Per Berglund

Summary

Affiliation: Royal Institute of Technology
Country: Sweden

Publications

  1. ncbi An efficient single-enzymatic cascade for asymmetric synthesis of chiral amines catalyzed by ω-transaminase
    Bo Wang
    KTH Royal Institute of Technology, Division of Biochemistry, School of Biotechnology, AlbaNova University Center, SE 106 91 Stockholm, Sweden
    Chem Commun (Camb) 49:161-3. 2013
  2. ncbi Engineered enzymes for improved organic synthesis
    Karl Hult
    Department of Biotechnology, Royal Institute of Technology KTH, AlbaNova University Center, SE 106 91 Stockholm, Sweden
    Curr Opin Biotechnol 14:395-400. 2003
  3. ncbi Direct epoxidation in Candida antarctica lipase B studied by experiment and theory
    Maria Svedendahl
    Department of Biochemistry, Royal Institute of Technology KTH, AlbaNova University Center, Stockholm, Sweden
    Chembiochem 9:2443-51. 2008
  4. ncbi Fast carbon-carbon bond formation by a promiscuous lipase
    Maria Svedendahl
    Department of Biochemistry, School of Biotechnology, Royal Institute of Technology (KTH, AlbaNova University Center, SE-106 91 Stockholm, Sweden
    J Am Chem Soc 127:17988-9. 2005
  5. ncbi Chromobacterium violaceum ω-transaminase variant Trp60Cys shows increased specificity for (S)-1-phenylethylamine and 4'-substituted acetophenones, and follows Swain-Lupton parameterisation
    Karim Engelmark Cassimjee
    KTH Royal Institute of Technology, Division of Biochemistry, School of Biotechnology, AlbaNova University Centre, SE 106 91 Stockholm, Sweden
    Org Biomol Chem 10:5466-70. 2012
  6. ncbi Crystal structures of the Chromobacterium violaceumω-transaminase reveal major structural rearrangements upon binding of coenzyme PLP
    Maria S Humble
    Division of Biochemistry, KTH Royal Institute of Technology, Stockholm, Sweden
    FEBS J 279:779-92. 2012
  7. ncbi Transaminations with isopropyl amine: equilibrium displacement with yeast alcohol dehydrogenase coupled to in situ cofactor regeneration
    Karim Engelmark Cassimjee
    Division of Biochemistry, School of Biotechnology, Royal Institute of Technology KTH, AlbaNova University Centre, SE 106 91 Stockholm, Sweden
    Chem Commun (Camb) 46:5569-71. 2010
  8. ncbi Enzyme promiscuity: mechanism and applications
    Karl Hult
    School of Biotechnology, Department of Biochemistry, Royal Institute of Technology KTH, AlbaNova University Center, SE 106 91 Stockholm, Sweden
    Trends Biotechnol 25:231-8. 2007
  9. ncbi One-step enzyme extraction and immobilization for biocatalysis applications
    Karim Engelmark Cassimjee
    Division of Biochemistry, School of Biotechnology, Royal Institute of Technology KTH, AlbaNova University Center, Stockholm, Sweden
    Biotechnol J 6:463-9. 2011
  10. ncbi Silica-immobilized His6-tagged enzyme: alanine racemase in hydrophobic solvent
    Karim Engelmark Cassimjee
    Department of Biochemistry, School of Biotechnology, Royal Institute of Technology KTH, AlbaNova University Center, SE 106 91 Stockholm, Sweden
    Biotechnol Bioeng 99:712-6. 2008

Collaborators

  • Bo Wang
  • Derek T Logan
  • Hans Jurgen Federsel
  • Björn Walse
  • Uwe T Bornscheuer
  • Mikael Widersten
  • Karim Engelmark Cassimjee
  • Karl Hult
  • Cecilia Branneby
  • Maria Svedendahl
  • Vahak Abedi
  • Peter Carlqvist
  • Tore Brinck
  • Maria S Humble
  • Karim E Cassimjee
  • Maria Håkansson
  • Sílvia Rodríguez Marín
  • Maria Svedendahl Humble
  • Henrik Land
  • Yengo R Kimbung
  • Nguyen Hong Thanh
  • Marianne Wittrup Larsen
  • Robert Kourist
  • Diana Lindberg
  • Andrew Wells
  • Martin Trummer
  • Olof Allnér
  • Anton Frise
  • Anders Magnusson

Detail Information

Publications13

  1. ncbi An efficient single-enzymatic cascade for asymmetric synthesis of chiral amines catalyzed by ω-transaminase
    Bo Wang
    KTH Royal Institute of Technology, Division of Biochemistry, School of Biotechnology, AlbaNova University Center, SE 106 91 Stockholm, Sweden
    Chem Commun (Camb) 49:161-3. 2013
    ....
  2. ncbi Engineered enzymes for improved organic synthesis
    Karl Hult
    Department of Biotechnology, Royal Institute of Technology KTH, AlbaNova University Center, SE 106 91 Stockholm, Sweden
    Curr Opin Biotechnol 14:395-400. 2003
    ..Both strategies of enzyme engineering can be successful and are very useful for improving the utility of enzymes for applied catalysis. Several examples illustrating these concepts in a variety of enzyme classes have appeared recently...
  3. ncbi Direct epoxidation in Candida antarctica lipase B studied by experiment and theory
    Maria Svedendahl
    Department of Biochemistry, Royal Institute of Technology KTH, AlbaNova University Center, Stockholm, Sweden
    Chembiochem 9:2443-51. 2008
    ..The active-site residue His224 functions as a general acid-base catalyst with support from Asp187. Oxyanion stabilization is facilitated by two hydrogen bonds from Thr40...
  4. ncbi Fast carbon-carbon bond formation by a promiscuous lipase
    Maria Svedendahl
    Department of Biochemistry, School of Biotechnology, Royal Institute of Technology (KTH, AlbaNova University Center, SE-106 91 Stockholm, Sweden
    J Am Chem Soc 127:17988-9. 2005
    ..The designed enzyme showed high rate enhancements with a catalytic proficiency higher than 108, which is on the same level as that observed for enzymes with native substrates...
  5. ncbi Chromobacterium violaceum ω-transaminase variant Trp60Cys shows increased specificity for (S)-1-phenylethylamine and 4'-substituted acetophenones, and follows Swain-Lupton parameterisation
    Karim Engelmark Cassimjee
    KTH Royal Institute of Technology, Division of Biochemistry, School of Biotechnology, AlbaNova University Centre, SE 106 91 Stockholm, Sweden
    Org Biomol Chem 10:5466-70. 2012
    ..On comparison with the wild type, reactions of the variant showed increased resonance dependence; this observation together with changed pH optimum and cofactor dependence suggests an altered reaction mechanism...
  6. ncbi Crystal structures of the Chromobacterium violaceumω-transaminase reveal major structural rearrangements upon binding of coenzyme PLP
    Maria S Humble
    Division of Biochemistry, KTH Royal Institute of Technology, Stockholm, Sweden
    FEBS J 279:779-92. 2012
    ....
  7. ncbi Transaminations with isopropyl amine: equilibrium displacement with yeast alcohol dehydrogenase coupled to in situ cofactor regeneration
    Karim Engelmark Cassimjee
    Division of Biochemistry, School of Biotechnology, Royal Institute of Technology KTH, AlbaNova University Centre, SE 106 91 Stockholm, Sweden
    Chem Commun (Camb) 46:5569-71. 2010
    ....
  8. ncbi Enzyme promiscuity: mechanism and applications
    Karl Hult
    School of Biotechnology, Department of Biochemistry, Royal Institute of Technology KTH, AlbaNova University Center, SE 106 91 Stockholm, Sweden
    Trends Biotechnol 25:231-8. 2007
    ..Exploiting enzyme catalytic promiscuity might lead to improvements in existing catalysts and provide novel synthesis pathways that are currently not available...
  9. ncbi One-step enzyme extraction and immobilization for biocatalysis applications
    Karim Engelmark Cassimjee
    Division of Biochemistry, School of Biotechnology, Royal Institute of Technology KTH, AlbaNova University Center, Stockholm, Sweden
    Biotechnol J 6:463-9. 2011
    ....
  10. ncbi Silica-immobilized His6-tagged enzyme: alanine racemase in hydrophobic solvent
    Karim Engelmark Cassimjee
    Department of Biochemistry, School of Biotechnology, Royal Institute of Technology KTH, AlbaNova University Center, SE 106 91 Stockholm, Sweden
    Biotechnol Bioeng 99:712-6. 2008
    ..This practical method is a first step towards a general immobilization method for synthesis applications with any enzyme suitable for His6-tagging...
  11. ncbi Carbon-carbon bonds by hydrolytic enzymes
    Cecilia Branneby
    Department of Biotechnology, KTH, AlbaNova University Center, SE-106 91 Stockholm, Sweden
    J Am Chem Soc 125:874-5. 2003
    ..We expect that the new catalytic activity, harbored in the stable protein scaffold of the lipase, will allow aldol additions of substrates, which cannot be reached by traditional aldolases...
  12. ncbi Synthesis of cyclic polyamines by enzymatic generation of an amino aldehyde in situ
    Karim Engelmark Cassimjee
    School of Biotechnology, AlbaNova University Center, Stockholm, Sweden
    Macromol Rapid Commun 33:1580-3. 2012
    ..The enzyme also had activity for 2-amino-propan-1-ol and 2-amino-2-phenyl-ethanol, for which the enantioselectivity was 330 (S) and 32 (R), respectively...
  13. ncbi Exploring the active-site of a rationally redesigned lipase for catalysis of Michael-type additions
    Peter Carlqvist
    Physical Chemistry, Royal Institute of Technology (KTH, 100 44 Stockholm, Sweden
    Chembiochem 6:331-6. 2005
    ..The enzyme proficiency was 10(7). Furthermore, the Michael-type reactions followed saturation kinetics and were confirmed to take place in the enzyme active site...