Research Topics
Genomes and Genes | P BjorntorpSummaryAffiliation: Sahlgrenska University Hospital Country: Sweden Publications
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Detail Information
Publications
Do stress reactions cause abdominal obesity and comorbidities?P Bjorntorp
Department of Heart and Lung Diseases, Sahlgren s Hospital, University of Goteborg, Sweden
Obes Rev 2:73-86. 2001..Based on this evidence it is suggested that environmental, perinatal and genetic factors induce neuroendocrine perturbations followed by abdominal obesity with its associated comorbidities...- Hypothalamic arousal, insulin resistance and Type 2 diabetes mellitusP Bjorntorp
Department of Heart and Lung Diseases, University of Gothenburg, Sahlgren s Hospital, Sweden
Diabet Med 16:373-83. 1999..Insulin resistance may be induced via psychoneuroendocrine pathways, a possibility which has received little previous attention... - The metabolic syndrome--a neuroendocrine disorder?P Bjorntorp
Department of Heart and Lung Diseases, University of Goteborg, Sahlgren s Hospital, Sweden
Br J Nutr 83:S49-57. 2000..These results suggest a complex neuroendocrine background to the metabolic syndrome, where the kinetics of the regulation of the HPA axis play a central role... - Obesity and cortisolP Bjorntorp
Department of Heart and Lung Diseases, Sahlgren s Hospital, University of Goteborg, Goteborg, Sweden
Nutrition 16:924-36. 2000..The mechanism involved is not known, but available information suggests that programming of the hypothalamic-pituitary-adrenal axis may be responsible... - ["Consolatory eating" is not a myth. Stress-induced increased cortisol levels result in leptin-resistant obesity]P Bjorntorp
Hjärt lunginstitutionen, Sahlgrenska Universitetssjukhuset, Goteborg
Lakartidningen 98:5458-61. 2001..This is a condition which carries a great risk for cardiovascular disease, type 2 diabetes mellitus and stroke... - A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamic-pituitary-adrenal axisR Rosmond
Department of Heart and Lung Diseases, Goteborg University, Sweden
Obes Res 8:211-8. 2000.... - Maternal endotoxemia results in obesity and insulin resistance in adult male offspringC Nilsson
Department of Heart and Lung Diseases, Goteborg University, Sweden
Endocrinology 142:2622-30. 2001..The results indicate that maternal endotoxemia leads to obesity, insulin resistance, and high serum levels of leptin in the adult male offspring. This study reports a novel animal model of obesity with features of the metabolic syndrome... - Allelic variants in the GABA(A)alpha6 receptor subunit gene (GABRA6) is associated with abdominal obesity and cortisol secretionR Rosmond
Department of Clinical Chemistry, Sahlgrenska University Hospital, Goteborg, Sweden
Int J Obes Relat Metab Disord 26:938-41. 2002..At the level of the brain, cortisol secretion is partly controlled by gamma-aminobutyric acid (GABA), which is the major inhibitory neurotransmitter in the vertebrate brain, and acts by binding to GABA(A) receptors... - Hypertension in obesity and the leptin receptor gene locusR Rosmond
Department of Heart and Lung Diseases, Sahlgrenska University Hospital, Goteborg, Sweden
J Clin Endocrinol Metab 85:3126-31. 2000..This might explain why not all obese men are hypertensive... - Polymorphisms of the beta2-adrenergic receptor gene (ADRB2) in relation to cardiovascular risk factors in menR Rosmond
Department of Heart and Lung Diseases, Goteborg University, Goteborg, Sweden
J Intern Med 248:239-44. 2000..To investigate the effect of polymorphisms in codon 16 (Arg16Gly) and codon 27 (Gln27Glu) of the beta2-adrenergic receptor gene (ADRB2) on anthropometric, endocrine, metabolic and haemodynamic variables... - A polymorphism in the regulatory region of the corticotropin-releasing hormone gene in relation to cortisol secretion, obesity, and gene-gene interactionR Rosmond
Department of Heart and Lung Diseases, Goteborg University, Goteborg, Sweden
Metabolism 50:1059-62. 2001..From these results, we conclude that an abnormal production rate of the CRH gene product in the presence of an inadequate glucocorticoid receptor density might lead to elevated cortisol levels... - A missense mutation in the human melanocortin-4 receptor gene in relation to abdominal obesity and salivary cortisolR Rosmond
Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
Diabetologia 44:1335-8. 2001.... - Treatment of abdominally obese men with a serotonin reuptake inhibitor: a pilot studyT Ljung
Department of Heart and Lung Diseases, Sahlgrenska University Hospital, Goteborg, Sweden
J Intern Med 250:219-24. 2001..To investigate the effects of a selective serotonin reuptake inhibitor (SSRI) on the neuroendocrine and autonomic nervous system perturbations found in abdominal obesity... - Phenotypic and genotypic characteristics of women in relation to personality traitsF Baghaei
Department of Heart and Lung Diseases, Sahlgren s Hospital University of Göteborg, Sweden
Int J Behav Med 10:365-78. 2003..It was concluded that a majority of women showed M type of personality traits, associated with normal hormones, somatic health, and a long microsatellite in the transactivating domain of the AR gene... - Occupational status, cortisol secretory pattern, and visceral obesity in middle-aged menR Rosmond
Department of Heart and Lung Diseases, University of Goteborg, Sahlgrenska University Hospital, Sweden
Obes Res 8:445-50. 2000..Despite several studies indicating that social gradients are predictive of cardiovascular mortality, the pathogenetic mechanisms remain incompletely understood... - Central and peripheral glucocorticoid receptor function in abdominal obesityT Ljung
Department of Heart and Lung Diseases, Sahlgrenska Hospital, University of Goteborg, Sweden
J Endocrinol Invest 25:229-35. 2002..There was no evidence for expansion of trinucleotide repeats. These results suggest that the central GR and the peripheral GR in adipose tissue exhibit functional differences in abdominal obesity... - Neuroendocrine abnormalities in visceral obesityP Bjorntorp
Department of Heart and Lung Diseases, Sahlgren s Hospital, University of Goteborg, Sweden
Int J Obes Relat Metab Disord 24:S80-5. 2000..The gene for this receptor has shown polymorphisms which are associated with poorly regulated cortisol secretion, central obesity, insulin resistance and hypertension... - Quality of life, overweight, and body fat distribution in middle-aged menR Rosmond
Department of Heart and Lung Diseases, University of Goteborg, Sahlgrenska University Hospital, Goteborg, Sweden
Behav Med 26:90-4. 2000..Impaired quality of life may be causally related to the development of abdominal obesity; the mechanism involved might be increased cortisol secretion, which can redistribute body fat to central adipose tissue depots... - Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressureG Johannsson
Research Center for Endocrinology and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
J Clin Endocrinol Metab 82:727-34. 1997..This includes a reduction in abdominal/visceral obesity, an improved insulin sensitivity, and favorable effects on lipoprotein metabolism and diastolic blood pressure... - G-308A polymorphism of the tumor necrosis factor alpha gene promoter and salivary cortisol secretionR Rosmond
Department of Heart and Lung Diseases, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
J Clin Endocrinol Metab 86:2178-80. 2001..However, to what extent this polymorphism is associated with these conditions is uncertain from the present data... - A C-1291G polymorphism in the alpha2A-adrenergic receptor gene (ADRA2A) promoter is associated with cortisol escape from dexamethasone and elevated glucose levelsR Rosmond
Department of Clinical Chemistry, Sahlgrenska University Hospital, Goteborg, Sweden
J Intern Med 251:252-7. 2002.... - Prenatal cytokine exposure results in obesity and gender-specific programmingJ Dahlgren
Goteborg Pediatric Growth Research Center, Institute for the Health of Women and Children, University of Goteborg, S 416 85 Goteborg, Sweden
Am J Physiol Endocrinol Metab 281:E326-34. 2001..The results suggest that prenatal exposure to cytokines or Dxm can induce gender-specific programming of neuroendocrine regulation with consequences in adult life... - Anthropometric variables and metabolism in polycystic ovarian diseaseM Rebuffe-Scrive
Department of Medicine I, University of Goteborg, Sweden
Horm Metab Res 21:391-7. 1989..It is suggested that the relative paucity of femoral adipose tissue is due to a lack of specific effects of progesterone on adipocytes in this region... - Polymorphism in exon 6 of the dopamine D(2) receptor gene (DRD2) is associated with elevated blood pressure and personality disorders in menR Rosmond
Department of Heart and Lung Diseases, Sahlgrenska University Hospital, Goteborg University, S 413 45 Goteborg, Sweden
J Hum Hypertens 15:553-8. 2001..Paranoid or schizoid personality disorders is also associated with a polymorphism of the DRD2, which might be associated with a previously demonstrated low density of this receptor... - Testosterone increases lipolysis and the number of beta-adrenoceptors in male rat adipocytesX F Xu
Wallenberg Laboratory, Sahlgren s Hospital, University of Goteborg, Sweden
Endocrinology 128:379-82. 1991.... - Serotonin transporter gene polymorphisms are associated with anxiety-related personality traits in womenJ Melke
Department of Pharmacology, Goteborg University, Goteborg, Sweden
Am J Med Genet 105:458-63. 2001..In addition, an association was found between the intron 2 polymorphism and one anxiety-related personality trait (somatic anxiety)...