H Hagberg

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. ncbi request reprint [Chorioamnionitis--risk factor of cerebral palsy in fullterm infants]
    Henrik Hagberg
    Perinatalmedicinskt centrum, Kvinnokliniken, Sahlgrenska akademin, Sahlgrenska Universitetssjukhuset Ostra, Goteborg
    Lakartidningen 101:2542. 2004
  2. ncbi request reprint Preconditioning and the developing brain
    Henrik Hagberg
    Department of Obstetrics and Gynecology, Institute of Women s and Children s Health, Goteborg University, Goteborg, Sweden
    Semin Perinatol 28:389-95. 2004
  3. doi request reprint Pharmacological and genetic inhibition of NADPH oxidase does not reduce brain damage in different models of perinatal brain injury in newborn mice
    Christina Doverhag
    Department of Physiology and Neuroscience, Perinatal Center, Sahlgrenska Academy, Goteborg University, Sweden
    Neurobiol Dis 31:133-44. 2008
  4. doi request reprint Inflammation during fetal and neonatal life: implications for neurologic and neuropsychiatric disease in children and adults
    Henrik Hagberg
    Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Sweden
    Ann Neurol 71:444-57. 2012
  5. pmc Treatments of pelvic girdle pain in pregnant women: adverse effects of standard treatment, acupuncture and stabilising exercises on the pregnancy, mother, delivery and the fetus/neonate
    Helen Elden
    Perinatal Center, Department of Obstetrics and Gynecology, Institute for Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital East, Gothenburg University, Gothenburg, SE 416 85, Sweden
    BMC Complement Altern Med 8:34. 2008
  6. ncbi request reprint [Increased mortality among infants born at night. A reflection of inadequate perinatal intensive care resources in the night-time?]
    Henrik Hagberg
    Avdelningen för obstetrik och gynekologi, Perinatalmedicinskt centrum, Sahlgrenska Universitetssjukhuset Ostra, Goteborg
    Lakartidningen 99:2142-4. 2002
  7. ncbi request reprint No correlation between cerebral palsy and cytokines in postnatal blood of preterms
    Henrik Hagberg
    Department of Obstetrics and Gynecology, Sahlgrenska University Hospital East, Sweden
    Pediatr Res 53:544-5. 2003
  8. ncbi request reprint Mitochondrial impairment in the developing brain after hypoxia-ischemia
    Henrik Hagberg
    Perinatal Center, Department for the Health of Women and Children, Sahlgrenska Academy, East Hospital, 416 85
    J Bioenerg Biomembr 36:369-73. 2004
  9. ncbi request reprint PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury
    Henrik Hagberg
    Perinatal Center, Sahlgrenska University Hospital, Goteborg, Sweden
    J Neurochem 90:1068-75. 2004
  10. ncbi request reprint Sequelae of chorioamnionitis
    Henrik Hagberg
    Perinatal Center, Department of Obstetrics and Gynecology, Sahlgrenska University Hospital East, Goteborg, Sweden
    Curr Opin Infect Dis 15:301-6. 2002

Collaborators

Detail Information

Publications100

  1. ncbi request reprint [Chorioamnionitis--risk factor of cerebral palsy in fullterm infants]
    Henrik Hagberg
    Perinatalmedicinskt centrum, Kvinnokliniken, Sahlgrenska akademin, Sahlgrenska Universitetssjukhuset Ostra, Goteborg
    Lakartidningen 101:2542. 2004
  2. ncbi request reprint Preconditioning and the developing brain
    Henrik Hagberg
    Department of Obstetrics and Gynecology, Institute of Women s and Children s Health, Goteborg University, Goteborg, Sweden
    Semin Perinatol 28:389-95. 2004
    ..Preconditioning of the brain or induction of tolerance of the immune system might be utilized in the future to decrease CNS vulnerability and the occurrence of perinatal brain injury...
  3. doi request reprint Pharmacological and genetic inhibition of NADPH oxidase does not reduce brain damage in different models of perinatal brain injury in newborn mice
    Christina Doverhag
    Department of Physiology and Neuroscience, Perinatal Center, Sahlgrenska Academy, Goteborg University, Sweden
    Neurobiol Dis 31:133-44. 2008
    ..The ROS-generating enzyme NADPH oxidase (Nox2) is present in inflammatory cells and contributes to brain injury in adult animal models...
  4. doi request reprint Inflammation during fetal and neonatal life: implications for neurologic and neuropsychiatric disease in children and adults
    Henrik Hagberg
    Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Sweden
    Ann Neurol 71:444-57. 2012
    ..Further studies are required to strengthen the associations in humans and to determine whether novel therapeutic interventions during the perinatal period can influence the occurrence of neurological disease later in life...
  5. pmc Treatments of pelvic girdle pain in pregnant women: adverse effects of standard treatment, acupuncture and stabilising exercises on the pregnancy, mother, delivery and the fetus/neonate
    Helen Elden
    Perinatal Center, Department of Obstetrics and Gynecology, Institute for Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital East, Gothenburg University, Gothenburg, SE 416 85, Sweden
    BMC Complement Altern Med 8:34. 2008
    ....
  6. ncbi request reprint [Increased mortality among infants born at night. A reflection of inadequate perinatal intensive care resources in the night-time?]
    Henrik Hagberg
    Avdelningen för obstetrik och gynekologi, Perinatalmedicinskt centrum, Sahlgrenska Universitetssjukhuset Ostra, Goteborg
    Lakartidningen 99:2142-4. 2002
  7. ncbi request reprint No correlation between cerebral palsy and cytokines in postnatal blood of preterms
    Henrik Hagberg
    Department of Obstetrics and Gynecology, Sahlgrenska University Hospital East, Sweden
    Pediatr Res 53:544-5. 2003
  8. ncbi request reprint Mitochondrial impairment in the developing brain after hypoxia-ischemia
    Henrik Hagberg
    Perinatal Center, Department for the Health of Women and Children, Sahlgrenska Academy, East Hospital, 416 85
    J Bioenerg Biomembr 36:369-73. 2004
    ..These data support the involvement of mitochondria-related mechanisms in perinatal brain injury...
  9. ncbi request reprint PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury
    Henrik Hagberg
    Perinatal Center, Sahlgrenska University Hospital, Goteborg, Sweden
    J Neurochem 90:1068-75. 2004
    ..The results indicate that hypoxia-ischemia activates Poly(ADP-ribose) polymerase-1 in the neonatal brain and that the sex of the animal strongly influences its role in the pathogenesis of brain injury...
  10. ncbi request reprint Sequelae of chorioamnionitis
    Henrik Hagberg
    Perinatal Center, Department of Obstetrics and Gynecology, Sahlgrenska University Hospital East, Goteborg, Sweden
    Curr Opin Infect Dis 15:301-6. 2002
    ..The infectious/inflammatory mechanisms involved are incompletely understood, and the types of microbes, as well as the genetic characteristics of the host adaptive and innate immune response, need to be better characterized...
  11. ncbi request reprint Models of white matter injury: comparison of infectious, hypoxic-ischemic, and excitotoxic insults
    Henrik Hagberg
    Perinatal Center, Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Goteberg, Sweden
    Ment Retard Dev Disabil Res Rev 8:30-8. 2002
    ....
  12. ncbi request reprint Brain injury in preterm infants--what can the obstetrician do?
    Henrik Hagberg
    Perinatal Center, Department of Obstetrics and Gynecology, Sahlgrenska Academy, East Hospital, 416 85 Goteborg, Sweden
    Early Hum Dev 81:231-5. 2005
    ....
  13. ncbi request reprint [A new monitoring method for safer child delivery. Lower number of metabolic acidosis cases with fetal ECG and cardiotocography]
    Henrik Hagberg
    Perinatalmedicinskt centrum, Sahlgrenska akademin, Goteborg
    Lakartidningen 101:3875-6, 3878, 3880-1. 2004
  14. ncbi request reprint Effect of inflammation on central nervous system development and vulnerability
    Henrik Hagberg
    Perinatal Center, Institute for the Health of Women and Children, Sahlgrenska Academy, Goteborg, Sweden
    Curr Opin Neurol 18:117-23. 2005
    ..In this brief review we present the hypothesis that systemic infection/inflammation can severely interfere with normal CNS function and development...
  15. ncbi request reprint [Spontaneous premature birth: physiopathology, predictors and management. The frequency is constant--early detection can improve therapeutic possibilities]
    H Hagberg
    Avdelningen för obstetrik och gynekologi, Sahlgrenska Universitetssjukhuset Ostra, Goteborg
    Lakartidningen 97:301-6, 308-10. 2000
    ....
  16. ncbi request reprint Antenatal brain injury: aetiology and possibilities of prevention
    H Hagberg
    Perinatal Center Dept of Obstetrics, Institute for the Health of Women and Children and Dept of Physiology, Sahlgrenska University Hospital Ostra, Goteborg, 416 85, Sweden
    Semin Neonatol 5:41-51. 2000
    ..Mothers can decrease the risk of injury by maintaining a good diet, avoiding smoking, alcohol intake and exposure to TORCH infections during pregnancy...
  17. ncbi request reprint Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: a mechanism of "pathological apoptosis"?
    K Blomgren
    Perinatal Center, Institute of Physiology and Pharmacology, Goteborg University, Sweden
    J Biol Chem 276:10191-8. 2001
    ..quot;..
  18. ncbi request reprint Calpastatin is up-regulated in response to hypoxia and is a suicide substrate to calpain after neonatal cerebral hypoxia-ischemia
    K Blomgren
    Perinatal Center, Inst of Physiology and Pharmacology, Goteborg University, SE 405 30 Goteborg, Sweden
    J Biol Chem 274:14046-52. 1999
    ..In summary, calpastatin was up-regulated in areas that remain undamaged and degraded in areas where excessive activation of calpains and infarction occurs...
  19. ncbi request reprint Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia
    C Zhu
    Institute of Neuroscience and Physiology, Goteborg University, Goteborg, Sweden
    Cell Death Differ 14:775-84. 2007
    ....
  20. ncbi request reprint Interleukin-6 and interleukin-8 in cervical fluid in a population of Swedish women in preterm labor: relationship to microbial invasion of the amniotic fluid, intra-amniotic inflammation, and preterm delivery
    Rose Marie Holst
    Perinatal Center, Department of Obstetrics and Gynecology, Institute for the Health of Women and Children, Sahlgrenska University Hospital, Goteborg, Sweden
    Acta Obstet Gynecol Scand 84:551-7. 2005
    ..The aim was to examine cervical interleukin (IL)-6 and IL-8 in relation to microbial invasion of the amniotic fluid, intra-amniotic inflammation, and preterm birth in women in preterm labor...
  21. doi request reprint Microglial MyD88 signaling regulates acute neuronal toxicity of LPS-stimulated microglia in vitro
    J M Dean
    Perinatal Centre, Department of Physiology and Neuroscience, Sahlgrenska Academy, Gothenburg University, Goteborg, Sweden
    Brain Behav Immun 24:776-83. 2010
    ..15 vs. MyD88 KO control). These data suggest that MyD88-dependent activation of microglia by LPS causes release of factors directly toxic to neurons...
  22. ncbi request reprint Fetal electrocardiography in labor and neonatal outcome: data from the Swedish randomized controlled trial on intrapartum fetal monitoring
    Håkan Norén
    Department of Obstetrics and Gynecology, Perinatal Center, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Am J Obstet Gynecol 188:183-92. 2003
    ..The purpose of this study was to analyze findings that were related to cases with a complicated/adverse neonatal outcome in the Swedish randomized controlled trial...
  23. ncbi request reprint Cervical length in women in preterm labor with intact membranes: relationship to intra-amniotic inflammation/microbial invasion, cervical inflammation and preterm delivery
    R M Holst
    Perinatal Center, Department of Obstetrics and Gynecology, Institute for the Health of Women and Children, Sahlgrenska Academy, Sahlgrenska University Hospital East, Goteborg, Sweden
    Ultrasound Obstet Gynecol 28:768-74. 2006
    ..The aim of this study was to evaluate if cervical length measured by transvaginal sonography could assist in the identification of women at high risk for IAI...
  24. doi request reprint Cerebral palsy and restricted growth status at birth: population-based case-control study
    B Jacobsson
    Perinatal Center, Department of Obstetrics and Gynaecology, Institute for the Health of Women and Children, Sahlgrenska University Hospital, Sweden
    BJOG 115:1250-5. 2008
    ..To evaluate the association between growth status at birth and subsequent development of cerebral palsy in preterm and term infants...
  25. ncbi request reprint Subcellular distribution of calcium and ultrastructural changes after cerebral hypoxia-ischemia in immature rats
    M Puka-Sundvall
    Perinatal Center, Department of Anatomy and Cell Biology, Goteborg University, Goteborg, Sweden
    Brain Res Dev Brain Res 125:31-41. 2000
    ..The results are discussed in relation to mitochondrial permeability transition and activation of apoptotic processes...
  26. ncbi request reprint Caspase-3 activation after neonatal rat cerebral hypoxia-ischemia
    X Wang
    Perinatal Center, Department of Physiology, , , Sweden
    Biol Neonate 79:172-9. 2001
    ..In conclusion, caspase-3 is activated extensively in the immature brain after HI. The subsequent cleavage of proteins involved in cellular homeostasis and repair may contribute to the process of brain injury...
  27. ncbi request reprint Interleukin-6 and interleukin-8 in cervical and amniotic fluid: relationship to microbial invasion of the chorioamniotic membranes
    Bo Jacobsson
    Perinatal Center, Department of Obstetrics and Gynaecology, Institute for the Health of Women and Children, Goteborg, Sweden
    BJOG 112:719-24. 2005
    ..To evaluate the levels of interleukin (IL)-6 and IL-8 in cervical and amniotic fluid in relation to the presence of bacteria in the membranes in women in preterm labour (PTL)...
  28. ncbi request reprint The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia
    C Zhu
    Department of Physiology, Goteborg University, Goteborg, Sweden
    Cell Death Differ 12:162-76. 2005
    ..To our knowledge, this is the first report demonstrating developmental regulation of AIF-mediated cell death as well as involvement of autophagy in a model of brain injury...
  29. ncbi request reprint Bacterial endotoxin sensitizes the immature brain to hypoxic--ischaemic injury
    S Eklind
    Perinatal Center, Department of Obstetrics and Gynecology, Institute of the Health of Women and Children, , , Sweden
    Eur J Neurosci 13:1101-6. 2001
    ..These results suggest that the innate immune system may be involved in the vulnerability of the immature brain following the combination of infection and hypoxia--ischaemia...
  30. ncbi request reprint Proteomic analysis using protein chips to detect biomarkers in cervical and amniotic fluid in women with intra-amniotic inflammation
    Ulla Ruetschi
    Department of Clinical Chemistry and Transfusion Medicine, Perinatal Center, Department of Obstetrics and Gynecology, Institute for the Health of Women and Children, Sahlgrenska University Hospital, Goteborg, Sweden
    J Proteome Res 4:2236-42. 2005
    ..Five of these were identified as human neutrophil protein 1-3, calgranulin A and B...
  31. ncbi request reprint Bcl-2 phosphorylation in the BH4 domain precedes caspase-3 activation and cell death after neonatal cerebral hypoxic-ischemic injury
    Ulrika Hallin
    Perinatal Center, Department of Physiology, Goteborg University, PO Box 432, SE 405 30 Goteborg, Sweden
    Neurobiol Dis 21:478-86. 2006
    ..In conclusion, phosphorylation of Bcl-2 at serine 24 was induced by hypoxia-ischemia, presumably resulting in loss of its anti-apoptotic function...
  32. ncbi request reprint Nitrosylation precedes caspase-3 activation and translocation of apoptosis-inducing factor in neonatal rat cerebral hypoxia-ischaemia
    Changlian Zhu
    Department of Physiology, Goteborg University, Goteborg, Sweden
    J Neurochem 90:462-71. 2004
    ..In summary, nitrotyrosine is an early marker of cellular injury and inhibition of nNOS and iNOS is a promising strategy for neuroprotection after perinatal HI...
  33. ncbi request reprint Interleukin-18 involvement in hypoxic-ischemic brain injury
    Maj Hedtjarn
    Department of Physiology and Pharmacology, Perinatal Center, Goteborg University, 405 30 Goteborg, Sweden
    J Neurosci 22:5910-9. 2002
    ..In conclusion, we found that IL-18 expression in microglia was markedly increased after HI and that IL-18 appears to be important for the development of HI brain injury...
  34. ncbi request reprint Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brain
    Changlian Zhu
    Perinatal Center, Department of Physiology, Goteborg University, Goteborg, Sweden
    J Neurochem 86:306-17. 2003
    ..In summary, AIF-mediated cell death may be an important mechanism of HI-induced neuronal loss in the immature brain...
  35. doi request reprint Role of mixed lineage kinase inhibition in neonatal hypoxia-ischemia
    Ylva Carlsson
    Department of Obstetrics and Gynecology, Perinatal Center, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
    Dev Neurosci 31:420-6. 2009
    ..In conclusion, the MLK inhibitor CEP-1347 has protective effects in a neonatal rat model of hypoxia-ischemia, which is mainly related to reduced apoptosis...
  36. doi request reprint Lipopolysaccharide sensitizes neonatal hypoxic-ischemic brain injury in a MyD88-dependent manner
    Xiaoyang Wang
    Perinatal Center, Department of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    J Immunol 183:7471-7. 2009
    ..Collectively, these findings indicate that MyD88 plays an essential role in LPS-sensitized HI neonatal brain injury, which involves both inflammatory and caspase-dependent pathways...
  37. ncbi request reprint Lipopolysaccharide-induced inflammation and perinatal brain injury
    Xiaoyang Wang
    Perinatal Center, Department of Neuroscience and Physiology, Sahlgrenska Academy, Goteborg University, 40530 Goteborg, Sweden
    Semin Fetal Neonatal Med 11:343-53. 2006
    ..Both antenatal and neonatal LPS exposures increase the sensitivity of the brain to subsequent hypoxic/ischaemic events, even in adulthood. These studies suggest that fetal inflammation is the strongest predictor of brain lesions...
  38. ncbi request reprint Interleukin-1alpha, interleukin-6 and interleukin-8 in cervico/vaginal secretion for screening of preterm birth in twin gestation
    U B Wennerholm
    Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Goteborg, Sweden
    Acta Obstet Gynecol Scand 77:508-14. 1998
    ..The purpose was to determine the prognostic value of interleukin (IL) 1-alpha, IL-6 and IL-8 in cervico/vaginal secretion for preterm birth (<37 weeks of gestation) in twin pregnancies...
  39. doi request reprint Cerebellar white matter injury following systemic endotoxemia in preterm fetal sheep
    J M Dean
    Department of Physiology and Neuroscience, Perinatal Centre, Sahlgrenska Academy, Gothenburg University, Goteborg, Sweden
    Neuroscience 160:606-15. 2009
    ....
  40. ncbi request reprint Cerebral hypoxia-ischemia in immature rats: involvement of mitochondrial permeability transition?
    M Puka-Sundvall
    Department of Anatomy and Cell Biology, Perinatal Center, Goteborg University, Sweden
    Dev Neurosci 23:192-7. 2001
    ..5-8 h of reperfusion. However, CsA did not affect brain injury or mitochondrial respiration. The data suggest that MPT occurred after HI but does not provide evidence for its involvement in the development of injury...
  41. doi request reprint Prediction of microbial invasion of the amniotic cavity in women with preterm labour: analysis of multiple proteins in amniotic and cervical fluids
    R M Holst
    Perinatal Centre, Department of Obstetrics and Gynaecology, Institute for Clinical Sciences, Sahlgrenska University Hospital East, Goteborg, Sweden
    BJOG 118:240-9. 2011
    ..The objective was to determine whether specific proteins in amniotic and cervical fluids alone, or in combination, could identify bacterial invasion...
  42. doi request reprint Acupuncture as an adjunct to standard treatment for pelvic girdle pain in pregnant women: randomised double-blinded controlled trial comparing acupuncture with non-penetrating sham acupuncture
    H Elden
    Perinatal Center, Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, East Hospital, Goteborg, Sweden
    BJOG 115:1655-68. 2008
    ..To investigate whether acupuncture has a greater treatment effect than non-penetrating sham acupuncture in women with pelvic girdle pain (PGP) during pregnancy...
  43. ncbi request reprint STAN in clinical practice--the outcome of 2 years of regular use in the city of Gothenburg
    Håkan Norén
    Department of Obstetrics and Gynecology, Perinatal Center, Sahlgrenska University Hospital, Gothenburg, Sweden
    Am J Obstet Gynecol 195:7-15. 2006
    ..The purpose of this study was to monitor the introduction of the STAN-methodology (Noventa Medical, Moelndal, Sweden)...
  44. ncbi request reprint Expression of cytokines and chemokines in cervical and amniotic fluid: relationship to histological chorioamnionitis
    Rose Marie Holst
    Department of Obstetrics and Gynecology, Perinatal Center, Institute for Clinical Sciences, Sahlgrenska Academy, East Hospital, Goteborg, Sweden
    J Matern Fetal Neonatal Med 20:885-93. 2007
    ..To correlate cervical and amniotic fluid cytokines and macrophage-related chemokines to the development of histological chorioamnionitis (HCA) in patients with preterm labor (PTL) and preterm prelabor rupture of the membranes (PPROM)...
  45. pmc White matter damage after chronic subclinical inflammation in newborn mice
    Xiaoyang Wang
    Perinatal Center, Department of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, S 405 30 Gothenburg, Sweden
    J Child Neurol 24:1171-8. 2009
    ..These data suggest chronic subclinical inflammation hampers development of white and gray matter in early life, which may be associated with insulin-like growth factor 1 deficiency...
  46. pmc Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury
    Xiaoyang Wang
    Perinatal Center, University of Gothenburg, SE 405 30 Gothenburg, Sweden
    J Neurosci 29:2588-96. 2009
    ..The role of CypD in HI shifts from a predominantly prosurvival protein in the immature to a cell death mediator in the adult brain...
  47. ncbi request reprint Monocyte chemotactic protein-1 in cervical and amniotic fluid: relationship to microbial invasion of the amniotic cavity, intra-amniotic inflammation, and preterm delivery
    Bo Jacobsson
    Department of Obstetrics and Gynecology, Perinatal Center, Institute for the Health of Women and Children, Goteborg, Sweden
    Am J Obstet Gynecol 189:1161-7. 2003
    ..The purpose of this study was to evaluate the role of monocyte chemotactic protein-1 in cervical and amniotic fluid in women in preterm labor and with preterm premature rupture of membranes...
  48. ncbi request reprint Activation of ERK1/2 after neonatal rat cerebral hypoxia-ischaemia
    Xiaoyang Wang
    Perinatal Center, Departments of Physiology and Pediatrics, Goteborg University, Goteborg, Sweden
    J Neurochem 86:351-62. 2003
    ..In summary, ERK1/2 activation occurred early in neurons after HI in the neonatal brain, and mainly in cells displaying signs of damage...
  49. ncbi request reprint Monocyte chemotactic protein-2 and -3 in amniotic fluid: relationship to microbial invasion of the amniotic cavity, intra-amniotic inflammation and preterm delivery
    Bo Jacobsson
    Perinatal Center, Department of Obstetrics and Gynecology, Institute for the Health of Women and Children, Sahlgrenska University Hospital, Goteborg, Sweden
    Acta Obstet Gynecol Scand 84:566-71. 2005
    ..To evaluate the presence of monocyte chemotactic protein (MCP)-2 and MCP-3 in cervical and amniotic fluid in women in preterm labor...
  50. ncbi request reprint Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia
    Changlian Zhu
    Arvid Carlsson Institute of Neuroscience at the Institute of Clinical Neuroscience, Goteborg University, Goteborg, Sweden
    J Neurochem 96:1016-27. 2006
    ..However, critical sex-dependent differences were demonstrated in vivo with regard to cellular, apoptosis-related mechanisms...
  51. ncbi request reprint Microbial invasion and cytokine response in amniotic fluid in a Swedish population of women in preterm labor
    Bo Jacobsson
    Perinatal Center, Department of Obstetrics and Gynecology, Institute for the Health of Women and Children, Goteborg, Sweden
    Acta Obstet Gynecol Scand 82:120-8. 2003
    ..The aim of this study was to investigate the occurrence of intra-amniotic microorganisms and cytokines (interleukin-6 and interleukin-8) in a Swedish population of women in preterm labor and their correlation with preterm birth...
  52. ncbi request reprint Microbial invasion and cytokine response in amniotic fluid in a Swedish population of women with preterm prelabor rupture of membranes
    Bo Jacobsson
    Perinatal Center, Department of Obstetrics and Gynecology, Institute for the Health of Women and Children, Sahlgrenska University Hospital, Goteborg, Sweden
    Acta Obstet Gynecol Scand 82:423-31. 2003
    ....
  53. doi request reprint Prediction of spontaneous preterm delivery in women with preterm labor: analysis of multiple proteins in amniotic and cervical fluids
    Rose Marie Holst
    Perinatal Center, Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska University Hospital East, Goteborg, Sweden
    Obstet Gynecol 114:268-77. 2009
    ..To analyze whether specific proteins in amniotic and cervical fluids, alone or in combination with risk factors, can identify women in preterm labor with intact membranes who will deliver spontaneously within 7 days of sampling...
  54. ncbi request reprint Combined deficiency of IL-1beta18, but not IL-1alphabeta, reduces susceptibility to hypoxia-ischemia in the immature brain
    Maj Hedtjarn
    Department of Physiology and Pharmacology, Perinatal Center, Goteborg University, Goteborg, Sweden
    Dev Neurosci 27:143-8. 2005
    ..These results indicate that IL-18, but not IL-1beta, or the combination of IL-1alpha and IL-1beta, is a contributor to HI injury in the immature brain...
  55. ncbi request reprint Hypoxic preconditioning confers long-term reduction of brain injury and improvement of neurological ability in immature rats
    Malin Gustavsson
    Perinatal Center, Department of Physiology, Box 432, 405 30 Goteborg, Sweden
    Pediatr Res 57:305-9. 2005
    ..Hypoxic PC before HI reduced brain injury by 72% at 8 wk after the insult and provided long-term improvement of sensorimotor and spatial/cognitive functions...
  56. ncbi request reprint Lipopolysaccharide induces both a primary and a secondary phase of sensitization in the developing rat brain
    Saskia Eklind
    Dept of Obstetrics and Gynecology, Sahlgrenska University Hospital, 413 45 Goteborg, Sweden
    Pediatr Res 58:112-6. 2005
    ..The long-term sensitizing effect of LPS has not been previously described...
  57. ncbi request reprint Levels of dimethylarginines and cytokines in mild and severe preeclampsia
    J Ellis
    Perinatal Center, Departments of Obstetrics and Gynecology, Anesthesiology and Clinical Pharmacology, Sahlgrenska University Hospital, , Sweden
    Acta Obstet Gynecol Scand 80:602-8. 2001
    ..Plasma levels of interleukin-6 and -8 were also elevated in severe preeclampsia but no direct correlations were found between these cytokines and dimethylarginines...
  58. ncbi request reprint Role of cytokines in preterm labour and brain injury
    Henrik Hagberg
    Perinatal Center, Department of Obstetrics and Gynecology, Sahlgrenska University Hospital Ostra, SE 416 85 Goteborg, Sweden
    BJOG 112:16-8. 2005
    ..Recently, IL-18 in umbilical blood was shown to correlate with brain injury in preterm infants and IL-18 deficiency in mice decreases CNS vulnerability...
  59. ncbi request reprint Electrocardiographic changes following umbilical cord occlusion in the midgestation fetal sheep
    Anna Karin Welin
    Department of Obstetrics and Gynecology, Perinatal Center, University of Goteborg, SE 416 85 Goteborg, Sweden
    Acta Obstet Gynecol Scand 84:122-8. 2005
    ..However, it is not known whether the preterm fetus responds in a similar fashion. The objective of the present study was to evaluate the FECGST response to umbilical cord occlusion in the preterm fetal sheep...
  60. ncbi request reprint N-acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injury
    Xiaoyang Wang
    Perinatal Center, Department of Physiology, Goteborg University, Goteborg, Sweden
    Ann Neurol 61:263-71. 2007
    ..This study evaluated the neuroprotective efficacy of a scavenging agent, N-acetylcysteine (NAC), in a clinically relevant model...
  61. ncbi request reprint Inflammation-induced preconditioning in the immature brain
    Carina Mallard
    Perinatal Center, Department of Neuroscience and Physiology, Sahlgrenska Academy, Goteborg University, Box 432, Goteborg, Sweden
    Semin Fetal Neonatal Med 12:280-6. 2007
    ..These results suggest that in addition to immune-related activation, transcription of cell death pathways may be important in LPS-induced preconditioning in the immature brain...
  62. ncbi request reprint Dual role of intrauterine immune challenge on neonatal and adult brain vulnerability to hypoxia-ischemia
    Xiaoyang Wang
    Departments of Physiology, Clinical Neurosciences, Perinatal Center, Sahlgrenska Academy, Goteborg, Sweden
    J Neuropathol Exp Neurol 66:552-61. 2007
    ....
  63. ncbi request reprint Interleukin-18 in cervical mucus and amniotic fluid: relationship to microbial invasion of the amniotic fluid, intra-amniotic inflammation and preterm delivery
    Bo Jacobsson
    Department of Obstetrics and Gynaecology, Institute for the Health of Women and Children, Sahlgrenska University Hospital East, Goteborg, Sweden
    BJOG 110:598-603. 2003
    ....
  64. doi request reprint Galectin-3 contributes to neonatal hypoxic-ischemic brain injury
    Christina Doverhag
    Perinatal Center, Dept of Physiology and Neuroscience and Dept of Paediatrics, Sahlgrenska Academy, University of Gothenburg, Sweden
    Neurobiol Dis 38:36-46. 2010
    ..In conclusion, galectin-3 contributes to neonatal HI injury particularly in male mice. Our results indicate that galectin-3 exerts its effect by modulating the inflammatory response...
  65. ncbi request reprint The role of glucose in brain injury following the combination of lipopolysaccharide or lipoteichoic acid and hypoxia-ischemia in neonatal rats
    Saskia Eklind
    Perinatal Center, Department of Obstetrics and Gynecology, Institute for the Health of Women and Children, Goteborg University, Goteborg, Sweden
    Dev Neurosci 26:61-7. 2004
    ....
  66. ncbi request reprint Cerebral palsy in preterm infants: a population-based case-control study of antenatal and intrapartal risk factors
    B Jacobsson
    Perinatal Center, Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Goteborg, Sweden
    Acta Paediatr 91:946-51. 2002
    ..Conclusion: Antenatal infections marginally increased the risk of CP. Low Apgar score and abruptio placentae were associated with CP, especially in moderately preterm infants with hemiplegic CP...
  67. ncbi request reprint Cytokine response in cerebrospinal fluid from preterm infants with posthaemorrhagic ventricular dilatation
    K Savman
    Perinatal Center, Department of Pediatrics, Goteborg University, The Queen Silvia Children s Hospital, SE 416 85 Goteborg, Sweden
    Acta Paediatr 91:1357-63. 2002
    ..The aim of this study was to determine the levels of proinflammatory cytokines in cerebrospinal fluid (CSF) from preterm infants with PHVD and to correlate the levels to white matter damage and neurodevelopmental outcome...
  68. ncbi request reprint White matter injury in the immature brain: role of interleukin-18
    Maj Hedtjarn
    Perinatal Center, Department of Physiology, Goteborg University, Box 432, 405 30 Goteborg, Sweden
    Neurosci Lett 373:16-20. 2005
    ..Taken together, these results indicate that release of IL-18 may play an important role in the development of white matter injury in the neonatal brain...
  69. ncbi request reprint Mitochondria and ischemic reperfusion damage in the adult and in the developing brain
    Klas Blomgren
    Department of Physiology, Perinatal Center, Goteborg University, P O Box 432, SE 405 30 Goteborg, Sweden
    Biochem Biophys Res Commun 304:551-9. 2003
    ..This review will summarize some of the current studies dealing with mitochondria-related mechanisms of ischemic brain damage, with special reference to developmental aspects...
  70. pmc Apoptotic mechanisms in the immature brain: involvement of mitochondria
    Henrik Hagberg
    Perinatal Center, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Goteborg University, Sweden
    J Child Neurol 24:1141-6. 2009
    ..Apoptosis-inducing factor interacts with cyclophilin A and induces chromatinolysis. Blockage of mitochondrial outer membrane permeabilization holds promise as a strategy for perinatal brain protection...
  71. ncbi request reprint Growth hormone-releasing peptide hexarelin reduces neonatal brain injury and alters Akt/glycogen synthase kinase-3beta phosphorylation
    Katarina G Brywe
    Perinatal Center, Department of Obstetrics and Gynecology, Sahlgrenska Academy, Box 432, 405 30 Goteborg, Sweden
    Endocrinology 146:4665-72. 2005
    ....
  72. ncbi request reprint High birthweight and shoulder dystocia: the strongest risk factors for obstetrical brachial plexus palsy in a Swedish population-based study
    Margareta Mollberg
    Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, University of Goteborg, Sweden
    Acta Obstet Gynecol Scand 84:654-9. 2005
    ..Obstetrical brachial plexus palsy (OBPP) is a serious form of neonatal morbidity...
  73. doi request reprint Expression of MMP-12 after neonatal hypoxic-ischemic brain injury in mice
    Pernilla Svedin
    Perinatal Center, Department of Physiology, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Dev Neurosci 31:427-36. 2009
    ..This study demonstrates that MMP-12 is upregulated after HI, suggesting that MMP-12 may contribute to injury in the immature brain, similar to that seen in the adult...
  74. ncbi request reprint Matrix metalloproteinase-9 gene knock-out protects the immature brain after cerebral hypoxia-ischemia
    Pernilla Svedin
    Department of Neuroscience and Physiology, Perinatal Center, Sahlgrenska Academy, Goteborg University, 405 30 Goteborg, Sweden
    J Neurosci 27:1511-8. 2007
    ..In contrast, apoptosis does not appear to be a major contributing factor...
  75. ncbi request reprint Effects of intrauterine inflammation on the developing mouse brain
    Xiaoyang Wang
    Perinatal Center, Dept of Physiology, Goteborg University, SE 405 30 Goteborg, Sweden
    Brain Res 1144:180-5. 2007
    ..Conclusions: Intrauterine inflammation impaired brain development and various brain lesions were produced in both the white and gray matter after intrauterine LPS administration in mice...
  76. ncbi request reprint Effect of lipopolysaccharide on global gene expression in the immature rat brain
    Saskia Eklind
    Department of Obstetrics and Gynecology, Institute for the Health of Women and Children, Goteborg University, Sweden
    Pediatr Res 60:161-8. 2006
    ..In addition to the inflammatory response, a significant number of cell death-associated genes were identified, which may contribute to increased vulnerability of the immature brain to hypoxia-ischemia (HI) following LPS exposure...
  77. pmc Disruption of interleukin-18, but not interleukin-1, increases vulnerability to preterm delivery and fetal mortality after intrauterine inflammation
    Xiaoyang Wang
    Perinatal Center, Department of Physiology, Goteborg University, Box 432, S 405 30 Goteborg, Sweden, and The Third Affiliated Hospital of Zhengzhou University, People s Republic of China
    Am J Pathol 169:967-76. 2006
    ....
  78. doi request reprint Regression of pelvic girdle pain after delivery: follow-up of a randomised single blind controlled trial with different treatment modalities
    H Elden
    Perinatal Center, Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Goteborg University, Sweden
    Acta Obstet Gynecol Scand 87:201-8. 2008
    ..The aim of this follow-up study was to describe regression of pelvic girdle pain after delivery in these women...
  79. ncbi request reprint Obstetric brachial plexus palsy: a prospective study on risk factors related to manual assistance during the second stage of labor
    Margareta Mollberg
    Perinatal Center, Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, University of Goteborg, Goteborg, Sweden
    Acta Obstet Gynecol Scand 86:198-204. 2007
    ..To evaluate the association between obstetric brachial plexus palsy and obstetrical maneuvers during the second stage of delivery...
  80. ncbi request reprint Global gene expression in the immature brain after hypoxia-ischemia
    Maj Hedtjarn
    Department of Physiology, Perinatal Center, Goteborg University, Goteborg, Sweden
    J Cereb Blood Flow Metab 24:1317-32. 2004
    ..Genes involved in transcription, stress, and apoptosis were induced early after the insult, and many new genes that may play important roles in the pathophysiology of neonatal hypoxia-ischemia were identified...
  81. ncbi request reprint A prospective observational study on tears during vaginal delivery: occurrences and risk factors
    Ellen Samuelsson
    Perinatal Center, Department of Obstetrics and Gynecology, Sahlgrenska University Hospital Ostra, 416 85 Goteborg, Sweden
    Acta Obstet Gynecol Scand 81:44-9. 2002
    ..To ascertain the occurrence and distribution of various types of I-IV degree tears, during childbirth, and analyze risk factors for perineal II degree tears...
  82. doi request reprint Neuroprotective effect of Bax-inhibiting peptide on neonatal brain injury
    Xiaoyang Wang
    Department of Physiology, Perinatal Center, Sahlgrenska Academy, University of Gothenburg, Box 432, S 405 30 Gothenburg, Sweden
    Stroke 41:2050-5. 2010
    ..The aim of this study was to evaluate the neuroprotective effect of a cell-penetrating Bax-inhibiting peptide (BIP) on neonatal mouse HI brain injury...
  83. ncbi request reprint Melatonin reduces inflammation and cell death in white matter in the mid-gestation fetal sheep following umbilical cord occlusion
    Anne Karin Welin
    Department of Obstetrics and Gynecology, Sahlgrenska Academy, Goteborg University, 405 30 Goteborg, Sweden
    Pediatr Res 61:153-8. 2007
    ..In conclusion, this study shows that melatonin attenuates cell death in the fetal brain in association with a reduced inflammatory response in the blood and the brain following intrauterine asphyxia in mid-gestation fetal sheep...
  84. pmc Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia
    Changlian Zhu
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Goteborg University, 405 30 Goteborg, Sweden
    J Exp Med 204:1741-8. 2007
    ....
  85. ncbi request reprint Global gene expression in the developing rat brain after hypoxic preconditioning: involvement of apoptotic mechanisms?
    Malin Gustavsson
    Department of Physiology, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Pediatr Res 61:444-50. 2007
    ....
  86. ncbi request reprint Mechanisms of hypoxic neurodegeneration in the developing brain
    Michael V Johnston
    Department of Neurology and Pediatrics and Kenedy Kreger Research Institute, John Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuroscientist 8:212-20. 2002
    ..Although these molecular changes enhance the developing brain's capacity for plasticity by helping to prune redundant synapses and neurons, they can become "Achilles heels" in the face of a brain energy crisis...
  87. ncbi request reprint Effects of selective nitric oxide synthase inhibition on IGF-1, caspases and cytokines in a newborn piglet model of perinatal hypoxia-ischaemia
    Cacha Peeters-Scholte
    Department of Neonatology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Dev Neurosci 24:396-404. 2002
    ....
  88. ncbi request reprint Role of caspase-3 activation in cerebral ischemia-induced neurodegeneration in adult and neonatal brain
    Ramanjit Gill
    F Hoffmann La Roche Ltd, Preclinical Research Basel, CNS Department, Basel, Switzerland
    J Cereb Blood Flow Metab 22:420-30. 2002
    ....
  89. ncbi request reprint Endotoxin-induced hypoxic-ischemic tolerance is mediated by up-regulation of corticosterone in neonatal rat
    Tomoaki Ikeda
    Department of Obstetrics and Gynecology, Miyazaki Medical College, University of Miyazaki, Kihara, Japan
    Pediatr Res 59:56-60. 2006
    ..9, 56.8, and 28.3 ng/mL at 6, 12, 24, and 48 h after the LPS injection, respectively). We conclude that endotoxin-induced up-regulation of endogenous corticosterone appears to be critical for acquiring endotoxin-induced HI tolerance...
  90. ncbi request reprint Deletion of the c-Jun N-terminal kinase 3 gene protects neonatal mice against cerebral hypoxic-ischaemic injury
    Grisha Pirianov
    Division of Clinical Sciences, Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    J Cereb Blood Flow Metab 27:1022-32. 2007
    ..These findings implicate JNK3 involvement in neural cell loss resulting from cerebral HII in the developing brain...
  91. ncbi request reprint Sex and the pathogenesis of cerebral palsy
    Michael V Johnston
    Kennedy Krieger Institute and The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Dev Med Child Neurol 49:74-8. 2007
    ..This information is relevant to understanding the pathogenesis of CP as well as to the design of future clinical trials of potential neuroprotective strategies...
  92. ncbi request reprint X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia
    Xiaoyang Wang
    Department of Neuroscience, Neurobiology, Uppsala University, Uppsala, SE 751 23, Sweden
    Neurobiol Dis 16:179-89. 2004
    ..These findings provide the first evidence that increased XIAP levels protect the neonatal brain against HI...
  93. ncbi request reprint Effects of allopurinol and deferoxamine on reperfusion injury of the brain in newborn piglets after neonatal hypoxia-ischemia
    Cacha Peeters-Scholte
    Department of Neonatology, Image Sciences Institute, University Medical Center, 3584 EA Utrecht, The Netherlands
    Pediatr Res 54:516-22. 2003
    ..We suggest that allopurinol and deferoxamine may have an additional value in the treatment of perinatal hypoxia-ischemia with other neuroprotective agents or in combination with hypothermia...
  94. ncbi request reprint Fetal brain injury in experimental intrauterine asphyxia and inflammation in Göttingen minipigs
    Kristin Lyng
    Department of Obstetrics and Gynecology, Rikshospitalet University Hospital, Oslo, Norway
    J Perinat Med 34:226-34. 2006
    ..To examine fetal brain injury in the Göttingen minipig following intrauterine asphyxia and infection/inflammation induced at 3/4 of gestational length...
  95. ncbi request reprint Delayed IGF-1 administration rescues oligodendrocyte progenitors from glutamate-induced cell death and hypoxic-ischemic brain damage
    Teresa L Wood
    Department of Neurology and Neuroscience, New Jersey Medical School, University of Medicine and Dentistry New Jersey, Newark, NJ 07103, USA
    Dev Neurosci 29:302-10. 2007
    ..These results suggest that delayed administration of IGF-1 will rescue OPs in the immature white matter and promote myelination following hypoxia-ischemia...
  96. ncbi request reprint Delayed peripheral administration of a GPE analogue induces astrogliosis and angiogenesis and reduces inflammation and brain injury following hypoxia-ischemia in the neonatal rat
    Pernilla Svedin
    The Liggins Institute, University of Auckland, Auckland, New Zealand
    Dev Neurosci 29:393-402. 2007
    ..The normalization of IL-6 levels and the promotion of both neovascularization and reactive astrocytosis may be potential mechanisms that underlie its protective effects...
  97. ncbi request reprint Models of cerebral palsy: which ones are best?
    Michael V Johnston
    Department of Neurology, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Child Neurol 20:984-7. 2005
  98. ncbi request reprint Fetal scalp pH and ST analysis of the fetal ECG as an adjunct to CTG. A multi-center, observational study
    Andreas K Luttkus
    Department of Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Perinat Med 32:486-94. 2004
    ..To evaluate the relationships between scalp-pH and CTG plus ST waveform analysis of the fetal ECG (STAN) clinical guidelines as indicators of intrapartum hypoxia in term fetuses born with cord artery acidemia...
  99. ncbi request reprint The dynamics of the LPS triggered inflammatory response of murine microglia under different culture and in vivo conditions
    Søren Lund
    H Lundbeck A S, Valby, Denmark
    J Neuroimmunol 180:71-87. 2006
    ..Although most inflammatory genes induced in vitro were transferable to our in vivo model, the observed discrepancy for some genes potentially represents regulatory factors present in the central nervous system (CNS) but not in vitro...
  100. ncbi request reprint Adult or perinatal brain injury: does sex matter?
    Patricia D Hurn
    Anesthesiology and Perioperative Medicine, Oregon Health Sciences University, 3181 SW Sam Jackson Pk Rd, UHS 2, Portland, OR 97239 3098, USA
    Stroke 36:193-5. 2005