- Cytosolic acidification and lysosomal alkalinization during TNF-alpha induced apoptosis in U937 cellsCathrine Nilsson
Division of Experimental Pathology, Faculty of Health Sciences, Linkoping University, S 581 85 Linkoping, Sweden
Apoptosis 11:1149-59. 2006..We, thus, suggest that lysosomal proton release is the cause of the cytosolic acidification of U937 cells exposed to TNF-alpha...
- Analysis of cytosolic and lysosomal pH in apoptotic cells by flow cytometryCathrine Nilsson
Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University, S 581 85 Linkoping, Sweden
Methods Cell Sci 25:185-94. 2003..2+/-0.1 to 5.8+/-0.1 and the lysosomal increased from 4.3+/-0.4 to 5.2+/-0.3. These methods will be useful in future attempts to evaluate the involvement of lysosomes in the acidification of the cytosol during apoptosis...
- Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulationHanna Appelqvist
Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
Am J Pathol 178:629-39. 2011..Cholesterol accumulation in lysosomes attenuates apoptosis by increasing lysosomal membrane stability...
- Intrinsic differences in cisplatin sensitivity of head and neck cancer cell lines: Correlation to lysosomal pHCathrine Nilsson
Experimental Pathology, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
Head Neck 32:1185-94. 2010..Cisplatin treatment is beneficial for approximately 20% of patients with head and neck squamous cell carcinoma (HNSCC). Tools to predict the clinical outcome and evaluate intrinsic cisplatin sensitivity are, therefore, required...