P Bjorntorp

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. ncbi request reprint Do stress reactions cause abdominal obesity and comorbidities?
    P Bjorntorp
    Department of Heart and Lung Diseases, Sahlgren s Hospital, University of Goteborg, Sweden
    Obes Rev 2:73-86. 2001
  2. ncbi request reprint ["Consolatory eating" is not a myth. Stress-induced increased cortisol levels result in leptin-resistant obesity]
    P Bjorntorp
    Hjärt lunginstitutionen, Sahlgrenska Universitetssjukhuset, Goteborg
    Lakartidningen 98:5458-61. 2001
  3. ncbi request reprint Hypothalamic arousal, insulin resistance and Type 2 diabetes mellitus
    P Bjorntorp
    Department of Heart and Lung Diseases, University of Gothenburg, Sahlgren s Hospital, Sweden
    Diabet Med 16:373-83. 1999
  4. ncbi request reprint The metabolic syndrome--a neuroendocrine disorder?
    P Bjorntorp
    Department of Heart and Lung Diseases, University of Goteborg, Sahlgren s Hospital, Sweden
    Br J Nutr 83:S49-57. 2000
  5. ncbi request reprint Obesity and cortisol
    P Bjorntorp
    Department of Heart and Lung Diseases, Sahlgren s Hospital, University of Goteborg, Goteborg, Sweden
    Nutrition 16:924-36. 2000
  6. ncbi request reprint A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamic-pituitary-adrenal axis
    R Rosmond
    Department of Heart and Lung Diseases, Goteborg University, Sweden
    Obes Res 8:211-8. 2000
  7. ncbi request reprint Allelic variants in the GABA(A)alpha6 receptor subunit gene (GABRA6) is associated with abdominal obesity and cortisol secretion
    R Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, Goteborg, Sweden
    Int J Obes Relat Metab Disord 26:938-41. 2002
  8. ncbi request reprint Maternal endotoxemia results in obesity and insulin resistance in adult male offspring
    C Nilsson
    Department of Heart and Lung Diseases, Goteborg University, Sweden
    Endocrinology 142:2622-30. 2001
  9. ncbi request reprint Hypertension in obesity and the leptin receptor gene locus
    R Rosmond
    Department of Heart and Lung Diseases, Sahlgrenska University Hospital, Goteborg, Sweden
    J Clin Endocrinol Metab 85:3126-31. 2000
  10. ncbi request reprint Polymorphisms of the beta2-adrenergic receptor gene (ADRB2) in relation to cardiovascular risk factors in men
    R Rosmond
    Department of Heart and Lung Diseases, Goteborg University, Goteborg, Sweden
    J Intern Med 248:239-44. 2000

Detail Information

Publications28

  1. ncbi request reprint Do stress reactions cause abdominal obesity and comorbidities?
    P Bjorntorp
    Department of Heart and Lung Diseases, Sahlgren s Hospital, University of Goteborg, Sweden
    Obes Rev 2:73-86. 2001
    ..Based on this evidence it is suggested that environmental, perinatal and genetic factors induce neuroendocrine perturbations followed by abdominal obesity with its associated comorbidities...
  2. ncbi request reprint ["Consolatory eating" is not a myth. Stress-induced increased cortisol levels result in leptin-resistant obesity]
    P Bjorntorp
    Hjärt lunginstitutionen, Sahlgrenska Universitetssjukhuset, Goteborg
    Lakartidningen 98:5458-61. 2001
    ..This is a condition which carries a great risk for cardiovascular disease, type 2 diabetes mellitus and stroke...
  3. ncbi request reprint Hypothalamic arousal, insulin resistance and Type 2 diabetes mellitus
    P Bjorntorp
    Department of Heart and Lung Diseases, University of Gothenburg, Sahlgren s Hospital, Sweden
    Diabet Med 16:373-83. 1999
    ..Insulin resistance may be induced via psychoneuroendocrine pathways, a possibility which has received little previous attention...
  4. ncbi request reprint The metabolic syndrome--a neuroendocrine disorder?
    P Bjorntorp
    Department of Heart and Lung Diseases, University of Goteborg, Sahlgren s Hospital, Sweden
    Br J Nutr 83:S49-57. 2000
    ..These results suggest a complex neuroendocrine background to the metabolic syndrome, where the kinetics of the regulation of the HPA axis play a central role...
  5. ncbi request reprint Obesity and cortisol
    P Bjorntorp
    Department of Heart and Lung Diseases, Sahlgren s Hospital, University of Goteborg, Goteborg, Sweden
    Nutrition 16:924-36. 2000
    ..The mechanism involved is not known, but available information suggests that programming of the hypothalamic-pituitary-adrenal axis may be responsible...
  6. ncbi request reprint A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamic-pituitary-adrenal axis
    R Rosmond
    Department of Heart and Lung Diseases, Goteborg University, Sweden
    Obes Res 8:211-8. 2000
    ....
  7. ncbi request reprint Allelic variants in the GABA(A)alpha6 receptor subunit gene (GABRA6) is associated with abdominal obesity and cortisol secretion
    R Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, Goteborg, Sweden
    Int J Obes Relat Metab Disord 26:938-41. 2002
    ..At the level of the brain, cortisol secretion is partly controlled by gamma-aminobutyric acid (GABA), which is the major inhibitory neurotransmitter in the vertebrate brain, and acts by binding to GABA(A) receptors...
  8. ncbi request reprint Maternal endotoxemia results in obesity and insulin resistance in adult male offspring
    C Nilsson
    Department of Heart and Lung Diseases, Goteborg University, Sweden
    Endocrinology 142:2622-30. 2001
    ..The results indicate that maternal endotoxemia leads to obesity, insulin resistance, and high serum levels of leptin in the adult male offspring. This study reports a novel animal model of obesity with features of the metabolic syndrome...
  9. ncbi request reprint Hypertension in obesity and the leptin receptor gene locus
    R Rosmond
    Department of Heart and Lung Diseases, Sahlgrenska University Hospital, Goteborg, Sweden
    J Clin Endocrinol Metab 85:3126-31. 2000
    ..This might explain why not all obese men are hypertensive...
  10. ncbi request reprint Polymorphisms of the beta2-adrenergic receptor gene (ADRB2) in relation to cardiovascular risk factors in men
    R Rosmond
    Department of Heart and Lung Diseases, Goteborg University, Goteborg, Sweden
    J Intern Med 248:239-44. 2000
    ..To investigate the effect of polymorphisms in codon 16 (Arg16Gly) and codon 27 (Gln27Glu) of the beta2-adrenergic receptor gene (ADRB2) on anthropometric, endocrine, metabolic and haemodynamic variables...
  11. ncbi request reprint Rise in morning saliva cortisol is associated with abdominal obesity in men: a preliminary report
    S Wallerius
    Department of Heart and Lung Diseases, University of Goteborg, Goteborg, Sweden
    J Endocrinol Invest 26:616-9. 2003
    ..The rise of cortisol immediately after awakening might be an indicator of an increased risk of developing serious, prevalent diseases via the metabolic syndrome...
  12. ncbi request reprint A polymorphism in the regulatory region of the corticotropin-releasing hormone gene in relation to cortisol secretion, obesity, and gene-gene interaction
    R Rosmond
    Department of Heart and Lung Diseases, Goteborg University, Goteborg, Sweden
    Metabolism 50:1059-62. 2001
    ..From these results, we conclude that an abnormal production rate of the CRH gene product in the presence of an inadequate glucocorticoid receptor density might lead to elevated cortisol levels...
  13. ncbi request reprint A 5-year follow-up study of disease incidence in men with an abnormal hormone pattern
    R Rosmond
    Cardiovascular Institute, Sahlgrenska University Hospital, Goteborg, Sweden
    J Intern Med 254:386-90. 2003
    ..Previous studies have suggested that abnormal levels of cortisol and testosterone might increase the risk of serious somatic diseases. To test this hypothesis, we conducted a 5-year follow-up study in middle-aged men...
  14. ncbi request reprint A missense mutation in the human melanocortin-4 receptor gene in relation to abdominal obesity and salivary cortisol
    R Rosmond
    Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Diabetologia 44:1335-8. 2001
    ....
  15. ncbi request reprint Treatment of abdominally obese men with a serotonin reuptake inhibitor: a pilot study
    T Ljung
    Department of Heart and Lung Diseases, Sahlgrenska University Hospital, Goteborg, Sweden
    J Intern Med 250:219-24. 2001
    ..To investigate the effects of a selective serotonin reuptake inhibitor (SSRI) on the neuroendocrine and autonomic nervous system perturbations found in abdominal obesity...
  16. ncbi request reprint Phenotypic and genotypic characteristics of women in relation to personality traits
    F Baghaei
    Department of Heart and Lung Diseases, Sahlgren s Hospital University of Göteborg, Sweden
    Int J Behav Med 10:365-78. 2003
    ..It was concluded that a majority of women showed M type of personality traits, associated with normal hormones, somatic health, and a long microsatellite in the transactivating domain of the AR gene...
  17. ncbi request reprint Occupational status, cortisol secretory pattern, and visceral obesity in middle-aged men
    R Rosmond
    Department of Heart and Lung Diseases, University of Goteborg, Sahlgrenska University Hospital, Sweden
    Obes Res 8:445-50. 2000
    ..Despite several studies indicating that social gradients are predictive of cardiovascular mortality, the pathogenetic mechanisms remain incompletely understood...
  18. ncbi request reprint Central and peripheral glucocorticoid receptor function in abdominal obesity
    T Ljung
    Department of Heart and Lung Diseases, Sahlgrenska Hospital, University of Goteborg, Sweden
    J Endocrinol Invest 25:229-35. 2002
    ..There was no evidence for expansion of trinucleotide repeats. These results suggest that the central GR and the peripheral GR in adipose tissue exhibit functional differences in abdominal obesity...
  19. ncbi request reprint Neuroendocrine abnormalities in visceral obesity
    P Bjorntorp
    Department of Heart and Lung Diseases, Sahlgren s Hospital, University of Goteborg, Sweden
    Int J Obes Relat Metab Disord 24:S80-5. 2000
    ..The gene for this receptor has shown polymorphisms which are associated with poorly regulated cortisol secretion, central obesity, insulin resistance and hypertension...
  20. ncbi request reprint Quality of life, overweight, and body fat distribution in middle-aged men
    R Rosmond
    Department of Heart and Lung Diseases, University of Goteborg, Sahlgrenska University Hospital, Goteborg, Sweden
    Behav Med 26:90-4. 2000
    ..Impaired quality of life may be causally related to the development of abdominal obesity; the mechanism involved might be increased cortisol secretion, which can redistribute body fat to central adipose tissue depots...
  21. ncbi request reprint G-308A polymorphism of the tumor necrosis factor alpha gene promoter and salivary cortisol secretion
    R Rosmond
    Department of Heart and Lung Diseases, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    J Clin Endocrinol Metab 86:2178-80. 2001
    ..However, to what extent this polymorphism is associated with these conditions is uncertain from the present data...
  22. ncbi request reprint Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure
    G Johannsson
    Research Center for Endocrinology and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    J Clin Endocrinol Metab 82:727-34. 1997
    ..This includes a reduction in abdominal/visceral obesity, an improved insulin sensitivity, and favorable effects on lipoprotein metabolism and diastolic blood pressure...
  23. ncbi request reprint A C-1291G polymorphism in the alpha2A-adrenergic receptor gene (ADRA2A) promoter is associated with cortisol escape from dexamethasone and elevated glucose levels
    R Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, Goteborg, Sweden
    J Intern Med 251:252-7. 2002
    ....
  24. ncbi request reprint Prenatal cytokine exposure results in obesity and gender-specific programming
    J Dahlgren
    Goteborg Pediatric Growth Research Center, Institute for the Health of Women and Children, University of Goteborg, S 416 85 Goteborg, Sweden
    Am J Physiol Endocrinol Metab 281:E326-34. 2001
    ..The results suggest that prenatal exposure to cytokines or Dxm can induce gender-specific programming of neuroendocrine regulation with consequences in adult life...
  25. ncbi request reprint Anthropometric variables and metabolism in polycystic ovarian disease
    M Rebuffe-Scrive
    Department of Medicine I, University of Goteborg, Sweden
    Horm Metab Res 21:391-7. 1989
    ..It is suggested that the relative paucity of femoral adipose tissue is due to a lack of specific effects of progesterone on adipocytes in this region...
  26. ncbi request reprint Polymorphism in exon 6 of the dopamine D(2) receptor gene (DRD2) is associated with elevated blood pressure and personality disorders in men
    R Rosmond
    Department of Heart and Lung Diseases, Sahlgrenska University Hospital, Goteborg University, S 413 45 Goteborg, Sweden
    J Hum Hypertens 15:553-8. 2001
    ..Paranoid or schizoid personality disorders is also associated with a polymorphism of the DRD2, which might be associated with a previously demonstrated low density of this receptor...
  27. ncbi request reprint Testosterone increases lipolysis and the number of beta-adrenoceptors in male rat adipocytes
    X F Xu
    Wallenberg Laboratory, Sahlgren s Hospital, University of Goteborg, Sweden
    Endocrinology 128:379-82. 1991
    ....
  28. ncbi request reprint Serotonin transporter gene polymorphisms are associated with anxiety-related personality traits in women
    J Melke
    Department of Pharmacology, Goteborg University, Goteborg, Sweden
    Am J Med Genet 105:458-63. 2001
    ..In addition, an association was found between the intron 2 polymorphism and one anxiety-related personality trait (somatic anxiety)...