Ruth H Palmer

Summary

Country: Sweden

Publications

  1. ncbi request reprint The ligand Jelly Belly (Jeb) activates the Drosophila Alk RTK to drive PC12 cell differentiation, but is unable to activate the mouse ALK RTK
    Hai ling Yang
    Department of Medical Biosciences, Umea University, Umeå S 901 87, Sweden
    J Exp Zool B Mol Dev Evol 308:269-82. 2007
  2. pmc ALK and NSCLC: Targeted therapy with ALK inhibitors
    Bengt Hallberg
    Department of Molecular Biology, Umea University, Umeå S 901 87 Sweden
    F1000 Med Rep 3:21. 2011
  3. pmc The Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogaster
    Margret Shirinian
    Department of Molecular Biology, Umea University, Umea, Sweden
    PLoS ONE 5:e9403. 2010
  4. pmc Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth
    Pei I Tsai
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    Neural Dev 3:26. 2008
  5. pmc Anaplastic lymphoma kinase: signalling in development and disease
    Ruth H Palmer
    Department of Molecular Biology, Umea University, Umea, Sweden
    Biochem J 420:345-61. 2009
  6. ncbi request reprint Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion
    Camilla Englund
    Umeå Center for Molecular Pathogenesis, Umea University, Umea, S 901 87, Sweden
    Nature 425:512-6. 2003
  7. ncbi request reprint Focal adhesion kinase is not required for integrin function or viability in Drosophila
    Caroline Grabbe
    Umeå Center for Molecular Pathogenesis, Building 6L, Umea University, Umea, 901 87, Sweden
    Development 131:5795-805. 2004
  8. doi request reprint Jeb/Alk signalling regulates the Lame duck GLI family transcription factor in the Drosophila visceral mesoderm
    Dmitry Popichenko
    Department of Molecular Biology, Building 6L, Umea University, Umea S 90187, Sweden
    Development 140:3156-66. 2013
  9. pmc Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma
    Damini Chand
    Department of Molecular Biology, Building 6L, Umea University, Umea 901 87, Sweden
    Dis Model Mech 6:373-82. 2013
  10. doi request reprint Activating ALK mutations found in neuroblastoma are inhibited by Crizotinib and NVP-TAE684
    Christina Schönherr
    Department of Molecular Biology, Building 6L, Umea University, Umea 901 87, Sweden
    Biochem J 440:405-13. 2011

Collaborators

Detail Information

Publications25

  1. ncbi request reprint The ligand Jelly Belly (Jeb) activates the Drosophila Alk RTK to drive PC12 cell differentiation, but is unable to activate the mouse ALK RTK
    Hai ling Yang
    Department of Medical Biosciences, Umea University, Umeå S 901 87, Sweden
    J Exp Zool B Mol Dev Evol 308:269-82. 2007
    ....
  2. pmc ALK and NSCLC: Targeted therapy with ALK inhibitors
    Bengt Hallberg
    Department of Molecular Biology, Umea University, Umeå S 901 87 Sweden
    F1000 Med Rep 3:21. 2011
    ..This article discusses the current knowledge and potential implications concerning ALK inhibitors and NSCLC...
  3. pmc The Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogaster
    Margret Shirinian
    Department of Molecular Biology, Umea University, Umea, Sweden
    PLoS ONE 5:e9403. 2010
    ..Taken together, we conclude that Drosophila C3G is a Rap1-specific GEF with important functions in maintaining muscle integrity during larval stages...
  4. pmc Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth
    Pei I Tsai
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    Neural Dev 3:26. 2008
    ..Neuronal function of FAK has been suggested to control axonal branching; however, the underlying mechanism in this process is not clear...
  5. pmc Anaplastic lymphoma kinase: signalling in development and disease
    Ruth H Palmer
    Department of Molecular Biology, Umea University, Umea, Sweden
    Biochem J 420:345-61. 2009
    ..In the present review we address the role of ALK in development and disease and discuss implications for the future...
  6. ncbi request reprint Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion
    Camilla Englund
    Umeå Center for Molecular Pathogenesis, Umea University, Umea, S 901 87, Sweden
    Nature 425:512-6. 2003
    ....
  7. ncbi request reprint Focal adhesion kinase is not required for integrin function or viability in Drosophila
    Caroline Grabbe
    Umeå Center for Molecular Pathogenesis, Building 6L, Umea University, Umea, 901 87, Sweden
    Development 131:5795-805. 2004
    ..Despite this, overexpressed Fak56 is a potent inhibitor of integrins binding to the extracellular matrix, suggesting that Fak56 may play a subtle role in the negative regulation of integrin adhesion...
  8. doi request reprint Jeb/Alk signalling regulates the Lame duck GLI family transcription factor in the Drosophila visceral mesoderm
    Dmitry Popichenko
    Department of Molecular Biology, Building 6L, Umea University, Umea S 90187, Sweden
    Development 140:3156-66. 2013
    ..Our results suggest that Lmd is a target of Jeb/Alk signalling in the VM of Drosophila embryos. ..
  9. pmc Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma
    Damini Chand
    Department of Molecular Biology, Building 6L, Umea University, Umea 901 87, Sweden
    Dis Model Mech 6:373-82. 2013
    ..Irrespective of the nature of the observed ALK mutants, in every case the activity of the mutant ALK receptors could be abrogated by the ALK inhibitor crizotinib (Xalkori/PF-02341066), albeit with differing levels of sensitivity...
  10. doi request reprint Activating ALK mutations found in neuroblastoma are inhibited by Crizotinib and NVP-TAE684
    Christina Schönherr
    Department of Molecular Biology, Building 6L, Umea University, Umea 901 87, Sweden
    Biochem J 440:405-13. 2011
    ..Importantly for neuroblastoma patients, all ALK mutations used in the present study can be blocked by the inhibitors, although some mutants exhibited higher levels of drug sensitivity than others...
  11. pmc Electrostatic interactions play a minor role in the binding of ExoS to 14-3-3 proteins
    Lubna Yasmin
    Department of Molecular Biology, Umea University, Sweden
    Biochem J 427:217-24. 2010
    ..Thus the interaction between the 'roof' of the groove of 14-3-3 and ExoS relies more on hydrophobic interaction forces, which probably contributes to induce cell death after ExoS infection and activation...
  12. ncbi request reprint Exoenzyme S of Pseudomonas aeruginosa is not able to induce apoptosis when cells express activated proteins, such as Ras or protein kinase B/Akt
    Anna L Jansson
    Department of Medical Biosciences Pathology, Umea University, S 901 87, Umea, Sweden
    Cell Microbiol 8:815-22. 2006
    ..In conclusion, we suggest that Ras proteins are an important cellular target for the P. aeruginosa toxin ExoS, which induces cell death during pathogenesis as a means of defending the bacterium against eukaryotic phagocytosis...
  13. ncbi request reprint Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation
    Charlotte E Edling
    Department of Medical Biosciences Pathology, Umea University, Umea, Sweden
    Br J Haematol 136:260-8. 2007
    ..This report showed that this specific feedback mechanism of c-PKC mediated phosphorylation of the c-Kit receptor has consequences for both proliferation and survival of HSC-like cell lines...
  14. pmc Characterisation of the role of Vrp1 in cell fusion during the development of visceral muscle of Drosophila melanogaster
    Therese Eriksson
    Department of Molecular Biology, Building 6L, Umea University, Umea S 90187, Sweden
    BMC Dev Biol 10:86. 2010
    ..While Verprolin has been shown to be important for somatic muscle cell fusion, the function of this protein in visceral muscle fusion has not been determined...
  15. pmc Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells
    Kamaraj Sattu
    Department of Molecular Biology, Umea University, Sweden
    FEBS J 280:5269-82. 2013
    ..These observations, together with a decreased level of MYCN and inhibition of neuroblastoma cell growth in the presence of STAT3 inhibitors, suggest that activation of STAT3 is important for ALK signaling activity in neuroblastoma...
  16. doi request reprint Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology
    Bengt Hallberg
    Department of Molecular Biology, Building 6L, Umea University, Umea S 90187, Sweden
    Nat Rev Cancer 13:685-700. 2013
    ..In this Review, we discuss our current understanding of ALK function in human cancer and the implications for tumour treatment. ..
  17. pmc Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation
    Yasuo Yamazaki
    Department of Molecular Biology, Umea University, Umea, Sweden
    EMBO J 32:524-37. 2013
    ..Thus, Goliath ubiquitin ligases play a novel role in regulating recycling endosome trafficking via ubiquitylation of the VAMP3 SNARE protein...
  18. ncbi request reprint The bHLH transcription factor Hand is regulated by Alk in the Drosophila embryonic gut
    Gaurav K Varshney
    Umeå Center for Molecular Pathogenesis, Building 6L, Umea University, Umeå S 901 87, Sweden
    Biochem Biophys Res Commun 351:839-46. 2006
    ..Finally, we have investigated the process of muscle fusion in the gut of Hand mutant animals and can find no obvious defects in this process, suggesting that Hand is not critical for visceral muscle fusion per se...
  19. pmc The Neuroblastoma ALK(I1250T) Mutation Is a Kinase-Dead RTK In Vitro and In Vivo
    Christina Schönherr
    Department of Molecular Biology, Umea University, Umea, Sweden
    Transl Oncol 4:258-65. 2011
    ..We suggest that the ALK(I1250T) mutation leads to a kinase-dead ALK RTK, in stark contrast to assumed gain-of-function status, with significant implications for patients reported to carry this particular ALK mutation...
  20. ncbi request reprint Activation of the MAP kinase pathway by c-Kit is PI-3 kinase dependent in hematopoietic progenitor/stem cell lines
    Ewa Wandzioch
    Umeå Center for Molecualr Medicine, and Department of Medical Biosciences Pathology, Umea University, S 901 87 Umea, Sweden
    Blood 104:51-7. 2004
    ....
  21. ncbi request reprint Miple1 and miple2 encode a family of MK/PTN homologues in Drosophila melanogaster
    Camilla Englund
    Umeå Center for Molecular Pathogenesis, Umea University, Umea, 901 87, Sweden
    Dev Genes Evol 216:10-8. 2006
    ..The identification of homologues of the MK/PTN family in this genetically tractable model organism should allow an analysis of their function during complex developmental processes...
  22. ncbi request reprint Tumour-associated mutations of PA-TM-RING ubiquitin ligases RNF167/RNF13 identify the PA domain as a determinant for endosomal localization
    Jesper R van Dijk
    Department of Molecular Biology, Umea University, 90187 Umea, Sweden
    Biochem J 459:27-36. 2014
    ..Thus the PA domain E3 ligases examined in the present study appear to require both E3 ligase activity as well as an intact PA domain to efficiently target and ubiquitylate their cellular substrates. ..
  23. pmc A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster
    Christina E Lorén
    Umeå Center for Molecular Pathogenesis, Umea University, Sweden
    EMBO Rep 4:781-6. 2003
    ..We propose that the main function of Drosophila Alk during early embryogenesis is in visceral mesoderm development...
  24. ncbi request reprint Delineation of exoenzyme S residues that mediate the interaction with 14-3-3 and its biological activity
    Lubna Yasmin
    Department of Medical Biosciences Pathology, Umea University, Sweden
    FEBS J 273:638-46. 2006
    ..Leucine-428 is also required for the ability of ExoS to modify the eukaryotic endogenous target Ras. Finally, single amino acid substitutions of positions 426-428 reduce the interaction potential of 14-3-3 with ExoS in vitro...
  25. ncbi request reprint Characterization of the expression of the ALK receptor tyrosine kinase in mice
    Emma Vernersson
    Department of Medical Biosciences Pathology, Building 6M, 2nd Floor, Umea University, S 901 87 Umea, Sweden
    Gene Expr Patterns 6:448-61. 2006
    ..Furthermore, ALK is also expressed in the eye, nasal epithelium, olfactory nerve, tongue, skin, tissue surrounding the esophagus, stomach and midgut but not the hindgut. Expression of ALK is also found in testis and ovary...