Affiliation: Sahlgrenska University Hospital
- Endogenous Acute Phase Serum Amyloid A Lacks Pro-Inflammatory Activity, Contrasting the Two Recombinant Variants That Activate Human Neutrophils through Different ReceptorsKarin Christenson
The Phagocyte Research Laboratory, Department of Rheumatology and Inflammation Research, EULAR Centre of Excellence in Rheumatology, Sahlgrenska Academy, University of Gothenburg Gothenburg, Sweden
Front Immunol 4:92. 2013..We conclude that even though recombinant SAAs can be valuable tools for studying neutrophil activation, they do not reflect the nature of the endogenous protein...
- Serum amyloid A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl peptide receptor like-1Lena Björkman
Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
J Leukoc Biol 83:245-53. 2008..Future identification and characterization of the SAA receptor could lead to development of novel, therapeutic targets for treatment of RA...
- The proinflammatory activity of recombinant serum amyloid A is not shared by the endogenous protein in the circulationLena Björkman
Sahlgrenska Academy, University of Gothenburg, Department of Rheumatology and Inflammation Research, Gothenburg, Sweden
Arthritis Rheum 62:1660-5. 2010..The present study was undertaken to investigate whether SAA in the plasma of patients with RA possesses proinflammatory properties and activates neutrophils in a manner similar to that of the recombinant protein...
- The two neutrophil members of the formylpeptide receptor family activate the NADPH-oxidase through signals that differ in sensitivity to a gelsolin derived phosphoinositide-binding peptideHuamei Fu
Department of Rheumatology and Inflammation Research, University of Goteborg, Sweden
BMC Cell Biol 5:50. 2004....
- Changes in the ratio between FPR and FPRL1 triggered superoxide production in human neutrophils-a tool in analysing receptor specific eventsHuamei Fu
Department of Rheumatology and Inflammation Research, University of Goteborg, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
J Immunol Methods 331:50-8. 2008....
- The human neutrophil subsets defined by the presence or absence of OLFM4 both transmigrate into tissue in vivo and give rise to distinct NETs in vitroAmanda Welin
The Phagocyte Research Group, Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden
PLoS ONE 8:e69575. 2013..Furthermore, we demonstrate NETs characterized by different markers for the first time, and our results open up for functions of OLFM4 itself in the extracellular space through exposure in NETs. ..
- A methodological approach to studies of desensitization of the formyl peptide receptor: Role of the read out system, reactive oxygen species and the specific agonist used to trigger neutrophilsJennie Karlsson
Department of Rheumatology and Inflammation Research, University of Gothenburg, Guldhedsgatan 10, 413 46 Goteborg, Sweden
J Immunol Methods 352:45-53. 2010....
- Serum amyloid A inhibits apoptosis of human neutrophils via a P2X7-sensitive pathway independent of formyl peptide receptor-like 1Karin Christenson
Department of Rheumatology and Inflammation Research, Goteborg University, Guldhedsgatan 10, 413 46 Goteborg, Sweden
J Leukoc Biol 83:139-48. 2008....
- Regulation of neutrophil apoptosis differs after in vivo transmigration to skin chambers and synovial fluid: a role for inflammasome-dependent interleukin-1β releaseKarin Christenson
The Phagocyte Research Laboratory, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
J Innate Immun 5:377-88. 2013....
- Collection of in vivo transmigrated neutrophils from human skinKarin Christenson
Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden
Methods Mol Biol 1124:39-52. 2014..Although slightly more artificial as compared to analysis of the blister content directly, the cellular yield of this skin chamber method is sufficient to perform a large number of functional analyses of in vivo transmigrated cells...
- A simple skin blister technique for the study of in vivo transmigration of human leukocytesLisa Davidsson
The Phagocyte Research Group, Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at the University of Gothenburg, Sweden
J Immunol Methods 393:8-17. 2013....
- Human synovial lubricin expresses sialyl Lewis x determinant and has L-selectin ligand activityChunsheng Jin
Department of Medical Biochemistry, Institute of Biomedicine, University of Gothenburg, 405 30 Gothenburg, Sweden
J Biol Chem 287:35922-33. 2012..These observations suggest that lubricin is able to bind to PMN via an L-selectin-dependent and -independent manner and may play a role in PMN-mediated inflammation...