Kjell Olmarker

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. ncbi request reprint Radicular pain - recent pathophysiologic concepts and therapeutic implications
    K Olmarker
    Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    Schmerz 15:425-9. 2001
  2. ncbi request reprint Pathogenesis of sciatic pain: a study of spontaneous behavior in rats exposed to experimental disc herniation
    Kjell Olmarker
    Department of Orthopaedics, Goteborg University, Sahlgrenska University Hospital, Gothenburg, Sweden
    Spine (Phila Pa 1976) 27:1312-7. 2002
  3. pmc Walking analysis of rats subjected to experimental disc herniation
    K Olmarker
    Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg University, Sweden
    Eur Spine J 7:394-9. 1998
  4. ncbi request reprint Changes in spontaneous behavior in rats exposed to experimental disc herniation are blocked by selective TNF-alpha inhibition
    Kjell Olmarker
    Department of Orthopaedics, Goteborg University, Sahlgrenska University Hospital, Gothenburg, Sweden
    Spine (Phila Pa 1976) 28:1635-41; discussion 1642. 2003
  5. ncbi request reprint Neovascularization and neoinnervation of subcutaneously placed nucleus pulposus and the inhibitory effects of certain drugs
    Kjell Olmarker
    Department of Orthopaedics, Goteborg University, Gothenburg, Sweden
    Spine (Phila Pa 1976) 30:1501-4. 2005
  6. doi request reprint Puncture of a lumbar intervertebral disc induces changes in spontaneous pain behavior: an experimental study in rats
    Kjell Olmarker
    Department of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska Academy, Goteborg University, Gothenburg, Sweden
    Spine (Phila Pa 1976) 33:850-5. 2008
  7. ncbi request reprint Infliximab attenuates immunoreactivity of brain-derived neurotrophic factor in a rat model of herniated nucleus pulposus
    Akira Onda
    Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Spine (Phila Pa 1976) 29:1857-61. 2004
  8. ncbi request reprint Nerve growth factor content in dorsal root ganglion as related to changes in pain behavior in a rat model of experimental lumbar disc herniation
    Akira Onda
    Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    Spine (Phila Pa 1976) 30:188-93. 2005
  9. doi request reprint Autologous nucleus pulposus primes T cells to develop into interleukin-4-producing effector cells: an experimental study on the autoimmune properties of nucleus pulposus
    Andrea Geiss
    Department of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    J Orthop Res 27:97-103. 2009
  10. doi request reprint New, clinically more relevant model for nerve root injury in the rat
    Oscar Finskas
    Musculoskeletal Research, Department of Medical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden and Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Spine (Phila Pa 1976) 38:1744-8. 2013

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Radicular pain - recent pathophysiologic concepts and therapeutic implications
    K Olmarker
    Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    Schmerz 15:425-9. 2001
    ..Disk-related cytokines, in particular tumor necrosis factor (TNF), have been found to mediate such changes, and clinical trials have now been initiated to assess the possibility of treating sciatica with selective inhibition of TNF...
  2. ncbi request reprint Pathogenesis of sciatic pain: a study of spontaneous behavior in rats exposed to experimental disc herniation
    Kjell Olmarker
    Department of Orthopaedics, Goteborg University, Sahlgrenska University Hospital, Gothenburg, Sweden
    Spine (Phila Pa 1976) 27:1312-7. 2002
    ..A new way to study pain in experimental animals without handling of the animals and based on registration of spontaneous behavior using video recordings...
  3. pmc Walking analysis of rats subjected to experimental disc herniation
    K Olmarker
    Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg University, Sweden
    Eur Spine J 7:394-9. 1998
    ..Although walking analysis may be a valuable assessment of sciatic pain, better modalities must be developed to analyze experimentally induced nerve root pain...
  4. ncbi request reprint Changes in spontaneous behavior in rats exposed to experimental disc herniation are blocked by selective TNF-alpha inhibition
    Kjell Olmarker
    Department of Orthopaedics, Goteborg University, Sahlgrenska University Hospital, Gothenburg, Sweden
    Spine (Phila Pa 1976) 28:1635-41; discussion 1642. 2003
    ..Study of pain behavior in animals by observation of changes in spontaneous behavior...
  5. ncbi request reprint Neovascularization and neoinnervation of subcutaneously placed nucleus pulposus and the inhibitory effects of certain drugs
    Kjell Olmarker
    Department of Orthopaedics, Goteborg University, Gothenburg, Sweden
    Spine (Phila Pa 1976) 30:1501-4. 2005
    ..An experimental study in the pig with autologous transfer of nucleus pulpous and retroperitoneal fat to the subcutaneous space of the back...
  6. doi request reprint Puncture of a lumbar intervertebral disc induces changes in spontaneous pain behavior: an experimental study in rats
    Kjell Olmarker
    Department of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska Academy, Goteborg University, Gothenburg, Sweden
    Spine (Phila Pa 1976) 33:850-5. 2008
    ..Changes in spontaneous behavior was studied in rats after a controlled puncture of a lumbar intervertebral disc...
  7. ncbi request reprint Infliximab attenuates immunoreactivity of brain-derived neurotrophic factor in a rat model of herniated nucleus pulposus
    Akira Onda
    Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Spine (Phila Pa 1976) 29:1857-61. 2004
    ..The effect of infliximab, a chimeric monoclonal antibody to TNF-alpha, on induction of brain-derived neurotrophic factor (BDNF) was examined using an experimental herniated nucleus pulposus (NP) model...
  8. ncbi request reprint Nerve growth factor content in dorsal root ganglion as related to changes in pain behavior in a rat model of experimental lumbar disc herniation
    Akira Onda
    Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    Spine (Phila Pa 1976) 30:188-93. 2005
    ..The time courses of nerve growth factor content and pain-related behavior were examined using experimental disc herniation models...
  9. doi request reprint Autologous nucleus pulposus primes T cells to develop into interleukin-4-producing effector cells: an experimental study on the autoimmune properties of nucleus pulposus
    Andrea Geiss
    Department of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    J Orthop Res 27:97-103. 2009
    ....
  10. doi request reprint New, clinically more relevant model for nerve root injury in the rat
    Oscar Finskas
    Musculoskeletal Research, Department of Medical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden and Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Spine (Phila Pa 1976) 38:1744-8. 2013
    ..Exposure to nucleus pulposus and displacement of intraspinal nervous structures with assessment of spontaneous behavioral changes in rats...
  11. ncbi request reprint Selective inhibition of tumor necrosis factor-alpha prevents nucleus pulposus-induced thrombus formation, intraneural edema, and reduction of nerve conduction velocity: possible implications for future pharmacologic treatment strategies of sciatica
    K Olmarker
    Department of Orthopaedics, , Gothenburg, Sweden
    Spine (Phila Pa 1976) 26:863-9. 2001
    ..The study therefore provides a basic scientific platform with potential clinical implications regarding the use of anti-tumor necrosis factor-alpha medication as treatment in patients with disc herniation and sciatica...
  12. ncbi request reprint Autoimmune properties of nucleus pulposus: an experimental study in pigs
    Andrea Geiss
    Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Spine (Phila Pa 1976) 32:168-73. 2007
    ..Assessment of activated T and B cells in a subcutaneous chamber filled with autologous nucleus pulposus using flow cytometry and immunohistochemistry...
  13. ncbi request reprint Disc related cytokines inhibit axonal outgrowth from dorsal root ganglion cells in vitro
    Karin Larsson
    Department of Orthopaedics, Goteborg University, Sahlgrenska University Hospital, Gothenburg, Sweden
    Spine (Phila Pa 1976) 30:621-4. 2005
    ..Application of nucleus pulposus and disc related cytokines in vitro on cultured dorsal root ganglion (DRG) cells...
  14. ncbi request reprint Methylprednisolone reduces the early vascular permeability increase in spinal nerve roots induced by epidural nucleus pulposus application
    G Byröd
    Department of Orthopaedics, Goteborg University, Sahlgrenska University Hospital, Gothenburg, Sweden
    J Orthop Res 18:983-7. 2000
    ..This increase can be partially prevented by pretreatment with high-dose methylprednisolone...
  15. doi request reprint Effect of lactoferrin peptide (PXL01) on rabbit digit mobility after flexor tendon repair
    Joakim Håkansson
    Department of Hand Surgery, and Institution of Surgical Science, Uppsala University, Uppsala, Sweden
    J Hand Surg Am 37:2519-25. 2012
    ....
  16. ncbi request reprint Local application of disc-related cytokines on spinal nerve roots
    Yoshihito Aoki
    Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg University, Gothenburg, Sweden
    Spine (Phila Pa 1976) 27:1614-7. 2002
    ....
  17. doi request reprint Pharmacological inhibition of tumor necrosis factor may reduce pain behavior changes induced by experimental disc puncture in the rat: an experimental study in rats
    Toshio Nakamae
    Department of Medical Chemistry and Cell Biology, Musculoskeletal Research, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Spine (Phila Pa 1976) 36:E232-6. 2011
    ..Pain behavior assessment in rats following disc puncture (DP) and simultaneous tumor necrosis factor (TNF) inhibition...
  18. pmc Proinflammatory cytokines in cerebrospinal fluid and serum in patients with disc herniation and sciatica
    H Brisby
    Department of Orthopaedics, Goteborg University, Sahlgrenska University Hospital, Gothenburg, Sweden
    Eur Spine J 11:62-6. 2002
    ..Further studies on the potential role of IL-8 as a biomarker for disc herniation are warranted...
  19. ncbi request reprint Tumor necrosis factor alpha and nucleus-pulposus-induced nerve root injury
    K Olmarker
    Department of Orthopaedics, Sahlgrenska University Hospital, , Sweden
    Spine (Phila Pa 1976) 23:2538-44. 1998
    ....
  20. ncbi request reprint Effects of methylprednisolone on nucleus pulposus-induced nerve root injury
    K Olmarker
    Department of Orthopaedics, University of Gothenburg, Sahlgren Hospital, Sweden
    Spine (Phila Pa 1976) 19:1803-8. 1994
    ..The light microscopic changes were probably not significant for the nerve function. Instead, a morphologic explanation on a subcellular level should probably be sought...
  21. ncbi request reprint Ultrastructural changes in spinal nerve roots induced by autologous nucleus pulposus
    K Olmarker
    Department of Orthopaedics, University of Gothenburg, Sahlgren Hospital, Sweden
    Spine (Phila Pa 1976) 21:411-4. 1996
    ..However, because axonal and Schwann cell changes affected only part of the nerve fibers, further causes of the impaired nerve conduction need to be determined...
  22. ncbi request reprint Nitric oxide as a mediator of nucleus pulposus-induced effects on spinal nerve roots
    H Brisby
    Department of Orthopaedics, Goteborg University, Sahlgrenska University Hospital, Sweden
    J Orthop Res 18:815-20. 2000
    ..Furthermore, the results suggest that nitric oxide is involved in the pathophysiological effects of nucleus pulposus in disc herniation...
  23. ncbi request reprint Markers of nerve tissue injury in the cerebrospinal fluid in patients with lumbar disc herniation and sciatica
    H Brisby
    Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg University, Sweden
    Spine (Phila Pa 1976) 24:742-6. 1999
    ..The light subunit of neurofilament protein, S-100 protein, neuron-specific enolase, and glial fibrillary acidic protein were determined in the cerebrospinal fluid in patients with lumbar disc herniation and in control patients...
  24. ncbi request reprint Immunoreactivity of brain-derived neurotrophic factor in rat dorsal root ganglion and spinal cord dorsal horn following exposure to herniated nucleus pulposus
    Akira Onda
    Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg University, SE 413 45 Gothenburg, Sweden
    Neurosci Lett 352:49-52. 2003
    ..These results thus show that herniated NP increases the BDNF production in the pain-processing neurons. Such changes can contribute to the development of inflammatory hyperalgesia...
  25. pmc Reduction of adhesion formation and promotion of wound healing after laminectomy by pharmacological inhibition of pro-inflammatory cytokines: an experimental study in the rat
    Kjell Olmarker
    Musculoskeletal Research, Department of Medical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden
    Eur Spine J 19:2117-21. 2010
    ....
  26. doi request reprint Model for assessment of mobility of toes and healing of tendons in rabbits
    Kjell Olmarker
    Musculoskeletal Research, Department of Medical Chemistry and Cell Biology, Inst of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg
    J Plast Surg Hand Surg 44:266-71. 2010
    ..The model is primarily intended to compare data among treated and non-treated digits of methods to limit the formation of adhesions after tendons have been repaired...
  27. ncbi request reprint Effects of diclofenac and ketoprofen on nerve conduction velocity in experimental nerve root compression
    M Cornefjord
    Department of Orthopaedics, Goteborg University, Gothenburg, Sweden
    Spine (Phila Pa 1976) 26:2193-7. 2001
    ..The effects of diclofenac and ketoprofen on nerve conduction velocity in experimental nerve root compression were evaluated in a setup using an established pig model...
  28. pmc Nucleus pulposus-induced nerve root injury: effects of diclofenac and ketoprofen
    M Cornefjord
    Department of Orthopaedics, Gothenburg University, Sweden
    Eur Spine J 11:57-61. 2002
    ..The aim of the present study was to assess the effects of two potent non-steroidal anti-inflammatory drugs (NSAIDs), diclofenac and ketoprofen, in experimental nucleus pulposus-induced spinal nerve root injury in a pig model...
  29. ncbi request reprint Cultured, autologous nucleus pulposus cells induce functional changes in spinal nerve roots
    S Kayama
    Department of Orthopaedics, , Sahlgrenska University Hospital, Gothenburg, Sweden
    Spine (Phila Pa 1976) 23:2155-8. 1998
    ..Because membranes of the nucleus pulposus cells had similar effects, it can be assumed that the effects are related to membrane-bound substances or structures...
  30. ncbi request reprint Inflammatogenic properties of nucleus pulposus
    K Olmarker
    Department of Orthopaedics, Sahlgren Hospital, Sweden
    Spine (Phila Pa 1976) 20:665-9. 1995
    ..It was not clear, however, it these reactions were induced by substances from the nucleus pulposus per se or from substances being liberated from other tissues as a response to an interaction with components of the nucleus pulposus...
  31. ncbi request reprint Autologous nucleus pulposus induces neurophysiologic and histologic changes in porcine cauda equina nerve roots
    K Olmarker
    Department of Orthopaedics, University of Gothenburg, Sahlgren Hospital, Sweden
    Spine (Phila Pa 1976) 18:1425-32. 1993
    ..Such mechanisms may be based on direct biochemical effects of nucleus pulposus components on nerve fiber structure and function and microvascular changes including inflammatory reactions in the nerve roots...
  32. ncbi request reprint The effects of normal, frozen, and hyaluronidase-digested nucleus pulposus on nerve root structure and function
    K Olmarker
    Department of Orthopaedics, University of Gothenburg, Sahlgrenska University Hospital, Sweden
    Spine (Phila Pa 1976) 22:471-5; discussion 476. 1997
    ..CONCLUSIONS: Because freezing of the nucleus pulposus probably kills the cells but does not affect other components, one may assume that the biologic effects induced by the nucleus pulposus may be related to its cell population...
  33. ncbi request reprint Effects of lidocaine on nucleus pulposus-induced nerve root injury. A neurophysiologic and histologic study of the pig cauda equina
    S Yabuki
    Department of Orthopaedics, Sahlgren University Hospital, Sweden
    Spine (Phila Pa 1976) 23:2383-9; discussion 2389-90. 1998
    ..Further studies are needed to clarify the therapeutic effects of nerve root infiltration and the pathophysiology of nucleus pulposus-induced nerve root injury...
  34. ncbi request reprint Effects of anulus fibrosus and experimentally degenerated nucleus pulposus on nerve root conduction velocity: relevance of previous experimental investigations using normal nucleus pulposus
    M Iwabuchi
    Department of Orthopaedic, , Gothenburg, Sweden
    Spine (Phila Pa 1976) 26:1651-5. 2001
    ....
  35. pmc Pain behavior changes following disc puncture relate to nucleus pulposus rather than to the disc injury per se: an experimental study in rats
    Elin Nilsson
    Department of Orthopaedics, Inst Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Open Orthop J 5:72-7. 2011
    ..In conclusion, the data from the study indicate that behavioral changes induced by disc puncture are more likely to relate to the epidural presence of nucleus pulposus than the disc injury per se...
  36. ncbi request reprint A model for chronic nerve root compression studies. Presentation of a porcine model for controlled, slow-onset compression with analyses of anatomic aspects, compression onset rate, and morphologic and neurophysiologic effects
    M Cornefjord
    Department of Orthopaedics, Sahlgren University Hospital, Gothenburg, Sweden
    Spine (Phila Pa 1976) 22:946-57. 1997
    ..This model allows for induction of a controlled graded chronic nerve root injury and can be used for research on basic pathophysiologic mechanisms and on the effects of various interventions on nerve root injury development...
  37. ncbi request reprint A novel polypeptide derived from human lactoferrin in sodium hyaluronate prevents postsurgical adhesion formation in the rat
    Elin Nilsson
    PharmaSurgics AB, Gothenburg, Sweden
    Ann Surg 250:1021-8. 2009
    ..The objective of the study was to evaluate whether a peptide derived from human lactoferrin, PXL01 could act safely to reduce the formation of peritoneal adhesions in the rat model and to map the molecular mechanisms of its action...
  38. ncbi request reprint A rapid transport route between the epidural space and the intraneural capillaries of the nerve roots
    G Byröd
    Department of Orthopaedics, Sahlgren Hospital, Gothenburg University, Sweden
    Spine (Phila Pa 1976) 20:138-43. 1995
    ..The possibility of epidurally applied substances reaching the intraneural capillaries of the spinal nerve roots and cauda equina was assessed in the pig sacrococcygeal spine...
  39. ncbi request reprint Edema formation in spinal nerve roots induced by experimental, graded compression. An experimental study on the pig cauda equina with special reference to differences in effects between rapid and slow onset of compression
    K Olmarker
    Department of Anatomy, Sahlgren Hospital, Gothenburg, Sweden
    Spine (Phila Pa 1976) 14:569-73. 1989
    ..The data in this study also indicate that intraneural edema might be more easily formed in nerve roots than in peripheral nerves after compression injury...
  40. ncbi request reprint Intermittent cauda equina compression. An experimental study of the porcine cauda equina with analyses of nerve impulse conduction properties
    S Konno
    Department of Orthopaedics, Sahlgren Hospital, , Sweden
    Spine (Phila Pa 1976) 20:1223-6. 1995
    ....
  41. ncbi request reprint Transport of epidurally applied horseradish peroxidase to the endoneurial space of dorsal root ganglia: a light and electron microscopic study
    G Byröd
    Department of Orthopaedics, Goteborg University, Sahlgrenska University Hospital, Gothenburg, Sweden
    J Peripher Nerv Syst 5:218-26. 2000
    ..The demonstrated transport route may have implications in the pathophysiology of sciatica in conjunction with lumbar disc herniation...
  42. ncbi request reprint Neuropeptide changes in compressed spinal nerve roots
    M Cornefjord
    Department of Orthopaedics, Sahlgren Hospital, University of Gothenburg, Sweden
    Spine (Phila Pa 1976) 20:670-3. 1995
    ..There were no significant differences in the VIP concentrations. The study thus indicates that changes in substance P are related to experimental chronic nerve root compression...
  43. ncbi request reprint Chondroitinase ABC (pharmaceutical grade) for chemonucleolysis. Functional and structural evaluation after local application on intraspinal nerve structures and blood vessels
    K Olmarker
    Department of Orthopaedics, Sahlgren University Hospital, Gothenburg, Sweden, USA
    Spine (Phila Pa 1976) 21:1952-6. 1996
    ..The effects on nerve tissue and blood vessels of locally applied chondroitinase ABC were studied in two experimental models using chymopapain and the vehicle of chondroitinase ABC for controls...
  44. doi request reprint The role of tumor necrosis factor-alpha in apoptosis of dorsal root ganglion cells induced by herniated nucleus pulposus in rats
    Yasuaki Murata
    Department of Orthopaedic Surgery, Shimoshizu National Hospital, Chiba, Japan
    Spine (Phila Pa 1976) 33:155-62. 2008
    ....
  45. ncbi request reprint Production of tumor necrosis factor-alpha from porcine nucleus pulposus cells at various time points in cell culture under conditions of nutritional deficiency
    Yasuaki Murata
    Department of Orthopaedic Surgery, School of Medicine, Chiba University, Chiba, Japan
    Cytokine 34:206-11. 2006
    ..These observations may suggest that a nutritional deficit is a possible turn-on switch for TNF up-regulation in the NP...
  46. ncbi request reprint Inflammatory cytokines released from the facet joint tissue in degenerative lumbar spinal disorders
    Akira Igarashi
    Department of Orthopaedic Surgery, School of Medicine, Fukushima Medical University, Fukushima City, Japan
    Spine (Phila Pa 1976) 29:2091-5. 2004
    ..A prospective study of surgical cases of degenerative lumbar spinal disorders demonstrated inflammatory cytokines in the facet joint tissue...
  47. ncbi request reprint Distribution and appearance of tumor necrosis factor-alpha in the dorsal root ganglion exposed to experimental disc herniation in rats
    Yasuaki Murata
    Department of Orthopaedics, School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 29:2235-41. 2004
    ..Distribution and appearance of tumor necrosis factor-alpha (TNF-alpha) in the dorsal root ganglion (DRG) exposed to experimental disc herniation were investigated using an immunohistochemical method in rats...
  48. ncbi request reprint Selective inhibition of tumor necrosis factor-alpha prevents nucleus pulposus-induced histologic changes in the dorsal root ganglion
    Yasuaki Murata
    Department of Orthopaedics, School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 29:2477-84. 2004
    ..The possibility to prevent nucleus pulposus-induced structural changes of the dorsal root ganglion (DRG) by selective tumor necrosis factor-alpha (TNF-alpha) inhibition was assessed in an experimental model in the rat spine...
  49. ncbi request reprint Changes in pain behavior and histologic changes caused by application of tumor necrosis factor-alpha to the dorsal root ganglion in rats
    Yasuaki Murata
    Department of Orthopaedic Surgery, School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 31:530-5. 2006
    ..Histologic changes in the dorsal root ganglion (DRG) and the nociceptive stimulation thresholds were studied in rats...
  50. ncbi request reprint Effects of selective tumor necrosis factor-alpha inhibition to pain-behavioral changes caused by nucleus pulposus-induced damage to the spinal nerve in rats
    Yasuaki Murata
    Department of Orthopaedic Surgery, School of Medicine, Chiba University, 1 8 1 Inohana, Chiba City, Chiba 260 8670, Japan
    Neurosci Lett 382:148-52. 2005
    ..Injection of infliximab seemed to prevent mechanical and thermal hyperalgesia caused by the combination of disk incision and nerve displacement...
  51. pmc Effects of lumbar sympathectomy on pain behavioral changes caused by nucleus pulposus-induced spinal nerve damage in rats
    Yasuaki Murata
    Orthopaedic Surgery, Shimoshizu National Hospital, 934 5 Shikawatashi, Yotsukaido City, Japan
    Eur Spine J 15:634-40. 2006
    ..No allodynia was observed in the sham groups. Sympathectomy seemed to prevent the pain behavioral changes caused by the combination of disk incision and nerve displacement...
  52. ncbi request reprint Nucleus pulposus-induced apoptosis in dorsal root ganglion following experimental disc herniation in rats
    Yasuaki Murata
    Department of Orthopaedic Surgery, School of Medicine, Chiba University, Chiba City, Chiba, Japan
    Spine (Phila Pa 1976) 31:382-90. 2006
    ....
  53. ncbi request reprint Incision of the intervertebral disc induces disintegration and increases permeability of the dorsal root ganglion capsule
    Yasuaki Murata
    Department of Orthopaedic Surgery, School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 30:1712-6. 2005
    ....
  54. ncbi request reprint Macrophage appearance in the epineurium and endoneurium of dorsal root ganglion exposed to nucleus pulposus
    Yasuaki Murata
    Department of Orthopaedics, School of Medicine, Chiba University, Chiba, Japan
    J Peripher Nerv Syst 9:158-64. 2004
    ..05). We conclude that experimental disc herniation with leakage of nucleus pulposus results in macrophage recruitment to the epineurium of the DRG 3 h after disc incision and to the endoneurium 24 and 72 h after disc incision...
  55. ncbi request reprint Lumbar sympathectomy increases blood flow in a dog model of chronic cauda equina compression
    Akira Onda
    Department of Orthopaedic Surgery, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima, Japan
    J Spinal Disord Tech 17:522-5. 2004
    ..This study was designed to assess changes in blood flow of the dog cauda equina after lumbar sympathectomy using an experimental chronic cauda compression model...