Mattias Lorentzon

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. ncbi request reprint The COMT val158met polymorphism is associated with peak BMD in men
    Mattias Lorentzon
    Center for Bone Research at the Sahlgrenska Academy, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Bone Miner Res 19:2005-11. 2004
  2. ncbi request reprint [Osteoporosis--a hereditary disease. Physiology and disease mechanisms]
    Mattias Lorentzon
    Sektionen för endokrinologi, Institutionen för medicin, Sahlgrenska akademin, Goteborg
    Lakartidningen 103:2970-1. 2006
  3. ncbi request reprint Smoking is associated with lower bone mineral density and reduced cortical thickness in young men
    Mattias Lorentzon
    Cente for Bone Resarch at the Sahlgrenska Academy, Gothenburg, Sweden
    J Clin Endocrinol Metab 92:497-503. 2007
  4. ncbi request reprint Leptin is a negative independent predictor of areal BMD and cortical bone size in young adult Swedish men
    Mattias Lorentzon
    Center for Bone Research at the Sahlgrenska Academy CBS, Department of Internal Medicine, Gothenburg University, Sweden
    J Bone Miner Res 21:1871-8. 2006
  5. ncbi request reprint Polymorphisms in the aromatase gene predict areal BMD as a result of affected cortical bone size: the GOOD study
    Mattias Lorentzon
    Center for Bone Research at the Sahlgrenska Academy CBS, Department of Internal Medicine, Gothenburg University, Gothenburg, Sweden
    J Bone Miner Res 21:332-9. 2006
  6. pmc Sport-specific association between exercise loading and the density, geometry, and microstructure of weight-bearing bone in young adult men
    M Nilsson
    Centre for Bone and Arthritis Research at the Sahlgrenska Academy, Department of Internal Medicine, University of Gothenburg, Gothenburg, Sweden
    Osteoporos Int 24:1613-22. 2013
  7. pmc Osteoporosis in ankylosing spondylitis - prevalence, risk factors and methods of assessment
    Eva Klingberg
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Guldhedsgatan 10A, S 413 46 Goteborg, Sweden
    Arthritis Res Ther 14:R108. 2012
  8. pmc Advancing maternal age is associated with lower bone mineral density in young adult male offspring
    R Rudäng
    Center for Bone and Arthritis Research at the Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden
    Osteoporos Int 23:475-82. 2012
  9. ncbi request reprint Age of attainment of peak bone mass is site specific in Swedish men--The GOOD study
    Mattias Lorentzon
    Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, Gothenburg University, Gothenburg, Sweden
    J Bone Miner Res 20:1223-7. 2005
  10. ncbi request reprint Association between physical activity and BMD in young men is modulated by catechol-O-methyltransferase (COMT) genotype: the GOOD study
    Mattias Lorentzon
    Center for Bone Research at the Sahlgrenska Academy CBS, Department of Internal Medicine, Gothenburg University, Gothenburg, Sweden
    J Bone Miner Res 22:1165-72. 2007

Detail Information

Publications46

  1. ncbi request reprint The COMT val158met polymorphism is associated with peak BMD in men
    Mattias Lorentzon
    Center for Bone Research at the Sahlgrenska Academy, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Bone Miner Res 19:2005-11. 2004
    ..The associations between the functional val158met polymorphism of the estrogen-degrading COMT enzyme and skeletal properties in young men were investigated. BMD was associated with COMT genotype...
  2. ncbi request reprint [Osteoporosis--a hereditary disease. Physiology and disease mechanisms]
    Mattias Lorentzon
    Sektionen för endokrinologi, Institutionen för medicin, Sahlgrenska akademin, Goteborg
    Lakartidningen 103:2970-1. 2006
  3. ncbi request reprint Smoking is associated with lower bone mineral density and reduced cortical thickness in young men
    Mattias Lorentzon
    Cente for Bone Resarch at the Sahlgrenska Academy, Gothenburg, Sweden
    J Clin Endocrinol Metab 92:497-503. 2007
    ..Smoking has previously been associated with reduced areal bone mineral density (aBMD) in elderly subjects, but the association remains controversial in adolescents...
  4. ncbi request reprint Leptin is a negative independent predictor of areal BMD and cortical bone size in young adult Swedish men
    Mattias Lorentzon
    Center for Bone Research at the Sahlgrenska Academy CBS, Department of Internal Medicine, Gothenburg University, Sweden
    J Bone Miner Res 21:1871-8. 2006
    ..We show that leptin is a negative independent predictor of aBMD (DXA), at several measured sites, and of cortical bone size (pQCT) in a large population of young men...
  5. ncbi request reprint Polymorphisms in the aromatase gene predict areal BMD as a result of affected cortical bone size: the GOOD study
    Mattias Lorentzon
    Center for Bone Research at the Sahlgrenska Academy CBS, Department of Internal Medicine, Gothenburg University, Gothenburg, Sweden
    J Bone Miner Res 21:332-9. 2006
    ..9 +/- 0.6 years of age). Several aromatase gene polymorphisms were found to be associated with serum testosterone levels and cortical bone size but not with trabecular volumetric BMD...
  6. pmc Sport-specific association between exercise loading and the density, geometry, and microstructure of weight-bearing bone in young adult men
    M Nilsson
    Centre for Bone and Arthritis Research at the Sahlgrenska Academy, Department of Internal Medicine, University of Gothenburg, Gothenburg, Sweden
    Osteoporos Int 24:1613-22. 2013
    ..We reveal that the association between exercise loading and bone parameters is sport-specific, indicating that nonspecific resistance exercise does not impact bone density, geometry, or microstructure in young men...
  7. pmc Osteoporosis in ankylosing spondylitis - prevalence, risk factors and methods of assessment
    Eva Klingberg
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Guldhedsgatan 10A, S 413 46 Goteborg, Sweden
    Arthritis Res Ther 14:R108. 2012
    ....
  8. pmc Advancing maternal age is associated with lower bone mineral density in young adult male offspring
    R Rudäng
    Center for Bone and Arthritis Research at the Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden
    Osteoporos Int 23:475-82. 2012
    ..In the present study, we demonstrate that advancing maternal age is independently associated with reduced bone mass in the young adult male offspring...
  9. ncbi request reprint Age of attainment of peak bone mass is site specific in Swedish men--The GOOD study
    Mattias Lorentzon
    Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, Gothenburg University, Gothenburg, Sweden
    J Bone Miner Res 20:1223-7. 2005
    ..Results from this study suggest that PBM has been attained in the spine and femoral neck, but not in the radius or tibia, in 18- to 20-year-old men, in which an endosteal contraction and increase in cortical volumetric BMD is observed...
  10. ncbi request reprint Association between physical activity and BMD in young men is modulated by catechol-O-methyltransferase (COMT) genotype: the GOOD study
    Mattias Lorentzon
    Center for Bone Research at the Sahlgrenska Academy CBS, Department of Internal Medicine, Gothenburg University, Gothenburg, Sweden
    J Bone Miner Res 22:1165-72. 2007
    ..In this large population-based study in young men, we show that the COMT val158met polymorphism modulates the association between physical activity, aBMD (DXA), and trabecular vBMD (pQCT)...
  11. ncbi request reprint Association of amount of physical activity with cortical bone size and trabecular volumetric BMD in young adult men: the GOOD study
    Mattias Lorentzon
    Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, Gothenburg University, Gothenburg, Sweden
    J Bone Miner Res 20:1936-43. 2005
    ..The lowest effective amount of PA was > or = 4 h/week...
  12. ncbi request reprint Free testosterone is a positive, whereas free estradiol is a negative, predictor of cortical bone size in young Swedish men: the GOOD study
    Mattias Lorentzon
    Center for Bone Research at the Sahlgrenska Academy CBS, Department of Internal Medicine, Gothenburg University, Gothenburg, Sweden
    J Bone Miner Res 20:1334-41. 2005
    ..Serum free estradiol was a negative predictor, whereas free testosterone and SHBG were positive predictors of cortical bone size...
  13. ncbi request reprint Reduced bone mineral density in SOCS-2-deficient mice
    Mattias Lorentzon
    Center for Bone Research at the Sahlgrenska Academy, Division of Endocrinology, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg University, 41345 Gothenburg, Sweden
    Pediatr Res 57:223-6. 2005
    ..These effects are not consistent with an augmented GH/IGF-I signaling and, therefore, the mechanism behind the reduced BMD remains to be elucidated...
  14. ncbi request reprint Androgens and glucuronidated androgen metabolites are associated with metabolic risk factors in men
    Liesbeth Vandenput
    Department of Internal Medicine, Gothenburg University, SE 41345 Gothenburg, Sweden
    J Clin Endocrinol Metab 92:4130-7. 2007
    ..Androgens are associated with metabolic risk factors in men. However, the independent impact of androgens and androgen metabolites on metabolic risk factors in men is unclear...
  15. doi request reprint Catch up in bone acquisition in young adult men with late normal puberty
    Anna Darelid
    Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    J Bone Miner Res 27:2198-207. 2012
    ..In conclusion, our results demonstrate that late puberty in males was associated with a substantial catch up in aBMD and BMC in young adulthood, leaving no deficits of the lumbar spine, femoral neck, or total body at age 24 years...
  16. doi request reprint Smoking is associated with impaired bone mass development in young adult men: a 5-year longitudinal study
    Robert Rudäng
    Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden
    J Bone Miner Res 27:2189-97. 2012
    ....
  17. ncbi request reprint The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men
    Charlotte Swanson
    Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, Goteborg University, SE 41345 Goteborg, Sweden
    J Clin Endocrinol Metab 92:4878-82. 2007
    ..Previous in vitro studies have demonstrated that the UDP glucuronosyltransferase (UGT)2B15 and UGT2B17 glucuronidate androgens and their metabolites...
  18. ncbi request reprint The COMT val158met polymorphism is associated with prevalent fractures in Swedish men
    Anna L Eriksson
    Center for Bone Research at the Sahlgrenska Academy, Departments of Internal Medicine and Geriatrics, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Bone 42:107-12. 2008
    ..We have previously reported that this polymorphism is associated with bone mineral density (BMD) in young men. The aim of this study was to investigate associations between COMT val158met, BMD and fractures in elderly men...
  19. doi request reprint Older men with low serum estradiol and high serum SHBG have an increased risk of fractures
    Dan Mellstrom
    Center for Bone Research, Sahlgrenska Academy, Department of Internal Medicine, University of Gothenburg, Gothenburg, Sweden
    J Bone Miner Res 23:1552-60. 2008
    ..3 pg/ml for fE2. In conclusion, older Swedish men with low serum E2 and high SHBG levels have an increased risk of fractures...
  20. pmc Age at adiposity rebound is associated with fat mass in young adult males-the GOOD study
    Claes Ohlsson
    Center for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
    PLoS ONE 7:e49404. 2012
    ..Age at adiposity rebound (AR) is associated with obesity and Type 2 Diabetes in adults. The aim of the present study was to investigate the role of age at AR in adult fat mass, fat distribution and pubertal timing for a Swedish cohort...
  21. pmc Genetic variations in sex steroid-related genes as predictors of serum estrogen levels in men
    Anna L Eriksson
    Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine Gothenburg University, SE 413 45 Gothenburg, Sweden
    J Clin Endocrinol Metab 94:1033-41. 2009
    ..The risk of many conditions, including prostate cancer, breast cancer, and osteoporosis, is associated with serum levels of sex steroids...
  22. doi request reprint Hip fracture prevalence in grandfathers is associated with reduced cortical cross-sectional bone area in their young adult grandsons
    Robert Rudäng
    AssociateDivision of Endocrinology, Department of Medicine, Grona Straket 8, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden
    J Clin Endocrinol Metab 95:1105-14. 2010
    ....
  23. doi request reprint Smoking predicts incident fractures in elderly men: Mr OS Sweden
    Hans Jutberger
    Centre for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine and Geriatrics, University of Gothenburg, Gothenburg, Sweden
    J Bone Miner Res 25:1010-6. 2010
    ..Current tobacco smoking in elderly men is associated with low BMD, prevalent vertebral fractures, and incident fractures, especially vertebral and hip fractures...
  24. doi request reprint Pubertal timing predicts leg length and childhood body mass index predicts sitting height in young adult men
    Mattias Lorentzon
    Center for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
    J Pediatr 158:452-7. 2011
    ..To investigate the impact of pubertal timing and childhood body mass index (BMI), both within normal range, on adult anthropometrics...
  25. pmc BMI changes during childhood and adolescence as predictors of amount of adult subcutaneous and visceral adipose tissue in men: the GOOD Study
    Jenny M Kindblom
    Center for Bone Research, Institute of Medicine, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
    Diabetes 58:867-74. 2009
    ..We hypothesized that there are critical periods during development for the prediction of adult subcutaneous and visceral fat mass by BMI changes during childhood and adolescence...
  26. ncbi request reprint Docosahexaenoic acid is associated with endosteal circumference in long bones in young males with cystic fibrosis
    Eva Gronowitz
    West Swedish CF Center, Sahlgrenska Academy, Gothenburg University, Queen Silvia Children s Hospital, 416 85 Gothenburg, Sweden
    Br J Nutr 99:160-7. 2008
    ..The association between DHA and long bone endosteal circumference suggested a later peak bone mass in those with CF compared with controls...
  27. doi request reprint Previous sport activity during childhood and adolescence is associated with increased cortical bone size in young adult men
    Martin Nilsson
    Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, University of Gothenburg, Gothenburg, Sweden
    J Bone Miner Res 24:125-33. 2009
    ..The results from this study indicate that sport activity during growth confers positive effects on bone geometry even though sport activity is ceased...
  28. pmc Increased physical activity is associated with enhanced development of peak bone mass in men: a five-year longitudinal study
    Martin Nilsson
    Centre for Bone and Arthritis Research, Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
    J Bone Miner Res 27:1206-14. 2012
    ..001). In conclusion, increased physical activity was related to an advantageous development of aBMD, trabecular vBMD and cortical bone size, indicating that exercise is important in optimizing peak bone mass in young men...
  29. doi request reprint Trabecular volumetric bone mineral density is associated with previous fracture during childhood and adolescence in males: the GOOD study
    Anna Darelid
    Center for Bone Research at Sahlgrenska Academy CBS, Department of Medicine, Gothenburg University, Gothenburg, Sweden
    J Bone Miner Res 25:537-44. 2010
    ..Further studies are needed to determine if assessment of trabecular vBMD could enhance prediction of fractures during growth in males...
  30. ncbi request reprint Free testosterone is an independent predictor of BMD and prevalent fractures in elderly men: MrOS Sweden
    Dan Mellstrom
    Center for Bone Research, Departments of Internal Medicine and Geriatrics at the Sahlgrenska Academy The Sahlgrenska Academy at Göteborg University, Goteborg, Sweden
    J Bone Miner Res 21:529-35. 2006
    ..We show that free testosterone within the normal range is a predictor of BMD at predominantly cortical bone sites and of previous osteoporosis-related fractures in elderly Swedish men...
  31. doi request reprint High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden
    Helena Johansson
    Centre for Bone and Arthritis Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    J Bone Miner Res 27:1390-6. 2012
    ..Its measurement holds promise as a risk factor for fracture in men...
  32. doi request reprint Cortical consolidation due to increased mineralization and endosteal contraction in young adult men: a five-year longitudinal study
    Claes Ohlsson
    Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden
    J Clin Endocrinol Metab 96:2262-9. 2011
    ....
  33. doi request reprint Vertebral fractures in ankylosing spondylitis are associated with lower bone mineral density in both central and peripheral skeleton
    Eva Klingberg
    Department of Rheumatology and Inflammation Research and the Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    J Rheumatol 39:1987-95. 2012
    ..To study the prevalence and risk factors for vertebral fractures (VF) in ankylosing spondylitis (AS) and the relation between VF, measures of disease activity, and bone mineral density (BMD) in different measurement sites...
  34. ncbi request reprint Sex steroid levels and cortical bone size in young men are associated with a uridine diphosphate glucuronosyltransferase 2B7 polymorphism (H268Y)
    Charlotte Swanson
    Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, Gothenburg University, SE 41345 Gothenburg, Sweden
    J Clin Endocrinol Metab 92:3697-704. 2007
    ..In vitro studies have indicated that the enzyme uridine diphosphate glucuronosyltransferase (UGT) 2B7 has the capacity to glucuronidate sex steroids and their metabolites...
  35. ncbi request reprint Pubertal timing predicts previous fractures and BMD in young adult men: the GOOD study
    Jenny M Kindblom
    Bone Research Center, Department of Medicine, The Sahlgrenska Academy at Gothenburg University, Sweden
    J Bone Miner Res 21:790-5. 2006
    ..Pubertal timing was found to predict both cortical and trabecular volumetric BMD and previous fractures in young adult men. Thus, late puberty is a risk factor for low BMD and previous fractures in young adult men...
  36. ncbi request reprint Pubertal timing is an independent predictor of central adiposity in young adult males: the Gothenburg osteoporosis and obesity determinants study
    Jenny M Kindblom
    Bone Research Center at the Institute of Medicine, Sahlgrenska Universitetssjukhuset Sahlgrenska, Grona Straket 8, 413 45 Gothenburg, Sweden
    Diabetes 55:3047-52. 2006
    ..In conclusion, we demonstrate that early pubertal onset specifically predicts a central fat mass distribution, while a predominantly subcutaneous obese phenotype is strongly predicted by a high prepubertal BMI...
  37. doi request reprint Low 25-OH vitamin D is associated with benign prostatic hyperplasia
    Mohammad Ali Haghsheno
    Department of Urology, Institute of Clinical Sciences, Sahlgrenska University Hospital, Goteborg, Sweden
    J Urol 190:608-14. 2013
    ..We also studied whether body composition, sex hormones, serum sex hormone-binding globulin, albumin corrected serum calcium, adiponectin and lipid status are associated with benign prostatic hyperplasia...
  38. pmc Genetic determinants of serum testosterone concentrations in men
    Claes Ohlsson
    Center for Bone and Arthritis Research, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden
    PLoS Genet 7:e1002313. 2011
    ..rs6258 is the first reported SHBG polymorphism, which affects testosterone binding to SHBG and the free testosterone fraction and could therefore influence the calculation of free testosterone using law-of-mass-action equation...
  39. pmc SOCS2 negatively regulates growth hormone action in vitro and in vivo
    Christopher J Greenhalgh
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research WEHI and the Cooperative Centre for Cellular Growth Factors, Parkville, Victoria, Australia
    J Clin Invest 115:397-406. 2005
    ..Together, the data provide clear evidence that SOCS2 is a negative regulator of GH signaling...
  40. ncbi request reprint Interleukin-6 promoter polymorphism is associated with bone quality assessed by calcaneus ultrasound and previous fractures in a cohort of 75-year-old women
    Anna Nordström
    Sports Medicine, Department of Surgical and Perioperative Sciences, Umea University Hospital, 901 85, Umea, Sweden
    Osteoporos Int 15:820-6. 2004
    ..This association may be related primarily to an altered bone quality identified by QUS and not a lower bone mass. This is also the first demonstration of association of IL-6 gene polymorphism to calcaneal QUS...
  41. ncbi request reprint Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism
    Jenny Jakobsson
    Clinical Pharmacology, C1 68, Karolinska Institutet at Karolinska University Hospital, S 141 86 Stockholm, Sweden
    J Clin Endocrinol Metab 91:687-93. 2006
    ..Uridine diphosphoglucuronosyl transferases have a key role in the homeostasis and metabolism of androgens. Recently a deletion polymorphism was detected in the UGT2B17 gene...
  42. ncbi request reprint Vitamin D receptor start codon polymorphism ( FokI) is related to bone mineral density in healthy adolescent boys
    Sara Strandberg
    Sports Medicine, Department of Surgical and Perioperative Sciences, Umea University, 90185 Umea, Sweden
    J Bone Miner Metab 21:109-13. 2003
    ..03), and total body BMD ( P < 0.05), but not femoral neck BMD. This study proves the FokI polymorphism to be an independent predictor of lumbar spine BMD are probably total body BMD, but not femoral neck BMD...
  43. ncbi request reprint Interleukin-1 system gene polymorphisms are associated with fat mass in young men
    Louise Strandberg
    Institute of Neuroscience and Physiology Endocrinology, Sahlgrenska Academy, Goteborg University, P O Box 434, SE 405 30 Goteborg, Sweden
    J Clin Endocrinol Metab 91:2749-54. 2006
    ..There is growing evidence for interactions between the regulation of body fat and the immune system. Studies of knockout mice indicate that IL-1 has an antiobesity effect...
  44. doi request reprint Increased cortical bone mineralization in imatinib treated patients with chronic myelogenous leukemia
    Sofia Jonsson
    Haematologica 93:1101-3. 2008
  45. pmc Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    JAMA 299:1277-90. 2008
    ..Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population...
  46. doi request reprint Genetic aspects of epitestosterone formation and androgen disposition: influence of polymorphisms in CYP17 and UGT2B enzymes
    Jenny Jakobsson Schulze
    Department of Laboratory Medicine, Karolinska Institutet at Division of Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden
    Pharmacogenet Genomics 18:477-85. 2008
    ..Our objective was to study the genetic aspects of epitestosterone formation, and to elucidate the impact of genetic variation in androgen-metabolizing enzymes...