Erik Portelius

Summary

Country: Sweden

Publications

  1. ncbi request reprint Altered cerebrospinal fluid levels of amyloid β and amyloid precursor-like protein 1 peptides in Down's syndrome
    Erik Portelius
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Neuromolecular Med 16:510-6. 2014
  2. pmc Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice
    Kathryn Rogers
    EnVivo Pharmaceuticals, Inc, 500 Arsenal Street, Watertown, MA 02472, USA
    Mol Neurodegener 7:61. 2012
  3. doi request reprint Mass spectrometric characterization of amyloid-β species in the 7PA2 cell model of Alzheimer's disease
    Erik Portelius
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 33:85-93. 2013
  4. pmc Amyloid-β(1-15/16) as a marker for γ-secretase inhibition in Alzheimer's disease
    Erik Portelius
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 31:335-41. 2012
  5. pmc The amyloid-β isoform pattern in cerebrospinal fluid in familial PSEN1 M139T- and L286P-associated Alzheimer's disease
    Erik Portelius
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Mol Med Rep 5:1111-5. 2012
  6. doi request reprint Evaluation of the performance of novel Aβ isoforms as theragnostic markers in Alzheimer's disease: from the cell to the patient
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Neurodegener Dis 10:138-40. 2012
  7. doi request reprint Acute effect on the Aβ isoform pattern in CSF in response to γ-secretase modulator and inhibitor treatment in dogs
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 21:1005-12. 2010
  8. pmc Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease
    Erik Portelius
    Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Acta Neuropathol 120:185-93. 2010
  9. pmc A novel Abeta isoform pattern in CSF reflects gamma-secretase inhibition in Alzheimer disease
    Erik Portelius
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, SE 431 80, Sweden
    Alzheimers Res Ther 2:7. 2010
  10. pmc Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, SE 431 80 Molndal, Sweden
    Neurodegener Dis 6:258-62. 2009

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Altered cerebrospinal fluid levels of amyloid β and amyloid precursor-like protein 1 peptides in Down's syndrome
    Erik Portelius
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Neuromolecular Med 16:510-6. 2014
    ..This study indicates that DS causes previously unknown specific alterations of APP and APLP1 metabolism...
  2. pmc Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice
    Kathryn Rogers
    EnVivo Pharmaceuticals, Inc, 500 Arsenal Street, Watertown, MA 02472, USA
    Mol Neurodegener 7:61. 2012
    ..This approach, frequently called γ-secretase modulation, appears more promising and has lead to the development of new therapeutic candidates for disease modification in Alzheimer's disease...
  3. doi request reprint Mass spectrometric characterization of amyloid-β species in the 7PA2 cell model of Alzheimer's disease
    Erik Portelius
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 33:85-93. 2013
    ..The formation of these AβPP/Aβ peptides may have implications for the use of the 7PA2 cell line as a model for Aβ pathology. The enzyme(s) responsible for this particular BACE1-independent AβPP-processing remains to be identified...
  4. pmc Amyloid-β(1-15/16) as a marker for γ-secretase inhibition in Alzheimer's disease
    Erik Portelius
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 31:335-41. 2012
    ..Our data shows that CSF levels of Aβ(1-15/16) increase during treatment with semagacestat supporting its feasibility as a pharmacodynamic biomarker for drug candidates aimed at inhibiting γ-secretase-mediated AβPP-processing...
  5. pmc The amyloid-β isoform pattern in cerebrospinal fluid in familial PSEN1 M139T- and L286P-associated Alzheimer's disease
    Erik Portelius
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Mol Med Rep 5:1111-5. 2012
    ....
  6. doi request reprint Evaluation of the performance of novel Aβ isoforms as theragnostic markers in Alzheimer's disease: from the cell to the patient
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Neurodegener Dis 10:138-40. 2012
    ....
  7. doi request reprint Acute effect on the Aβ isoform pattern in CSF in response to γ-secretase modulator and inhibitor treatment in dogs
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 21:1005-12. 2010
    ..The data presented suggests that the γ-secretase modulator E-2012 alters the cleavage site preference of γ-secretase. The increase in Aβ(1-37) may inhibit Aβ(1-42) oligomerization and toxicity...
  8. pmc Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease
    Erik Portelius
    Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Acta Neuropathol 120:185-93. 2010
    ..No prominent differences in Abeta isoform patterns between FAD and SAD patients were seen, underscoring the similarity in the amyloid pathology of these two disease entities...
  9. pmc A novel Abeta isoform pattern in CSF reflects gamma-secretase inhibition in Alzheimer disease
    Erik Portelius
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, SE 431 80, Sweden
    Alzheimers Res Ther 2:7. 2010
    ..These Abeta isoforms may be novel sensitive biomarkers to monitor the biochemical effect in clinical trials. TRIAL REGISTRATION : Clinical Trials.gov NCT00244322...
  10. pmc Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, SE 431 80 Molndal, Sweden
    Neurodegener Dis 6:258-62. 2009
    ..g. Abeta1-15 and Abeta1-16), and that the levels of these shorter isoforms are elevated in media from cells that have been treated with gamma-secretase inhibitors...
  11. doi request reprint A novel pathway for amyloid precursor protein processing
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, S 431 80 Molndal, Sweden
    Neurobiol Aging 32:1090-8. 2011
    ....
  12. doi request reprint Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal fluid
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, S 431 80 Molndal, Sweden
    Exp Neurol 223:351-8. 2010
    ....
  13. ncbi request reprint Determination of beta-amyloid peptide signatures in cerebrospinal fluid using immunoprecipitation-mass spectrometry
    Erik Portelius
    Institute of Clinical Neuroscience, Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, 43180 Mölndal, Sweden
    J Proteome Res 5:1010-6. 2006
    ..Finally, the Abeta fragment signatures may prove useful as a diagnostic test for AD...
  14. ncbi request reprint An Alzheimer's disease-specific beta-amyloid fragment signature in cerebrospinal fluid
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, Molndal, Sweden
    Neurosci Lett 409:215-9. 2006
    ..Here, we provide direct evidence that an Abeta fragment signature consisting of Abeta1-16, Abeta1-33, Abeta1-39, and Abeta1-42 in CSF distinguishes sporadic AD patients from non-demented controls with an overall accuracy of 86%...
  15. ncbi request reprint Novel aβ isoforms in Alzheimer's disease - their role in diagnosis and treatment
    Erik Portelius
    Clinical Neurochemistry Laboratory Institute of Neuroscience and Physiology Dept of Psychiatry and Neurochemistry The Sahlgrenska Academy at the University of Gothenburg Sahlgrenska University Hospital, Mölndal SE 431 80 Mölndal, Sweden
    Curr Pharm Des 17:2594-602. 2011
    ..Here, we review the many aspects of Aβ and its isoforms with special focus on their potential role as diagnostic and theragnostic markers...
  16. ncbi request reprint Characterization of amyloid beta peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, S 431 80 Molndal, Sweden
    J Proteome Res 6:4433-9. 2007
    ..Finally, we report the finding of two novel Abeta peptides (Abeta2-17 and Abeta3-17)...
  17. doi request reprint Characterization of tau in cerebrospinal fluid using mass spectrometry
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, S 431 80 Molndal, Sweden
    J Proteome Res 7:2114-20. 2008
    ..Nineteen tryptic fragments of tau were detected, of which 16 are found in all tau isoforms while 3 represented unique tau isoforms. These results pave the way for clinical CSF studies on the tauopathies...
  18. doi request reprint Targeted proteomics in Alzheimer's disease: focus on amyloid-beta
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Expert Rev Proteomics 5:225-37. 2008
    ..From a longer perspective, establishment of the most effective combinations of different biomarkers and other diagnostic modalities may be foreseen...
  19. doi request reprint Identification of novel APP/Abeta isoforms in human cerebrospinal fluid
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, Molndal, Sweden
    Neurodegener Dis 6:87-94. 2009
    ..A lot of research has focused on Abeta production and the neurotoxic 42-amino-acid form of Abeta (Abeta1-42), while less is known about the nonamyloidogenic pathway and how Abeta is degraded...
  20. doi request reprint Soluble amyloid precursor protein α and β in CSF in Alzheimer's disease
    Gunnar Brinkmalm
    Department of Psychiatry and Neurochemistry, Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Brain Res 1513:117-26. 2013
    ..Conclusion: Using high resolution MS, we show here for the first time that sAPPα in CSF ends at Q686 and K687. The findings also support the conclusion from several previous studies that sAPPα and sAPPβ levels are unaltered in AD...
  21. doi request reprint Cerebrospinal fluid biomarkers of β-amyloid metabolism in multiple sclerosis
    Kristin Augutis
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Mult Scler 19:543-52. 2013
    ....
  22. doi request reprint Amyloid-β metabolism in Niemann-Pick C disease models and patients
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Gothenburg, Sweden
    Metab Brain Dis 27:573-85. 2012
    ..The preliminary findings from NPC cats suggest that treatment with cyclodextrin may have an impact on APP processing pathways. CSF Aβ, sAPP and tau biomarkers were dynamically altered over time in human NPC patients...
  23. doi request reprint An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid β and amyloid precursor protein in human and cat cerebrospinal fluid
    Gunnar Brinkmalm
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    J Mass Spectrom 47:591-603. 2012
    ..We here describe a detailed characterization of endogenous APP/Aβ peptide species in CSF by using an online top-down MS-based method...
  24. doi request reprint Aβ1-15/16 as a potential diagnostic marker in neurodegenerative diseases
    Magdalena Nutu
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital Molndal, S 431 80, Molndal, Sweden
    Neuromolecular Med 15:169-79. 2013
    ..We found reduced levels of Aβ1-15 in parkinsonian disease groups. The molecular mechanism behind this reduction is at present unknown...
  25. doi request reprint Longitudinal cerebrospinal fluid biomarkers over four years in mild cognitive impairment
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 30:767-78. 2012
    ..Knowledge on these biomarkers and their trajectories may facilitate early diagnosis of AD and be useful in future clinical trials to track effects of disease modifying drugs...
  26. ncbi request reprint Proteomics/peptidomics tools to find CSF biomarkers for neurodegenerative diseases
    Ann Westman-Brinkmalm
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neuochemistry, The Sahlgrenska Academy at Goteborg University, Sweden
    Front Biosci (Landmark Ed) 14:1793-806. 2009
    ..In this review we discuss our experience in the field of neuroproteomics/peptidomics, with special focus on biomarker discovery studies that have been performed on CSF samples from well-defined patient and control populations...
  27. pmc BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    PLoS ONE 7:e31084. 2012
    ..The described CSF Aβ pattern may be used as a pharmacodynamic fingerprint to detect biochemical effects of BACE1-therapies in clinical trials, which might accelerate development of novel therapies...
  28. doi request reprint Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid β42
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Molndal, Sweden
    Biomark Med 6:409-17. 2012
    ..We describe possible technical approaches, focusing on a selected reaction monitoring mass spectrometry assay as a candidate reference method for quantification of CSF amyloid β42...
  29. doi request reprint A selected reaction monitoring (SRM)-based method for absolute quantification of Aβ38, Aβ40, and Aβ42 in cerebrospinal fluid of Alzheimer's disease patients and healthy controls
    Josef Pannee
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 33:1021-32. 2013
    ..We suggest this SRM-based method for Aβ peptide quantification in human CSF valuable for clinical research and trials...
  30. pmc Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid beta-peptides in human cerebrospinal fluid
    Adnan Halim
    Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, University of Gothenburg, SE 413 45 Gothenburg, Sweden
    Proc Natl Acad Sci U S A 108:11848-53. 2011
    ..APP/Aβ sialylated O-glycans, including that of a Tyr residue, the first in a mammalian protein, may modulate APP processing, inhibiting the amyloidogenic pathway associated with AD...
  31. doi request reprint Multiplexing and multivariate analysis in neurodegeneration
    Ulf Andreasson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Methods 56:464-70. 2012
    ..An introduction to one such algorithm is presented followed by examples from the literature, in the field of neurodegeneration, where multiplex and multivariate methods have been used...
  32. doi request reprint Synaptic retrogenesis and amyloid-beta in Alzheimer's disease
    Pontus Wasling
    Department of Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    J Alzheimers Dis 16:1-14. 2009
    ..Here, we review the literature on the possible physiological roles of Abeta and its precursor protein AbetaPP during development with special focus on electrophysiological findings...
  33. ncbi request reprint The amyloid-β degradation pattern in plasma-A possible tool for clinical trials in Alzheimer's disease
    Josef Pannee
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Neurosci Lett 573:7-12. 2014
    ....
  34. ncbi request reprint Evaluation of sample fractionation using micro-scale liquid-phase isoelectric focusing on mass spectrometric identification and quantitation of proteins in a SILAC experiment
    Annika Thorsell
    Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Goteborg University, Sahlgrenska University Hospital, Molndal, Sweden
    Rapid Commun Mass Spectrom 21:771-8. 2007
    ..Furthermore, the fractionation enhanced the number of identified proteins and improved their quantitation...
  35. ncbi request reprint Mapping abeta amyloid fibril secondary structure using scanning proline mutagenesis
    Angela D Williams
    Graduate School of Medicine, R221, University of Tennessee, 1924 Alcoa Highway, Knoxville, TN 37920, USA
    J Mol Biol 335:833-42. 2004
    ....