A Nordberg

Summary

Country: Sweden

Publications

  1. ncbi Cholinesterase inhibitors in the treatment of Alzheimer's disease: a comparison of tolerability and pharmacology
    A Nordberg
    Department of Clinical Neuroscience and Family Medicine, Karolinska Institutet, Huddinge University Hospital, Sweden
    Drug Saf 19:465-80. 1998
  2. ncbi PET imaging of the in vivo brain acetylcholinesterase activity and nicotine binding in galantamine-treated patients with AD
    A Kadir
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Neurobiol Aging 29:1204-17. 2008
  3. ncbi Reduced expression of neuronal nicotinic acetylcholine receptors during the early stages of damage by oxidative stress in PC12 cells
    Z Z Guan
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Division of Molecular Neuropharmacology, Huddinge University Hospital, Karolinska Institutet, S 14136 Stockholm, Sweden
    J Neurosci Res 66:551-8. 2001
  4. ncbi Inhibition of acetylcholinesterase in CSF versus brain assessed by 11C-PMP PET in AD patients treated with galantamine
    T Darreh-Shori
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Division of Molecular Neuropharmacology, Novum, 5th Floor, 141 86 Stockholm, Sweden
    Neurobiol Aging 29:168-84. 2008
  5. doi Transgenic mice overexpressing human acetylcholinesterase and the Swedish amyloid precursor protein mutation: effect of nicotine treatment
    M M Hedberg
    Karolinska Institutet, Department of Neurobiology Care Sciences and Society, Division of Alzheimer Neurobiology, Karolinska University Hospital, Huddinge, Novum 5th floor, S 141 86 Stockholm, Sweden
    Neuroscience 152:223-33. 2008
  6. ncbi Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia
    A Marutle
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research (NEUROTEC, Division of Molecular Neuropharmacology, Huddinge University Hospital, B84, S-141 86, Stockholm, Sweden
    J Chem Neuroanat 22:115-26. 2001
  7. ncbi Expression of nicotinic acetylcholine receptors in human and rat adrenal medulla
    M Mousavi
    Karolinska Institutet, Department of Neurotec, Huddinge University Hospital, Stockholm, Sweden
    Life Sci 70:577-90. 2001
  8. ncbi Postnatal upregulation of alpha4 and alpha3 nicotinic receptor subunits in the brain of alpha7 nicotinic receptor-deficient mice
    W F Yu
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
    Neuroscience 146:1618-28. 2007
  9. ncbi High PIB retention in Alzheimer's disease is an early event with complex relationship with CSF biomarkers and functional parameters
    A Forsberg
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Curr Alzheimer Res 7:56-66. 2010
  10. ncbi Longitudinal changes in quantitative EEG during long-term tacrine treatment of patients with Alzheimer's disease
    V Jelic
    Karolinska Institute, Department of Clinical Neuroscience and Family Medicine, Huddinge University Hospital, Sweden
    Neurosci Lett 254:85-8. 1998

Detail Information

Publications31

  1. ncbi Cholinesterase inhibitors in the treatment of Alzheimer's disease: a comparison of tolerability and pharmacology
    A Nordberg
    Department of Clinical Neuroscience and Family Medicine, Karolinska Institutet, Huddinge University Hospital, Sweden
    Drug Saf 19:465-80. 1998
    ..For some cholinesterase inhibitors, such as rivastigmine, the cholinergic adverse effects such as nausea, vomiting, dizziness, diarrhoea and abdominal pain can be reduced by slowing the rate of dose titration...
  2. ncbi PET imaging of the in vivo brain acetylcholinesterase activity and nicotine binding in galantamine-treated patients with AD
    A Kadir
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Neurobiol Aging 29:1204-17. 2008
    ..At the individual level, the in vivo cortical AChE inhibition and (11)C-nicotine binding were associated with changes in the attention domain of cognition rather than episodic memory...
  3. ncbi Reduced expression of neuronal nicotinic acetylcholine receptors during the early stages of damage by oxidative stress in PC12 cells
    Z Z Guan
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Division of Molecular Neuropharmacology, Huddinge University Hospital, Karolinska Institutet, S 14136 Stockholm, Sweden
    J Neurosci Res 66:551-8. 2001
    ....
  4. ncbi Inhibition of acetylcholinesterase in CSF versus brain assessed by 11C-PMP PET in AD patients treated with galantamine
    T Darreh-Shori
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Division of Molecular Neuropharmacology, Novum, 5th Floor, 141 86 Stockholm, Sweden
    Neurobiol Aging 29:168-84. 2008
    ..A positive cognitive response seems to dependent on the AChE inhibition level, which is balanced by an increased protein level of the AChE-R variant in the patients...
  5. doi Transgenic mice overexpressing human acetylcholinesterase and the Swedish amyloid precursor protein mutation: effect of nicotine treatment
    M M Hedberg
    Karolinska Institutet, Department of Neurobiology Care Sciences and Society, Division of Alzheimer Neurobiology, Karolinska University Hospital, Huddinge, Novum 5th floor, S 141 86 Stockholm, Sweden
    Neuroscience 152:223-33. 2008
    ..The results in this study emphasize the importance of using different transgenic mouse models for evaluating the effect of new drug candidates for the treatment of Alzheimer's disease...
  6. ncbi Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia
    A Marutle
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research (NEUROTEC, Division of Molecular Neuropharmacology, Huddinge University Hospital, B84, S-141 86, Stockholm, Sweden
    J Chem Neuroanat 22:115-26. 2001
    ....
  7. ncbi Expression of nicotinic acetylcholine receptors in human and rat adrenal medulla
    M Mousavi
    Karolinska Institutet, Department of Neurotec, Huddinge University Hospital, Stockholm, Sweden
    Life Sci 70:577-90. 2001
    ..Sub-chronic treatment of nicotine to rats did not influence level of the nAChRs in the adrenal medulla. In conclusion, the expression of nAChRs in adrenal medulla is age- related and species dependent...
  8. ncbi Postnatal upregulation of alpha4 and alpha3 nicotinic receptor subunits in the brain of alpha7 nicotinic receptor-deficient mice
    W F Yu
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
    Neuroscience 146:1618-28. 2007
    ..These data suggest that increased levels of alpha4, alpha3-containing nAChRs, co-assembled with the alpha5 nAChR subunit, may contribute to the normal brain development of alpha7 -/- and alpha7 +/- mice...
  9. ncbi High PIB retention in Alzheimer's disease is an early event with complex relationship with CSF biomarkers and functional parameters
    A Forsberg
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Curr Alzheimer Res 7:56-66. 2010
    ..In this study we investigated how (11)C-PIB retention is related to cerebral glucose metabolism, episodic memory and CSF biomarkers...
  10. ncbi Longitudinal changes in quantitative EEG during long-term tacrine treatment of patients with Alzheimer's disease
    V Jelic
    Karolinska Institute, Department of Clinical Neuroscience and Family Medicine, Huddinge University Hospital, Sweden
    Neurosci Lett 254:85-8. 1998
    ..These findings suggest that slowing in fast EEG frequencies during chronic treatment with AChE inhibitors may provide an early indicator of declining treatment efficiency...
  11. ncbi A follow-up study of the family with the Swedish APP 670/671 Alzheimer's disease mutation
    L O Wahlund
    Department of Clinical Neuroscience and Family Medicine, Division of Geriatric Medicine, B 56, Huddinge University Hospital, Karolinska Institute, Huddinge, Sweden
    Dement Geriatr Cogn Disord 10:526-33. 1999
    ..To study the progression of Alzheimer's disease (AD) at a very early stage and to evaluate clinical markers of presymptomatic AD...
  12. ncbi Regional distribution of subtypes of nicotinic receptors in human brain and effect of aging studied by (+/-)-[3H]epibatidine
    A Marutle
    Department of Neuroscience and Family Medicine, Division of Molecular Neuropharmacology, Karolinska Institutet, Huddinge University Hospital, B 84 Huddinge S 141 86, Sweden
    Brain Res 801:143-9. 1998
    ..The findings indicate that a specifically modulate regional nicotinic receptors in human brain...
  13. ncbi Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE epsilon4 allele, in relation to cognitive function and cerebral glucose metabolism
    T Darreh-Shori
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Molecular Neuropharmacology, Stockholm, Sweden
    Neurobiol Dis 24:326-33. 2006
    ..Thus, low BuChE in a patient's CSF may predict extensive incorporation in neuritic plaques, increased neurotoxicity and greater central neurodegeneration...
  14. ncbi Preserved cognitive function after 12 months of treatment with rivastigmine in mild Alzheimer's disease in comparison with untreated AD and MCI patients
    O Almkvist
    Neurotec Department, Karolinska Institutet, Stockholm, Sweden
    Eur J Neurol 11:253-61. 2004
    ..In conclusion, a clear beneficial effect of rivastigmine was shown on cognitive function for patients with mild AD and plasma values of ChE inhibition were associated with attention...
  15. ncbi Suppressed expression of nicotinic acetylcholine receptors by nanomolar beta-amyloid peptides in PC12 cells
    Z Z Guan
    Division of Molecular Neuropharmacology, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research (NEUROTEC, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden
    J Neural Transm 108:1417-33. 2001
    ..The results presented in this study lead to a hypothesis that Abeta can degenerate nAChRs early in the course of AD before the formation of abundant Abeta fibrils...
  16. ncbi Impaired cerebral glucose metabolism and cognitive functioning predict deterioration in mild cognitive impairment
    E Arnaiz
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy, and Elderly Care Research NEUROTEC, Huddinge University Hospital, Sweden
    Neuroreport 12:851-5. 2001
    ..Measures of temporoparietal cerebral metabolism and visuospatial function may aid in predicting the evolution to AD for patients with MCI...
  17. ncbi Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease
    Z Z Guan
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Huddinge University Hospital, Karolinska Institutet, Sweden
    J Neurochem 74:237-43. 2000
    ..These results reveal brain region-specific changes in the protein levels of the nAChR alpha3, alpha4, and alpha7 subunits in AD...
  18. ncbi Reduced levels of Abeta 40 and Abeta 42 in brains of smoking controls and Alzheimer's patients
    E Hellström-Lindahl
    Department of Neurotec, Division of Molecular Neuropharmacology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Neurobiol Dis 15:351-60. 2004
    ..These results indicate that selective nicotinic receptor agonists may be a novel protective therapy in AD by reducing Abeta levels as well as the loss of nicotinic receptors in AD brain...
  19. ncbi Quantitative electroencephalography in mild cognitive impairment: longitudinal changes and possible prediction of Alzheimer's disease
    V Jelic
    Karolinska Institutet, Neurotec, Division of Geriatric Medicine, B 84, Huddinge University Hospital, S 141 86, Huddinge, Sweden
    Neurobiol Aging 21:533-40. 2000
    ....
  20. ncbi Longitudinal PET evaluation of cerebral glucose metabolism in rivastigmine treated patients with mild Alzheimer's disease
    E Stefanova
    Division of Molecular Neuropharmacology, Neurotec Department, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Neural Transm 113:205-18. 2006
    ..5-12'mg) of rivastigmine. These results suggest a stabilization effect of rivastigmine on CMRglc in mild AD patients receiving long-term rivastigmine treatment...
  21. ncbi Influence of lipid peroxidation on the nicotinic acetylcholine receptors in PC12 cells
    Z Guan
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Division of Molecular Neuropharmacology, Huddinge University Hospital B84, Karolinska Institutet, S 141 86, Huddinge, Sweden
    Neurosci Lett 286:163-6. 2000
    ..These results demonstrate that lipid peroxidation in cellular membranes can induce a reduction in numbers of neuronal nAChRs...
  22. ncbi Smoking during early pregnancy affects the expression pattern of both nicotinic and muscarinic acetylcholine receptors in human first trimester brainstem and cerebellum
    L Falk
    Karolinska Institutet, Neurotec Department, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge, S 141 86, Stockholm, Sweden
    Neuroscience 132:389-97. 2005
    ..The findings indicate that early prenatal nicotine exposure affects the normal developmental pattern of the cholinergic system in human fetal brain...
  23. ncbi PET studies and cholinergic therapy in Alzheimer's disease
    A Nordberg
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research NEUROTEC, Huddinge, Sweden
    Rev Neurol (Paris) 155:S53-63. 1999
    ....
  24. ncbi Cerebral glucose metabolism, cerebrospinal fluid-beta-amyloid1-42 (CSF-Abeta42), tau and apolipoprotein E genotype in long-term rivastigmine and tacrine treated Alzheimer disease (AD) patients
    E Stefanova
    Karolinska Institutet, Department of Clinical Neuroscience Occupational Therapy and Elderly Care Research NEUROTEC, Division of Molecular Neuropharmacology, Huddinge University Hospital, B84, 141 86, Stockholm, Sweden
    Neurosci Lett 338:159-63. 2003
    ..There was no significant change in Abeta42 after 1-year treatment with either rivastigmine or tacrine. This study shows that the two long-term cholinesterase inhibitor treatments exert different effects on biological markers for AD...
  25. ncbi Increased levels of tau protein in SH-SY5Y cells after treatment with cholinesterase inhibitors and nicotinic agonists
    E Hellström-Lindahl
    Department of Clinical Neuroscience, Occupational Therapy, and Elderly Care Research, Karolinska Institute, Huddinge University Hospital, Sweden
    J Neurochem 74:777-84. 2000
    ..Additional work is needed to determine the exact mechanism by which cholinesterase inhibitors and nicotinic agonists modulate phosphorylation and levels of tau protein...
  26. ncbi Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
    B Winblad
    Division of Geriatric Medicine, Neurotec Department, Karolinska Institutet, 11382 Stockholm, Sweden
    J Intern Med 256:240-6. 2004
    ....
  27. ncbi Protein and mRNA levels of nicotinic receptors in brain of tobacco using controls and patients with Alzheimer's disease
    M Mousavi
    Karolinska Institute, Department of Neurotec, Division of Molecular Neuropharmacology, Huddinge University Hospital, B84, 141 86, Stockholm, Sweden
    Neuroscience 122:515-20. 2003
    ..The up-regulation of nAChRs in smoking groups and the loss of these receptors in AD patients were not correlated to any changes at the mRNA level suggesting that these changes may reflect post-transcriptional events...
  28. ncbi Rats exhibiting acute behavioural tolerance to nicotine have more [125I]alpha-bungarotoxin binding sites in brain than rats not exhibiting tolerance
    X Zhang
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Karolinska Institutet, Huddinge University Hospital, Sweden
    Behav Brain Res 113:105-15. 2000
    ..These data may also be central to understanding the variability of tobacco use in humans, which may be contingent on the ability of the receptors binding to alpha-bungarotoxin to be responsive to nicotine-induced desensitization...
  29. ncbi Sustained cholinesterase inhibition in AD patients receiving rivastigmine for 12 months
    T Darreh-Shori
    Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Neurology 59:563-72. 2002
    ..To study the long-term dual inhibitory effects of rivastigmine on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in patients with AD...
  30. ncbi Nicotinic receptor abnormalities of Alzheimer's disease: therapeutic implications
    A Nordberg
    Department of Neurotec, Division of Molecular Neuropharmacology, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden
    Biol Psychiatry 49:200-10. 2001
    ..Treatment with cholinergic drugs in AD patients indicate improvement of the nAChRs in the brain, as visualized by PET. Further studies on neuroprotective mechanisms mediated via nAChR subtypes are exciting new avenues...
  31. ncbi Effect of memantine on the alpha 7 neuronal nicotinic receptors, synaptophysin- and low molecular weight MAP-2 levels in the brain of transgenic mice over-expressing human acetylcholinesterase
    C Unger
    Karolinska Institutet, Neurotec Department, Division of Molecular Neuropharmacology, Huddinge University Hospital, Stockholm, Sweden
    J Neural Transm 112:255-68. 2005
    ..Whether the effect of memantine on alpha7 nAChRs, synaptophysin- and LMW MAP-2 levels is a direct effect, or an indirect effect via the NMDA receptors, has to be further evaluated...