Lars Barregard

..Mercury is nephrotoxic and dental amalgam is a source of mercury exposure...

..Cadmium is a wide-spread pollutant. Observational studies suggest associations between cadmium and prevalence of type 2 diabetes. Experimental studies indicate that cadmium may cause impaired insulin production...

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..These factors may be involved in the mechanisms whereby particulate air pollution affects cardiovascular morbidity and mortality. The exposure setup could be used to establish which particle characteristics are critical for the effects...

..6 (95% CI: 4.8-6.3) days. The results indicate that mercury from thimerosal is not accumulated in blood in adults. This is in accordance with short half-lives and rapid metabolism of EtHg to inorganic mercury...

..Particulate air pollution affects cardiovascular and pulmonary disease and mortality. A main hypothesis about the mechanisms involved is that particles induce inflammation in lower airways, systemic inflammation and oxidative stress...

..To assess the incidence of leukaemia in an area downwind of a large oil refinery emitting carcinogenic volatile organic compounds (VOCs) including benzene...

..To assess the association between hypertension and traffic noise...

..Assessment of metal concentrations in kidney biopsies from living subjects can be combined with information about exposure sources like smoking, diet, and occupation supplied by the biopsied subjects themselves...

..By varying the combustion and dilution of the wood smoke, different exposure scenarios can be achieved and thus, knowledge about which of the properties of particles and gaseous compounds are crucial for the effects...

..Wood smoke is a significant contributor to air pollution, with complex and varying composition. We examined airway effects of two kinds of wood smoke in a chamber study...

..The within-individual (day-to-day) variability dominated for personal exposure to both PM(2.5) and BS(2.5) in non-smokers...

..50 (0.82-2.53). VOC levels were low. Taking estimated exposure and demographic factors into account, our assessment is that occurrence of cancer was not affected by industrial emissions in any of the studied sites...

..Post hoc power calculations showed that if the background mercury exposure is low it may be possible to demonstrate an increase in U-Hg of as little as about 10 ng/m(3) as a contribution to ambient mercury from a point source...

..The cancer risk from these compounds at exposure to wood smoke is, however, estimated to be low in developed countries...

..In general, this study indicates no significant adverse effects of Hg 0 on neuromotor function at the exposure levels studied...

..Timed urine specimens were collected from 29 healthy volunteers at fixed time points over 24 h on two separate days. Volumes, creatinine and specific gravity were determined. All samples were analysed with a commercial ELISA for A1M...

..Nevertheless, hand-arm vibrations cause VWF in a significant number of car mechanics. The method of observing workers intermittently seemed to work well...

..The 24-h and 6-day sampling periods yield a relatively low within-individual variability for formaldehyde measurements with GMD samplers...

..The aim of the present study was to investigate whether previous long-term exposure to manganese (Mn) via inhalation of welding fumes can cause persistent impairment in neuromotor function even long after cessation of exposure...

..The choice of sampling period and adjustment technique could, however, potentially induce bias. The aim of the study was to compare 24-h urine and spot urine sampling and two dilution adjustment techniques, when assessing U-Cd...

..There was an association between serum CC16 (S-CC16) and U-CC16 in morning samples. With optimal methods for sampling U-CC16, urine samples may be used in experimental studies of air pollution...

..No differences were seen for crustal elements. Air mass origin should be taken into account in the description and interpretation of time series studies of air pollution and health...

..The differences were small, however, and overall, this study indicates no significant adverse effects on tremor at these exposure levels...

..However, associations with kidney Cd have not been examined. The aim of this study was to explore the relation between kidney Cd and urinary calcium excretion, or bone mineral density...

..Health-risk worry due to industrial air pollution was associated with female sex, having children, annoyance due to dust/soot in the air, and worry of traffic air pollution...

..The convenience of SPMD technology facilitates its use for semi-quantitative screening and monitoring of various persistent organic compounds indoors in dwellings and working environments...

..This interaction effect was significant from 59 dB and increased gradually with higher sound levels. Effects of the total sound exposure should be considered in risk assessments and in noise mitigation activities...

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..Our objectives were to determine the relationship between cadmium in kidney, urine, and blood, and calculate the elimination half-time of Cd from the kidney...

..Associations between cadmium (Cd) and kidney function have been reported even at low levels of exposure in the general population. Recently, the causality of these associations has been questioned...

..The urinary level of CRP seems to distinguish between children with UTI and other febrile conditions. A combination of these biomarkers may be useful in the clinical assessment of children with UTI...

..Does long term occupational exposure to organic solvents lead to aggravated cognitive impairment later in life?..

..Dose-effect relationships were seen mainly for contact adhesives, and there was partial evidence for an interaction between exposure and aging...

..9, resulting in a relative risk of 5.6 (95% CI 1.8-13). Exposure to diphenyl may have contributed to this PD cluster, but chance is an alternative explanation...

..To assess the occurrence of hand-arm vibration syndrome (HAVS) in Swedish car mechanics, and the relation between HAVS and duration of exposure...

..The inverse association between temperature and AMI hospitalisations (entire year and warm period) in Gothenburg is in accordance with the majority of the few other studies that investigated this subtype of CVD...

..Students with voice problems according to Screen6 scored 23.1 (mean Sw-VHI) compared with 7.8 for students without voice problems...

..In wooden houses, the difference was somewhat greater. Our results indicate a current contribution to personal gamma radiation in this area of about 0.2 mSv per year from the Chernobyl fallout...

..Therefore, the use of creatinine-corrected markers seems to be a good choice in practice, with the caveat that daytime and overnight samples are not comparable...

..Exposure to particulate matter is associated with risk of cardiovascular events, possibly through endothelial dysfunction, and indoor air may be most important...

..We investigated if asphalt workers showed signs of lung epithelial injury as shown by increased Clara cell protein 16 (CC16) in serum after 6 months of exposure...

..Our findings support that exposure to wood smoke causes systemic effects, although we could not demonstrate genotoxic effects, possibly explained by enhanced repair and timing of sampling...

..TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00065988...

..3 microg/g creatinine ranged from 4% to 6%. Number of amalgam restorations had a significant dose-response relationship with U-Hg level. Daily gum chewing in the presence of amalgam was associated with high U-Hg...

..Urinary mercury (U-Hg) excretion is a commonly used biomarker for mercury exposure from dental amalgam restorations...