychologic factors
    Magnus Simren
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Clin Gastroenterol Hepatol 5:201-8. 2007
    ..Duodenal lipid infusion increases colonic hypersensitivity in irritable bowel syndrome (IBS). Whether this is affected by bowel habit, psychologic factors, or sex is unknown...
  11. ncbi request reprint Nutrient-dependent enhancement of rectal sensitivity in irritable bowel syndrome (IBS)
    M Simren
    Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Goteborg, Sweden
    Neurogastroenterol Motil 19:20-9. 2007
    ..In IBS, a liquid meal enhances rectal sensitivity, and this seems to be partly nutrient dependent as a fatty meal has more pronounced effects than a carbohydrate meal. This might be of relevance for their postprandial symptoms...
  12. doi request reprint Clinical trial: the effects of a fermented milk containing three probiotic bacteria in patients with irritable bowel syndrome - a randomized, double-blind, controlled study
    M Simren
    Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Aliment Pharmacol Ther 31:218-27. 2010
    ..The effects of probiotic bacteria in IBS remain controversial...
  13. ncbi request reprint Quality of life and illness costs in irritable bowel syndrome
    Magnus Simren
    Department of Internal Medicine, Sahlgrenska University Hospital, SE 41345 Goteborg, Sweden
    Digestion 69:254-61. 2004
    ..Drawbacks and advantages with existing instruments to assess quality of life and costs were discussed and the clinical and scientific relevance of the current knowledge was assessed. A summary from the meeting is presented in this paper...
  14. ncbi request reprint Food-related gastrointestinal symptoms in the irritable bowel syndrome
    M Simren
    Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Goteborg, Sweden
    Digestion 63:108-15. 2001
    ..We explored the prevalence of subjective food-related gastrointestinal (GI) symptoms and its relationship to clinical characteristics and psychological factors in IBS...
  15. ncbi request reprint Quality of life in patients with irritable bowel syndrome seen in referral centers versus primary care: the impact of gender and predominant bowel pattern
    M Simren
    Dept of Internal Medicine, Institute of Clinical Neuroscience, Section of Psychiatry, Sahlgrenska University Hospital, Goteborg, Sweden
    Scand J Gastroenterol 36:545-52. 2001
    ..This study aimed to explore these relationships...
  16. ncbi request reprint Physical activity and the gastrointestinal tract
    Magnus Simren
    Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden
    Eur J Gastroenterol Hepatol 14:1053-6. 2002
    ..In particular, the relationship between the training intensity and duration and positive and negative alterations in gastrointestinal physiology needs to be addressed further...
  17. ncbi request reprint Abnormal levels of neuropeptide Y and peptide YY in the colon in irritable bowel syndrome
    Magnus Simren
    Section of Gastroenterology, Department of Internal Medicine, Sahlgrenska University Hosptial, Goteborg, Sweden
    Eur J Gastroenterol Hepatol 15:55-62. 2003
    ..To assess the levels of gut peptides involved in gastrointestinal motor, secretory and sensory function in colonic biopsies in irritable bowel syndrome (IBS) patients and healthy controls...
  18. ncbi request reprint Treatment with hypnotherapy reduces the sensory and motor component of the gastrocolonic response in irritable bowel syndrome
    Magnus Simren
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Psychosom Med 66:233-8. 2004
    ..Postprandial symptoms in irritable bowel syndrome are common and relate to an exaggerated motor and sensory component of the gastrocolonic response. We investigated whether this response can be affected by hypnotherapy...
  19. doi request reprint Randomised clinical trial: The ileal bile acid transporter inhibitor A3309 vs. placebo in patients with chronic idiopathic constipation--a double-blind study
    M Simren
    Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Aliment Pharmacol Ther 34:41-50. 2011
    ..One half of patients with constipation are not satisfied with available therapies, hence there is a need for more effective and well-tolerated drugs...
  20. ncbi request reprint Nutritional aspects in patients with functional gastrointestinal disorders and motor dysfunction in the gut. Working team report of the Swedish Motility Group (SMoG)
    M Simren
    Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Dig Liver Dis 39:495-504. 2007
    ....
  21. ncbi request reprint Gastric electrical stimulation for intractable vomiting in patients with chronic intestinal pseudoobstruction
    S Andersson
    Departments of Internal Medicine and Surgery, Sahlgrenska University Hospital, Goteborg, Sweden
    Neurogastroenterol Motil 18:823-30. 2006
    ..01) at last visit. In patients with CIP and medically refractory vomiting, GES seems to have an anti-vomiting effect comparable to that seen in patients with severe DGP. GES should be considered as a therapeutic option for these patients...
  22. doi request reprint Indirect evidence for increased mechanosensitivity of jejunal secretomotor neurones in patients with idiopathic bile acid malabsorption
    A Bajor
    Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Acta Physiol (Oxf) 197:129-37. 2009
    ..The phase III-generated voltage was related to the degree of BAM quantified by the (75)SeHCAT test...
  23. ncbi request reprint Impact of sex and psychological factors on the water loading test in functional dyspepsia
    H Strid
    Dept of Internal Medicine, Boras Hospital, Sweden
    Scand J Gastroenterol 36:725-30. 2001
    ..Our aim was to determine the impact of sex, age and psychological factors on the results of WLT in FD patients, FD-subgroups and healthy controls (HCs), and to evaluate the safety of the test...
  24. ncbi request reprint Lipid-induced colonic hypersensitivity in irritable bowel syndrome: the role of 5-HT3 receptors
    M Simren
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteburg, Sweden
    Aliment Pharmacol Ther 17:279-87. 2003
    ..Irritable bowel syndrome patients demonstrate colonic hypersensitivity after duodenal lipid infusion...
  25. ncbi request reprint Gastrointestinal transit abnormalities are frequently detected in patients with unexplained GI symptoms at a tertiary centre
    R Sadik
    Division of Gastroenterology, Institute of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Neurogastroenterol Motil 20:197-205. 2008
    ..Large-scale transit measurements frequently detect transit abnormalities in clinical practice and may elucidate the relationship between some GI symptoms and abnormal motility...
  26. pmc Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress
    I Posserud
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Gut 53:1102-8. 2004
    ..Stress often worsens the symptoms of irritable bowel syndrome (IBS). We hypothesised that this might be explained by altered neuroendocrine and visceral sensory responses to stress in IBS patients. Subjects and..
  27. ncbi request reprint Subtyping the irritable bowel syndrome by predominant bowel habit: Rome II versus Rome III
    A Ersryd
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Aliment Pharmacol Ther 26:953-61. 2007
    ..The agreement between subtyping irritable bowel syndrome (IBS) patients based on Rome II criteria versus Rome III criteria is unknown...
  28. doi request reprint Temporary percutaneous gastric electrical stimulation: a novel technique tested in patients with non-established indications for gastric electrical stimulation
    S Andersson
    Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Digestion 83:3-12. 2011
    ..To test temporary percutaneous gastric electrical stimulation (TPGES) in patients with drug-refractory nausea/vomiting and nonestablished indications for GES...
  29. ncbi request reprint Gastrointestinal-specific anxiety: an important factor for severity of GI symptoms and quality of life in IBS
    P Jerndal
    Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, S 41345 Goteborg, Sweden
    Neurogastroenterol Motil 22:646-e179. 2010
    ..The Visceral Sensitivity Index (VSI) is a recently developed, reliable and valid measure of GSA. Our aim was to evaluate the association between GSA, GI symptom severity, and QOL in IBS patients...
  30. ncbi request reprint B-cell activation in patients with irritable bowel syndrome (IBS)
    L Ohman
    Institute of Medicine, The Sahlgren s Academy, University of Gothenburg, Sweden
    Neurogastroenterol Motil 21:644-50, e27. 2009
    ..These data suggest that B-cell antigen presentation in IBS patients is associated with altered capacity of providing costimulation to T cells...
  31. ncbi request reprint Fatigue in patients with primary sclerosing cholangitis
    E Bjornsson
    Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
    Scand J Gastroenterol 39:961-8. 2004
    ..The occurrence of fatigue in primary sclerosing cholangitis (PSC), its impact on quality of life and the role of concomitant inflammatory bowel disease (IBD) and coexisting irritable bowel syndrome (IBS) is unexplored...
  32. doi request reprint Characterization of IBS-like symptoms in patients with ulcerative colitis in clinical remission
    B Jonefjäll
    Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Neurogastroenterol Motil 25:756-e578. 2013
    ..The aim of this study was to characterize IBS-like symptoms in patients with Ulcerative Colitis (UC) in clinical remission by assessing inflammatory markers, psychological symptoms, and quality of life...
  33. doi request reprint Exploration of the effects of gender and mild esophagitis on esophageal pain thresholds in the normal and sensitized state of asymptomatic young volunteers
    A L Krarup
    Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Neurogastroenterol Motil 25:766-e580. 2013
    ..The aim was to measure the effect of gender and mild esophagitis on esophageal pain perception...
  34. ncbi request reprint Delay in gastric emptying in patients with chronic renal failure
    H Strid
    Dept of Internal Medicine, Sahlgrenska University Hosptial, Goteborg, Sweden
    Scand J Gastroenterol 39:516-20. 2004
    ..The aims of this study were to evaluate gastric emptying in patients with CRF and to correlate the findings with GI symptoms and evaluate the impact of Helicobacter pylori infection in CRF patients on gastric emptying...
  35. doi request reprint Patient satisfaction after gut-directed hypnotherapy in irritable bowel syndrome
    P Lindfors
    Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Neurogastroenterol Motil 25:169-e86. 2013
    ..Gut-directed hypnotherapy is an effective treatment option for irritable bowel syndrome (IBS). However, clinical observations suggest that patient satisfaction with hypnotherapy is not always associated with improvement in IBS symptoms...
  36. ncbi request reprint Discontinuation of proton pump inhibitors in patients on long-term therapy: a double-blind, placebo-controlled trial
    E Bjornsson
    Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
    Aliment Pharmacol Ther 24:945-54. 2006
    ..The proportion of proton pump inhibitor users on long-term therapy who can discontinue proton pump inhibitor (PPI) medication without developing symptoms is unknown...
  37. doi request reprint Infliximab inhibits activation and effector functions of peripheral blood T cells in vitro from patients with clinically active ulcerative colitis
    R Dahlen
    Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Department of Microbiology and Immunology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Scand J Immunol 78:275-84. 2013
    ..These data suggest that suppression of T cell activity may be important for infliximab-mediated disease remission in patients with UC. ..
  38. ncbi request reprint Percutaneous implantation of gastric electrodes - a novel technique applied in animals and in patients
    A Elfvin
    Departments of Internal Medicine and Surgery, Sahlgrenska University Hospital, Goteborg, Sweden
    Neurogastroenterol Motil 19:103-9. 2007
    ..Temporary percutaneous gastric leads can easily be implanted and may be used for testing of GES and study of gastric electrophysiology...
  39. ncbi request reprint CD4+CD25+ regulatory T cells in irritable bowel syndrome patients
    N Holmén
    Department of Internal Medicine, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Neurogastroenterol Motil 19:119-25. 2007
    ..In conclusion, the low-grade intestinal inflammation recorded in patients with IBS is not associated with an altered function or frequency of CD25(+) Treg cells...
  40. doi request reprint Nutrient intake in patients with irritable bowel syndrome compared with the general population
    L Bohn
    Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Neurogastroenterol Motil 25:23-30.e1. 2013
    ....
  41. ncbi request reprint New insights into the pathogenesis and pathophysiology of irritable bowel syndrome
    L Ohman
    Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Dig Liver Dis 39:201-15. 2007
    ..To conclude, a complex picture of the pathogenesis and pathophysiology of irritable bowel syndrome is emerging, with interactions between several different alterations resulting in the divergent symptom pattern in these patients...
  42. ncbi request reprint Measurement of gastric emptying by radiopaque markers in patients with diabetes: correlation with scintigraphy and upper gastrointestinal symptoms
    E A Olausson
    Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Neurogastroenterol Motil 25:e224-32. 2013
    ..Therefore, we compared emptying of radiopaque markers (ROM) from the stomach, by use of fluoroscopy, with scintigraphy in patients with insulin-treated diabetes...
  43. ncbi request reprint Overuse of acid suppressive therapy in hospitalised patients with pulmonary diseases
    A Niklasson
    Section of Gastroenterology, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Respir Med 97:1143-50. 2003
    ..We assessed the use of and indication for AST and upper endoscopic investigations in hospitalised patients on a pulmonary ward compared with patients on other wards...
  44. ncbi request reprint Peripheral factors in the pathophysiology of irritable bowel syndrome
    J Gunnarsson
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Dig Liver Dis 41:788-93. 2009
    ..It can be modulated by several external and internal factors and recent studies support an association between colorectal sensitivity and the symptoms reported by the patients, especially pain...