C Ohlsson

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. pmc Liver-derived endocrine IGF-I is not critical for activation of skeletal muscle protein synthesis following oral feeding
    Britt Marie Iresjö
    Department of Surgery Sahlgrenska University Hospital Kir, Metabol lab Bruna Stråket 20, Gothenburg Sweden
    BMC Physiol 13:7. 2013
  2. pmc Fibroblast growth factor 23, mineral metabolism and mortality among elderly men (Swedish MrOs)
    Per Anton Westerberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    BMC Nephrol 14:85. 2013
  3. pmc Comparisons of immunoassay and mass spectrometry measurements of serum estradiol levels and their influence on clinical association studies in men
    Claes Ohlsson
    Centre for Bone and Arthritis Research, Sahlgrenska Academy, University of Gothenburg, Vita Stråket 11, SE 413 45 Gothenburg, Sweden
    J Clin Endocrinol Metab 98:E1097-102. 2013
  4. doi request reprint Bone metabolism in 2012: Novel osteoporosis targets
    Claes Ohlsson
    Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Sweden
    Nat Rev Endocrinol 9:72-4. 2013
  5. pmc Estrogen receptor-α expression in neuronal cells affects bone mass
    Claes Ohlsson
    Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden
    Proc Natl Acad Sci U S A 109:983-8. 2012
  6. pmc Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-ncf1*/* mice with collagen-induced chronic arthritis
    Caroline Jochems
    Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    BMC Musculoskelet Disord 11:284. 2010
  7. pmc Estren promotes androgen phenotypes in primary lymphoid organs and submandibular glands
    Ulrika Islander
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, Goteborg University, Sweden
    BMC Immunol 6:16. 2005
  8. pmc Combined treatment with dexamethasone and raloxifene totally abrogates osteoporosis and joint destruction in experimental postmenopausal arthritis
    Ulrika Islander
    Centre for Bone and Arthritis Research, The Sahlgrenska Academy, University of Gothenburg, Box 480, 405 30 Gothenburg, Sweden
    Arthritis Res Ther 13:R96. 2011
  9. pmc Osteoporosis in experimental postmenopausal polyarthritis: the relative contributions of estrogen deficiency and inflammation
    Caroline Jochems
    Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Goteborg, Sweden
    Arthritis Res Ther 7:R837-43. 2005
  10. pmc Prevalence and risk factors of vertebral compression fractures in female SLE patients
    Katarina Almehed
    Department of Rheumatology and Inflammation Research, University of Gothenburg, Goteborg, Sweden
    Arthritis Res Ther 12:R153. 2010

Detail Information

Publications92

  1. pmc Liver-derived endocrine IGF-I is not critical for activation of skeletal muscle protein synthesis following oral feeding
    Britt Marie Iresjö
    Department of Surgery Sahlgrenska University Hospital Kir, Metabol lab Bruna Stråket 20, Gothenburg Sweden
    BMC Physiol 13:7. 2013
    ..In the present study the role of liver-derived endocrine IGF-I for activation of skeletal muscle protein synthesis following feeding was evaluated...
  2. pmc Fibroblast growth factor 23, mineral metabolism and mortality among elderly men (Swedish MrOs)
    Per Anton Westerberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    BMC Nephrol 14:85. 2013
    ..The primary aim of this study is to examine the association between FGF23 and mortality, in relation to renal function in the community. A secondary aim is to examine the association between FGF23 and CVD related death...
  3. pmc Comparisons of immunoassay and mass spectrometry measurements of serum estradiol levels and their influence on clinical association studies in men
    Claes Ohlsson
    Centre for Bone and Arthritis Research, Sahlgrenska Academy, University of Gothenburg, Vita Stråket 11, SE 413 45 Gothenburg, Sweden
    J Clin Endocrinol Metab 98:E1097-102. 2013
    ..Different measurement techniques may be responsible for the conflicting results of associations between serum E2 and clinical phenotypes in men...
  4. doi request reprint Bone metabolism in 2012: Novel osteoporosis targets
    Claes Ohlsson
    Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Sweden
    Nat Rev Endocrinol 9:72-4. 2013
    ....
  5. pmc Estrogen receptor-α expression in neuronal cells affects bone mass
    Claes Ohlsson
    Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden
    Proc Natl Acad Sci U S A 109:983-8. 2012
    ....
  6. pmc Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-ncf1*/* mice with collagen-induced chronic arthritis
    Caroline Jochems
    Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    BMC Musculoskelet Disord 11:284. 2010
    ..We also examined whether treatment would prevent the development of inflammation-triggered generalized osteoporosis...
  7. pmc Estren promotes androgen phenotypes in primary lymphoid organs and submandibular glands
    Ulrika Islander
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, Goteborg University, Sweden
    BMC Immunol 6:16. 2005
    ..Estrogen receptors (ERs) were blocked by treatment of mice with the ER-antagonist ICI 182,780; also, knock-out mice lacking one or both ERs were used...
  8. pmc Combined treatment with dexamethasone and raloxifene totally abrogates osteoporosis and joint destruction in experimental postmenopausal arthritis
    Ulrika Islander
    Centre for Bone and Arthritis Research, The Sahlgrenska Academy, University of Gothenburg, Box 480, 405 30 Gothenburg, Sweden
    Arthritis Res Ther 13:R96. 2011
    ....
  9. pmc Osteoporosis in experimental postmenopausal polyarthritis: the relative contributions of estrogen deficiency and inflammation
    Caroline Jochems
    Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Goteborg, Sweden
    Arthritis Res Ther 7:R837-43. 2005
    ..Markers of bone remodeling and bone marrow lymphocyte phenotypes indicate different mechanisms for the development of osteoporosis caused by ovariectomy and arthritis in this model...
  10. pmc Prevalence and risk factors of vertebral compression fractures in female SLE patients
    Katarina Almehed
    Department of Rheumatology and Inflammation Research, University of Gothenburg, Goteborg, Sweden
    Arthritis Res Ther 12:R153. 2010
    ..Our objective was to determine the frequency of and factors associated with prevalent vertebral compression fractures in female systemic lupus erythematosus (SLE) patients attending rheumatologists in western Sweden...
  11. pmc Hormone replacement therapy, calcium and vitamin D3 versus calcium and vitamin D3 alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial [ISRCTN46523456]
    Helena Forsblad d'Elia
    Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Arthritis Res Ther 6:R457-68. 2004
    ..We suggest that biochemical markers of bone and cartilage turnover may provide a useful tool for assessing novel treatment modalities in arthritis, concerning both joint protection and prevention of osteoporosis...
  12. pmc Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice
    Li Bian
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Guldhedsgatan 10A, Box 480, SE 405 30, Gothenburg, Sweden
    Arthritis Res Ther 11:R132. 2009
    ..The pro-apoptotic and anti-proliferative properties of DCA prompted us to investigate the effects of this compound in arthritis...
  13. doi request reprint Older men with low serum IGF-1 have an increased risk of incident fractures: the MrOS Sweden study
    Claes Ohlsson
    Centre for Bone and Arthritis Research at the Sahlgrenska Academy, Institute of Medicine, University of Goteborg, Goteborg, Sweden
    J Bone Miner Res 26:865-72. 2011
    ..The association between serum IGF-1 and fracture risk is partly mediated via BMD...
  14. doi request reprint The role of estrogens for male bone health
    Claes Ohlsson
    Center for Bone Research, Division of Endocrinology, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE 41345 Gothenburg, Sweden
    Eur J Endocrinol 160:883-9. 2009
    ..Taken together, even though these findings do not exclude an important role for testosterone in male skeletal homeostasis, it is now well-established that estrogens are important regulators of bone health in men...
  15. ncbi request reprint Obesity and disturbed lipoprotein profile in estrogen receptor-alpha-deficient male mice
    C Ohlsson
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, S 41345, Sweden
    Biochem Biophys Res Commun 278:640-5. 2000
    ..In conclusion, ERalpha but not ERbeta-inactivated male mice develop obesity after sexual maturation...
  16. ncbi request reprint The relative importance of endocrine versus autocrine/paracrine insulin-like growth factor-I in the regulation of body growth
    C Ohlsson
    Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Pediatr Nephrol 14:541-3. 2000
    ....
  17. pmc The role of liver-derived insulin-like growth factor-I
    Claes Ohlsson
    Division of Endocrinology, Institute of Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Endocr Rev 30:494-535. 2009
    ..All of the described multiple endocrine effects of liver-derived IGF-I should be considered in the development of possible novel treatment strategies aimed at increasing or reducing endocrine IGF-I activity...
  18. pmc Genetic determinants of serum testosterone concentrations in men
    Claes Ohlsson
    Center for Bone and Arthritis Research, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden
    PLoS Genet 7:e1002313. 2011
    ..rs6258 is the first reported SHBG polymorphism, which affects testosterone binding to SHBG and the free testosterone fraction and could therefore influence the calculation of free testosterone using law-of-mass-action equation...
  19. ncbi request reprint Effects of growth hormone and insulinlike growth factor-I on body growth and adult bone metabolism
    C Ohlsson
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Curr Opin Rheumatol 12:346-8. 2000
    ..Future clinical studies will determine whether some patients with decreased bone mass for other reasons will benefit from treatment with GH alone or in combination with other treatments...
  20. ncbi request reprint Estrogen receptor alpha, but not estrogen receptor beta, is involved in the regulation of the OPG/RANKL (osteoprotegerin/receptor activator of NF-kappa B ligand) ratio and serum interleukin-6 in male mice
    M K Lindberg
    Division of Endocrinology, Department of Internal Medicine, Sahlgrenska University Hospital, , Sweden
    J Endocrinol 171:425-33. 2001
    ..These results demonstrate that ER alpha, but not ER beta, is involved in the regulation of the vertebral OPG/RANKL ratio, serum levels of IL-6 and TRAP 5b in male mice...
  21. ncbi request reprint Liver-derived IGF-I is permissive for ovariectomy-induced trabecular bone loss
    M K Lindberg
    Center for Bone Research, Department of Internal Medicine, Div of Endocrinology, Sahlgrenska Academy, Goteborg University, Bruna Straket 16, 41345 Gothenburg, Sweden
    Bone 38:85-92. 2006
    ..A major part of serum IGF-I is derived from the liver. The aim of the present study was to investigate the role of liver-derived IGF-I for ovariectomy (ovx)-induced trabecular bone loss...
  22. doi request reprint The role of the G protein-coupled receptor GPR30 in the effects of estrogen in ovariectomized mice
    S H Windahl
    Institute of Medicine, Sahlgrenska Academy, Goteborg University, Goteborg
    Am J Physiol Endocrinol Metab 296:E490-6. 2009
    ..These in vivo findings demonstrate that GPR30 is not required for normal estrogenic responses on several major well-known estrogen-regulated parameters. In contrast, GPR30 is required for a normal estrogenic response in the growth plate...
  23. ncbi request reprint Disproportional skeletal growth and markedly decreased bone mineral content in growth hormone receptor -/- mice
    K Sjogren
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, S 413 45, Sweden
    Biochem Biophys Res Commun 267:603-8. 2000
    ....
  24. pmc Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice
    O Vidal
    Department of Internal Medicine, Division of Endocrinology, Sahlgrenska University Hospital, S 41345 Goteborg, Sweden
    Proc Natl Acad Sci U S A 97:5474-9. 2000
    ..Therefore, ERalpha, but not ERbeta, mediates important effects of estrogen in the skeleton of male mice during growth and maturation...
  25. pmc Roles of transactivating functions 1 and 2 of estrogen receptor-alpha in bone
    A E Börjesson
    Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, S 41345 Gothenburg, Sweden
    Proc Natl Acad Sci U S A 108:6288-93. 2011
    ..Selective ER modulators stimulating ERα with minimal activation of ERα AF-1 could retain beneficial actions in cortical bone, constituting 80% of the skeleton, while minimizing effects on reproductive organs...
  26. ncbi request reprint Estrogen receptor specificity in the regulation of the skeleton in female mice
    M K Lindberg
    Division of Endocrinology, Department of Internal Medicine, Sahlgrenska University Hospital, S 41345 Gothenburg, Sweden
    J Endocrinol 171:229-36. 2001
    ..Thus, ER alpha and ER beta may have separate effects (regulation of fat), opposing effects (longitudinal bone growth) or partial redundant effects (trabecular BMD at 60 days of age), depending on which parameter is studied...
  27. pmc Estren-mediated inhibition of T lymphopoiesis is estrogen receptor-independent whereas its suppression of T cell-mediated inflammation is estrogen receptor-dependent
    U Islander
    Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Goteborg, Sweden
    Clin Exp Immunol 139:210-5. 2005
    ..Thus, our study is the first to show that estren inhibits T lymphopoiesis via ER-independent pathways, whereas its suppressive effects on inflammation are ER-dependent...
  28. ncbi request reprint Estrogen receptor specificity for the effects of estrogen in ovariectomized mice
    M K Lindberg
    Division of Endocrinology, Department of Internal Medicine, Grona Straket 8, Sahlgrenska University Hospital, S 41345 Goteborg, Sweden
    J Endocrinol 174:167-78. 2002
    ..Other effects of estrogen, such as increased trabecular bone mineral density, thymic atrophy, fat reduction and increased uterine weight, were mainly ERalpha mediated...
  29. ncbi request reprint Liver-derived IGF-I is of importance for normal carbohydrate and lipid metabolism
    K Sjogren
    Research Center for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Diabetes 50:1539-45. 2001
    ..Furthermore, they had increased serum levels of cholesterol. We conclude that liver-derived IGF-I is of importance for carbohydrate and lipid metabolism...
  30. pmc Oestrogen receptor specificity in oestradiol-mediated effects on B lymphopoiesis and immunoglobulin production in male mice
    M C Erlandsson
    Department of Rheumatology and Inflammation Research, Department of Internal Medicine, Goteborg University, Guldhedsgatan 10A, S 413 46 Goteborg, Sweden
    Immunology 108:346-51. 2003
    ..In conclusion our results clearly show that both ERalpha and ERbeta are required for complete down-regulation of B lymphopoiesis while only ERalpha is needed to up-regulate immunoglobulin production in both bone marrow and spleen...
  31. ncbi request reprint The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats
    J Svensson
    Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    J Endocrinol 165:569-77. 2000
    ....
  32. pmc The role of estrogen receptor-α and its activation function-1 for growth plate closure in female mice
    A E Börjesson
    Centre for Bone and Arthritis Research, Klin Farm Lab, Vita Stråket 11, Dept of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    Am J Physiol Endocrinol Metab 302:E1381-9. 2012
    ..This suggests that growth plate closure is induced by functions of ERα that do not require AF-1 and that ERαAF-1 opposes growth plate closure...
  33. ncbi request reprint Identification of target cells for the genomic effects of estrogens in bone
    S H Windahl
    Department of Internal Medicine, Division of Endocrinology, Grona Straket 8, Gothenburg, Sweden
    Endocrinology 148:5688-95. 2007
    ..Furthermore, our findings indicate that possible direct estrogenic effects on the majority of osteocytes, not staining positive for luciferase, on proliferative chondrocytes and on mature lymphocytes are mediated by non-ERE actions...
  34. ncbi request reprint A transgenic model to determine the physiological role of liver-derived insulin-like growth factor I
    K Sjogren
    Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    Minerva Endocrinol 27:299-311. 2002
    ..Furthermore, it regulates adult axial skeletal growth and cortical radial growth while it is not required for appendicular skeletal growth...
  35. pmc A variant near the interleukin-6 gene is associated with fat mass in Caucasian men
    N Andersson
    Department of Physiology Endocrinology, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    Int J Obes (Lond) 34:1011-9. 2010
    ..Regulation of fat mass appears to be associated with immune functions. Studies of knockout mice show that endogenous interleukin (IL)-6 can suppress mature-onset obesity...
  36. ncbi request reprint Disproportional body growth in female estrogen receptor-alpha-inactivated mice
    O Vidal
    Department of Internal Medicine, Division of Endocrinology, Sahlgrenska University Hospital, Goteborg, S 41345, Sweden
    Biochem Biophys Res Commun 265:569-71. 1999
    ....
  37. pmc Sport-specific association between exercise loading and the density, geometry, and microstructure of weight-bearing bone in young adult men
    M Nilsson
    Centre for Bone and Arthritis Research at the Sahlgrenska Academy, Department of Internal Medicine, University of Gothenburg, Gothenburg, Sweden
    Osteoporos Int 24:1613-22. 2013
    ..We reveal that the association between exercise loading and bone parameters is sport-specific, indicating that nonspecific resistance exercise does not impact bone density, geometry, or microstructure in young men...
  38. doi request reprint The role of estrogen receptor α in the regulation of bone and growth plate cartilage
    A E Börjesson
    Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Cell Mol Life Sci 70:4023-37. 2013
    ....
  39. pmc Role of oestrogen receptors alpha and beta in immune organ development and in oestrogen-mediated effects on thymus
    M C Erlandsson
    Department of Rheumatology, University of Goteborg, Sweden
    Immunology 103:17-25. 2001
    ....
  40. ncbi request reprint Liver-derived IGF-I regulates GH secretion at the pituitary level in mice
    K Wallenius
    Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Goteborg SE 413 45, Sweden
    Endocrinology 142:4762-70. 2001
    ..The enhanced GH release in turn affects several liver parameters, in line with the existence of a pituitary-liver axis...
  41. ncbi request reprint Body fat content can be predicted in vivo in mice using a modified dual-energy X-ray absorptiometry technique
    K Sjogren
    Department of Internal Medicine, Division of Endocrinology, Sahlgrenska University Hospital, SE 41345 Goteborg, Sweden
    J Nutr 131:2963-6. 2001
    ..97, P < 0.001). In summary, the percentage of fat area, as measured with the dual-energy X-ray/image combined procedure, provides a good in vivo estimation of total body fat content in mice...
  42. ncbi request reprint Effects of growth hormone and its secretagogues on bone
    J Svensson
    Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    Endocrine 14:63-6. 2001
    ..In rodents, GHS treatment increase bone mineral content, but it has not yet been shown that GHS treatment can affect bone mass in adult humans...
  43. ncbi request reprint Raloxifene- and estradiol-mediated effects on uterus, bone and B lymphocytes in mice
    M C Erlandsson
    Department of Rheumatology and Inflammation Research, University of Goteborg, Sweden
    J Endocrinol 175:319-27. 2002
    ..Our results are discussed in the context of estrogen receptor biology, relations between the immune system and bone metabolism and also with respect to the estrogen-mediated effects on rheumatic diseases...
  44. doi request reprint Variants of the interleukin-1 receptor antagonist gene are associated with fat mass in men
    N Andersson
    Department of Neuroscience and Physiology Endocrinology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Int J Obes (Lond) 33:525-33. 2009
    ..Immune functions seem to have connections to variations in body fat mass. Studies of knockout mice indicate that endogenous interleukin (IL)-1 can suppress mature-onset obesity...
  45. ncbi request reprint Possible roles of insulin-like growth factor in regulation of physiological and pathophysiological liver growth
    S Skrtic
    Research Center for Endocrinology and Metabolism (RCEM, Sahlgrenska University Hospital, , Sweden
    Horm Res 55:1-6. 2001
    ..It remains to be investigated whether these effects are of importance for liver regeneration or pathological conditions...
  46. ncbi request reprint The somatomedin hypothesis revisited in a transgenic model
    O Isaksson
    Research Center for Endocrinology and Metabolism, Sahlgrenska University Hospital, , Sweden
    Growth Horm IGF Res 11:S49-52. 2001
    ..Therefore, extrahepatic IGF-I is sufficient for maintenance of postnatal body growth in mice. Further investigations are needed to assess whether liver-derived circulating IGF-I is essential for other biological functions...
  47. doi request reprint Low serum vitamin D is associated with increased mortality in elderly men: MrOS Sweden
    H Johansson
    Centre for Bone and Arthritis Research, Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gibraltargatan 1 C, 411 32 Gothenburg, Sweden
    Osteoporos Int 23:991-9. 2012
    ..In elderly man, low serum 25-hydroxyvitamin D (25(OH)D) was associated with a substantial excess risk of death compared to 25(OH)D values greater than 50-70 nmol/l, but the association attenuated with time...
  48. ncbi request reprint Endocrine, liver-derived IGF-I is of importance for spatial learning and memory in old mice
    J Svensson
    Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Grona Straket 8, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    J Endocrinol 189:617-27. 2006
    ..The decline in serum IGF-I with increasing age may therefore be important for the age-related decline in memory function...
  49. ncbi request reprint GH substitution reverses the growth phenotype but not the defective ossification in thyroid hormone receptor alpha 1-/-beta-/- mice
    J M Kindblom
    Research Center of Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    J Endocrinol 171:15-22. 2001
    ..Our data suggest that TRs are of importance both for the regulation of the GH/IGF-I axis and for direct effects on cartilage...
  50. ncbi request reprint Prevalence and risk factors of osteoporosis in female SLE patients-extended report
    K Almehed
    Department of Rheumatology and Inflammation Reserch, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Rheumatology (Oxford) 46:1185-90. 2007
    ..In addition, to evaluate if adequate anti-osteoporotic treatment was provided...
  51. ncbi request reprint SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density
    A L Eriksson
    Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, Division of Endocrinology, Goteborg University, Sweden
    J Clin Endocrinol Metab 91:5029-37. 2006
    ..Twin studies have demonstrated that genetic factors largely account for interindividual variation in SHBG levels. Glucuronidated androgen metabolites have been proposed as markers of androgenic activity...
  52. doi request reprint Association of physical activity with trabecular microstructure and cortical bone at distal tibia and radius in young adult men
    M Nilsson
    Center for Bone Research at the Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, 416 45 Gothenburg, Sweden
    J Clin Endocrinol Metab 95:2917-26. 2010
    ..The relationship between physical activity, trabecular microstructure, and cortical geometry in weight-bearing and non-weight-bearing bone has not previously been studied in men...
  53. pmc Long-term anti-arthritic and anti-osteoporotic effects of raloxifene in established experimental postmenopausal polyarthritis
    C Jochems
    Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Clin Exp Immunol 152:593-7. 2008
    ..The serum levels of antibodies to collagen were not affected by raloxifene-treatment. Long-term treatment with raloxifene has both anti-arthritic and anti-osteoporotic effects in established experimental postmenopausal polyarthritis...
  54. doi request reprint Low bone mineral density is associated with increased mortality in elderly men: MrOS Sweden
    H Johansson
    Center for Bone Research at the Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gibraltargatan 1C, 411 32 Gothenburg, Sweden
    Osteoporos Int 22:1411-8. 2011
    ..020). Low BMD was associated with a substantial excess risk of death, whilst a higher than average BMD had little impact on mortality...
  55. pmc Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice
    K Sjogren
    Department of Internal Medicine, Division of Endocrinology, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Proc Natl Acad Sci U S A 96:7088-92. 1999
    ..However, the reduction in serum IGF-I concentration had no discernible effect on postnatal body growth. We conclude that postnatal body growth is preserved despite complete absence of IGF-I production by the hepatocytes...
  56. ncbi request reprint Metabolic functions of liver-derived (endocrine) insulin-like growth factor I
    O G Isaksson
    RCEM, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Horm Res 55:18-21. 2001
    ..In conclusion, liver-derived or endocrine IGF-I is not required for post-natal statural growth, but seems to be of vital importance for normal carbohydrate and lipid metabolism...
  57. ncbi request reprint A common polymorphism in the interleukin-6 gene promoter is associated with overweight
    I Wernstedt
    Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
    Int J Obes Relat Metab Disord 28:1272-9. 2004
    ..Moreover, a SNP at position -572 in the IL-6 promoter has recently been reported to affect transcription. The objective was to investigate the association between the IL-6 gene promoter SNPs and obesity...
  58. pmc Advancing maternal age is associated with lower bone mineral density in young adult male offspring
    R Rudäng
    Center for Bone and Arthritis Research at the Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden
    Osteoporos Int 23:475-82. 2012
    ..In the present study, we demonstrate that advancing maternal age is independently associated with reduced bone mass in the young adult male offspring...
  59. ncbi request reprint Retarded liver growth in interleukin-6-deficient and tumor necrosis factor receptor-1-deficient mice
    V Wallenius
    Research Center for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
    Endocrinology 142:2953-60. 2001
    ..The results of TNFalpha and IL-6 treatment further indicate that the effects of TNF receptor-1 and IL-6 depend on each other for full stimulation of liver growth...
  60. doi request reprint Competitive physical activity early in life is associated with bone mineral density in elderly Swedish men
    M Nilsson
    Center for Bone Research at the Sahlgrenska Academy, Dept of Internal Medicine, Gothenburg University, Gothenburg, Sweden
    Osteoporos Int 19:1557-66. 2008
    ..We demonstrate that a high frequency of competitive sports early in life is associated with BMD at several bone sites, indicating that increases in BMD following PA are preserved longer than previously believed...
  61. ncbi request reprint Affected skeletal growth but normal bone mineralization in rat offspring after prenatal dexamethasone exposure
    Diana Swolin-Eide
    Research Center for Endocrinology and Metabolism, Department of Internal Medicine, Grona Straket 8, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    J Endocrinol 174:411-8. 2002
    ..In conclusion, prenatal Dex exposure affects skeletal growth in a gender-specific manner, while the mineralization of bones is unaffected in both male and female offspring...
  62. ncbi request reprint Androgens and the skeleton
    M K Lindberg
    Division of Endocrinology, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Minerva Endocrinol 30:15-25. 2005
    ..In conclusion, androgens may protect men against osteoporosis via maintenance of cancellous bone mass and expansion of cortical bone. This androgen action on bone is mediated by the AR and ER alpha...
  63. ncbi request reprint GH and bone--experimental and clinical studies
    O G Isaksson
    Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, University of Goteborg, Sweden
    Endocr J 47:S9-16. 2000
    ..It should be emphasized that the "Biphasic model" of GH action in bone remodeling is proposed based on findings in GHD adults, and it remains to be clarified whether or not it is valid for subjects with normal GH secretion...
  64. ncbi request reprint rhIGF-I/IGFBP-3 complex, but not free rhIGF-I, supports muscle protein biosynthesis in rats during semistarvation
    E Svanberg
    Goteborg University, Goteborg, Sweden
    Eur J Clin Invest 30:438-46. 2000
    ..The aim of this study was to evaluate the effect of insulin like growth factor-I (rhIGF-I) in complex with binding protein 3 (IGFBP 3) compared to the effect of free IGF-I on muscle protein biosynthesis in undernourished animals...
  65. ncbi request reprint Growth hormone and bone
    C Ohlsson
    Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    Endocr Rev 19:55-79. 1998
    ..The advantage of GH-releasing factors over GH is that some of them can be administered orally and that they may induce a more physiological GH secretion. (ABSTRACT TRUNCATED)..
  66. ncbi request reprint Expression and localization of estrogen receptor-beta in murine and human bone
    O Vidal
    Endocrine Bone Unit, Research Center for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    J Bone Miner Res 14:923-9. 1999
    ..The present study demonstrates that ERbeta is present in all the cellular compartments involved in bone formation and bone resorption, both in human and in murine bone tissue...
  67. ncbi request reprint Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development
    J M Kindblom
    Research Center for Endocrinology and Metabolism, Department of Internal Medicine, The Sahlgrenska Academy at Gothenburg University, SE 413 45 Gothenburg, Sweden
    J Endocrinol 174:R1-6. 2002
    ..Our results suggest that Ihh and PTHrP are present in the human growth plate and that Ihh and PTHrP may be involved in the regulation of pubertal growth in humans...
  68. doi request reprint Low holotranscobalamin and cobalamins predict incident fractures in elderly men: the MrOS Sweden
    C Lewerin
    Section of Hematology and Coagulation, Department of Internal Medicine, Institute of Medicine, Sahlgrenska AcademyUniversity of Gothenburg, Gothenburg, Sweden
    Osteoporos Int 25:131-40. 2014
    ..9 years, we found that low levels of metabolically active and total cobalamins predict incident fractures, independently of body mass index (BMI), bone mineral density (BMD), plasma total homocysteine (tHcy), and cystatin C...
  69. ncbi request reprint Haplotype association analysis of the polymorphisms Arg16Gly and Gln27Glu of the adrenergic beta2 receptor in a Swedish hypertensive population
    S M Wallerstedt
    Department of Clinical Pharmacology, Sahlgrenska University Hospital Sahlgrenska, Goteborg, Sweden
    J Hum Hypertens 19:705-8. 2005
    ..The present study found no evidence that haplotype for the two most common polymorphisms in the beta2AR are associated with development of MI in a Swedish hypertensive population, but haplotype may be associated with SBP...
  70. doi request reprint Importance of circulating IGF-1 for normal cardiac morphology, function and post infarction remodeling
    M Scharin Tang
    Wallenberg Laboratory at Sahlgrenska Academy, Gothenburg, Sweden
    Growth Horm IGF Res 22:206-11. 2012
    ..These findings indicate an important role of circulating IGF-1 in preserving cardiac structure and function both in physiological settings and post MI...
  71. ncbi request reprint Expression of exon 3-retaining and exon 3-excluding isoforms of the human growth hormone-receptor is regulated in an interindividual, rather than a tissue-specific, manner
    R B Wickelgren
    Department of Internal Medicine, Sahlgrenska, Hospital, University of Goteborg, Sweden
    J Clin Endocrinol Metab 80:2154-7. 1995
    ..Instead, the expression of the GHR isoforms appears to be specific for each individual, suggesting that it is under the control of factors that affect all tissues in the body...
  72. ncbi request reprint Natural (ghrelin) and synthetic (hexarelin) GH secretagogues stimulate H9c2 cardiomyocyte cell proliferation
    I Pettersson
    Research Center for Endocrinology and Metabolism, Department of Internal Medicine, Grona Straket 8, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    J Endocrinol 175:201-9. 2002
    ..These findings support potential peripheral effects of GHS on the cardiovascular system independent of an increased GH secretion...
  73. pmc Ghrelin treatment reverses the reduction in weight gain and body fat in gastrectomised mice
    C Dornonville de la Cour
    Department of Pharmacology, Institute of Physiological Sciences, University of Lund, BMC F13, S 221 84 Lund, Sweden
    Gut 54:907-13. 2005
    ..We investigated the long term effects of gastrectomy evoked ghrelin deficiency and of daily ghrelin injections on daily food intake, body weight, fat mass, lean body mass, and bone mass in mice...
  74. ncbi request reprint Female estrogen receptor beta-/- mice are partially protected against age-related trabecular bone loss
    S H Windahl
    Department of Biosciences, Karolinska Institutet, Novum, Huddinge, Sweden
    J Bone Miner Res 16:1388-98. 2001
    ....
  75. pmc Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice
    S H Windahl
    Department of Biosciences, Karolinska Institute, Novum, S 14157 Huddinge, Sweden
    J Clin Invest 104:895-901. 1999
    ..In summary, ERbeta is essential for the pubertal feminization of the cortical bone in female mice but is not required for the protective effect of estrogens on trabecular BMD...
  76. ncbi request reprint Effects of estrogen on the vascular injury response in estrogen receptor alpha, beta (double) knockout mice
    R H Karas
    Molecular Cardiology Research Institute, Department of Medicine, Division of Cardiology, New England Medical Center Hospitals and Tufts University School of Medicine, Boston, Massachusetts, USA
    Circ Res 89:534-9. 2001
    ..These possibilities may be resolved by studies of mice in which ERalpha has been fully disrupted (ERalphaKO(St)), which are in progress...
  77. ncbi request reprint Gene expression profiling identifies liver X receptor alpha as an estrogen-regulated gene in mouse adipose tissue
    L Lundholm
    Department of Biosciences at Novum, Karolinska Institutet, SE 141 57 Huddinge, Sweden
    J Mol Endocrinol 32:879-92. 2004
    ..Finally, we show that ERalpha is the main estrogen receptor expressed in mouse white adipose tissue (WAT) with mRNA levels several hundred times higher than those of ERbeta mRNA...
  78. ncbi request reprint Estrogen receptor-beta inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice
    A S Chagin
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden
    J Bone Miner Res 19:72-7. 2004
    ..Our results show that ER beta inhibits appendicular and axial skeletal growth and has the capacity to induce fusion of the growth plates...
  79. ncbi request reprint Dietary n-6:n-3 fatty acid ratio in the perinatal period affects bone parameters in adult female rats
    M Korotkova
    Department of Pediatrics, Goteborg University, Sweden
    Br J Nutr 92:643-8. 2004
    ..The results suggest that regulatory mechanisms were influenced by the n-6:n-3 FA ratio early in life and not compensated for by the introduction of an ordinary diet after weaning...
  80. ncbi request reprint Perinatal essential fatty acid deficiency influences body weight and bone parameters in adult male rats
    M Korotkova
    Department of Pediatrics, Goteborg University, The Queen Silvia Children s Hospital, SE 41685 Goteborg, Sweden
    Biochim Biophys Acta 1686:248-54. 2005
    ..The results indicate that regulatory mechanisms related to bone mass seemed to be programmed by EFA in the perinatal period. The nature of this modulation needs to be identified...
  81. pmc Influence of oestrogen receptor alpha and beta on the immune system in aged female mice
    U Islander
    Department of Rheumatology, Goteborg University, Sweden
    Immunology 110:149-57. 2003
    ..Results from this study provide valuable information regarding the specific functions of ER-alpha and ER-beta in the aged immune system...
  82. ncbi request reprint Skeletal changes in type-2 diabetic Goto-Kakizaki rats
    T Ahmad
    Department of Surgical Sciences, Section of Orthopaedics, Karolinska Institute, Stockholm, Sweden
    J Endocrinol 178:111-6. 2003
    ..The approach described may prove to be useful in the early detection of osteopathy in diabetic patients who may be amenable to preventive treatment...
  83. ncbi request reprint Estrogenic agonism and antagonism of the soy isoflavone genistein in uterus, bone and lymphopoiesis in mice
    M C Erlandsson
    Department of Rheumatology and Inflammation Research, Goteborg University, Sweden
    APMIS 113:317-23. 2005
    ..The only agonistic effect of Gen was shown by increased BMD in OVX mice. Our results are discussed in the context of estrogen receptor biology...
  84. ncbi request reprint Effects of combined estrogen/testosterone therapy on bone and body composition in oophorectomized women
    A Flöter
    Department of Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden
    Gynecol Endocrinol 20:155-60. 2005
    ..To evaluate the effect of adding testosterone undecanoate 40 mg daily to estrogen therapy on bone markers, bone mineral density and body composition in oophorectomized women...
  85. ncbi request reprint Reductions in adipose tissue and skeletal growth in rat adult offspring after prenatal leptin exposure
    C Nilsson
    Institute of Cardiovascular Disease, Goteborg University, Sweden
    J Endocrinol 176:13-21. 2003
    ..The results demonstrate that maternally administered leptin is involved in fetal growth and development, leading to lean offspring with reduced skeletal growth...
  86. ncbi request reprint Drug-induced prevention of gastrectomy- and ovariectomy-induced osteopaenia in the young female rat
    N Andersson
    Department of Pharmacology, Institute of Physiological Sciences, Lund University, BMC F 13, S 221 84 Lund, Sweden
    J Endocrinol 175:695-703. 2002
    ..The ability of alendronate, and probably also other bisphosphonates, to prevent Gx-evoked osteopaenia in the rat might be of potential clinical interest when dealing with post-Gx osteopaenia in humans...
  87. ncbi request reprint Ablation of TRalpha2 and a concomitant overexpression of alpha1 yields a mixed hypo- and hyperthyroid phenotype in mice
    C Salto
    Department of Cell and Molecular Biology, Karolinska Institute, S 171 77 Stockholm, Sweden
    Mol Endocrinol 15:2115-28. 2001
    ..The phenotypes suggest that the balance of TRalpha1:TRalpha2 expressed from the TRalpha gene provides an additional level of tuning the control of growth and homeostasis in mammalian species...
  88. pmc Radiographic joint destruction in postmenopausal rheumatoid arthritis is strongly associated with generalised osteoporosis
    H Forsblad d'Elia
    Department of Rheumatology and Inflammation Research, Goteborg University, Sweden
    Ann Rheum Dis 62:617-23. 2003
    ....
  89. ncbi request reprint Feather pecking in chickens is genetically related to behavioural and developmental traits
    P Jensen
    IFM Biology, Linkoping University, Sweden
    Physiol Behav 86:52-60. 2005
    ..Hence, a wide array of behavioural and developmental traits were genetically linked to FP...
  90. pmc Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation
    S Gothe
    Laboratory of Developmental Biology, CMB, Karolinska Institute, Stockholm, S 17 177, Sweden
    Genes Dev 13:1329-41. 1999
    ..These distinctions suggest that T3-independent actions of T3 receptors, demonstrated previously in vitro, may be a significant function in vivo...
  91. ncbi request reprint p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1
    C Ohlsson
    Diabetes Branch, National Institute of Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1770, USA
    Endocrinology 139:1101-7. 1998
    ..These data indicate that the IGF-I receptor is a physiological target for p53 in osteosarcoma cells. Furthermore, data supporting an interaction between p53 and Sp1 in the regulation of the promoter activity of IGF-IR are presented...
  92. ncbi request reprint Enhanced spontaneous locomotor activity in bovine GH transgenic mice involves peripheral mechanisms
    M Bohlooly-Y
    Department of Physiology, , , Sweden S-40530
    Endocrinology 142:4560-7. 2001
    ..These results suggest that free T(3) and/or IGF-I, affecting dopamine and serotonin systems in the central nervous system, may mediate the enhanced locomotor activity observed in transgenic mice with general overexpression of bovine GH...