Research Topics
Species | Einar BjornssonSummaryAffiliation: Sahlgrenska University Hospital Country: Sweden Publications
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Detail Information
Publications
Gastrointestinal symptoms in patients with liver cirrhosis: associations with nutritional status and health-related quality of lifeEvangelos Kalaitzakis
Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Scand J Gastroenterol 41:1464-72. 2006..Our aim was to prospectively evaluate gastrointestinal symptoms, malnutrition, and QoL in patients with cirrhosis...
Fatigue measurements in patients with primary biliary cirrhosis and the risk of mortality during follow-upEinar Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Liver Int 30:251-8. 2010..Fatigue was recently suggested to predict an increased risk of mortality in a primary biliary cirrhosis (PBC) cohort during follow-up...
[Acute liver failure--rapid multidisciplinary management]Einar Bjornsson
Medicinkliniken, Gastrosektionen, Sahlgrenska Universitetssjukhuset, Goteborg
Lakartidningen 104:210-3. 2007
Immunoglobulin G4 associated cholangitis: description of an emerging clinical entity based on review of the literatureEinar Bjornsson
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
Hepatology 45:1547-54. 2007
The impact of eosinophilia and hepatic necrosis on prognosis in patients with drug-induced liver injuryE Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Aliment Pharmacol Ther 25:1411-21. 2007..Drug-induced liver injury may be immunologically mediated or metabolically induced. Peripheral eosinophilia and liver eosinophilia in suspected drug-induced liver injury generally supports the role of drug aetiology...
Long-term follow-up of patients with mild to moderate drug-induced liver injuryE Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Aliment Pharmacol Ther 26:79-85. 2007..To evaluate the long-term prognosis of patients diagnosed with drug-induced liver injury, and the nature of the liver injury...
Non-alcoholic fatty liver diseaseEinar Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Scand J Gastroenterol 42:1023-30. 2007
The clinical aspects of non-alcoholic fatty liver diseaseE Bjornsson
Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Minerva Gastroenterol Dietol 54:7-18. 2008..Some pharmacological pilot trials have been undertaken in NAFLD, but no proved treatment for all patients with NAFLD and/or NASH is available at the current time...
Hepatotoxicity associated with antiepileptic drugsE Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Acta Neurol Scand 118:281-90. 2008..Early referral of patients with severe liver reactions and coagulopathy to liver transplant centers before encephalopathy can be the difference between liver transplantation and death...
The natural history of small-duct primary sclerosing cholangitisEinar Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Gastroenterology 134:975-80. 2008..We aimed at determining the natural history and long-term outcomes of a large number of patients with small-duct PSC...
Immunoglobulin G4-associated cholangitisEinar Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Curr Opin Gastroenterol 24:389-94. 2008..This review is focused mainly on the most recent studies published during the last 2 years that have increased our understanding of this clinical entity...
Fate of patients with obstructive jaundiceEinar Bjornsson
Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
J Hosp Med 3:117-23. 2008..Systematic data are limited on the etiology and prognosis of unselected patients with obstructive jaundice (OJ). We aimed to review the clinical features, etiology, and prognosis of patients with OJ...
The long-term follow-up after idiosyncratic drug-induced liver injury with jaundiceEinar Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
J Hepatol 50:511-7. 2009..Chronic evolution after drug-induced liver injury (DILI) has been reported. How often this leads to liver-related morbidity and mortality is unexplored...
Small-duct primary sclerosing cholangitisEinar Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Med Pol II, SE 413 45 Gothenburg, Sweden
Curr Gastroenterol Rep 11:37-41. 2009..Recurrence of small-duct PSC after liver transplantation has been reported. Cholangiocarcinoma, the most feared complication of PSC, has not been described in a patient with small-duct PSC without progression first to large-duct PSC...
Management of primary sclerosing cholangitisE Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Minerva Gastroenterol Dietol 55:163-72. 2009..No curative therapy for PSC is available at the current time except liver transplantation. The etiopathogenesis of PSC is unknown but the underlying pathophysiology of PSC is beyond the scope of this paper...
Health-related quality of life in patients with different stages of liver disease induced by hepatitis CEinar Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Scand J Gastroenterol 44:878-87. 2009..The aim of this study was to determine HRQoL in patients in different stages of hepatitis C virus (HCV) and to compare HRQoL in HCV cirrhosis with non-HCV-induced cirrhosis...
The natural history of drug-induced liver injuryEinar Bjornsson
Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Semin Liver Dis 29:357-63. 2009..Recent studies have shown that DILI can infrequently evolve into chronic liver injury including cirrhosis and even liver-related morbidity and mortality in a minority of patients...
Discontinuation of proton pump inhibitors in patients on long-term therapy: a double-blind, placebo-controlled trialE Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Aliment Pharmacol Ther 24:945-54. 2006..The proportion of proton pump inhibitor users on long-term therapy who can discontinue proton pump inhibitor (PPI) medication without developing symptoms is unknown...
Clinical characteristics and prognostic markers in disulfiram-induced liver injuryEinar Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
J Hepatol 44:791-7. 2006..Limited systematic data exists on the incidence of drug-induced hepatotoxicity due to disulfiram and the most important prognostic markers. We aimed to determine the nature and frequency of suspected disulfiram hepatotoxicity in Sweden...
Long-term follow-up of patients with alcoholic liver disease after liver transplantation in Sweden: impact of structured management on recidivismEinar Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, SE 413 45 Gothenburg, Sweden
Scand J Gastroenterol 40:206-16. 2005..Data are limited on the impact of structured management of the alcohol problem on the risk of recidivism following transplantation in ALD...
Fatigue is not a specific symptom in patients with primary biliary cirrhosisEinar Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg Sweden
Eur J Gastroenterol Hepatol 17:351-7. 2005..Limited data exist on comparison with fatigue in the general population and comparison with patients with other chronic gastrointestinal disorders are lacking...
[Interpretation of liver tests is decisive for the choice of examination in hepatocellular jaundice]Einar Bjornsson
Medicinkliniken, Gastrosektionen, Sahlgrenska Universitetssjukhuset, Goteborg
Lakartidningen 102:2154-7. 2005..It is concluded that specialized units should investigate patients with jaundice and a medical gastroenterologist should be contacted early in the hospitalization of these patients...
Fulminant drug-induced hepatic failure leading to death or liver transplantation in SwedenEinar Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Scand J Gastroenterol 40:1095-101. 2005..The aim of this study was to determine the nature and number of suspected adverse drug-induced liver disease associated with fatalities and/or liver transplantation since reporting of adverse drug reactions (ADRs) started in Sweden...
Intestinal permeability and bacterial growth of the small bowel in patients with primary sclerosing cholangitisEinar Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Scand J Gastroenterol 40:1090-4. 2005..Small-bowel intestinal permeability was assessed as the differential urinary excretion of lactulose/L-rhamnose...
Fatigue in patients with primary sclerosing cholangitisE Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Scand J Gastroenterol 39:961-8. 2004..The occurrence of fatigue in primary sclerosing cholangitis (PSC), its impact on quality of life and the role of concomitant inflammatory bowel disease (IBD) and coexisting irritable bowel syndrome (IBS) is unexplored...
Effects of duodenal lipids on gastric sensitivity and relaxation in patients with ulcer-like and dysmotility-like dyspepsiaEinar Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Digestion 67:209-17. 2003..Our aim was to elucidate the differences in gastric sensorimotor function in these subgroups of FD. 13 healthy controls (HC) and 20 patients with FD, 10 ULD and 10 DLD, were included...
Severe jaundice in Sweden in the new millennium: causes, investigations, treatment and prognosisE Bjornsson
Dept of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Scand J Gastroenterol 38:86-94. 2003....
Patients with small duct primary sclerosing cholangitis have a favourable long term prognosisE Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Gut 51:731-5. 2002..Patients with cholestatic liver function tests and histological features of primary sclerosing cholangitis (PSC) but a normal cholangiogram are considered to have small duct PSC. The natural history of this condition is unknown...
Drug-induced liver injury: Hy's rule revisitedEinar Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Clin Pharmacol Ther 79:521-8. 2006
Suspected drug-induced liver fatalities reported to the WHO databaseE Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Med Pol II, SE 413 45 Gothenburg, Sweden
Dig Liver Dis 38:33-8. 2006..World Health Organisation drug monitoring started in 1968. No systematic investigation has been carried out using this database of adverse drug reactions with liver injury associated with fatalities...
Increased risk for malignant neoplasms among patients with cirrhosisEvangelos Kalaitzakis
Institute of Internal Medicine, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden
Clin Gastroenterol Hepatol 9:168-74. 2011..It is not clear how cirrhosis affects the risks for hepatocellular carcinoma (HCC) and non-HCC cancers, which are rare among these patients. We assessed the risk for malignant neoplasms in patients with cirrhosis...
High prevalence of small duct primary sclerosing cholangitis among patients with overlapping autoimmune hepatitis and primary sclerosing cholangitisRolf Olsson
Department of Medicine, Sahlgrenska University Hospital Sahlgrenska, Goteborg, Sweden
Eur J Intern Med 20:190-6. 2009..We describe a high prevalence of small duct primary sclerosing cholangitis among patients with overlapping autoimmune hepatitis and primary sclerosing cholangitis...
Factors related to fatigue in patients with cirrhosis before and after liver transplantationEvangelos Kalaitzakis
Institute of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Clin Gastroenterol Hepatol 10:174-81, 181.e1. 2012..We performed a prospective study to evaluate fatigue and identify potential determinants among patients with cirrhosis. We also studied the effects of liver transplantation on fatigue in these patients...
Primary sclerosing cholangitis associated with elevated immunoglobulin G4: clinical characteristics and response to therapyEinar Bjornsson
Division of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Am J Ther 18:198-205. 2011..Most patients had a good biochemical response to steroids, but adverse effects were common. Future work should be directed at finding therapy that is more effective, better tolerated, and of more lasting benefit...
Autoimmune hepatitis-PBC overlap syndrome: a simplified scoring system may assist in the diagnosisMatthias Neuhauser
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
Am J Gastroenterol 105:345-53. 2010..Furthermore, we sought to compare the outcome in PBC patients with and without the features of AIH overlap...
Long-term follow-up of patients with acute liver failure of indeterminate aetiologyGu Wei
Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Scand J Gastroenterol 43:984-91. 2008....
Type and etiology of liver cirrhosis are not related to the presence of hepatic encephalopathy or health-related quality of life: a cross-sectional studyEvangelos Kalaitzakis
Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
BMC Gastroenterol 8:46. 2008..We aimed to determine the impact of cirrhosis etiology on hepatic encephalopathy and whether hepatic encephalopathy affects health-related QoL among patients with cirrhosis of different etiologies...
Prevalence of gastrointestinal symptoms in patients with chronic obstructive pulmonary diseaseAnna Niklasson
Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
Eur J Gastroenterol Hepatol 20:335-41. 2008....
Role of gastric sensorimotor dysfunction in gastrointestinal symptoms and energy intake in liver cirrhosisEvangelos Kalaitzakis
Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Scand J Gastroenterol 42:237-46. 2007..The aim of this study was to investigate gastric accommodation to a meal and sensitivity to gastric distension with reference to energy intake, nutritional status and gastrointestinal symptoms in liver cirrhosis...
Malnutrition and diabetes mellitus are related to hepatic encephalopathy in patients with liver cirrhosisEvangelos Kalaitzakis
Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Liver Int 27:1194-201. 2007..Our aim was to investigate the effects of malnutrition and diabetes mellitus on HE in unselected patients with liver cirrhosis...
Factors that reduce health-related quality of life in patients with primary sclerosing cholangitisMaria Benito de Valle
Institute of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Clin Gastroenterol Hepatol 10:769-775.e2. 2012..We aimed to evaluate HRQL and its potential determinants in 2 population-based cohorts of patients with PSC and to study the prevalence of fatigue among these patients...
Drug-induced autoimmune hepatitis: clinical characteristics and prognosisEinar Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Landspitali University Hospital, Reykjavik, Iceland
Hepatology 51:2040-8. 2010..These two groups have similar clinical and histological patterns. However, DIAIH patients do not seem to require long-term immunosuppressive therapy...
Outcome and prognostic markers in severe drug-induced liver diseaseEinar Bjornsson
Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
Hepatology 42:481-9. 2005..In conclusion, hepatocellular jaundice has a high but variable mortality rate, depending on the drug involved. The AST and bilirubin levels are the most important predictors of death or liver transplantation...
The relationship between symptoms, body mass index, gastrointestinal transit and stool frequency in patients with irritable bowel syndromeRiadh Sadik
Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg 41345, Sweden
Eur J Gastroenterol Hepatol 22:102-8. 2010..The aim of this prospective study was to characterize the relationships between symptoms in IBS, GI transit, as a measure of GI motility, and BMI...
Dyspeptic symptom development after discontinuation of a proton pump inhibitor: a double-blind placebo-controlled trialAnna Niklasson
Department of Internal Medicine, Section of Gastroenterology, Sahlgrenska University Hospital, Richertsgatan 18, Göteborg 412 60, Sweden
Am J Gastroenterol 105:1531-7. 2010..Conflicting data exist on whether discontinuation of proton pump inhibitors (PPIs) is associated with rebound secretion of gastric acid...
Intestinal permeability in cirrhotic patients with and without ascitesEvangelos Kalaitzakis
Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Scand J Gastroenterol 41:326-30. 2006..The aim of this study was to assess whether intestinal permeability is altered in cirrhotic patients with and without ascites...
Dominant strictures in patients with primary sclerosing cholangitisEinar Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University, Gothenburg, Sweden
Am J Gastroenterol 99:502-8. 2004..We aimed to determine the prevalence of DS in patients with PSC and the spontaneous course of ALP and bilirubin, up to a year from diagnosis in patients with and without DS...
Inadequate use of proton-pump inhibitors in patients with liver cirrhosisEvangelos Kalaitzakis
Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Eur J Gastroenterol Hepatol 20:512-8. 2008..Patients with liver cirrhosis have a high prevalence of gastrointestinal symptoms. The use of antiacid therapy (AAT) in these patients is unexplored. We aimed to assess the use of AAT in cirrhotic patients...
Gut transit is associated with gastrointestinal symptoms and gut hormone profile in patients with cirrhosisEvangelos Kalaitzakis
Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Clin Gastroenterol Hepatol 7:346-52. 2009....
Impact of peri-transplant heart failure & left-ventricular diastolic dysfunction on outcomes following liver transplantationAxel Josefsson
Institute of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Liver Int 32:1262-9. 2012..Assess the prevalence of peri-transplant heart failure and its potential relation to post-transplant morbidity and mortality...
Effects of gut-directed hypnotherapy on IBS in different clinical settings-results from two randomized, controlled trialsPerjohan Lindfors
Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Am J Gastroenterol 107:276-85. 2012..The objective of this study was to study the effect of gut-directed hypnotherapy in IBS in different clinical settings outside the traditional research units...
Coronary artery disease in patients with liver cirrhosisEvangelos Kalaitzakis
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden
Dig Dis Sci 55:467-75. 2010..We aimed to determine the prevalence and predictive factors of CAD in a cohort of consecutive patients with cirrhosis of various etiologies compared to the general population...
Altered postprandial glucose, insulin, leptin, and ghrelin in liver cirrhosis: correlations with energy intake and resting energy expenditureEvangelos Kalaitzakis
Department of Internal Medicine, Faculty of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Am J Clin Nutr 85:808-15. 2007..Liver cirrhosis is associated with reduced energy intake and increased resting energy expenditure...
Incidence and prevalence of primary sclerosing cholangitis in a defined adult population in SwedenBjorn Lindkvist
Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Hepatology 52:571-7. 2010..The prevalence of PSC at the end of the study period is the highest reported to date. This implies that the medical burden of PSC may be higher than estimated previously...
Liver cirrhosis in Iceland and Sweden: incidence, aetiology and outcomesSteingerdur Anna Gunnarsdottir
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Scand J Gastroenterol 44:984-93. 2009..The incidence and mortality of liver cirrhosis in Iceland has been reported to be the lowest in the Western world. There are very few data on aetiology, incidence and prognosis among cirrhotics in Sweden...
Pharmacokinetic study of esomeprazole in patients with hepatic impairmentHenrik Sjovall
Sahlgrenska University Hospital, Goteborg, Sweden
Eur J Gastroenterol Hepatol 14:491-6. 2002..To evaluate the pharmacokinetics and safety of esomeprazole (Nexium), the S-isomer of omeprazole, after repeated oral dosing in patients with hepatic impairment...
Renal function and cognitive impairment in patients with liver cirrhosisEvangelos Kalaitzakis
Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Scand J Gastroenterol 42:1238-44. 2007..Renal function has been shown to be important for ammonia metabolism in cirrhosis. Although renal dysfunction is common in cirrhotic patients, its effect on cognitive function is largely unexplored...
The AST/ALT ratio as an indicator of cirrhosis in patients with PBCHelena Nyblom
Department of Internal Medicine, Sahlgrenska University Hospital, , , Sweden
Liver Int 26:840-5. 2006..In a multivariate analysis, bilirubin and ALP were predictors of poor prognosis. CONCLUSION: The AST/ALT ratio seems to be of clinical value as a hint to the diagnosis of cirrhosis in patients with PBC but not as a prognostic factor...
Hepatotoxicity associated with statins: reports of idiosyncratic liver injury post-marketingEinar Bjornsson
Department of Internal Medicine, Section of Gastroenterology and Hepatology, The National University Hospital, Reykjavik, Iceland
J Hepatol 56:374-80. 2012..Limited data exist on drug-induced liver injury (DILI) associated with statins...
[Helicobacter pylori can in rare cases be the cause of iron and vitamin B 12 deficiency. No increased risk of iron and vitamin B 12 deficiency due to proton pump inhibitors]Niklas Mattsson
Sahlgrenska Universitetssjukhuset, Goteborg
Lakartidningen 101:2014-5. 2004..The safety of long-term use of PPI is well documented, but it is still unclear whether PPI accelerates the development of atrophic corpus gastritis in the presence of H pylori...
A review of esomeprazole in the treatment of gastroesophageal reflux disease (GERD)Evangelos Kalaitzakis
Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital Gothenburg, Sweden
Ther Clin Risk Manag 3:653-63. 2007....
Abstinence in patients with alcoholic liver cirrhosis: A follow-up studyEvangelos Kalaitzakis
Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Hepatol Res 38:869-76. 2008..Cirrhosis severity (expressed as the MELD) and alcohol abuse treatment during follow up were related to short-term mortality...
