L Ohman

Summary

Country: Sweden

Publications

  1. doi request reprint Increased TLR2 expression on blood monocytes in irritable bowel syndrome patients
    Lena Ohman
    Department of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Eur J Gastroenterol Hepatol 24:398-405. 2012
  2. doi request reprint Altered levels of fecal chromogranins and secretogranins in IBS: relevance for pathophysiology and symptoms?
    Lena Ohman
    Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Am J Gastroenterol 107:440-7. 2012
  3. doi request reprint T-cell activation in patients with irritable bowel syndrome
    Lena Ohman
    Department of Internal Medicine, Institute of Medicine, The Sahlgren s Academy, University of Gothenburg, Gothenburg, Sweden
    Am J Gastroenterol 104:1205-12. 2009
  4. doi request reprint B-cell activation in patients with irritable bowel syndrome (IBS)
    L Ohman
    Institute of Medicine, The Sahlgren s Academy, University of Gothenburg, Sweden
    Neurogastroenterol Motil 21:644-50, e27. 2009
  5. ncbi request reprint A controlled study of colonic immune activity and beta7+ blood T lymphocytes in patients with irritable bowel syndrome
    Lena Ohman
    Department of Internal Medicine, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Clin Gastroenterol Hepatol 3:980-6. 2005
  6. pmc Acellular Bordetella pertussis vaccine enhances mucosal interleukin-10 production, induces apoptosis of activated Th1 cells and attenuates colitis in Galphai2-deficient mice
    L Ohman
    Department of Clinical Immunology, The Sahlgrenska Academy of Göteborg University, Sweden
    Clin Exp Immunol 141:37-46. 2005
  7. doi request reprint Clinical trial: the effects of a fermented milk containing three probiotic bacteria in patients with irritable bowel syndrome - a randomized, double-blind, controlled study
    M Simren
    Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Aliment Pharmacol Ther 31:218-27. 2010
  8. ncbi request reprint CD4+CD25+ regulatory T cells in irritable bowel syndrome patients
    N Holmén
    Department of Internal Medicine, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Neurogastroenterol Motil 19:119-25. 2007
  9. doi request reprint Indirect evidence for increased mechanosensitivity of jejunal secretomotor neurones in patients with idiopathic bile acid malabsorption
    A Bajor
    Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Acta Physiol (Oxf) 197:129-37. 2009
  10. doi request reprint Infliximab Inhibits Activation and Effector Functions of Peripheral Blood T Cells in vitro from Patients with Clinically Active Ulcerative Colitis
    R Dahlen
    Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Department of Microbiology and Immunology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Scand J Immunol 78:275-84. 2013

Collaborators

Detail Information

Publications20

  1. doi request reprint Increased TLR2 expression on blood monocytes in irritable bowel syndrome patients
    Lena Ohman
    Department of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Eur J Gastroenterol Hepatol 24:398-405. 2012
    ..We hypothesized that monocytes are more activated in patients with IBS than in the healthy population. We therefore examined activation phenotype and cytokine secretion of blood monocytes...
  2. doi request reprint Altered levels of fecal chromogranins and secretogranins in IBS: relevance for pathophysiology and symptoms?
    Lena Ohman
    Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Am J Gastroenterol 107:440-7. 2012
    ..We therefore performed a hypothesis generating study to evaluate the association between fecal levels of CgA, CgB, SgII, and SgIII, with the clinical and pathophysiological phenotype of irritable bowel syndrome (IBS) patients...
  3. doi request reprint T-cell activation in patients with irritable bowel syndrome
    Lena Ohman
    Department of Internal Medicine, Institute of Medicine, The Sahlgren s Academy, University of Gothenburg, Gothenburg, Sweden
    Am J Gastroenterol 104:1205-12. 2009
    ..Irritable bowel syndrome (IBS) has been found to be associated with low-grade immune activation in a subset of patients. We therefore investigated blood and colonic T-cell activity in IBS patients...
  4. doi request reprint B-cell activation in patients with irritable bowel syndrome (IBS)
    L Ohman
    Institute of Medicine, The Sahlgren s Academy, University of Gothenburg, Sweden
    Neurogastroenterol Motil 21:644-50, e27. 2009
    ..These data suggest that B-cell antigen presentation in IBS patients is associated with altered capacity of providing costimulation to T cells...
  5. ncbi request reprint A controlled study of colonic immune activity and beta7+ blood T lymphocytes in patients with irritable bowel syndrome
    Lena Ohman
    Department of Internal Medicine, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Clin Gastroenterol Hepatol 3:980-6. 2005
    ..The aim of this study was to characterize the phenotype and homing properties of colonic and peripheral blood lymphocytes in patients with IBS...
  6. pmc Acellular Bordetella pertussis vaccine enhances mucosal interleukin-10 production, induces apoptosis of activated Th1 cells and attenuates colitis in Galphai2-deficient mice
    L Ohman
    Department of Clinical Immunology, The Sahlgrenska Academy of Göteborg University, Sweden
    Clin Exp Immunol 141:37-46. 2005
    ..pertussis vaccine containing filamentous haemagglutinin increases the production of IL-10 in the intestinal mucosa, induces apoptosis of activated Th1 cells and attenuates colitis in Galphai2(-/-) mice...
  7. doi request reprint Clinical trial: the effects of a fermented milk containing three probiotic bacteria in patients with irritable bowel syndrome - a randomized, double-blind, controlled study
    M Simren
    Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Aliment Pharmacol Ther 31:218-27. 2010
    ..The effects of probiotic bacteria in IBS remain controversial...
  8. ncbi request reprint CD4+CD25+ regulatory T cells in irritable bowel syndrome patients
    N Holmén
    Department of Internal Medicine, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Neurogastroenterol Motil 19:119-25. 2007
    ..In conclusion, the low-grade intestinal inflammation recorded in patients with IBS is not associated with an altered function or frequency of CD25(+) Treg cells...
  9. doi request reprint Indirect evidence for increased mechanosensitivity of jejunal secretomotor neurones in patients with idiopathic bile acid malabsorption
    A Bajor
    Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Acta Physiol (Oxf) 197:129-37. 2009
    ..The phase III-generated voltage was related to the degree of BAM quantified by the (75)SeHCAT test...
  10. doi request reprint Infliximab Inhibits Activation and Effector Functions of Peripheral Blood T Cells in vitro from Patients with Clinically Active Ulcerative Colitis
    R Dahlen
    Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Department of Microbiology and Immunology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Scand J Immunol 78:275-84. 2013
    ..These data suggest that suppression of T cell activity may be important for infliximab-mediated disease remission in patients with UC. ..
  11. ncbi request reprint Decreased leptin production in mice after onset of ulcerative colitis-like disease
    O H Hultgren
    Department of Clinical Immunology, Goteborg University, Sweden
    Scand J Gastroenterol 39:1166-7. 2004
  12. pmc Regression of Peyer's patches in G alpha i2 deficient mice prior to colitis is associated with reduced expression of Bcl-2 and increased apoptosis
    L Ohman
    Department of Clinical Immunology, Goteborg University, Sweden
    Gut 51:392-7. 2002
    ..Previous studies have demonstrated that gut T cells are hyperreactive to the endogenous microflora in most IBD models...
  13. ncbi request reprint New insights into the pathogenesis and pathophysiology of irritable bowel syndrome
    L Ohman
    Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Dig Liver Dis 39:201-15. 2007
    ..To conclude, a complex picture of the pathogenesis and pathophysiology of irritable bowel syndrome is emerging, with interactions between several different alterations resulting in the divergent symptom pattern in these patients...
  14. doi request reprint Characterization of IBS-like symptoms in patients with ulcerative colitis in clinical remission
    B Jonefjäll
    Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Neurogastroenterol Motil 25:756-e578. 2013
    ..The aim of this study was to characterize IBS-like symptoms in patients with Ulcerative Colitis (UC) in clinical remission by assessing inflammatory markers, psychological symptoms, and quality of life...
  15. pmc Impaired B cell responses to orally administered antigens in lamina propria but not Peyer's patches of Galphai2-deficient mice prior to colitis
    Lena Ohman
    Department of Clinical Immunology, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Immunology 115:271-8. 2005
    ....
  16. doi request reprint Apoptotic neutrophils containing Staphylococcus epidermidis stimulate macrophages to release the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-6
    Asa Wilsson
    School of Health Sciences, Jonkoping University, Jonkoping, Sweden
    FEMS Immunol Med Microbiol 53:126-35. 2008
    ..epidermidis might represent an important mechanism to combat the infective agent. This activation of macrophages may contribute to the development of chronic inflammation instead of inflammation resolution...
  17. ncbi request reprint Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity
    Nathalie Holmén
    Department of Internal Medicine, Sahlgrenka Academy, Goteborg University, Goteborg, Sweden
    Inflamm Bowel Dis 12:447-56. 2006
    ..Therefore, the aims of this study were to determine whether colonic Tregs have suppressive effects on colonic effector T cells in UC and to analyze the association between segmental colonic Treg distribution and disease activity...
  18. ncbi request reprint Normal or increased bile acid uptake in isolated mucosa from patients with bile acid malabsorption
    Antal Bajor
    Division of Gastroenterology, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Eur J Gastroenterol Hepatol 18:397-403. 2006
    ..Bile acid malabsorption as reflected by an abnormal Se-labelled homocholic acid-taurine (SeHCAT) test is associated with diarrhoea, but the mechanisms and cause-and-effect relations are unclear...
  19. ncbi request reprint Inflammation as a cause of functional bowel disorders
    Hans Tornblom
    Karolinska Institutet, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Scand J Gastroenterol 40:1140-8. 2005
  20. ncbi request reprint The influence of plasma proteins and platelets on oxygen radical production and F-actin distribution in neutrophils adhering to polymer surfaces
    Ghada Nimeri
    Department of Health and Environment, Faculty of Health Sciences, Linkoping University, Sweden
    Biomaterials 23:1785-95. 2002
    ..Our results suggest that the acute inflammatory reaction on a biomaterial surface is highly dependent on the nature and composition of the first adsorbed protein layer and the extent of platelet activation...