Stefano Romeo

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. pmc Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant
    Colin N A Palmer
    Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom
    PLoS ONE 7:e39362. 2012
  2. pmc Cardiovascular events after bariatric surgery in obese subjects with type 2 diabetes
    Stefano Romeo
    Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Diabetes Care 35:2613-7. 2012
  3. pmc Lack of effect of apolipoprotein C3 polymorphisms on indices of liver steatosis, lipid profile and insulin resistance in obese Southern Europeans
    Federica Sentinelli
    Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Italy
    Lipids Health Dis 10:93. 2011
  4. pmc The COBLL1 C allele is associated with lower serum insulin levels and lower insulin resistance in overweight and obese children
    Rosellina Margherita Mancina
    Institute of Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Bruna Straket 16, Goteborg, Sweden
    Diabetes Metab Res Rev 29:413-6. 2013
  5. doi request reprint Alcohol consumption and alcohol problems after bariatric surgery in the Swedish obese subjects study
    Per Arne Svensson
    Department of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at Gothenburg University, SE 41345 Gothenburg, Sweden
    Obesity (Silver Spring) 21:2444-51. 2013
  6. pmc Evaluation of current eligibility criteria for bariatric surgery: diabetes prevention and risk factor changes in the Swedish obese subjects (SOS) study
    Kajsa Sjöholm
    University of Gothenburg, Gothenburg, Sweden
    Diabetes Care 36:1335-40. 2013
  7. doi request reprint The IRS1 rs2943641 variant and risk of future cancer among morbidly obese individuals
    Cristina Maglio
    Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, The Sahlgrenska Academy, University of Gothenburg, S 413 45 Gothenburg, Sweden
    J Clin Endocrinol Metab 98:E785-9. 2013
  8. doi request reprint Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function
    Piero Pingitore
    Department BEST Biologia, Ecologia, Scienze della Terra, Unit of Biochemistry and Molecular Biotechnology, University of Calabria, Via P Bucci 4c, 87036 Arcavacata di Rende, Italy Department of Chemistry and Molecular Biology, University of Gothenburg, PO Box 462, SE 405 30 Goteborg, Sweden
    Biochim Biophys Acta 1841:574-80. 2014
  9. pmc Long-term effect of bariatric surgery on liver enzymes in the Swedish Obese Subjects (SOS) study
    Maria Antonella Burza
    Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 8:e60495. 2013
  10. doi request reprint Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro
    Carlo Pirazzi
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden
    J Hepatol 57:1276-82. 2012

Collaborators

Detail Information

Publications19

  1. pmc Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant
    Colin N A Palmer
    Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom
    PLoS ONE 7:e39362. 2012
    ..Aim of this study is to examine the relationship between PNPLA3 I148M genotypes and serum triglycerides, insulin resistance and T2D susceptibility by testing a gene-environment interaction model with severe obesity...
  2. pmc Cardiovascular events after bariatric surgery in obese subjects with type 2 diabetes
    Stefano Romeo
    Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Diabetes Care 35:2613-7. 2012
    ..The aim of the present study was to examine the effect of bariatric surgery on cardiovascular events in the SOS study participants with type 2 diabetes...
  3. pmc Lack of effect of apolipoprotein C3 polymorphisms on indices of liver steatosis, lipid profile and insulin resistance in obese Southern Europeans
    Federica Sentinelli
    Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Italy
    Lipids Health Dis 10:93. 2011
    ..Apolipoprotein C3 (APOC3) is a component of triglyceride-rich lipoproteins, and APOC3 rs2854116 and rs2854117 polymorphisms have been associated with non-alcoholic fatty liver disease, hypertriglyceridaemia, and insulin-resistance...
  4. pmc The COBLL1 C allele is associated with lower serum insulin levels and lower insulin resistance in overweight and obese children
    Rosellina Margherita Mancina
    Institute of Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Bruna Straket 16, Goteborg, Sweden
    Diabetes Metab Res Rev 29:413-6. 2013
    ..The aim of the study was to investigate if the association between COBLL1 rs7607980 genetic variant and lower insulin resistance was present early in life...
  5. doi request reprint Alcohol consumption and alcohol problems after bariatric surgery in the Swedish obese subjects study
    Per Arne Svensson
    Department of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at Gothenburg University, SE 41345 Gothenburg, Sweden
    Obesity (Silver Spring) 21:2444-51. 2013
    ..Increased sensitivity to alcohol after gastric bypass has been described. The aim of this study was to investigate whether bariatric surgery is associated with alcohol problems...
  6. pmc Evaluation of current eligibility criteria for bariatric surgery: diabetes prevention and risk factor changes in the Swedish obese subjects (SOS) study
    Kajsa Sjöholm
    University of Gothenburg, Gothenburg, Sweden
    Diabetes Care 36:1335-40. 2013
    ..We used Swedish obese subjects (SOS) to explore long-term outcomes in noneligible versus eligible patients...
  7. doi request reprint The IRS1 rs2943641 variant and risk of future cancer among morbidly obese individuals
    Cristina Maglio
    Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, The Sahlgrenska Academy, University of Gothenburg, S 413 45 Gothenburg, Sweden
    J Clin Endocrinol Metab 98:E785-9. 2013
    ..Obesity and insulin resistance are risk factors for cancer development. The IRS1 rs2943641 genetic variant has been widely associated with insulin resistance...
  8. doi request reprint Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function
    Piero Pingitore
    Department BEST Biologia, Ecologia, Scienze della Terra, Unit of Biochemistry and Molecular Biotechnology, University of Calabria, Via P Bucci 4c, 87036 Arcavacata di Rende, Italy Department of Chemistry and Molecular Biology, University of Gothenburg, PO Box 462, SE 405 30 Goteborg, Sweden
    Biochim Biophys Acta 1841:574-80. 2014
    ..Our data show that PNPLA3 has a predominant lipase activity and I148M mutation results in a loss of function. ..
  9. pmc Long-term effect of bariatric surgery on liver enzymes in the Swedish Obese Subjects (SOS) study
    Maria Antonella Burza
    Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 8:e60495. 2013
    ..Bariatric surgery is effective in obtaining and maintaining weight loss. Aim of the present study was to examine the long-term effects of bariatric surgery on transaminase levels in obese individuals...
  10. doi request reprint Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro
    Carlo Pirazzi
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden
    J Hepatol 57:1276-82. 2012
    ....
  11. doi request reprint PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals
    Maria Antonella Burza
    Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Dig Liver Dis 44:1037-41. 2012
    ..In the present study we examined the association between the PNPLA3 I148M genetic variant and hepatocellular carcinoma in obese individuals from the Swedish Obese Subjects cohort (n = 4047)...
  12. pmc PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells
    Carlo Pirazzi
    Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory and
    Hum Mol Genet 23:4077-85. 2014
    ..Importantly, this indicates a potential novel link between HSCs, retinoid metabolism and PNPLA3 in determining the susceptibility to chronic liver disease. ..
  13. doi request reprint Bariatric surgery and prevention of type 2 diabetes in Swedish obese subjects
    Lena M S Carlsson
    Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    N Engl J Med 367:695-704. 2012
    ..In an analysis of data from a nonrandomized, prospective, controlled study, we examined the effects of bariatric surgery on the prevention of type 2 diabetes...
  14. pmc PNPLA 3 I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infection
    Karolina Rembeck
    Department of Infectious Diseases Virology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
    BMC Med Genet 13:82. 2012
    ..To evaluate the impact of PNPLA3 I148M variant on metabolic traits and treatment response in HCV genotype 2 and 3 infected patients...
  15. ncbi request reprint The expression of NAD(P)H:quinone oxidoreductase 1 is high in human adipose tissue, reduced by weight loss, and correlates with adiposity, insulin sensitivity, and markers of liver dysfunction
    Jenny Palming
    Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    J Clin Endocrinol Metab 92:2346-52. 2007
    ..Studies in mice deficient in NQO1 activity suggest that NQO1 may also play an important role in metabolism...
  16. doi request reprint Carotid intima-media thickness: a target or a marker?
    Tiziana Montalcini
    1Department of Medical and Surgical Sciences, University of Catanzaro, Catanzaro, Italy and 2Department of Molecular and Clinical Medicine, Sahlgrenska Center for Cardiovascolar and Metabolic Research, University of Gothenburg, Gothenburg, Sweden
    Am J Ther 21:535-9. 2014
    ....
  17. pmc Monitoring of lipids, enzymes, and creatine kinase in patients on lipid-lowering drug therapy
    Olov Wiklund
    Wallenberg Laboratory, Department of Experimental and Clinical Medicine, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, 413 45, Goteborg, Sweden
    Curr Cardiol Rep 15:397. 2013
    ..In stable conditions during treatment, the focus should be on clinical symptoms that may alert muscle or liver complications. Routine measurement of CK or ALT is not necessary during treatment with statins. ..
  18. pmc PNPLA3 I148M (rs738409) genetic variant and age at onset of at-risk alcohol consumption are independent risk factors for alcoholic cirrhosis
    Maria Antonella Burza
    Institute of Medicine, Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Gothenburg, Sweden
    Liver Int 34:514-20. 2014
    ..The aim of this study was to investigate the role of age at onset of at-risk alcohol consumption and PNPLA3 I148M variant on alcoholic cirrhosis incidence...
  19. pmc The androgen receptor confers protection against diet-induced atherosclerosis, obesity, and dyslipidemia in female mice
    Johan B Fagman
    Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Laboratory for Experimental Medicine and Endocrinology, Department of Experimental Medicine, Katholieke Universiteit Leuven, Leuven, Belgium Department of Physiology, Institute of Neuroscience and Physiology, and Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Nordic School of Public Health, Gothenburg, Sweden and Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    FASEB J 29:1540-50. 2015
    ..In conclusion, we demonstrate that the AR protects against diet-induced atherosclerosis in female mice and propose that this is mediated by modulation of body composition and lipid metabolism...