Bengt I Eriksson

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. doi Oral rivaroxaban for the prevention of symptomatic venous thromboembolism after elective hip and knee replacement
    B I Eriksson
    University of Gothenburg, Gothenburg, Sweden
    J Bone Joint Surg Br 91:636-44. 2009
  2. pmc Type of anaesthesia and the safety and efficacy of thromboprophylaxis with enoxaparin or dabigatran etexilate in major orthopaedic surgery: pooled analysis of three randomized controlled trials
    Nadia Rosencher
    Staff Anaesthesiologist, Department of Anaesthesiology and Intensive Care, Paris Descartes University, Cochin Hospital AP HP, rue du Faubourg Saint Jacques, 75014, Paris, France
    Thromb J 10:9. 2012
  3. doi Dabigatran is effective with a favourable safety profile in normal and overweight patients undergoing major orthopaedic surgery: a pooled analysis
    Bengt I Eriksson
    Department of Ortopaedics, Institute of Clinical Sciences, University of Gothenburg, Sahlgrenska University Hospital, SE 43180 Molndal, Sweden
    Thromb Res 130:818-20. 2012
  4. doi Evaluation of the acute coronary syndrome safety profile of dabigatran etexilate in patients undergoing major orthopedic surgery: findings from four Phase 3 trials
    Bengt I Eriksson
    University Hospital Sahlgrenska, Gothenburg, Sweden
    Thromb Res 130:396-402. 2012
  5. doi Concomitant use of medication with antiplatelet effects in patients receiving either rivaroxaban or enoxaparin after total hip or knee arthroplasty
    Bengt I Eriksson
    Department of Orthopaedics, Sahlgrenska University Hospital Molndal, Molndal, Sweden
    Thromb Res 130:147-51. 2012
  6. pmc Potent anticoagulants are associated with a higher all-cause mortality rate after hip and knee arthroplasty
    Bengt I Eriksson
    Clin Orthop Relat Res 466:2009-11; author reply 2012-4. 2008
  7. ncbi A once-daily, oral, direct Factor Xa inhibitor, rivaroxaban (BAY 59-7939), for thromboprophylaxis after total hip replacement
    Bengt I Eriksson
    Department of Orthopaedics, Sahlgrenska University Hospital Ostra, SE 416 85 Gothenburg, Sweden
    Circulation 114:2374-81. 2006
  8. ncbi Dose escalating safety study of a new oral direct thrombin inhibitor, dabigatran etexilate, in patients undergoing total hip replacement: BISTRO I
    B I Eriksson
    Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    J Thromb Haemost 2:1573-80. 2004
  9. ncbi Prevention of venous thromboembolism following orthopaedic surgery: clinical potential of direct thrombin inhibitors
    Bengt I Eriksson
    Department of Orthopaedic Surgery, Sahlgrenska University Hospital Ostra, SE 416 85 Goteborg, Sweden
    Drugs 64:577-95. 2004
  10. ncbi The direct thrombin inhibitor melagatran followed by oral ximelagatran compared with enoxaparin for the prevention of venous thromboembolism after total hip or knee replacement: the EXPRESS study
    B I Eriksson
    Department of Orthopedics, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    J Thromb Haemost 1:2490-6. 2003

Detail Information

Publications92

  1. doi Oral rivaroxaban for the prevention of symptomatic venous thromboembolism after elective hip and knee replacement
    B I Eriksson
    University of Gothenburg, Gothenburg, Sweden
    J Bone Joint Surg Br 91:636-44. 2009
    ..3% vs 0.2%). Rivaroxaban started six to eight hours after surgery was more effective than enoxaparin started the previous evening in preventing symptomatic venous thromboembolism and all-cause mortality, without increasing major bleeding...
  2. pmc Type of anaesthesia and the safety and efficacy of thromboprophylaxis with enoxaparin or dabigatran etexilate in major orthopaedic surgery: pooled analysis of three randomized controlled trials
    Nadia Rosencher
    Staff Anaesthesiologist, Department of Anaesthesiology and Intensive Care, Paris Descartes University, Cochin Hospital AP HP, rue du Faubourg Saint Jacques, 75014, Paris, France
    Thromb J 10:9. 2012
    ..abstract:..
  3. doi Dabigatran is effective with a favourable safety profile in normal and overweight patients undergoing major orthopaedic surgery: a pooled analysis
    Bengt I Eriksson
    Department of Ortopaedics, Institute of Clinical Sciences, University of Gothenburg, Sahlgrenska University Hospital, SE 43180 Molndal, Sweden
    Thromb Res 130:818-20. 2012
    ..Obesity is an established independent risk factor for VTE...
  4. doi Evaluation of the acute coronary syndrome safety profile of dabigatran etexilate in patients undergoing major orthopedic surgery: findings from four Phase 3 trials
    Bengt I Eriksson
    University Hospital Sahlgrenska, Gothenburg, Sweden
    Thromb Res 130:396-402. 2012
    ..Four Phase 3 trials of dabigatran etexilate in major orthopedic surgery incorporated measures to assess the risk of acute coronary syndrome (ACS) events during and after treatment...
  5. doi Concomitant use of medication with antiplatelet effects in patients receiving either rivaroxaban or enoxaparin after total hip or knee arthroplasty
    Bengt I Eriksson
    Department of Orthopaedics, Sahlgrenska University Hospital Molndal, Molndal, Sweden
    Thromb Res 130:147-51. 2012
    ..This analysis compared the safety of concomitant use of specified medications with rivaroxaban and enoxaparin by evaluating postoperative bleeding rates from the pooled RECORD1-4 data...
  6. pmc Potent anticoagulants are associated with a higher all-cause mortality rate after hip and knee arthroplasty
    Bengt I Eriksson
    Clin Orthop Relat Res 466:2009-11; author reply 2012-4. 2008
  7. ncbi A once-daily, oral, direct Factor Xa inhibitor, rivaroxaban (BAY 59-7939), for thromboprophylaxis after total hip replacement
    Bengt I Eriksson
    Department of Orthopaedics, Sahlgrenska University Hospital Ostra, SE 416 85 Gothenburg, Sweden
    Circulation 114:2374-81. 2006
    ..Rivaroxaban (BAY 59-7939)--an oral, direct Factor Xa inhibitor--could be an alternative to heparins and warfarin for the prevention and treatment of thromboembolic disorders...
  8. ncbi Dose escalating safety study of a new oral direct thrombin inhibitor, dabigatran etexilate, in patients undergoing total hip replacement: BISTRO I
    B I Eriksson
    Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    J Thromb Haemost 2:1573-80. 2004
    ..Following oral administration, dabigatran etexilate is rapidly converted to its active form dabigatran (BIBR 953 ZW)...
  9. ncbi Prevention of venous thromboembolism following orthopaedic surgery: clinical potential of direct thrombin inhibitors
    Bengt I Eriksson
    Department of Orthopaedic Surgery, Sahlgrenska University Hospital Ostra, SE 416 85 Goteborg, Sweden
    Drugs 64:577-95. 2004
    ..Ximelagatran can be used with an oral fixed dose without the need for coagulation monitoring or dose adjustment. Hence, it offers significant potential to facilitate the management of anticoagulation in or out of hospital...
  10. ncbi The direct thrombin inhibitor melagatran followed by oral ximelagatran compared with enoxaparin for the prevention of venous thromboembolism after total hip or knee replacement: the EXPRESS study
    B I Eriksson
    Department of Orthopedics, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    J Thromb Haemost 1:2490-6. 2003
    ..Ximelagatran and its subcutaneous (s.c.) form melagatran are novel direct thrombin inhibitors for the prevention and treatment of thromboembolic disease...
  11. doi Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development
    Bengt I Eriksson
    Orthopaedics Department, University Hospital Sahlgrenska Ostra, Gothenburg, Sweden
    Clin Pharmacokinet 48:1-22. 2009
    ..Here, we compare the pharmacokinetic and pharmacodynamic features of these new oral agents...
  12. doi Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty
    Bengt I Eriksson
    Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
    N Engl J Med 358:2765-75. 2008
    ..This phase 3 trial compared the efficacy and safety of rivaroxaban, an oral direct inhibitor of factor Xa, with those of enoxaparin for extended thromboprophylaxis in patients undergoing total hip arthroplasty...
  13. ncbi Clinical experience of melagatran/ximelagatran in major orthopaedic surgery
    Bengt I Eriksson
    Department of Orthopaedic Surgery, Sahlgrenska University Ostra, Göteborg S 41685, Sweden
    Thromb Res 109:S23-9. 2003
    ..The METHRO II and III studies demonstrate that s.c. melagatran combined with oral ximelagatran are well tolerated and effective for the prevention of VTE following major orthopaedic surgery...
  14. ncbi Clinical experience with ximelagatran in orthopaedic surgery
    Bengt Eriksson
    Department of Orthopaedics, Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
    Drugs 64:27-35. 2004
    ..As ximelagatran can be given in fixed oral dosing without coagulation monitoring, it is an attractive choice for the prevention of venous thromboembolism in major elective orthopaedic surgery...
  15. ncbi A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: the BISTRO II randomized trial
    B I Eriksson
    Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    J Thromb Haemost 3:103-11. 2005
    ..Dabigatran etexilate is an oral direct thrombin inhibitor undergoing evaluation for the prevention of venous thromboembolism (VTE) following orthopedic surgery...
  16. ncbi Ximelagatran in orthopaedic surgery
    Bengt Eriksson
    Department of Orthopedics, Sahlgrenska University Hospital Ostra, SE 41685 Gothenburg, Sweden
    Pathophysiol Haemost Thromb 34:10-7. 2005
    ....
  17. ncbi Partial factor IXa inhibition with TTP889 for prevention of venous thromboembolism: an exploratory study
    B I Eriksson
    Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    J Thromb Haemost 6:457-63. 2008
    ..We investigated the anticoagulant potential of oral TTP889, a small molecule that inhibits up to 90% of FIXa activity at therapeutic doses, using a clinical model of extended prophylaxis in hip fracture surgery (HFS)...
  18. ncbi Oral, direct Factor Xa inhibition with BAY 59-7939 for the prevention of venous thromboembolism after total hip replacement
    B I Eriksson
    Sahlgrenska University HospitalOstra, Gothenburg, Sweden
    J Thromb Haemost 4:121-8. 2006
    ..Joint replacement surgery is an appropriate model for dose-ranging studies investigating new anticoagulants...
  19. ncbi Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial
    Bengt I Eriksson
    Department of Orthopaedic Surgery, Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
    Lancet 370:949-56. 2007
    ..After hip replacement surgery, prophylaxis following discharge from hospital is recommended to reduce the risk of venous thromboembolism. Our aim was to assess the oral, direct thrombin inhibitor dabigatran etexilate for such prophylaxis...
  20. ncbi Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial
    B I Eriksson
    Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
    J Thromb Haemost 5:2178-85. 2007
    ....
  21. ncbi Oral anticoagulants in development: focus on thromboprophylaxis in patients undergoing orthopaedic surgery
    Bengt I Eriksson
    Department of Orthopaedics Surgery, Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
    Drugs 66:1411-29. 2006
    ....
  22. ncbi Dose-escalation study of rivaroxaban (BAY 59-7939)--an oral, direct Factor Xa inhibitor--for the prevention of venous thromboembolism in patients undergoing total hip replacement
    Bengt I Eriksson
    Department of Orthopaedics, Sahlgrenska University Hospital Ostra, SU Ostra sjukhuset, SE 41685 Goteborg, Sweden
    Thromb Res 120:685-93. 2007
    ..Rivaroxaban (BAY 59-7939) is a novel, oral, direct Factor Xa inhibitor in clinical development for the prevention of thromboembolic disorders. The aim of this study was to demonstrate proof-of-principle for rivaroxaban...
  23. ncbi Duration of prophylaxis against venous thromboembolism with fondaparinux after hip fracture surgery: a multicenter, randomized, placebo-controlled, double-blind study
    Bengt I Eriksson
    Orthopedics Department, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Arch Intern Med 163:1337-42. 2003
    ..The benefit of thromboprophylaxis for 1 month has never been evaluated in patients undergoing hip fracture surgery, a setting in the highest risk category for postoperative venous thromboembolism (VTE)...
  24. ncbi A dose-ranging study of the oral direct thrombin inhibitor, ximelagatran, and its subcutaneous form, melagatran, compared with dalteparin in the prophylaxis of thromboembolism after hip or knee replacement: METHRO I. MElagatran for THRombin inhibition in
    Bengt I Eriksson
    Department of Orthopaedic Surgery, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Thromb Haemost 87:231-7. 2002
    ..Ximelagatran and melagatran were well tolerated. In conclusion, ximelagatran and its active form melagatran appear to be promising agents for the prevention of venous thromboembolism following orthopaedic surgery...
  25. doi Oral dabigatran versus enoxaparin for thromboprophylaxis after primary total hip arthroplasty (RE-NOVATE II*). A randomised, double-blind, non-inferiority trial
    Bengt I Eriksson
    University of Gothenburg, Department of Orthopaedics, Sahlgrenska University Hospital, Molndal, Sweden
    Thromb Haemost 105:721-9. 2011
    ..The risk of bleeding and safety profiles were similar...
  26. ncbi Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery
    B I Eriksson
    Orthopedics Department, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    N Engl J Med 345:1298-304. 2001
    ..Surgery for hip fracture carries a high risk of venous thromboembolism, despite the use of current thromboprophylactic treatments. Fondaparinux, a synthetic pentasaccharide, is a new antithrombotic agent that may reduce this risk...
  27. ncbi A dose escalation study of YM150, an oral direct factor Xa inhibitor, in the prevention of venous thromboembolism in elective primary hip replacement surgery
    B I Eriksson
    Department of Orthopaedics, Sahlgrenska University Ostra Hospital, Gothenburg, Sweden
    J Thromb Haemost 5:1660-5. 2007
    ..YM150, a new oral direct factor Xa inhibitor is used as prophylaxis for venous thromboembolism (VTE), a well-known risk after orthopaedic surgery...
  28. doi Prevention of venous thromboembolism with an oral factor Xa inhibitor, YM150, after total hip arthroplasty. A dose finding study (ONYX-2)
    B I Eriksson
    Department of Orthopaedics, Sahlgrenska University Hospital, Gothenburg, Sweden
    J Thromb Haemost 8:714-21. 2010
    ....
  29. doi Novel oral factor Xa and thrombin inhibitors in the management of thromboembolism
    Bengt I Eriksson
    Department of Orthopaedics, Sahlgrenska University Hospital, Molndal, Sweden
    Annu Rev Med 62:41-57. 2011
    ..Edoxaban, an oral FXa inhibitor, is also being evaluated in phase III clinical trials. This review summarizes the pharmacology, clinical trial results, and future role of the new oral anticoagulants in clinical practice...
  30. ncbi Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: the METHRO II randomised trial
    Bengt I Eriksson
    Department of Orthopaedic Surgery, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Lancet 360:1441-7. 2002
    ..We aimed to compare the efficacy and safety with that of dalteparin...
  31. ncbi Direct thrombin inhibitor melagatran followed by oral ximelagatran in comparison with enoxaparin for prevention of venous thromboembolism after total hip or knee replacement
    Bengt I Eriksson
    Orthopaedics Department, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Thromb Haemost 89:288-96. 2003
    ..0%) and 306/1122 (27.3%) patients in the ximelagatran and enoxaparin group, respectively, a difference in risk of 3.7% in favour of enoxaparin (p = 0.053). Bleeding was comparable between the two groups...
  32. doi Major functional deficits persist 2 years after acute Achilles tendon rupture
    Nicklas Olsson
    Department of Orthopaedics, Institute of Clinical Sciences at Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Sweden
    Knee Surg Sports Traumatol Arthrosc 19:1385-93. 2011
    ..The focus was to evaluate whether any improvements occurred between the one and 2-year evaluation...
  33. ncbi Pharmacokinetics of melagatran and the effect on ex vivo coagulation time in orthopaedic surgery patients receiving subcutaneous melagatran and oral ximelagatran: a population model analysis
    Ulf G Eriksson
    AstraZeneca R and D Molndal, Molndal, Sweden
    Clin Pharmacokinet 42:687-701. 2003
    ..To support the design of a pivotal dose-finding study, the impact of individualised dosage based on bodyweight and calculated creatinine clearance was examined...
  34. ncbi Prophylaxis of venous thromboembolism with subcutaneous melagatran in total hip or total knee replacement: results from Phase II studies
    Bengt I Eriksson
    Department of Orthopaedic Surgery, Sahlgrenska University Hospital Ostra, S 41685, Goteborg, Sweden
    Thromb Res 105:371-8. 2002
    ..In conclusion, subcutaneous melagatran 1.5-4.5 mg bid in saline or depot formulation was well tolerated and resulted in a low frequency of VTE...
  35. doi Efficacy of delayed thromboprophylaxis with dabigatran: pooled analysis
    Bengt I Eriksson
    Department of Orthopaedics, Institute of Clinical Sciences, University of Gothenburg, Sahlgrenska University Hospital, SE 43180 Molndal, Sweden
    Thromb Res 130:871-6. 2012
    ..However, a delay in dosing could occur for clinical or logistical reasons. A post hoc analysis was carried out to determine if patients with delayed dosing received adequate anticoagulation...
  36. ncbi A randomized, controlled study of a rehabilitation model to improve knee-function self-efficacy with ACL injury
    Pia Thomeé
    Department of Orthopedics, Goteborg University, Goteborg, Sweden
    J Sport Rehabil 19:200-13. 2010
    ..Preoperative knee-function self-efficacy has also been shown to have a predictive ability in terms of outcome 1 y after ACL reconstruction...
  37. ncbi Improvements in the prevention of postoperative venous thromboembolism in hip fracture patients
    Bengt I Eriksson
    Department of Orthopedics, Sahlgrenska University Hospital Ostra, S 41685 Göteborg, Sweden
    Orthopedics 26:s851-8. 2003
    ..4% (relative risk reduction: 95.9%; P<.001). Based on these findings, 4-week fondaparinux treatment may become the standard thromboprophylaxis after hip fracture surgery...
  38. doi Dabigatran etexilate: pivotal trials for venous thromboembolism prophylaxis after hip or knee arthroplasty
    Bengt I Eriksson
    Orthopedics Department, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Clin Appl Thromb Hemost 15:25S-31S. 2009
    ..With the practical advantages of once-daily oral dosing, dabigatran etexilate can be considered an attractive alternative to conventional thromboprophylaxis regimens in patients undergoing elective total hip and knee arthroplasty...
  39. doi A new surgical method to treat chronic ruptures and reruptures of the Achilles tendon
    Katarina Nilsson-Helander
    Department of Orthopaedics, Kungsbacka Hospital, Goteborg University, Gamla Göteborgsvägen, 434 40, Kungsbacka, Sweden
    Knee Surg Sports Traumatol Arthrosc 16:614-20. 2008
    ..The use of a single incision in combination with a free flap augmentation produced favourable results...
  40. doi Acute achilles tendon rupture: a randomized, controlled study comparing surgical and nonsurgical treatments using validated outcome measures
    Katarina Nilsson-Helander
    Katarina Nilsson Helander, Department of Orthopaedics, Kungsbacka Hospital, SE 434 40 Kungsbacka, Sweden
    Am J Sports Med 38:2186-93. 2010
    ..Few randomized controlled studies have compared outcomes after surgical or nonsurgical treatment with both groups receiving early mobilization...
  41. ncbi Efficacy of fondaparinux for thromboprophylaxis in hip fracture patients
    Bengt I Eriksson
    Sahlgrenska Univesrity Hospital Ostra, Goteborg, Sweden
    J Arthroplasty 19:78-81. 2004
    ..063). Risk of VTE was continued following short course fondaparinux in hip fracture patients, but was significantly reduced by extending prophylaxis, without significant risk of major bleeding...
  42. doi Will early reconstruction prevent abnormal kinematics after ACL injury? Two-year follow-up using dynamic radiostereometry in 14 patients operated with hamstring autografts
    Jonas Isberg
    Department of Orthopaedics, Sahlgrenska University Hospital Molndal, 413 80, Molndal, Sweden
    Knee Surg Sports Traumatol Arthrosc 19:1634-42. 2011
    ....
  43. doi A new measurement of heel-rise endurance with the ability to detect functional deficits in patients with Achilles tendon rupture
    Karin Gravare Silbernagel
    Department of Orthopaedics, Institute of Clinical Sciences at Sahlgrenska Academy, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden
    Knee Surg Sports Traumatol Arthrosc 18:258-64. 2010
    ....
  44. doi High incidence of deep venous thrombosis after Achilles tendon rupture: a prospective study
    Katarina Nilsson-Helander
    Department of Orthopaedics, Kungsbacka Hospital, Gamla Göteborgsvägen, Kungsbacka 434 40, Sweden
    Knee Surg Sports Traumatol Arthrosc 17:1234-8. 2009
    ..The incidence of asymptomatic and symptomatic deep venous thrombosis is high after Achilles tendon rupture and there is a need to define the possible benefit of thromboprophylaxis...
  45. ncbi Factor V Leiden (G1691A) and prothrombin gene G20210A mutations as potential risk factors for venous thromboembolism after total hip or total knee replacement surgery
    K Wahlander
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Thromb Haemost 87:580-5. 2002
    ..03 and p = 0.05, respectively). However, since 90% of the patients with these genetic risk factors will not suffer a VTE event, a general pre-operative genotyping is, in our opinion, of questionable value...
  46. pmc The Ilizarov external fixator--a useful alternative for the treatment of proximal tibial fractures. A prospective observational study of 30 consecutive patients
    Telmo Ramos
    Department of Orthopaedics, Central Hospital Kärnsjukhuset, Skövde SE 541 85, Sweden
    BMC Musculoskelet Disord 14:11. 2013
    ..Minimally-invasive techniques using external fixation are an alternative. The aim of this study was to analyse the clinical and radiological results using the Ilizarov technique in both uni- and bicondylar tibial fractures...
  47. ncbi Continued sports activity, using a pain-monitoring model, during rehabilitation in patients with Achilles tendinopathy: a randomized controlled study
    Karin Gravare Silbernagel
    Lundberg Laboratory of Orthopaedic Research, Department of Orthopaedics, Goteborg University, Sahlgrenska University Hospital, Gröna Stråket 12, 413 45 Goteborg, Sweden
    Am J Sports Med 35:897-906. 2007
    ..Achilles tendinopathy is a common overuse injury, especially among athletes involved in activities that include running and jumping. Often an initial period of rest from the pain-provoking activity is recommended...
  48. pmc The application of evidence-based measures to reduce surgical site infections during orthopedic surgery - report of a single-center experience in Sweden
    Annette Erichsen Andersson
    University of Gothenburg, The Sahlgrenska Academy, Institute of Health and Care Sciences, Gothenburg, Sweden
    Patient Saf Surg 6:11. 2012
    ..abstract:..
  49. ncbi Determinants of self-efficacy in the rehabilitation of patients with anterior cruciate ligament injury
    Pia Thomeé
    Lundberg Laboratory for Orthopaedic Research, Gröna Stråket 12, Sahlgrenska University Hospital, Goteborg, Sweden
    J Rehabil Med 39:486-92. 2007
    ..To explore physical and psychological measures believed to determine patients' perceived self-efficacy in the rehabilitation of patients with anterior cruciate ligament injury...
  50. pmc Full symptomatic recovery does not ensure full recovery of muscle-tendon function in patients with Achilles tendinopathy
    Karin Gravare Silbernagel
    Sportrehab Physical Therapy and Sports Medicine Clinic, Goteborg, Sweden
    Br J Sports Med 41:276-80; discussion 280. 2007
    ..To assess the relationship between muscle-tendon function and symptoms in patients with Achilles tendinopathy using a validated test battery...
  51. ncbi Self-efficacy, symptoms and physical activity in patients with an anterior cruciate ligament injury: a prospective study
    P Thomeé
    Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg, Sweden
    Scand J Med Sci Sports 17:238-45. 2007
    ..Furthermore, self-efficacy differed significantly with gender, age and physical activity level early in the rehabilitation process...
  52. ncbi Self-efficacy of knee function as a pre-operative predictor of outcome 1 year after anterior cruciate ligament reconstruction
    Pia Thomeé
    Department of Orthopaedics, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Knee Surg Sports Traumatol Arthrosc 16:118-27. 2008
    ....
  53. ncbi Is a knee brace advantageous after anterior cruciate ligament surgery? A prospective, randomised study with a two-year follow-up
    S Brandsson
    Department of Orthopaedics, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Scand J Med Sci Sports 11:110-4. 2001
    ..However, there were no differences in terms of function or knee laxity at the two-year follow-up...
  54. ncbi Subacute versus delayed reconstruction of the anterior cruciate ligament in the competitive athlete
    J Karlsson
    Department of Orthopaedics, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Knee Surg Sports Traumatol Arthrosc 7:146-51. 1999
    ..Furthermore, meniscal injuries were significantly more frequent if the reconstruction was delayed...
  55. ncbi Analysis of subjective, objective and functional examination tests after anterior cruciate ligament reconstruction. A follow-up of 527 patients
    N Sernert
    Department of Orthopaedics, Northern Alvsborg Uddevalla County Hospital, Trollhattan, Sweden
    Knee Surg Sports Traumatol Arthrosc 7:160-5. 1999
    ..We conclude that the IKDC evaluation system is a reliable and useful tool for evaluating the post-operative outcome after an ACL reconstruction...
  56. ncbi Complications following arthroscopic anterior cruciate ligament reconstruction. A 2-5-year follow-up of 604 patients with special emphasis on anterior knee pain
    J Kartus
    Department of Orthopaedics, Norra Alvsborgs County Hospital, Trollhattan, Sweden
    Knee Surg Sports Traumatol Arthrosc 7:2-8. 1999
    ..Anterior knee pain and problems with knee-walking were correlated with the loss of range of motion and anterior knee sensitivity...
  57. doi Detection of slow-cycling and stem/progenitor cells in different regions of rat Achilles tendon: response to treadmill exercise
    Eva Runesson
    Department of Orthopaedics, Institute of Clinical Sciences, University of Goteborg, Goteborg, Sweden
    Knee Surg Sports Traumatol Arthrosc 21:1694-703. 2013
    ..In the present study, we attempted to determine where in the rat Achilles tendon stem/progenitor cells reside and to investigate the effect of exercise on cell proliferation in the in vivo situation...
  58. ncbi The Achilles tendon Total Rupture Score (ATRS): development and validation
    Katarina Nilsson-Helander
    Lundberg Laboratory for Orthopaedic Research, Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg University, Sweden
    Am J Sports Med 35:421-6. 2007
    ..There is a need for a patient-relevant instrument to evaluate outcome after treatment in patients with a total Achilles tendon rupture...
  59. ncbi A new instrument for measuring self-efficacy in patients with an anterior cruciate ligament injury
    P Thomeé
    Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg, Sweden
    Scand J Med Sci Sports 16:181-7. 2006
    ..The K-SES is recommended for studies designed to evaluate prognostic and outcome expectations of perceived self-efficacy in patients with an ACL-insufficient knee...
  60. doi Traffic flow in the operating room: an explorative and descriptive study on air quality during orthopedic trauma implant surgery
    Annette Erichsen Andersson
    Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Am J Infect Control 40:750-5. 2012
    ....
  61. ncbi Magnetic resonance imaging of the patellar tendon after harvesting its central third: a comparison between traditional and subcutaneous harvesting techniques
    J Kartus
    Department of Orthopaedics, Norra Alvsborg Hospital, Trollhattan, Sweden
    Arthroscopy 15:587-93. 1999
    ..0001). At 2-year follow-up, the subcutaneous graft-harvesting technique resulted in less disturbance of anterior knee sensitivity and a smaller donor-site gap than the traditional technique...
  62. ncbi Kinematics after tear in the anterior cruciate ligament: dynamic bilateral radiostereometric studies in 11 patients
    S Brandsson
    Department of Orthopaedics, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Acta Orthop Scand 72:372-8. 2001
    ..Changes in the kinematics of the knee joint due to rupture of the anterior cruciate ligament can result in an abnormal joint load, which may increase the risk of damage to the cartilage and the menisci...
  63. pmc Treatment of distal tibial fractures with the Ilizarov external fixator--a prospective observational study in 39 consecutive patients
    Telmo Ramos
    Department of Orthopaedics, Central Hospital Kärnsjukhuset, SE 541 85, Skovde, Sweden
    BMC Musculoskelet Disord 14:30. 2013
    ..The aim of this prospective study was to analyze the clinical and radiographic outcome the Ilizarov technique in patients with distal metaphyseal tibial fractures, with or without intra-articular involvement...
  64. ncbi Early active extension after anterior cruciate ligament reconstruction does not result in increased laxity of the knee
    Jonas Isberg
    Department of Orthopaedics, Sahlgrenska University Hospital, 416 85 Goteborg, Sweden
    Knee Surg Sports Traumatol Arthrosc 14:1108-15. 2006
    ....
  65. ncbi Kinematics and laxity of the knee joint after anterior cruciate ligament reconstruction: pre- and postoperative radiostereometric studies
    Sveinbjörn Brandsson
    Department of Orthopaedics, Sahlgrenska University Hospital, SE 416 85 Goteborg, Sweden
    Am J Sports Med 30:361-7. 2002
    ..In studies of cadaveric knees, investigators have examined the effect of anterior cruciate ligament reconstruction on knee kinematics, but the effect on dynamic knee motion is not known...
  66. ncbi KT-1000 records smaller side-to-side differences than radiostereometric analysis before and after an ACL reconstruction
    Jonas Isberg
    Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg University, 41685, Goteborg, Sweden
    Knee Surg Sports Traumatol Arthrosc 14:529-35. 2006
    ....
  67. ncbi A prospective four- to seven-year follow-up after arthroscopic anterior cruciate ligament reconstruction
    S Brandsson
    Department of Orthopaedics, Sahlgrenska University Hospital/Ostra, , Sweden
    Scand J Med Sci Sports 11:23-7. 2001
    ....
  68. ncbi Intraarticular morphine after arthroscopic ACL reconstruction: a double-blind placebo-controlled study of 40 patients
    S Brandsson
    Department of Orthopedics, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Acta Orthop Scand 71:280-5. 2000
    ..The analgesic effect of intraarticular morphine together with the low levels of morphine and morphine-6-glucuronide in plasma further strengthens the view that opioids have a peripheral mechanism of action...
  69. ncbi Biodegradable and metallic interference screws in anterior cruciate ligament reconstruction surgery using hamstring tendon grafts: prospective randomized study of radiographic results and clinical outcome
    Gauti Laxdal
    Department of Orthopaedics, Sahlgrenska University Hospital Ostra, SE 416 85 Goteborg, Sweden
    Am J Sports Med 34:1574-80. 2006
    ..The use of biodegradable screws in anterior cruciate ligament reconstruction has grown in popularity...
  70. ncbi The localization of the infrapatellar nerves in the anterior knee region with special emphasis on central third patellar tendon harvest: a dissection study on cadaver and amputated specimens
    J Kartus
    Department of Orthopaedics, Norra Alvsborg Hospital, Trollhattan, Sweden
    Arthroscopy 15:577-86. 1999
    ....
  71. ncbi Postoperative fondaparinux versus preoperative enoxaparin for prevention of venous thromboembolism in elective hip-replacement surgery: a randomised double-blind comparison
    Michael Rud Lassen
    Department of Orthopaedics, University Hospital of Copenhagen Hillerød, DK 3400, Hillerød, Denmark
    Lancet 359:1715-20. 2002
    ..We aimed to assess the ability of the pentasaccharide fondaparinux, the first of a new class of synthetic antithrombotic agents, to further reduce this risk...
  72. ncbi Postoperative fondaparinux versus postoperative enoxaparin for prevention of venous thromboembolism after elective hip-replacement surgery: a randomised double-blind trial
    Alexander G G Turpie
    Department of Medicine, General Division, Hamilton Health Sciences Corporation, Ontario, Hamilton, Canada
    Lancet 359:1721-6. 2002
    ..We aimed to see whether the pentasaccharide fondaparinux, the first drug of a new class of synthetic antithrombotic agents, could reduce this risk to a greater extent than other available treatments...
  73. ncbi Factor Xa inhibition in the prevention of venous thromboembolism and treatment of patients with venous thromboembolism
    Kenneth A Bauer
    VA Boston Healthcare System and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Curr Opin Pulm Med 8:398-404. 2002
    ..Fondaparinux also appears to be a very promising candidate for the treatment of patients with existing VTE...
  74. ncbi Fondaparinux vs enoxaparin for the prevention of venous thromboembolism in major orthopedic surgery: a meta-analysis of 4 randomized double-blind studies
    Alexander G G Turpie
    Department of Medicine, Hamilton Health Sciences General Hospital, 237 Barton, Hamilton, Ontario, Canada L8L 2X2
    Arch Intern Med 162:1833-40. 2002
    ..Fondaparinux, the first of a new class of synthetic selective factor Xa inhibitors, may further reduce this risk compared with currently available thromboprophylactic treatments...
  75. ncbi Antihirudin antibodies following low-dose subcutaneous treatment with desirudin for thrombosis prophylaxis after hip-replacement surgery: incidence and clinical relevance
    Andreas Greinacher
    Institute for Immunology and Transfusion Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
    Blood 101:2617-9. 2003
    ..However, the total number of immunized patients observed was low and so infrequent (but severe) effects of antihirudin antibodies cannot be excluded...
  76. ncbi A meta-analysis of fondaparinux versus enoxaparin in the prevention of venous thromboembolism after major orthopaedic surgery
    Alexander G G Turpie
    Department of Medicine, Hamilton Health Sciences General Hospital, Hamilton, Ontario, Canada
    J South Orthop Assoc 11:182-8. 2002
    ..4%. The overall incidence of clinically relevant bleeding was low and did not differ between the two groups. The benefit of fondaparinux was consistent across all types of surgery and all subgroups...
  77. pmc Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: a population model analysis
    Karl Heinz Liesenfeld
    Boehringer Ingelheim Pharma GmbH and Co, KG, Ingelheim, Germany
    Br J Clin Pharmacol 62:527-37. 2006
    ....
  78. ncbi Rivaroxaban for thromboprophylaxis after orthopaedic surgery: pooled analysis of two studies
    William D Fisher
    McGill University Health Centre, 1650 Cedar Avenue, Montreal, Quebec, H3G 1A4, Canada
    Thromb Haemost 97:931-7. 2007
    ..Overall, rivaroxaban total daily doses of 5-20 mg had the most favorable balance of efficacy and safety, relative to enoxaparin, for the prevention of VTE after major orthopaedic surgery...
  79. ncbi Assessment of bleeding after concomitant administration of antiplatelet and anticoagulant agents in lower limb arthroplasty
    Ola E Dahl
    International Surgical Thrombosis Forum, Thrombosis Research Institute, London, UK
    Pathophysiol Haemost Thromb 35:428-34. 2006
    ..4-12 h) when compared with preoperative (12 h) administration of enoxaparin. Transfusion rates were significantly lower with administration of melagatran/ximelagatran compared with enoxaparin...
  80. pmc Anti-platelet factor 4/heparin antibodies in orthopedic surgery patients receiving antithrombotic prophylaxis with fondaparinux or enoxaparin
    Theodore E Warkentin
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Blood 106:3791-6. 2005
    ..We conclude that despite similar immunogenicity of fondaparinux and LMWH, PF4/fondaparinux, but not PF4/LMWH, is recognized poorly by the antibodies generated, suggesting that the risk of HIT with fondaparinux likely is very low...
  81. ncbi Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement
    Joachim Stangier
    Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse, Biberach an der Riss, D 88397, Germany
    J Clin Pharmacol 45:555-63. 2005
    ..These pharmacokinetic characteristics confirm the suitability of this oral solid dosage form for use in future clinical trials...
  82. ncbi Fondaparinux
    Alexander G G Turpie
    Department of Medicine, Hamilton Health Sciences Hamilton General Hospital and McMaster University, Hamilton, Ontario, Canada
    J Am Acad Orthop Surg 12:371-5. 2004
  83. ncbi Population pharmacokinetics and pharmacodynamics of rivaroxaban--an oral, direct factor Xa inhibitor--in patients undergoing major orthopaedic surgery
    Wolfgang Mueck
    Clinical Pharmacology, Bayer HealthCare AG, Aprather Weg 18a, Wuppertal, Germany
    Clin Pharmacokinet 47:203-16. 2008
    ....
  84. ncbi Superiority of fondaparinux over enoxaparin in preventing venous thromboembolism in major orthopedic surgery using different efficacy end points
    Alexander G G Turpie
    Department of Medicine, Hamilton Health Sciences General Hospital, 237 Barton St East, Hamilton, ON, L8L 2X2, Canada
    Chest 126:501-8. 2004
    ....
  85. ncbi Significantly lower need for blood transfusions associated with post-operatively initiated subcutaneous melagatran/oral ximelagatran compared with enoxaparin
    Bengt I Eriksson
    Thromb Haemost 92:428-30. 2004
  86. doi Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial
    Ajay K Kakkar
    Barts and the London School of Medicine and Dentistry, London, UK
    Lancet 372:31-9. 2008
    ..Our aim was to compare the use of rivaroxaban for extended thromboprophylaxis with short-term thromboprophylaxis with enoxaparin...
  87. doi Dabigatran etexilate
    Bengt I Eriksson
    Nat Rev Drug Discov 7:557-8. 2008
  88. ncbi New pentasaccharides for the prophylaxis of venous thromboembolism: clinical studies
    Alexander G G Turpie
    Department of Medicine, Hamilton Health Sciences General Hospital, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada
    Chest 124:371S-378S. 2003
    ..Fondaparinux has been recently approved for use in thromboprophylaxis after major orthopedic surgery. The clinical development of fondaparinux in other thromboprophylactic indications is ongoing...
  89. ncbi Fondaparinux and prevention of venous thromboembolism after orthopaedic surgery
    Alexander G G Turpie
    Lancet 362:1582-3. 2003
  90. ncbi Fondaparinux, the first selective factor Xa inhibitor
    Alexander G G Turpie
    Hamilton Health Sciences General Hospital, Hamilton, Ontario, Canada
    Curr Opin Hematol 10:327-32. 2003
    ..Finally, the efficacy and safety of fondaparinux in the treatment of venous thromboembolism and acute coronary syndromes appears promising...
  91. ncbi A new antithrombotic strategy, the selective inhibition of coagulation factors, and its importance to the orthopedic specialist
    Kenneth A Bauer
    Department of Medicine, VA Boston Healthcare System and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J South Orthop Assoc 11:197-202. 2002
    ..Fondaparinux has demonstrated its efficacy compared to a widely used low-molecular-weight heparin in a number of thromboprophylaxis trials after major orthopedic surgery and is approved for use in this setting...
  92. ncbi Population pharmacokinetics and pharmacodynamics of once- and twice-daily rivaroxaban for the prevention of venous thromboembolism in patients undergoing total hip replacement
    Wolfgang Mueck
    Bayer HealthCare AG, Aprather Weg 18a, Wuppertal, Germany
    Thromb Haemost 100:453-61. 2008
    ....