Jan Hedner

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. ncbi request reprint Obstructive apneic events induce alpha-receptor mediated digital vasoconstriction
    Ding Zou
    Sleep Laboratory, Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Sleep 27:485-9. 2004
  2. ncbi request reprint Pharmacological treatment of sleep apnea: current situation and future strategies
    Jan Hedner
    Sleep Laboratory, Department of Pulmonary Medicine and Allergology, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden
    Sleep Med Rev 12:33-47. 2008
  3. ncbi request reprint Reduction of sleep-disordered breathing after physostigmine
    Jan Hedner
    Sleep Laboratory, Department of Pulmonary Medicine and Allergology, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Am J Respir Crit Care Med 168:1246-51. 2003
  4. doi request reprint A double-blind, crossover study of Doxazosin and Enalapril on peripheral vascular tone and nocturnal blood pressure in sleep apnea patients
    Ding Zou
    Sleep Laboratory, Department of Pulmonary Medicine, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
    Sleep Med 11:325-8. 2010
  5. ncbi request reprint Nocturnal pulse wave attenuation is associated with office blood pressure in a population based cohort
    Ding Zou
    Sleep Laboratory, Department of Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Sleep Med 10:836-43. 2009
  6. pmc Sleep staging based on autonomic signals: a multi-center validation study
    Jan Hedner
    Sleep Laboratory, Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    J Clin Sleep Med 7:301-6. 2011
  7. ncbi request reprint Validation a portable monitoring device for sleep apnea diagnosis in a population based cohort using synchronized home polysomnography
    Ding Zou
    Sleep Laboratory, Department of Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Sleep 29:367-74. 2006
  8. pmc Increased neck soft tissue mass and worsening of obstructive sleep apnea after growth hormone treatment in men with abdominal obesity
    Mahssa Karimi
    Sleep Laboratory, Department of Pulmonary Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    J Clin Sleep Med 6:256-63. 2010
  9. ncbi request reprint A novel adaptive wrist actigraphy algorithm for sleep-wake assessment in sleep apnea patients
    Jan Hedner
    Sleep Laboratory, Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Sleep 27:1560-6. 2004
  10. doi request reprint Oximeter-based autonomic state indicator algorithm for cardiovascular risk assessment
    Ludger Grote
    Sleep Disorders Center, Department of Pulmonary Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, Sweden
    Chest 139:253-9. 2011

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Obstructive apneic events induce alpha-receptor mediated digital vasoconstriction
    Ding Zou
    Sleep Laboratory, Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Sleep 27:485-9. 2004
    ..To characterize the role of alpha-receptors in autonomic control of digital skin blood flow change in response to obstructive apnea-hypopnea events...
  2. ncbi request reprint Pharmacological treatment of sleep apnea: current situation and future strategies
    Jan Hedner
    Sleep Laboratory, Department of Pulmonary Medicine and Allergology, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden
    Sleep Med Rev 12:33-47. 2008
    ..This review will list some potential shortcomings and possibilities of pharmacological treatment in OSA, and discuss some of the already attempted modes of treatment...
  3. ncbi request reprint Reduction of sleep-disordered breathing after physostigmine
    Jan Hedner
    Sleep Laboratory, Department of Pulmonary Medicine and Allergology, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Am J Respir Crit Care Med 168:1246-51. 2003
    ..77, p < 0.02). This, predominantly REM-related, reduction of obstructive sleep apnea after PHYS may provide a new treatment option if the effects are maintained in long-term studies...
  4. doi request reprint A double-blind, crossover study of Doxazosin and Enalapril on peripheral vascular tone and nocturnal blood pressure in sleep apnea patients
    Ding Zou
    Sleep Laboratory, Department of Pulmonary Medicine, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
    Sleep Med 11:325-8. 2010
    ..We compared the effect of Doxazosin (DO, a peripheral alpha-receptor inhibitor) and Enalapril (EN, an ACE inhibitor) on digital vasoconstriction and nocturnal blood pressure (BP) in hypertensive OSA patients...
  5. ncbi request reprint Nocturnal pulse wave attenuation is associated with office blood pressure in a population based cohort
    Ding Zou
    Sleep Laboratory, Department of Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Sleep Med 10:836-43. 2009
    ..The nocturnal attenuation of PWA has been shown to reflect sympathetic activation during sleep. We assessed the relationship between nocturnal PWA attenuation and office blood pressure (BP)...
  6. pmc Sleep staging based on autonomic signals: a multi-center validation study
    Jan Hedner
    Sleep Laboratory, Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    J Clin Sleep Med 7:301-6. 2011
    ..We assessed an algorithm determining 4 different stages: wake, light sleep, deep sleep, and REM sleep using signals derived from the portable monitor Watch-PAT100 (PAT recorder)...
  7. ncbi request reprint Validation a portable monitoring device for sleep apnea diagnosis in a population based cohort using synchronized home polysomnography
    Ding Zou
    Sleep Laboratory, Department of Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Sleep 29:367-74. 2006
    ..To propose a new standard for limited-channel device validation using synchronized polysomnography (PSG) home recordings and a population-based cohort...
  8. pmc Increased neck soft tissue mass and worsening of obstructive sleep apnea after growth hormone treatment in men with abdominal obesity
    Mahssa Karimi
    Sleep Laboratory, Department of Pulmonary Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    J Clin Sleep Med 6:256-63. 2010
    ..OSA is associated with both growth hormone (GH) excess and severe GH deficiency in adults. Adults with abdominal obesity have markedly suppressed GH secretion...
  9. ncbi request reprint A novel adaptive wrist actigraphy algorithm for sleep-wake assessment in sleep apnea patients
    Jan Hedner
    Sleep Laboratory, Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Sleep 27:1560-6. 2004
    ....
  10. doi request reprint Oximeter-based autonomic state indicator algorithm for cardiovascular risk assessment
    Ludger Grote
    Sleep Disorders Center, Department of Pulmonary Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, Sweden
    Chest 139:253-9. 2011
    ..Cardiovascular (CV) risk assessment is important in clinical practice. An autonomic state indicator (ASI) algorithm based on pulse oximetry was developed and validated for CV risk assessment...
  11. ncbi request reprint A randomized placebo-controlled trial of an NMDA receptor antagonist in sleep-disordered breathing
    Stefan Torvaldsson
    Sleep Laboratory, Department of Allergology and Pulmonary Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    J Sleep Res 14:149-55. 2005
    ..The previously postulated role of glutamate in SDB could not be confirmed after AR-R15896AR induced NMDA-receptor blockade...
  12. ncbi request reprint CPAP treatment of a population-based sample--what are the benefits and the treatment compliance?
    Eva Lindberg
    Department of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Akademiska sjukhuset, Uppsala, and Sleep Laboratory, Department of Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Sleep Med 7:553-60. 2006
    ..Another purpose was to investigate the compliance to CPAP in this population...
  13. ncbi request reprint Finger plethysmography--a method for monitoring finger blood flow during sleep disordered breathing
    Ludger Grote
    Sleep Laboratory, Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Respir Physiol Neurobiol 136:141-52. 2003
    ..Thus, finger plethysmography may be a useful complement to current vascular research techniques, in particular to monitor sympathetic influences on skin blood flow in the finger...
  14. ncbi request reprint The heart rate response to exercise is blunted in patients with sleep-related breathing disorder
    Ludger Grote
    Sleep Disorders Center, Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Cardiology 102:93-9. 2004
    ..This study addressed the hypothesis that cardiovascular reactivity during graded bicycle exercise is influenced by a coexisting sleep-related breathing disorder (SRBD)...
  15. ncbi request reprint [Sleep apnea a risk factor of cardiovascular disease]
    Yuksel Peker
    Sömnlaboratoriet, avdelningen för lungmedicin och allergologi, Sahlgrenska Universitetssjukhuset, Goteborg
    Lakartidningen 99:4473-9. 2002
    ..Continuous intense research into pathophysiological mechanisms and therapeutic possibilities of CVD related to OSA appears to be an important and potentially rewarding area of disease prevention...
  16. ncbi request reprint A randomized, double-blind, placebo controlled, multi-center study of intravenous iron sucrose and placebo in the treatment of restless legs syndrome
    Ludger Grote
    Sleep Disorders Center, Department of Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Mov Disord 24:1445-52. 2009
    ..Further studies on target patient groups, dosing and dosing intervals are warranted before iron sucrose could be considered for treatment of iron deficient patients with RLS...
  17. ncbi request reprint Increased incidence of cardiovascular disease in middle-aged men with obstructive sleep apnea: a 7-year follow-up
    Yuksel Peker
    Sleep Laboratory, Department of Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Am J Respir Crit Care Med 166:159-65. 2002
    ..Furthermore, efficient treatment of OSA reduces the excess CVD risk and may be considered also in relatively mild OSA without regard to daytime sleepiness...
  18. doi request reprint Effects of continuous positive airway pressure treatment and withdrawal in patients with obstructive sleep apnea on arterial stiffness and central BP
    Craig L Phillips
    Sleep Research Group, Woolcock Institute of Medical Research, University of Sydney, Royal Prince Alfred Hospital, 431 Glebe Point Rd, Glebe, NSW 2037, Australia
    Chest 134:94-100. 2008
    ....
  19. ncbi request reprint Interaction between the angiotensin-converting enzyme gene insertion/deletion polymorphism and obstructive sleep apnoea as a mechanism for hypertension
    Kristina Bengtsson Boström
    Department of Clinical Sciences, Diabetes and Endocrinology, Skaraborg Institute, Skovde, Sweden
    J Hypertens 25:779-83. 2007
    ..The aim of this study was to explore the interaction between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and OSA in the association with hypertension...
  20. ncbi request reprint Diurnal and obstructive sleep apnea influences on arterial stiffness and central blood pressure in men
    Craig Phillips
    Sleep Research Group, Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    Sleep 28:604-9. 2005
    ..Using pulse wave analysis, we examined the effect of OSA on arterial stiffness and central aortic blood pressure to assess whether each would be elevated independent of diurnal changes in peripheral blood pressure...
  21. ncbi request reprint Plasma vascular endothelial growth factor in sleep apnea syndrome: effects of nasal continuous positive air pressure treatment
    Lena Lavie
    Unit of Anatomy and Cell Biology, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Am J Respir Crit Care Med 165:1624-8. 2002
    ..9 +/- 23.6 versus 54.0 +/- 21.5 pg/ml, ns). These results raise the possibility that VEGF may contribute to the long-term adaptation of sleep apnea syndrome to recurrent nocturnal hypoxia...
  22. ncbi request reprint Association between estrus cycle-related aggression and tidal volume variability in female Wistar rats
    Lydia K Melchior
    Department of Pharmacology, Goteborg University, Goteborg, Sweden
    Psychoneuroendocrinology 29:1097-100. 2004
    ..In our opinion, they also strengthen the concept of this animal model as a model of premenstrual irritability...
  23. ncbi request reprint Improvement in neuropsychological performance following surgical treatment for obstructive sleep apnea syndrome
    Pia Dahlöf
    Institute of Clinical Neuroscience, Section of Psychiatry, Sahlgrenska University Hospital S, Goteborg, Sweden
    Acta Otolaryngol 122:86-91. 2002
    ..9, p < 0.001) and arterial minimum oxygen saturation (mean change 4.5%, SD 10.2%, p < 0.01). Surgical treatment seems to improve verbal learning, memory and recall and executive functions in parallel with better oxygenation in OSAS...