Fredrik Petersson

..The proliferative index as measured immunohistochemically (Mib-1/Ki-67) was 5%. The extent of these atypical histological features has not previously been described. One-year follow-up has been uneventful...

..Strong immunohistochemical expression of p53 was documented in both the carcinomatous and sarcomatous components as well as in the atypical epithelial component in the transition zone associated with the hyalinized pleomorphic adenoma...

..The intracranial tumor was associated with prominent intracerebral edema and displayed, in addition to a prominent intratumoral T-cell component, a hitherto unreported component of prominent intratumoral B cells and plasma cells...

..2). Subsequent urological examination confirmed a locally advanced prostatic carcinoma with significantly increased serum-PSA (4,561 μg/l) and bone scintigraphy showed widespread metastasis...

..Adjuvant radiotherapy was administered. No local recurrence or metastatic disease has been detected during a follow up period of 28 months...

..Although the malignant component displayed patchy areas with nuclear p53 immunoreactivity with variable intensity, no mutation in the TP53 gene was identified...

..Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases...

..This is the first reported case of a sarcomatoid CRCC where the sarcomatous component displayed features of a pleomorphic liposarcoma. The patient died from widespread metastatic disease 12 months after nephrectomy...

..There were strong cytomorphological similarities between the invasive carcinoma and the low-grade ductal carcinoma in situ, which also showed significant overlap in the immunohistochemical findings...

..The proliferative activity (Mib-1/Ki-67) was low; 3-4%. In the molecular genetic study we found no mutations at position 1799 (exon 15) in the BRAF-gene, (BRAFV600E) or in exons 9 and 11 of the KIT-gene...

..Mib-1/Ki-67 showed an average proliferation of 60-70%. Fluorescent in situ hybridization revealed no EWS-gene translocation. In situ hybridization for EBER was negative...

..This unique presentation emphasizes the importance of considering this pathologic entity when solitary smooth muscle tumors with the histological features of an angioleiomyoma are encountered in immunocompromised patients...

..The proliferative activity (Mib-1/Ki-67) was low (1-2%) in the benign component whereas increased proliferation was seen in the DCIS and in the areas with pseudoinfiltration which also featured atypical mitoses...

..Awareness of the histological spectrum of NK-NPC is important in clinical practice and this is not always adequately highlighted in currently used standard textbooks of head and neck pathology...

..Intralesional small neurites positive for neurofilament and perilesional perineural cells positive for epithelial membrane antigen were documented immunohistochemically...

..The proliferative activity was low (<5%) in areas both with and without matrix production. Despite significant tumor volume and high-grade histologic features, an 8-year follow-up has been uneventful...

..These are compared with all the previously published cases. Clinical and histopathological differential diagnoses are discussed, and a literature review is presented...

..The latter are especially important in some extraordinary cases in which there may be an associated intraepithelial melanocytic hyperplasia...

..4 (95% CI 1.2-16.8). For the first time, we herein show a positive correlation with LVI in melanoma detected with immunohistochemistry and distant metastasis, overall survival and disease-free survival...

..Owing to the small number of published ASPSs in the cervix, the optimal treatment strategy has yet to be determined...

..pylori infection. There are some differences regarding inflammation, proliferative activity, and p53 expression between the cardia and other regions of the stomach, yet the significance of these differences remains to be clarified...

..p63 was positive in the peripheral parts of the neoplastic ducts with negative reaction in the luminal cells...

..No other germ cell tumor components were found. To the best of our knowledge, we herein present the first tumor of a pure classical seminoma with an associated low-grade sarcomatous component...

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..No von Hippel-Lindau tumor suppressor gene mutation, promotor methylation or loss of heterozygosity of 3p was found. Losses of part of chromosome 1 and chromosome 22 were found in one case...

..At worst, these tumors could have a low malignant potential, which only can be found out with longer follow-up...

..All tumors behaved in a benign fashion during follow-up (mean, 3.1 years; median, 1 year)...

..No immunohistochemical evidence of neuroendocrine differentiation was identified with synaptophysin, chromogranin A, and CD56...

..This tumor displayed a complex karyotype. A novel germ line mutation in the VHL gene (c.439A>G/p.I147V) was also identified in this patient...

..pylori infection. The action of p53 appears to be independent of p21 activity...

..Multiple chromosomal aberrations were identified, some of them located in regions with known tumor suppressor genes and oncogenes...

..The authors aim to characterize the clinicopathological features and survival outcomes of nonexophytic NPC in a high-incidence area...

..This case emphasizes the importance of considering this pathologic entity when solitary smooth muscle actin-expressing tumors are encountered in the larynx of immunocompromised patients...

..In agreement with Lazenby's statement: "Focusing solely on the collagen band can result in both over- and underdiagnosis"..

..The patient is alive and well 3 years after the orchiectomy without additional treatment...

..This appearance of the tumor simulated a metastasis that was excluded by exhaustive radiologic and clinicopathologic investigations...

..KRAS genetic analysis did not reveal any mutations of codons 12, 13 and 61...

..Serrated adenomas of the cardia seem to have a particular proclivity to evolve into invasive carcinomas...

..Short follow-up precludes conclusion on the implication of positive margins in conjunction with adjuvant radiotherapy for one of the patients presented herein...

..Although educated pathologists were faster, the level of pathology training is not crucial for obtaining reproducible results in the analysis of TMA-based studies...

..Desmoplastic small round cell tumor should be considered in the differential diagnosis of a salivary gland neoplasm with a basaloid or small cell pattern on fine-needle aspiration cytology...

..To document and clarify the nature of intranuclear inclusions of luminal epithelium in benign proliferative breast lesions...

..The tumor displayed a heretofore unpublished combination of extensive metaplastic bone formation and prominent non-psammomatous calcifications with focal chicken-wire pattern...