Fredrik Backhed

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. doi request reprint Host responses to the human microbiome
    Fredrik Backhed
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory and Department of Molecular and Clinical Medicine, University of Gothenburg, S 413 45 Gothenburg, Sweden
    Nutr Rev 70:S14-7. 2012
  2. doi request reprint Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life
    Fredrik Backhed
    The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, 41345, Gothenburg, Sweden Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark Electronic address
    Cell Host Microbe 17:690-703. 2015
  3. pmc Symptomatic atherosclerosis is associated with an altered gut metagenome
    Fredrik H Karlsson
    Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg SE 412 96, Sweden
    Nat Commun 3:1245. 2012
  4. pmc Lactobacillus reuteri prevents diet-induced obesity, but not atherosclerosis, in a strain dependent fashion in Apoe-/- mice
    Frida Fåk
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 7:e46837. 2012
  5. doi request reprint Changes in intestinal microflora in obesity: cause or consequence?
    Fredrik Backhed
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden
    J Pediatr Gastroenterol Nutr 48:S56-7. 2009
  6. pmc Coordinated regulation of the metabolome and lipidome at the host-microbial interface
    Fredrik Backhed
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory and Department of Molecular and Clinical Medicine, University of Gothenburg, S 413 45 Gothenburg, Sweden
    Biochim Biophys Acta 1801:240-5. 2010
  7. pmc 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: the normal gut microbiota in health and disease
    F Backhed
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, Goteborg, Sweden
    Clin Exp Immunol 160:80-4. 2010
  8. doi request reprint Programming of host metabolism by the gut microbiota
    Fredrik Backhed
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory and Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden
    Ann Nutr Metab 58:44-52. 2011
  9. doi request reprint Gut metagenome in European women with normal, impaired and diabetic glucose control
    Fredrik H Karlsson
    Department of Chemical and Biological Engineering, Chalmers University of Technology, SE 412 96 Gothenburg, Sweden
    Nature 498:99-103. 2013
  10. pmc Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice
    Robert Caesar
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, Gothenburg, Sweden
    Gut 61:1701-7. 2012

Collaborators

Detail Information

Publications36

  1. doi request reprint Host responses to the human microbiome
    Fredrik Backhed
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory and Department of Molecular and Clinical Medicine, University of Gothenburg, S 413 45 Gothenburg, Sweden
    Nutr Rev 70:S14-7. 2012
    ..Recent findings suggest that an altered gut microbial composition is associated with inflammatory bowel disease and obesity, indicating that the gut microbiota should be considered a contributing factor in several common diseases...
  2. doi request reprint Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life
    Fredrik Backhed
    The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, 41345, Gothenburg, Sweden Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark Electronic address
    Cell Host Microbe 17:690-703. 2015
    ..Our findings establish a framework for understanding the interplay between the gut microbiome and the human body in early life. ..
  3. pmc Symptomatic atherosclerosis is associated with an altered gut metagenome
    Fredrik H Karlsson
    Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg SE 412 96, Sweden
    Nat Commun 3:1245. 2012
    ..Our findings suggest that the gut metagenome is associated with the inflammatory status of the host and patients with symptomatic atherosclerosis harbor characteristic changes in the gut metagenome...
  4. pmc Lactobacillus reuteri prevents diet-induced obesity, but not atherosclerosis, in a strain dependent fashion in Apoe-/- mice
    Frida Fåk
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 7:e46837. 2012
    ..To investigate whether the specific strains of Lactobacillus reuteri modulates the metabolic syndrome in Apoe-/- mice...
  5. doi request reprint Changes in intestinal microflora in obesity: cause or consequence?
    Fredrik Backhed
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden
    J Pediatr Gastroenterol Nutr 48:S56-7. 2009
    ..Experiments using germ-free mice have begun to reveal some mechanisms by which the gut microbiota may affect the development of obesity...
  6. pmc Coordinated regulation of the metabolome and lipidome at the host-microbial interface
    Fredrik Backhed
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory and Department of Molecular and Clinical Medicine, University of Gothenburg, S 413 45 Gothenburg, Sweden
    Biochim Biophys Acta 1801:240-5. 2010
    ..These studies therefore demonstrate that the gut microbiota is an "environmental" influence whose synergistic interdependence with its host strongly suggests that we are in fact "supraorganisms."..
  7. pmc 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: the normal gut microbiota in health and disease
    F Backhed
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, Goteborg, Sweden
    Clin Exp Immunol 160:80-4. 2010
    ..Furthermore, emerging data suggest that the gut microbiota may predispose or protect against other important diseases such as cardiovascular disease and diabetes...
  8. doi request reprint Programming of host metabolism by the gut microbiota
    Fredrik Backhed
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory and Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden
    Ann Nutr Metab 58:44-52. 2011
    ..Accordingly, reprogramming the gut microbiota, or its function, in early life may have beneficial effects on host metabolism later in life...
  9. doi request reprint Gut metagenome in European women with normal, impaired and diabetic glucose control
    Fredrik H Karlsson
    Department of Chemical and Biological Engineering, Chalmers University of Technology, SE 412 96 Gothenburg, Sweden
    Nature 498:99-103. 2013
    ..Therefore, metagenomic predictive tools for T2D should be specific for the age and geographical location of the populations studied...
  10. pmc Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice
    Robert Caesar
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, Gothenburg, Sweden
    Gut 61:1701-7. 2012
    ..Obesity is associated with accumulation of macrophages in white adipose tissue (WAT), which contribute to the development of insulin resistance. Germ-free (GF) mice have reduced adiposity and are protected against diet-induced obesity,..
  11. doi request reprint Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation
    Valentina Tremaroli
    The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, SE 413 45 Gothenburg, Sweden
    Cell Metab 22:228-38. 2015
    ..Our results suggest that the gut microbiota may play a direct role in the reduction of adiposity observed after bariatric surgery. ..
  12. doi request reprint Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization
    Malin E V Johansson
    Department of Medical Biochemistry, University of Gothenburg, SE 405 30 Gothenburg, Sweden
    Cell Host Microbe 18:582-92. 2015
    ..These findings highlight the dynamics of mucus layer development and indicate that studies of mature microbe-mucus interactions should be conducted weeks after colonization. ..
  13. doi request reprint Microbial modulation of energy availability in the colon regulates intestinal transit
    Anita Wichmann
    Wallenberg Laboratory Sahlgrenska Center for Cardiovascular and Metabolic Research, Sahlgrenska University Hospital, Gothenburg 40530, Sweden Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg 41345, Sweden
    Cell Host Microbe 14:582-90. 2013
    ..Thus, microbiota regulate the basal levels of GLP-1, and increasing these levels may be an adaptive response to insufficient energy availability in the colon that slows intestinal transit and allows for greater nutrient absorption...
  14. pmc Assessing the human gut microbiota in metabolic diseases
    Fredrik Karlsson
    Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
    Diabetes 62:3341-9. 2013
    ..A combination of classical microbiology, sequencing, and animal experiments may provide further insights into how the gut microbiota affect host metabolism and physiology. ..
  15. doi request reprint Functional interactions between the gut microbiota and host metabolism
    Valentina Tremaroli
    Wallenberg Laboratory for Cardiovascular and Metabolic Research, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden
    Nature 489:242-9. 2012
    ..Through increased knowledge of the mechanisms involved in the interactions between the microbiota and its host, we will be in a better position to develop treatments for metabolic disease...
  16. doi request reprint Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling
    Robert Caesar
    The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, 41345 Gothenburg, Sweden Electronic address
    Cell Metab 22:658-68. 2015
    ..These results indicate that gut microbiota exacerbates metabolic inflammation through TLR signaling upon challenge with a diet rich in saturated lipids...
  17. pmc Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88
    Erik Larsson
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden
    Gut 61:1124-31. 2012
    ..Microorganisms are recognised by pattern recognition receptors such as Toll-like receptors, which signal through the adaptor molecule MyD88...
  18. doi request reprint Intestinal permeability is associated with visceral adiposity in healthy women
    Anders Gummesson
    Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Obesity (Silver Spring) 19:2280-2. 2011
    ....
  19. pmc Regulation of serum amyloid A3 (SAA3) in mouse colonic epithelium and adipose tissue by the intestinal microbiota
    Christopher S Reigstad
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 4:e5842. 2009
    ..6+/-0.1-fold, respectively). Our data suggest that LPS, and potentially other products of the indigenous gut microbiota, might elevate cytokine expression in tissues and thus exacerbate chronic low-grade inflammation observed in obesity...
  20. doi request reprint The gut microbiota modulates host amino acid and glutathione metabolism in mice
    Adil Mardinoglu
    Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden
    Mol Syst Biol 11:834. 2015
    ..Our analyses revealed that the gut microbiota influences host amino acid and glutathione metabolism in mice. ..
  21. doi request reprint Inflammation- and tumor-induced anorexia and weight loss require MyD88 in hematopoietic/myeloid cells but not in brain endothelial or neural cells
    Johan Ruud
    Division of Cell Biology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    FASEB J 27:1973-80. 2013
    ..Instead, we identify MyD88 signaling in hematopoietic/myeloid cells as a critical component for acute inflammatory-driven anorexia, as well as for chronic anorexia and weight loss associated with malignant disease...
  22. doi request reprint Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella
    Petia Kovatcheva-Datchary
    Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg 41345, Sweden
    Cell Metab 22:971-82. 2015
    ..Our findings indicate that Prevotella plays a role in the BKB-induced improvement in glucose metabolism observed in certain individuals, potentially by promoting increased glycogen storage. ..
  23. pmc The composition of the gut microbiota shapes the colon mucus barrier
    Hedvig E Jakobsson
    Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden
    EMBO Rep 16:164-77. 2015
    ..It also highlights that genetically identical animals housed in the same facility can have rather distinct microbiotas and barrier structures. ..
  24. pmc The gut microbiota modulates glycaemic control and serum metabolite profiles in non-obese diabetic mice
    Thomas U Greiner
    The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 9:e110359. 2014
    ..Additionally, germ-free NOD mice had a metabolite profile similar to that of pre-diabetic children. Our data suggest that germ-free NOD mice have reduced glycaemic control and dysregulated immunologic and metabolic responses. ..
  25. pmc The gut microbiota regulates bone mass in mice
    Klara Sjögren
    Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    J Bone Miner Res 27:1357-67. 2012
    ..Further studies are required to evaluate the gut microbiota as a novel therapeutic target for osteoporosis...
  26. doi request reprint Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist
    Sama I Sayin
    Wallenberg Laboratory, Department of Molecular and Clinical Medicine and Sahlgrenska Center for Cardiovascular and Metabolic Research, University of Gothenburg, 413 45 Gothenburg, Sweden
    Cell Metab 17:225-35. 2013
    ..These studies suggest that the gut microbiota not only regulates secondary bile acid metabolism but also inhibits bile acid synthesis in the liver by alleviating FXR inhibition in the ileum...
  27. doi request reprint Oral microbiota in patients with atherosclerosis
    Frida Fåk
    Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, University of Gothenburg, SE 413 45 Gothenburg, Sweden Electronic address
    Atherosclerosis 243:573-8. 2015
    ..We previously showed that bacteria from the oral cavity and the gut could be found in atherosclerotic plaques...
  28. pmc Site-specific programming of the host epithelial transcriptome by the gut microbiota
    Felix Sommer
    The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, 41345, Sweden
    Genome Biol 16:62. 2015
    ....
  29. doi request reprint The gut microbiota--masters of host development and physiology
    Felix Sommer
    Wallenberg Laboratory for Cardiovascular and Metabolic Research, Sahlgrenska University Hospital, Department of Molecular and Clinical Medicine, University of Gothenburg, SE 413 45 Gothenburg, Sweden
    Nat Rev Microbiol 11:227-38. 2013
    ....
  30. doi request reprint Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications
    Fredrik Backhed
    The Wallenberg Laboratory, University of Gothenburg, Sahlgrenska University Hospital, Goteborg, Sweden 41345
    Cell Host Microbe 12:611-22. 2012
    ....
  31. doi request reprint Effects of the gut microbiota on obesity and glucose homeostasis
    Thomas Greiner
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, S 413 45 Gothenburg, Sweden
    Trends Endocrinol Metab 22:117-23. 2011
    ..The gut microbiota could thus be considered to be an environmental factor that modulates obesity and other metabolic diseases...
  32. doi request reprint Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission
    Tulika Arora
    Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 10:e0126401. 2015
    ..Thus, metabolic alterations are induced soon after surgery and subjects with diabetes remission differ in the metabolic profiles at pre- and early post-surgery time points compared to patients not in remission. ..
  33. doi request reprint Linking Microbiota to Human Diseases: A Systems Biology Perspective
    Hao Wu
    The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, 41345 Gothenburg, Sweden
    Trends Endocrinol Metab 26:758-70. 2015
    ....
  34. pmc Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal architecture
    Felix Sommer
    The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden Mucin Biology Group, Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 9:e85254. 2014
    ..Thus, the mucus layer plays a role in the regulation of gut microbiota composition, balancing intestinal inflammation, and affects gut architecture. ..
  35. ncbi request reprint Intestinal microbiota during infancy and its implications for obesity
    Christoph Reinhardt
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden
    J Pediatr Gastroenterol Nutr 48:249-56. 2009
    ..We discuss how the gut microbiota regulates obesity and how environmental factors that affect the establishment of the gut microbiota during infancy may contribute to obesity later in life...
  36. pmc Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling
    Christoph Reinhardt
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, University of Gothenburg, 413 45 Gothenburg, Sweden
    Nature 483:627-31. 2012
    ..Thus, the microbiota-induced extravascular TF-PAR1 signalling loop is a novel pathway that may be modulated to influence vascular remodelling in the small intestine...