Fredrik Backhed

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. Backhed F. Host responses to the human microbiome. Nutr Rev. 2012;70 Suppl 1:S14-7 pubmed publisher
    ..Recent findings suggest that an altered gut microbial composition is associated with inflammatory bowel disease and obesity, indicating that the gut microbiota should be considered a contributing factor in several common diseases. ..
  2. Wahlström A, Kovatcheva Datchary P, Ståhlman M, Khan M, Backhed F, Marschall H. Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota. J Lipid Res. 2017;58:412-419 pubmed publisher
    ..We show that a human microbiota can change BA composition and induce FXR signaling in colonized mice, but the levels of secondary BAs produced are lower than in mice colonized with a mouse microbiota. ..
  3. Kovatcheva Datchary P, Shoaie S, Lee S, Wahlström A, Nookaew I, Hallén A, et al. Simplified Intestinal Microbiota to Study Microbe-Diet-Host Interactions in a Mouse Model. Cell Rep. 2019;26:3772-3783.e6 pubmed publisher
    ..Our SIM model can be used in future studies to help clarify how microbiota-diet interactions contribute to metabolic diseases. ..
  4. Molinaro A, Caesar R, L homme L, Koh A, Ståhlman M, Staels B, et al. Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet feeding. Mol Metab. 2019;23:82-87 pubmed publisher
    ..Our data indicate that liver deletion of RORα does not have a pivotal role in the regulation of hepatic glucose and lipid metabolism on chow or western-style diet. ..
  5. Backhed F. 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: the normal gut microbiota in health and disease. Clin Exp Immunol. 2010;160:80-4 pubmed publisher
    ..Furthermore, emerging data suggest that the gut microbiota may predispose or protect against other important diseases such as cardiovascular disease and diabetes. ..
  6. Lee Y, De Vadder F, Tremaroli V, Wichmann A, Mithieux G, Backhed F. Insulin-like peptide 5 is a microbially regulated peptide that promotes hepatic glucose production. Mol Metab. 2016;5:263-270 pubmed publisher
    ..We propose that INSL5 is a hormone that could play a role in promoting hepatic glucose production during periods of energy deprivation. ..
  7. Lindskog Jonsson A, Caesar R, Akrami R, Reinhardt C, Fåk Hållenius F, Boren J, et al. Impact of Gut Microbiota and Diet on the Development of Atherosclerosis in Apoe-/- Mice. Arterioscler Thromb Vasc Biol. 2018;: pubmed publisher
    ..Furthermore, the microbiota was required for trimethylamine N-oxide production from dietary choline, but this process could not be linked to increased atherosclerosis in this model. ..
  8. Caesar R, Tremaroli V, Kovatcheva Datchary P, Cani P, Bäckhed F. Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling. Cell Metab. 2015;22:658-68 pubmed publisher
    ..These results indicate that gut microbiota exacerbates metabolic inflammation through TLR signaling upon challenge with a diet rich in saturated lipids. ..
  9. Sommer F, Nookaew I, Sommer N, Fogelstrand P, Bäckhed F. Site-specific programming of the host epithelial transcriptome by the gut microbiota. Genome Biol. 2015;16:62 pubmed publisher
    ..Understanding host-microbiota interactions on a cellular level may facilitate signaling pathways that contribute to health and disease and thus provide new therapeutic strategies. ..

More Information

Publications29

  1. Schéle E, Grahnemo L, Anesten F, Hallén A, Bäckhed F, Jansson J. Regulation of body fat mass by the gut microbiota: Possible mediation by the brain. Peptides. 2016;77:54-9 pubmed publisher
    ..A recent study from our lab shows, for the first time, a link between gut microbiota and energy balance circuitries in the hypothalamus and brainstem. In this article we will review this study further. ..
  2. Arora T, Wegmann U, Bobhate A, Lee Y, Greiner T, Drucker D, et al. Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice. Mol Metab. 2016;5:725-730 pubmed publisher
    ..The L. lactis strain genetically modified to produce GLP-1 is capable of stimulating insulin secretion from islets and improving glucose tolerance in mice. ..
  3. De Vadder F, Grasset E, Mannerås Holm L, Karsenty G, Macpherson A, Olofsson L, et al. Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks. Proc Natl Acad Sci U S A. 2018;115:6458-6463 pubmed publisher
    ..Taken together, these findings show that the microbiota modulates the anatomy of the adult ENS in a 5-HT-dependent fashion with concomitant changes in intestinal transit. ..
  4. Khan M, Nieuwdorp M, Bäckhed F. Microbial modulation of insulin sensitivity. Cell Metab. 2014;20:753-760 pubmed publisher
    ..Increased mechanistic insights of how the microbiota modulates metabolic disease in humans may pave the way for identification of innovative microbiota-based diagnostics and/or therapeutics. ..
  5. Sommer F, Ståhlman M, Ilkayeva O, Arnemo J, Kindberg J, Josefsson J, et al. The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos. Cell Rep. 2016;14:1655-1661 pubmed publisher
  6. Arora T, Backhed F. The gut microbiota and metabolic disease: current understanding and future perspectives. J Intern Med. 2016;280:339-49 pubmed publisher
  7. Zietak M, Kovatcheva Datchary P, Markiewicz L, Ståhlman M, Kozak L, Backhed F. Altered Microbiota Contributes to Reduced Diet-Induced Obesity upon Cold Exposure. Cell Metab. 2016;23:1216-1223 pubmed publisher
    ..Thus, a microbiota-liver-BAT axis may mediate protection against obesity at reduced temperature. ..
  8. Mardinoglu A, Wu H, Björnson E, Zhang C, Hakkarainen A, Räsänen S, et al. An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans. Cell Metab. 2018;27:559-571.e5 pubmed publisher
    ..Our results highlight the potential of exploring diet-microbiota interactions for treating NAFLD. ..
  9. Bäckhed F, Roswall J, Peng Y, Feng Q, Jia H, Kovatcheva Datchary P, et al. Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life. Cell Host Microbe. 2015;17:690-703 pubmed publisher
    ..Our findings establish a framework for understanding the interplay between the gut microbiome and the human body in early life. ..
  10. Jonsson A, Bäckhed F. Drug the Bug!. Cell. 2015;163:1565-6 pubmed publisher
    ..Now, Wang et al. demonstrate that inhibition of microbial TMA lyases, essential for production of pro-atherogenic trimethylamines, prevents atherosclerosis in vivo. ..
  11. Fåk F, Tremaroli V, Bergström G, Bäckhed F. Oral microbiota in patients with atherosclerosis. Atherosclerosis. 2015;243:573-8 pubmed publisher
    ..In conclusion, abundance of Anaeroglobus in the oral cavity could be associated with symptomatic atherosclerosis. ..
  12. Arora T, Akrami R, Pais R, Bergqvist L, Johansson B, Schwartz T, et al. Microbial regulation of the L cell transcriptome. Sci Rep. 2018;8:1207 pubmed publisher
    ..Thus, the microbiota has a rapid and pronounced effect on the L cell transcriptome, predominantly in the ileum. ..
  13. Schroeder B, Birchenough G, Ståhlman M, Arike L, Johansson M, Hansson G, et al. Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration. Cell Host Microbe. 2018;23:27-40.e7 pubmed publisher
    ..We hypothesize that the presence of distinct bacteria is crucial for proper mucus function. If confirmed in humans, these findings may help to better understand diseases with an affected mucus layer, such as ulcerative colitis. ..
  14. Kovatcheva Datchary P, Nilsson A, Akrami R, Lee Y, De Vadder F, Arora T, et al. Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella. Cell Metab. 2015;22:971-82 pubmed publisher
    ..Our findings indicate that Prevotella plays a role in the BKB-induced improvement in glucose metabolism observed in certain individuals, potentially by promoting increased glycogen storage. ..
  15. De Vadder F, Kovatcheva Datchary P, Zitoun C, Duchampt A, Backhed F, Mithieux G. Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis. Cell Metab. 2016;24:151-7 pubmed publisher
    ..Thus, microbiota-produced succinate is a previously unsuspected bacterial metabolite improving glycemic control through activation of IGN. ..
  16. Wu H, Tremaroli V, Bäckhed F. Linking Microbiota to Human Diseases: A Systems Biology Perspective. Trends Endocrinol Metab. 2015;26:758-70 pubmed publisher
  17. Molinaro A, Caesar R, Holm L, Tremaroli V, Cani P, Backhed F. Host-microbiota interaction induces bi-phasic inflammation and glucose intolerance in mice. Mol Metab. 2017;6:1371-1380 pubmed publisher
    ..Our results provide new insights on host-microbiota interaction during colonization of GF mice and the resulting effects on adiposity and glucose metabolism in a time resolved fashion. ..
  18. Lindskog Jonsson A, Hållenius F, Akrami R, Johansson E, Wester P, Arnerlöv C, et al. Bacterial profile in human atherosclerotic plaques. Atherosclerosis. 2017;263:177-183 pubmed publisher
  19. Tremaroli V, Karlsson F, Werling M, Ståhlman M, Kovatcheva Datchary P, Olbers T, et al. Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation. Cell Metab. 2015;22:228-38 pubmed publisher
    ..Our results suggest that the gut microbiota may play a direct role in the reduction of adiposity observed after bariatric surgery. ..
  20. Fåk F, Backhed F. Lactobacillus reuteri prevents diet-induced obesity, but not atherosclerosis, in a strain dependent fashion in Apoe-/- mice. PLoS ONE. 2012;7:e46837 pubmed publisher
    ..In conclusion, the probiotic L. reuteri strain ATCC PTA 4659 partly prevented diet-induced obesity, possibly via a previously unknown mechanism of inducing liver expression of Cpt1a. ..