Per Arne Oldenborg

Summary

Country: Sweden

Publications

  1. pmc Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes
    Miri Gitik
    Dept of Medical Neurobiology, IMRIC, Hebrew University Hadassah Medical School, P O B 12272, Jerusalem 91120, Israel
    J Neuroinflammation 8:24. 2011
  2. ncbi request reprint Insulin-stimulated chemokinesis in normal human neutrophils is dependent on D-glucose concentration and sensitive to inhibitors of tyrosine kinase and phosphatidylinositol 3-kinase
    P A Oldenborg
    Department of Histology and Cell Biology, Umea University, Sweden
    J Leukoc Biol 63:203-8. 1998
  3. ncbi request reprint Role of CD47 in erythroid cells and in autoimmunity
    Per Arne Oldenborg
    Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, SE 901 87 Umea, Sweden
    Leuk Lymphoma 45:1319-27. 2004
  4. ncbi request reprint Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice
    Per Arne Oldenborg
    Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, Umea, Sweden
    Blood 99:3500-4. 2002
  5. pmc CD47-signal regulatory protein alpha (SIRPalpha) regulates Fcgamma and complement receptor-mediated phagocytosis
    P A Oldenborg
    Division of Infectious Diseases, Department of Internal Medicine and Department of Molecular Microbiology and Pathogenesis, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 193:855-62. 2001
  6. ncbi request reprint Different effects of glucose on extracellular and intracellular respiratory burst response in normal human neutrophils activated with the soluble agonist fMet-Leu-Phe
    P A Oldenborg
    Department of Integrative Medical Biology, Umea University, Sweden
    Diabet Med 17:532-7. 2000
  7. ncbi request reprint The glucose concentration modulates N-formyl-methionyl-leucyl-phenylalanine (fMet-Leu-Phe)-stimulated chemokinesis in normal human neutrophils
    P A Oldenborg
    Department of Histology and Cell Biology, Umea University, Sweden
    Biosci Rep 19:511-23. 1999
  8. ncbi request reprint Hyperglycemia in vitro attenuates insulin-stimulated chemokinesis in normal human neutrophils. Role of protein kinase C activation
    P A Oldenborg
    Department of Histology and Cell Biology, Umea University, Sweden
    J Leukoc Biol 65:635-40. 1999
  9. ncbi request reprint Effects of insulin on N-formyl-methionyl-leucyl-phenylalanine (fMet-Leu-Phe)-stimulated production of reactive oxygen metabolites from normal human neutrophils
    P A Oldenborg
    Department of Histology and Cell Biology, Umea University, Sweden
    Inflamm Res 48:404-11. 1999
  10. pmc Lack of CD47 impairs bone cell differentiation and results in an osteopenic phenotype in vivo due to impaired signal regulatory protein α (SIRPα) signaling
    Cecilia Koskinen
    From the Departments of Odontology, Section for Molecular Periodontology, Umea University, 901 87 Umea, Sweden
    J Biol Chem 288:29333-44. 2013

Collaborators

Detail Information

Publications36

  1. pmc Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes
    Miri Gitik
    Dept of Medical Neurobiology, IMRIC, Hebrew University Hadassah Medical School, P O B 12272, Jerusalem 91120, Israel
    J Neuroinflammation 8:24. 2011
    ..g. complement receptor-3), which has been previously studied. Down-regulation, which we test here, follows binding of myelin CD47 to the immune inhibitory receptor SIRPα (signal regulatory protein-α) on macrophages and microglia...
  2. ncbi request reprint Insulin-stimulated chemokinesis in normal human neutrophils is dependent on D-glucose concentration and sensitive to inhibitors of tyrosine kinase and phosphatidylinositol 3-kinase
    P A Oldenborg
    Department of Histology and Cell Biology, Umea University, Sweden
    J Leukoc Biol 63:203-8. 1998
    ..This indicates that the insulin effect on locomotion is indeed mediated by receptor-associated tyrosine kinase activation and involving phosphatidylinositol 3-kinase...
  3. ncbi request reprint Role of CD47 in erythroid cells and in autoimmunity
    Per Arne Oldenborg
    Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, SE 901 87 Umea, Sweden
    Leuk Lymphoma 45:1319-27. 2004
    ..The interaction between CD47 and SIRPalpha seems to be important to limit destruction of host cells in autoimmune diseases like autoimmune hemolytic anemia (AIHA), where macrophages destroy antibody or complement opsonized cells...
  4. ncbi request reprint Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice
    Per Arne Oldenborg
    Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, Umea, Sweden
    Blood 99:3500-4. 2002
    ..Thus, CD47-SIRPalpha signaling can have a profound influence on the severity of AIHA, making manipulation of this signaling pathway a theoretically appealing avenue in the treatment of the disease...
  5. pmc CD47-signal regulatory protein alpha (SIRPalpha) regulates Fcgamma and complement receptor-mediated phagocytosis
    P A Oldenborg
    Division of Infectious Diseases, Department of Internal Medicine and Department of Molecular Microbiology and Pathogenesis, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 193:855-62. 2001
    ..Thus, augmentation of inhibitory CD47-SIRPalpha signaling may prevent or attenuate RBC clearance in AIHA...
  6. ncbi request reprint Different effects of glucose on extracellular and intracellular respiratory burst response in normal human neutrophils activated with the soluble agonist fMet-Leu-Phe
    P A Oldenborg
    Department of Integrative Medical Biology, Umea University, Sweden
    Diabet Med 17:532-7. 2000
    ..The study evaluated the effects of glucose concentration on the extracellular and intracellular activation of the respiratory burst in fMet-Leu-Phe-stimulated normal human neutrophils...
  7. ncbi request reprint The glucose concentration modulates N-formyl-methionyl-leucyl-phenylalanine (fMet-Leu-Phe)-stimulated chemokinesis in normal human neutrophils
    P A Oldenborg
    Department of Histology and Cell Biology, Umea University, Sweden
    Biosci Rep 19:511-23. 1999
    ..These results indicate that the chemokinetic effects of fMet-Leu-Phe are regulated by the glucose concentration by inducing locomotor activity in otherwise non-locomoting cells and by improving adhesion to the substratum...
  8. ncbi request reprint Hyperglycemia in vitro attenuates insulin-stimulated chemokinesis in normal human neutrophils. Role of protein kinase C activation
    P A Oldenborg
    Department of Histology and Cell Biology, Umea University, Sweden
    J Leukoc Biol 65:635-40. 1999
    ..These results therefore suggest that glucose-induced PKC activation may mediate the inhibitory effects of high glucose levels on insulin-stimulated chemokinesis in normal human neutrophils...
  9. ncbi request reprint Effects of insulin on N-formyl-methionyl-leucyl-phenylalanine (fMet-Leu-Phe)-stimulated production of reactive oxygen metabolites from normal human neutrophils
    P A Oldenborg
    Department of Histology and Cell Biology, Umea University, Sweden
    Inflamm Res 48:404-11. 1999
    ..To further understand the mechanisms behind defective neutrophil function in diabetes mellitus, the ability of insulin to affect the production and metabolism of reactive oxygen metabolites in normal human neutrophils was studied...
  10. pmc Lack of CD47 impairs bone cell differentiation and results in an osteopenic phenotype in vivo due to impaired signal regulatory protein α (SIRPα) signaling
    Cecilia Koskinen
    From the Departments of Odontology, Section for Molecular Periodontology, Umea University, 901 87 Umea, Sweden
    J Biol Chem 288:29333-44. 2013
    ..In conclusion, lack of CD47 strongly impairs SIRPα-dependent osteoblast differentiation, deteriorate bone formation, and cause reduced formation of osteoclasts. ..
  11. pmc Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia
    Mattias Olsson
    Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, SE 901 87 Umea, Sweden
    Blood 105:3577-82. 2005
    ..In conclusion, we suggest that inhibitory CD47/SIRPalpha signaling is involved in regulating platelet phagocytosis in ITP, and that targeting SIRPalpha may be a new means of reducing platelet clearance in ITP...
  12. ncbi request reprint Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system
    Hideki Okazawa
    Biosignal Research Center, Institute for Molecular and Cellular Regulation, and Department of Dermatology, Graduate School of Medicine, Gunma University, Showa machi, Maebashi, Gunma, Japan
    J Immunol 174:2004-11. 2005
    ..The inhibition of phagocytosis by the SHPS-1-SHP-1 complex may be mediated at the level of Syk or PI3K signaling...
  13. ncbi request reprint Dose-dependent inhibitory effect of CD47 in macrophage uptake of IgG-opsonized murine erythrocytes
    Mattias Olsson
    Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, SE 901 87 Umea, Sweden
    Biochem Biophys Res Commun 352:193-7. 2007
    ..This may have relevance for transfusion of stored RBCs, where loss of CD47 is seen over time, and in clearance of these cells by antibody-dependent phagocytosis...
  14. pmc Hyperglycemia-induced protein kinase C activation inhibits phagocytosis of C3b- and immunoglobulin g-opsonized yeast particles in normal human neutrophils
    Daniel Saiepour
    Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, Umea, Sweden
    Exp Diabesity Res 4:125-32. 2003
    ..The authors conclude that elevated glucose concentrations can inhibit complement receptor and Fcgamma receptor-mediated phagocytosis in normal human neutrophils by activating PKCalpha and/or PKCbeta, an effect possibly mediated by DAG...
  15. ncbi request reprint Deficit of CD47 results in a defect of marginal zone dendritic cells, blunted immune response to particulate antigen and impairment of skin dendritic cell migration
    Sven Hagnerud
    Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, SE 901 87 Umea, Sweden
    J Immunol 176:5772-8. 2006
    ..These results demonstrate a fundamental role of CD47 in DC migration in vivo and in vitro and in the function of marginal zone DCs...
  16. doi request reprint CD47 on experimentally senescent murine RBCs inhibits phagocytosis following Fcgamma receptor-mediated but not scavenger receptor-mediated recognition by macrophages
    Mattias Olsson
    Department of Integrative Medical Biology, Umea University, Umea, Sweden
    Blood 112:4259-67. 2008
    ..These data suggest that based on the specific prophagocytic receptors mediating uptake of senescent RBCs, the phagocytosis-inhibitory role of CD47 may be more or less involved...
  17. pmc The distribution of macrophages with a M1 or M2 phenotype in relation to prognosis and the molecular characteristics of colorectal cancer
    Sofia Edin
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    PLoS ONE 7:e47045. 2012
    ....
  18. ncbi request reprint Mutational analysis of the mechanism of negative regulation by SRC homology 2 domain-containing protein tyrosine phosphatase substrate-1 of phagocytosis in macrophages
    Hiroshi Ikeda
    Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, Japan
    J Immunol 177:3123-32. 2006
    ..Moreover, SHPS-1 may regulate the attachment of RBCs to macrophages by an as yet unidentified mechanism...
  19. ncbi request reprint CD47 augments Fas/CD95-mediated apoptosis
    Partha P Manna
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:29637-44. 2005
    ..Primary T cells from CD47-null mice are also protected from Fas-mediated killing relative to wild type T cells. Thus CD47 associates with Fas upon its activation and augments Fas-mediated apoptosis...
  20. ncbi request reprint Absence of CD47 in protein 4.2-deficient hereditary spherocytosis in man: an interaction between the Rh complex and the band 3 complex
    Lesley J Bruce
    Department of Biochemistry, University of Bristol, and International Blood Group Reference Laboratory, Bristol, United Kingdom
    Blood 100:1878-85. 2002
    ..2, glycophorin A) and the Rh complex (Rh-associated glycoprotein, Rh polypeptides, glycophorin B, CD47, LW) and define a point of attachment between the Rh complex and the red cell cytoskeleton...
  21. ncbi request reprint Enhanced phagocytosis of CD47-deficient red blood cells by splenic macrophages requires SHPS-1
    Tomomi Ishikawa-Sekigami
    Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi, Gunma 371 8512, Japan
    Biochem Biophys Res Commun 343:1197-200. 2006
    ..These results thus suggest an additional role for CD47 on RBCs in the negative regulation of phagocytosis by macrophages and in determination of the life span of circulating RBCs...
  22. pmc Phenotypic skewing of macrophages in vitro by secreted factors from colorectal cancer cells
    Sofia Edin
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    PLoS ONE 8:e74982. 2013
    ..This suggests that re-education of macrophages might allow for important therapeutic advances in the treatment of human cancer. ..
  23. doi request reprint CD47 promotes both phosphatidylserine-independent and phosphatidylserine-dependent phagocytosis of apoptotic murine thymocytes by non-activated macrophages
    Anna Nilsson
    Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, Umea, Sweden
    Biochem Biophys Res Commun 387:58-63. 2009
    ..Thus, CD47 does not inhibit, but rather support, both PS-independent and PS-dependent uptake of apoptotic cells in the murine system. This mechanism only comes into play in non-activated macrophages...
  24. doi request reprint Macrophage expression of LRP1, a receptor for apoptotic cells and unopsonized erythrocytes, can be regulated by glucocorticoids
    Anna Nilsson
    Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, Umea, Sweden
    Biochem Biophys Res Commun 417:1304-9. 2012
    ..In conclusion, these data suggest that GC-stimulated macrophage uptake of apoptotic cells may involve an upregulation of macrophage LRP1 expression and enhanced LRP1-mediated phagocytosis...
  25. ncbi request reprint Target cell CD47 regulates macrophage activation and erythrophagocytosis
    M Olsson
    Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, SE 901 87 Umea, Sweden
    Transfus Clin Biol 13:39-43. 2006
    ....
  26. pmc Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells
    Hui Wang
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Proc Natl Acad Sci U S A 104:13744-9. 2007
    ..The findings highlight the potential importance of nonhematopoietic cells in the regulation of macrophage function, and suggest a previously uncharacterized mechanism of macrophage tolerance...
  27. ncbi request reprint Osteoclast formation is strongly reduced both in vivo and in vitro in the absence of CD47/SIRPalpha-interaction
    Pernilla Lundberg
    Department of Odontology, Section for Oral Cell Biology, Umea University, Sweden
    Biochem Biophys Res Commun 352:444-8. 2007
    ..We conclude that the CD47/SIRPalpha interaction is important for M-CSF/RANKL-stimulated osteoclast formation both in vivo and in vitro, and that absence of CD47 results in decreased numbers of osteoclasts in CD47-/- mice...
  28. doi request reprint Neutrophil apoptosis is associated with loss of signal regulatory protein alpha (SIRPα) from the cell surface
    Asa Stenberg
    Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, Umea, Sweden
    J Leukoc Biol 93:403-12. 2013
    ..Our data suggest that neutrophils reduce their SIRPα expression during apoptosis, which may be part of the functional down-regulation seen in apoptotic neutrophils...
  29. pmc The absence of CD47 promotes nerve fiber growth from cultured ventral mesencephalic dopamine neurons
    Franziska Marschinke
    Department of Integrative Medical Biology, Umea University, Umea, Sweden
    PLoS ONE 7:e45218. 2012
    ..In conclusion, long-distance growing nerve fiber formation is promoted by the absence of CD47, even though the presence of astrocytes is not inhibited...
  30. ncbi request reprint Insulin inhibits phagocytosis in normal human neutrophils via PKCalpha/beta-dependent priming of F-actin assembly
    D Saiepour
    Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, 901 87, Umea, Sweden
    Inflamm Res 55:85-91. 2006
    ..This study investigated the effects of insulin on the phagocytosis of C3bi - and IgG-opsonized yeast particles in normal human neutrophils...
  31. ncbi request reprint Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte
    Shyra J Gardai
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, Colorado 80206, USA
    Cell 123:321-34. 2005
    ....
  32. ncbi request reprint Selective increase of autoimmune epitope expression on aged erythrocytes in mice: implications in anti-erythrocyte autoimmune responses
    Liliane Fossati-Jimack
    Department of Pathology, University of Geneva, Switzerland
    J Autoimmun 18:17-25. 2002
    ....
  33. pmc Attenuation of phagocytosis of xenogeneic cells by manipulating CD47
    Hui Wang
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, MGH East, Bldg 149 5102, 13th St, Boston, MA 02129, USA
    Blood 109:836-42. 2007
    ....
  34. doi request reprint Transfusion of cryopreserved human red blood cells into healthy humans is associated with rapid extravascular hemolysis without a proinflammatory cytokine response
    Andreas Hult
    Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, Umea, SE 90187, Sweden
    Transfusion 53:28-33. 2013
    ..Therefore, we here investigated if transfusion of 2 units of cryopreserved autologous RBCs induced a proinflammatory response in healthy human volunteers...
  35. pmc Colorectal cancer cells activate adjacent fibroblasts resulting in FGF1/FGFR3 signaling and increased invasion
    Maria L Henriksson
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Am J Pathol 178:1387-94. 2011
    ..Our findings provide evidence of a possible molecular mechanism involved in the cross talk between cancer cells and fibroblasts leading to cancer cell invasion...
  36. ncbi request reprint CD47 promotes neuronal development through Src- and FRG/Vav2-mediated activation of Rac and Cdc42
    Takaaki Murata
    Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma 371 8512, Japan
    J Neurosci 26:12397-407. 2006
    ..These results indicate that CD47 promotes development of dendrites and axons in hippocampal neurons in a manner dependent, at least in part, on activation of Cdc42 and Rac mediated by Src as well as by FRG and Vav2...