Torbjörn K Nilsson

Summary

Affiliation: Orebro University Hospital
Country: Sweden

Publications

  1. ncbi A folate receptor alpha double-mutated haplotype 1816delC-1841A is distributed throughout Eurasia and associated with lower erythrocyte folate levels
    Torbjörn K Nilsson
    Department of Laboratory Medicine, Clinical Chemistry, Orebro University Hospital, and School of Health and Medical Sciences, Orebro University, 701 85, Orebro, Sweden
    Mol Biol Rep 39:4471-8. 2012
  2. ncbi Quantitative measurement of carotid atherosclerosis in relation to levels of von Willebrand factor and fibrinolytic variables in plasma--a 2-year follow-up study
    Torbjörn K Nilsson
    Dept of Clinical Chemistry, Umea University Hospital, London, Canada
    J Cardiovasc Risk 9:215-21. 2002
  3. ncbi Genotyping of the reduced folate carrier-1 c.80G>A polymorphism by pyrosequencing technology: importance of PCR and pre-PCR optimization
    T K Nilsson
    Department of Clinical Chemistry, Orebro University Hospital, Orebro, Sweden
    Scand J Clin Lab Invest 68:166-70. 2008
  4. ncbi Simultaneous genotyping of the three lactose tolerance-linked polymorphisms LCT -13907C>G, LCT -13910C>T and LCT -13915T>G with Pyrosequencing technology
    Torbjörn K Nilsson
    Department of Clinical Chemistry, Orebro University Hospital, Orebro, Sweden
    Clin Chem Lab Med 46:80-4. 2008
  5. ncbi Comparison of soluble thrombomodulin, von Willebrand factor, tPA/PAI-1 complex, and high-sensitivity CRP concentrations in serum, EDTA plasma, citrated plasma, and acidified citrated plasma (Stabilyte) stored at -70 degrees C for 8-11 years
    Torbjörn K Nilsson
    Department of Clinical Chemistry, Orebro University Hospital, Orebro, Sweden
    Thromb Res 116:249-54. 2005
  6. ncbi High folate intake is related to better academic achievement in Swedish adolescents
    Torbjörn K Nilsson
    Department of Laboratory Medicine, Orebro University Hospital, Sweden
    Pediatrics 128:e358-65. 2011
  7. ncbi A novel method for diagnosis of adult hypolactasia by genotyping of the -13910 C/T polymorphism with Pyrosequencing technology
    T K Nilsson
    Dept of Clinical Chemistry and the Clinical Research Center, Orebro University Hospital, Orebro, Sweden
    Scand J Gastroenterol 39:287-90. 2004
  8. ncbi Changes in plasma C-reactive protein and hemostatic factors prior to and after a first myocardial infarction with a median follow-up time of 8 years
    Anna M Thøgersen
    Department of Public Health and Clinical Medicine, Umea University Hospital, Umea, Sweden
    Blood Coagul Fibrinolysis 20:340-6. 2009
  9. ncbi Prospective study of first stroke in relation to plasma homocysteine and MTHFR 677C>T and 1298A>C genotypes and haplotypes - evidence for an association with hemorrhagic stroke
    Johan Hultdin
    Clinical Chemistry, Department of Medical Biosciences, Umea University, Umea, Sweden
    Clin Chem Lab Med 49:1555-62. 2011
  10. ncbi Associations between lactase persistence and the metabolic syndrome in a cross-sectional study in the Canary Islands
    Ricardo Almon
    Family Medicine Research Centre, Orebro University, Sweden
    Eur J Nutr 49:141-6. 2010

Detail Information

Publications34

  1. ncbi A folate receptor alpha double-mutated haplotype 1816delC-1841A is distributed throughout Eurasia and associated with lower erythrocyte folate levels
    Torbjörn K Nilsson
    Department of Laboratory Medicine, Clinical Chemistry, Orebro University Hospital, and School of Health and Medical Sciences, Orebro University, 701 85, Orebro, Sweden
    Mol Biol Rep 39:4471-8. 2012
    ....
  2. ncbi Quantitative measurement of carotid atherosclerosis in relation to levels of von Willebrand factor and fibrinolytic variables in plasma--a 2-year follow-up study
    Torbjörn K Nilsson
    Dept of Clinical Chemistry, Umea University Hospital, London, Canada
    J Cardiovasc Risk 9:215-21. 2002
    ....
  3. ncbi Genotyping of the reduced folate carrier-1 c.80G>A polymorphism by pyrosequencing technology: importance of PCR and pre-PCR optimization
    T K Nilsson
    Department of Clinical Chemistry, Orebro University Hospital, Orebro, Sweden
    Scand J Clin Lab Invest 68:166-70. 2008
    ..A combination of these two modifications of the standard pyrosequencing PCR protocol gave the best results. We conclude that, with these modifications, the RFC1 c.80G>A SNP can be reliably assayed by pyrosequencing...
  4. ncbi Simultaneous genotyping of the three lactose tolerance-linked polymorphisms LCT -13907C>G, LCT -13910C>T and LCT -13915T>G with Pyrosequencing technology
    Torbjörn K Nilsson
    Department of Clinical Chemistry, Orebro University Hospital, Orebro, Sweden
    Clin Chem Lab Med 46:80-4. 2008
    ....
  5. ncbi Comparison of soluble thrombomodulin, von Willebrand factor, tPA/PAI-1 complex, and high-sensitivity CRP concentrations in serum, EDTA plasma, citrated plasma, and acidified citrated plasma (Stabilyte) stored at -70 degrees C for 8-11 years
    Torbjörn K Nilsson
    Department of Clinical Chemistry, Orebro University Hospital, Orebro, Sweden
    Thromb Res 116:249-54. 2005
    ..Indeed, using acidified Stabilyte plasma as the single medium would substantially simplify sampling for many epidemiological studies...
  6. ncbi High folate intake is related to better academic achievement in Swedish adolescents
    Torbjörn K Nilsson
    Department of Laboratory Medicine, Orebro University Hospital, Sweden
    Pediatrics 128:e358-65. 2011
    ..Folate status and Hcy metabolism are linked to cognitive functions, but academic achievement by adolescents has not been studied in this respect...
  7. ncbi A novel method for diagnosis of adult hypolactasia by genotyping of the -13910 C/T polymorphism with Pyrosequencing technology
    T K Nilsson
    Dept of Clinical Chemistry and the Clinical Research Center, Orebro University Hospital, Orebro, Sweden
    Scand J Gastroenterol 39:287-90. 2004
    ....
  8. ncbi Changes in plasma C-reactive protein and hemostatic factors prior to and after a first myocardial infarction with a median follow-up time of 8 years
    Anna M Thøgersen
    Department of Public Health and Clinical Medicine, Umea University Hospital, Umea, Sweden
    Blood Coagul Fibrinolysis 20:340-6. 2009
    ..A first myocardial infarction did not in this study induce significantly different changes in plasma levels of hs-CRP and hemostatic factors among patients compared with referents during follow-up...
  9. ncbi Prospective study of first stroke in relation to plasma homocysteine and MTHFR 677C>T and 1298A>C genotypes and haplotypes - evidence for an association with hemorrhagic stroke
    Johan Hultdin
    Clinical Chemistry, Department of Medical Biosciences, Umea University, Umea, Sweden
    Clin Chem Lab Med 49:1555-62. 2011
    ....
  10. ncbi Associations between lactase persistence and the metabolic syndrome in a cross-sectional study in the Canary Islands
    Ricardo Almon
    Family Medicine Research Centre, Orebro University, Sweden
    Eur J Nutr 49:141-6. 2010
    ..The single nucleotide polymorphism (SNP) LCT -13910 C>T, associated with genetically determined phenotypes of lactase persistence (LP) or non-persistence (LNP), was studied in relation to the metabolic syndrome (MS)...
  11. ncbi Folate, vitamin B12, and risk of ischemic and hemorrhagic stroke: a prospective, nested case-referent study of plasma concentrations and dietary intake
    Bethany Van Guelpen
    Department of Medical Biosciences, Umea University Hospital, Umea, Sweden
    Stroke 36:1426-31. 2005
    ....
  12. ncbi Association of total plasma homocysteine with methylenetetrahydrofolate reductase genotypes 677C>T, 1298A>C, and 1793G>A and the corresponding haplotypes in Swedish children and adolescents
    Anna K Böttiger
    Department of Clinical Chemistry, Orebro University Hospital, SE 701 85 Orebro, Sweden
    Int J Mol Med 19:659-65. 2007
    ..40). The major genetic impact on tHcy concentrations is attributable to the MTHFR 677C>T polymorphism. The common 1298A>C polymorphism had a minor elevating effect on tHcy, whereas the 1793G>A polymorphism had a lowering effect on tHcy...
  13. ncbi Prevalence and trends in adult-type hypolactasia in different age cohorts in Central Sweden diagnosed by genotyping for the adult-type hypolactasia-linked LCT -13910C > T mutation
    Ricardo Almon
    Family Medicine Research Centre, Department of Clinical Medicine, Orebro University, Sweden
    Scand J Gastroenterol 42:165-70. 2007
    ..The aims of this study were to estimate the prevalence of AtH by genotyping and to investigate whether AtH prevalence has changed in Sweden during the 20th century...
  14. ncbi Novel mutations in the 5'-UTR of the FOLR1 gene
    Anna K Börjel
    Department of Clinical Chemistry, Orebro University Hospital, Orebro, Sweden
    Clin Chem Lab Med 44:161-7. 2006
    ..Further studies of mutations in the 5'-UTR of FOLR1, and in particular of their interplay with folate intake status, are warranted...
  15. ncbi CSF/serum folate gradient: physiology and determinants with special reference to dementia
    Nils Olof Hagnelius
    Department of Geriatrics, Orebro University Hospital, Orebro, Sweden
    Dement Geriatr Cogn Disord 25:516-23. 2008
    ..Folate depletion has been implicated as a risk factor for neurodegenerative disorders. We hypothesized that transport of folate to the cerebrospinal fluid (CSF) compartment could be involved in the pathophysiology of these disorders...
  16. ncbi Mutations in exons 2 and 3 of the FOLR1 gene in demented and non-demented elderly subjects
    Anna K Böttiger
    Department of Clinical Chemistry, Orebro University Hospital, Orebro, Sweden
    Int J Mol Med 20:653-62. 2007
    ..Only a few of the rare mutations may potentially be associated with raised plasma tHcy concentrations. No association with dementia was found...
  17. ncbi Interactions between fibrinolysis, lipoproteins and leptin related to a first myocardial infarction
    Anna M Thøgersen
    Department of Medicine and Public Health, Umea University Hospital, Umea, Sweden
    Eur J Cardiovasc Prev Rehabil 11:33-40. 2004
    ....
  18. ncbi Hypermethylation of promoter regions of the APC1A and p16INK4a genes in relation to prognosis and tumor characteristics in cervical cancer patients
    Zarah M Löf-Öhlin
    Department of Laboratory Medicine, Clinical Chemistry, Orebro University Hospital, Orebro, Sweden
    Int J Oncol 39:683-8. 2011
    ....
  19. ncbi Improved fibrinolytic activity during exercise may be an effect of the adipocyte-derived hormones leptin and adiponectin
    Maria Eriksson
    Department of Public Health and Clinical Medicine, Medicine, Umea University Hospital, Umea, Sweden
    Thromb Res 122:701-8. 2008
    ..In this study, we explored if improved fibrinolytic activity during exercise could be linked to changes in leptin and adiponectin levels...
  20. ncbi DNA methylation pattern of the SLC25A43 gene in breast cancer
    Breezy Malakkaran Lindqvist
    School of Health and Medical Sciences, Orebro University, Orebro, Sweden
    Epigenetics 7:300-6. 2012
    ..Also, associations between site-specific methylation and clinicopathological parameters suggest that epigenetic changes in SLC25A43 gene could be of importance in breast carcinogenesis...
  21. ncbi Has folate a role in the developing nervous system after birth and not just during embryogenesis and gestation?
    Lars H Breimer
    Departments of Laboratory Medicine Orebro University Hospital, Orebro, Sweden
    Scand J Clin Lab Invest 72:185-91. 2012
    ..This review assesses the current state of evidence and sets the data in context of whether folate has a role in the development and plasticity of the nervous system even after birth, with particular emphasis on childhood and adolescence...
  22. ncbi Relative telomere length in patients with late-onset Alzheimer's dementia or vascular dementia
    Zarah M Löf-Öhlin
    Department of Clinical Chemistry, Orebro University Hospital, Sweden
    Neuroreport 19:1199-202. 2008
    ..315) nor women (P=0.12). Thus, we could not confirm that the length of telomeres would predict which form of dementia, late-onset AD or VaD that develops...
  23. ncbi Promoter methylation in the PTCH gene in cervical epithelial cancer and ovarian cancer tissue as studied by eight novel Pyrosequencing® assays
    Zarah M Löf-Öhlin
    Department of Laboratory Medicine, Orebro University Hospital, Orebro, Sweden
    Int J Oncol 38:685-92. 2011
    ..Our data suggest that methylation of the PTCH promoter is not a high-prevalence feature of squamous cell cervical cancer or ovarian cancer, but Pyrosequencing assays are a good method for studying promoter methylation...
  24. ncbi A laboratory algorithm with homocysteine as the primary parameter reduces the cost of investigation of folate and cobalamin deficiency
    Göran Schedvin
    University Hospital, Department of Clinical Chemistry, Orebro, Sweden
    Clin Chem Lab Med 43:1065-8. 2005
    ..A typical annual saving in one of these counties (ca. 260,000 inhabitants) by implementing this algorithm would be ca 100,000...
  25. ncbi Pyrosequencing assay for genotyping of the Transcobalamin II 776C>G polymorphism
    A K Böttiger
    Department of Clinical Chemistry, Orebro University Hospital, Orebro, Sweden
    Scand J Clin Lab Invest 67:247-51. 2007
    ..The prevalence of the mutated allele in the studied Swedish population was q=0.445. It is concluded that the TC II 776C>G polymorphism can be reliably genotyped by Pyrosequencing technology...
  26. ncbi Epigenetic alterations in folate transport genes in placental tissue from fetuses with neural tube defects and in leukocytes from subjects with hyperhomocysteinemia
    Sanja A Farkas
    Department of Laboratory Medicine, Orebro University Hospital, Orebro, Sweden
    Epigenetics 8:303-16. 2013
    ....
  27. ncbi Pyrosequencing assays to study promoter CpG site methylation of the O6-MGMT, hMLH1, p14ARF, p16INK4a, RASSF1A, and APC1A genes
    Zarah M Löf-Öhlin
    Department of Clinical Chemistry, Orebro University Hospital, S 70185 Orebro, Sweden
    Oncol Rep 21:721-9. 2009
    ..This approach provides a more comprehensive picture of the distribution of DNA methylation throughout the promoter regions of the studied set of six genes, which will be of benefit in oncological research...
  28. ncbi Subjective well-being in Swedish active seniors or seniors with cognitive complaints and its relation to commonly available biomarkers
    Lovisa A Olsson
    Department of Laboratory Medicine Clinical Chemistry, Orebro University, Sweden
    Arch Gerontol Geriatr 56:303-8. 2013
    ..We conclude that the nosological grouping variable (AS vs. DGM cohort) and a cognitive factor were the main independent predictors of SWB in this sample of elderly Swedes, whereas biomarkers of somatic health played a subordinated role...
  29. ncbi Blood Concentrations of Homocysteine and Methylmalonic Acid among Demented and Non-Demented Swedish Elderly with and without Home Care Services and Vitamin B(12) Prescriptions
    Nils Olof Hagnelius
    Department of Geriatric Medicine, Orebro University Hospital, School of Health and Medical Sciences, Orebro University, Umea, Sweden
    Dement Geriatr Cogn Dis Extra 2:387-99. 2012
    ..We examined whether vitamin B(12) prescriptions, a family history of dementia, or the need for home care service might be associated with tHcy values...
  30. ncbi Activation of fibrinolysis and coagulation in non-occlusive intestinal ischaemia in a pig model
    Stefan Acosta
    Department of Surgery, Blekinge County Hospital, Orebro University Hospital, Sweden
    Blood Coagul Fibrinolysis 15:69-76. 2004
    ..After constriction of the SMA, there was a rapidly reversed peak in the coagulation marker soluble fibrin and a strong tendency of alteration of the fibrinolytic marker tPA/PAI-1 complex...
  31. ncbi Whole blood RNA expression profiles in ovarian cancer patients with or without residual tumors after primary cytoreductive surgery
    Helena S Isaksson
    Department of Laboratory Medicine, Section for Clinical Chemistry, Orebro University Hospital, and Health and Medical Sciences, Orebro University, SE 701 85 Orebro, Sweden
    Oncol Rep 27:1331-5. 2012
    ..Preoperatively it may serve as a guide to the biology of the tumor and postoperatively in the optimization of adjuvant treatment of ovarian cancer patients...
  32. ncbi A proposed stoichiometrical calibration procedure to achieve transferability of D-dimer measurements and to characterize the performance of different methods
    Bror Edlund
    Department of Clinical Chemistry, Orebro University Hospital, SE 70185 Orebro, Sweden
    Clin Biochem 39:137-42. 2006
    ..There is little transferability between D-dimer levels obtained by different reagents today. This makes it difficult to compare results from different clinical studies...
  33. ncbi DNA methylation of the p14ARF, RASSF1A and APC1A genes as an independent prognostic factor in colorectal cancer patients
    Torbjörn K Nilsson
    Department of Laboratory Medicine, Orebro University Hospital, Orebro, Sweden
    Int J Oncol 42:127-33. 2013
    ..O6-MGMT methylation may play a protective role...
  34. ncbi Novel insertion and deletion mutations in the 5'-UTR of the folate receptor-alpha gene: an additional contributor to hyperhomocysteinemia?
    Torbjörn K Nilsson
    Division of Biomedicine, Orebro University, S 70185 Orebro, Sweden
    Clin Biochem 37:224-9. 2004
    ..To search for mutations in the 5'-UTR and proximal promoter region of the folate receptor-alpha (FR-alpha) gene, whose exons are known to be virtually free of genetic variation in the population...