Jan Nedergaard

Summary

Country: Sweden

Publications

  1. ncbi UCP1 mRNA does not produce heat
    Jan Nedergaard
    Dept of Molecular Biosciences, The Wenner Gren Institute, Stockholm University, Stockholm, Sweden Electronic address
    Biochim Biophys Acta 1831:943-9. 2013
  2. ncbi UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency
    J Nedergaard
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochim Biophys Acta 1504:82-106. 2001
  3. ncbi Life without UCP1: mitochondrial, cellular and organismal characteristics of the UCP1-ablated mice
    J Nedergaard
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochem Soc Trans 29:756-63. 2001
  4. ncbi The changed metabolic world with human brown adipose tissue: therapeutic visions
    Jan Nedergaard
    The Wenner Gren Institute, The Arrhenius Laboratories, Stockholm University, SE 10691 Stockholm, Sweden
    Cell Metab 11:268-72. 2010
  5. ncbi Unexpected evidence for active brown adipose tissue in adult humans
    Jan Nedergaard
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Am J Physiol Endocrinol Metab 293:E444-52. 2007
  6. ncbi The 'novel' 'uncoupling' proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions
    Jan Nedergaard
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Exp Physiol 88:65-84. 2003
  7. ncbi PPARgamma in the control of brown adipocyte differentiation
    Jan Nedergaard
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochim Biophys Acta 1740:293-304. 2005
  8. ncbi Three years with adult human brown adipose tissue
    Jan Nedergaard
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Ann N Y Acad Sci 1212:E20-36. 2010
  9. ncbi Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocyt
    Natasa Petrovic
    Wenner Gren Institute, The Arrhenius Laboratories, Stockholm University, SE 106 91 Stockholm, Sweden
    J Biol Chem 285:7153-64. 2010
  10. ncbi Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectively
    Irina G Shabalina
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochem J 399:405-14. 2006

Collaborators

Detail Information

Publications58

  1. ncbi UCP1 mRNA does not produce heat
    Jan Nedergaard
    Dept of Molecular Biosciences, The Wenner Gren Institute, Stockholm University, Stockholm, Sweden Electronic address
    Biochim Biophys Acta 1831:943-9. 2013
    ..This article is part of a Special Issue entitled Brown and White Fat: From Signaling to Disease...
  2. ncbi UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency
    J Nedergaard
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochim Biophys Acta 1504:82-106. 2001
    ..It is concluded that UCP1 is unique amongst the uncoupling proteins and is the only protein able to mediate adaptive non-shivering thermogenesis and the ensuing metabolic inefficiency...
  3. ncbi Life without UCP1: mitochondrial, cellular and organismal characteristics of the UCP1-ablated mice
    J Nedergaard
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochem Soc Trans 29:756-63. 2001
    ..UCP1 (thermogenin) thus remains the only protein the activity of which can be recruited for the purpose of facultative thermogenesis...
  4. ncbi The changed metabolic world with human brown adipose tissue: therapeutic visions
    Jan Nedergaard
    The Wenner Gren Institute, The Arrhenius Laboratories, Stockholm University, SE 10691 Stockholm, Sweden
    Cell Metab 11:268-72. 2010
    ..Adaptive adrenergic thermogenesis in humans represents brown adipose tissue activity, the absence of which may contribute to middle-age obesity...
  5. ncbi Unexpected evidence for active brown adipose tissue in adult humans
    Jan Nedergaard
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Am J Physiol Endocrinol Metab 293:E444-52. 2007
    ....
  6. ncbi The 'novel' 'uncoupling' proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions
    Jan Nedergaard
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Exp Physiol 88:65-84. 2003
    ..Thus, the novel UCPs should probably be considered as mitochondrial carriers, and the challenge now is to identify the transported molecule...
  7. ncbi PPARgamma in the control of brown adipocyte differentiation
    Jan Nedergaard
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochim Biophys Acta 1740:293-304. 2005
    ....
  8. ncbi Three years with adult human brown adipose tissue
    Jan Nedergaard
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Ann N Y Acad Sci 1212:E20-36. 2010
    ..The decline in brown adipose tissue amount with increasing age may account for or aggravate middle-age obesity. Maintained activation of brown adipose tissue throughout life may thus protect against obesity and diabetes...
  9. ncbi Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocyt
    Natasa Petrovic
    Wenner Gren Institute, The Arrhenius Laboratories, Stockholm University, SE 106 91 Stockholm, Sweden
    J Biol Chem 285:7153-64. 2010
    ....
  10. ncbi Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectively
    Irina G Shabalina
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochem J 399:405-14. 2006
    ..The data are therefore compatible with a tentative model in which the ANT2 isoform mediates fatty-acid-induced uncoupling, whereas the ANT1 isoform may mediate a significant part of the high basal proton leak in brown-fat mitochondria...
  11. ncbi Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects
    Irina G Shabalina
    The Wenner Gren Institute, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochim Biophys Acta 1797:968-80. 2010
    ....
  12. ncbi Inhibitory effects of halothane on the thermogenic pathway in brown adipocytes: localization to adenylyl cyclase and mitochondrial fatty acid oxidation
    Kerstin B E Ohlson
    The Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE-106 91 Stockholm, Sweden
    Biochem Pharmacol 68:463-77. 2004
    ..The results thus explain the inhibition of nonshivering thermogenesis by identifying two sites of action of halothane in brown adipocytes. In addition, the results may open for new formulations of the molecular background to anesthesia...
  13. ncbi UCP1 is essential for adaptive adrenergic nonshivering thermogenesis
    Valeria Golozoubova
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91, Stockholm, Sweden
    Am J Physiol Endocrinol Metab 291:E350-7. 2006
    ..UCP1 is thus the only protein capable of mediating cold acclimation-recruited adaptive adrenergic nonshivering thermogenesis...
  14. ncbi Thermogenically competent nonadrenergic recruitment in brown preadipocytes by a PPARgamma agonist
    Natasa Petrovic
    Wenner Gren Institute, Arrhenius Laboratories, Stockholm University, Stockholm, Sweden
    Am J Physiol Endocrinol Metab 295:E287-96. 2008
    ..Thus the PPARgamma pathway represents an alternative, potent, and fully competent mechanism for BAT recruitment, which may be the cellular explanation for the enigmatic recruitment in prehibernation and prenatal states...
  15. ncbi UCP1 and defense against oxidative stress. 4-Hydroxy-2-nonenal effects on brown fat mitochondria are uncoupling protein 1-independent
    Irina G Shabalina
    Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    J Biol Chem 281:13882-93. 2006
    ..Additionally, it was concluded that at least in brown adipose tissue, conditions of high mitochondrial membrane potential, high oxygen tension, and high substrate supply do not necessarily lead to increased oxidative damage...
  16. ncbi Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids
    Irina G Shabalina
    Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    J Biol Chem 279:38236-48. 2004
    ..We conclude that, when examined in its native environment, UCP1 functions as a proton (equivalent) carrier in the absence of exogenous or endogenous fatty acids...
  17. ncbi SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity
    Jose P Silva
    Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    EMBO J 24:4061-70. 2005
    ..These results strongly suggest that endogenously generated matrix superoxide does not regulate UCP activity and in vivo energy expenditure...
  18. ncbi Uncoupling proteins: a role in protection against reactive oxygen species--or not?
    Barbara Cannon
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochim Biophys Acta 1757:449-58. 2006
    ..We conclude that, concerning UCP1, it is unlikely that it has such a role; concerning UCP2/UCP3, most evidence for physiologically significant roles in this respect is still circumstantial...
  19. ncbi Cold-induced expression of the VEGF gene in brown adipose tissue is independent of thermogenic oxygen consumption
    J Magnus Fredriksson
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Sweden
    FEBS Lett 579:5680-4. 2005
    ..These results demonstrate that generation of low oxygen levels does not contribute to cold-induced VEGF expression in brown adipose tissue, but the results are consistent with an adrenergic regulation of expression...
  20. ncbi Non-transactivational, dual pathways for LPA-induced Erk1/2 activation in primary cultures of brown pre-adipocytes
    Therese E Holmström
    Department of Physiology, The Wenner Gren Institute, Stockholm University, SE 106 91 Stockholm, Sweden
    Exp Cell Res 316:2664-75. 2010
    ..The present study implies that in non-transformed systems, RTK transactivation may not be involved in the mediation of GPCR-induced Erk1/2 MAP kinase activation...
  21. ncbi UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
    Helena M Feldmann
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
    Cell Metab 9:203-9. 2009
    ....
  22. ncbi Uncoupling protein-1 is not leaky
    Irina G Shabalina
    The Wenner Gren Institute, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochim Biophys Acta 1797:773-84. 2010
    ....
  23. ncbi Differential involvement of caveolin-1 in brown adipocyte signaling: impaired beta3-adrenergic, but unaffected LPA, PDGF and EGF receptor signaling
    Charlotte L Mattsson
    Department of Physiology, The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochim Biophys Acta 1803:983-9. 2010
    ..Thus, in brown adipocytes, Cav1 is apparently required for an intact response to adenylyl cyclase-linked agonists/activators, whereas other signaling pathways examined function without Cav1...
  24. ncbi Within brown-fat cells, UCP1-mediated fatty acid-induced uncoupling is independent of fatty acid metabolism
    Irina G Shabalina
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochim Biophys Acta 1777:642-50. 2008
    ..Thus, neither the ability to be metabolized nor an innate uncoupling/protonophoric ability is a necessary property of UCP1 activators within brown-fat cells...
  25. ncbi Alpha1- and beta1-adrenoceptor signaling fully compensates for beta3-adrenoceptor deficiency in brown adipocyte norepinephrine-stimulated glucose uptake
    Ekaterina Chernogubova
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, SE 106 91 Sweden
    Endocrinology 146:2271-84. 2005
    ..The alpha1-adrenergic receptor component (that is not evident in wild-type cells) stimulates glucose uptake through a phosphatidylinositol 3-kinase and protein kinase C pathway in the beta3-KO cells...
  26. ncbi An essential role for Tbx15 in the differentiation of brown and "brite" but not white adipocytes
    Valentina Gburcik
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Am J Physiol Endocrinol Metab 303:E1053-60. 2012
    ..Therefore, Tbx15 may be essential for the development of the adipogenic and thermogenic programs in adipocytes/adipomyocytes capable of developing brown adipocyte features...
  27. ncbi Recruited vs. nonrecruited molecular signatures of brown, "brite," and white adipose tissues
    Tomas B Walden
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
    Am J Physiol Endocrinol Metab 302:E19-31. 2012
    ..The significance of the gene expression patterns for classifying the depots and for understanding the developmental background of the depots is discussed, as are the possible regulatory functions of the genes...
  28. ncbi Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all hormone-binding thyroid hormone receptors
    Valeria Golozoubova
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91, Stockholm, Sweden
    Mol Endocrinol 18:384-401. 2004
    ....
  29. ncbi PPARalpha does not suppress muscle-associated gene expression in brown adipocytes but does influence expression of factors that fingerprint the brown adipocyte
    Tomas B Walden
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochem Biophys Res Commun 397:146-51. 2010
    ..Thus, it would not seem that PPARalpha represses muscle-associated genes, but PPARalpha may still play a role in the regulation of the bifurcation of the adipomyocyte precursor into a brown adipocyte or myocyte phenotype...
  30. ncbi Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) gamma2 gene expression in brown adipocytes: intracellular signalling and effects on PPARgamma2 and PPARgamma1 protein levels
    Eva M Lindgren
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochem J 382:597-606. 2004
    ....
  31. ncbi Uncoupling protein-1: involvement in a novel pathway for beta-adrenergic, cAMP-mediated intestinal relaxation
    Irina Shabalina
    Wenner Gren Institute, Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Am J Physiol Gastrointest Liver Physiol 283:G1107-16. 2002
    ....
  32. ncbi Mitochondrial ATP synthase levels in brown adipose tissue are governed by the c-Fo subunit P1 isoform
    Tatiana V Kramarova
    The Wenner Gren Institute, The Arrhenius Laboratories, Stockholm University, SE 106 91 Stockholm, Sweden
    FASEB J 22:55-63. 2008
    ..The level of c-Fo subunit may be a determining factor for F1Fo-ATPase assembly in all higher eukaryotes...
  33. ncbi Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes
    Tomas B Walden
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
    J Cell Physiol 218:444-9. 2009
    ....
  34. ncbi Mitochondrial ('mild') uncoupling and ROS production: physiologically relevant or not?
    Irina G Shabalina
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochem Soc Trans 39:1305-9. 2011
    ..g. the absence of the truly uncoupling protein UCP1 is not associated with increased oxidative damage. Thus present evidence does not support mild uncoupling as a physiologically relevant alleviator of oxidative damage...
  35. ncbi Norepinephrine but not hypoxia stimulates HIF-1alpha gene expression in brown adipocytes
    Hideki Nikami
    The Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE-106 91 Stockholm, Sweden
    Biochem Biophys Res Commun 337:121-6. 2005
    ..Thus, by elevating HIF-1alpha gene expression, norepinephrine may mediate an increased potential to respond to hypoxia in brown adipose tissue and possibly in other tissues...
  36. ncbi A sequence predicted to form a stem-loop is proposed to be required for formation of an RNA-protein complex involving the 3'UTR of beta-subunit F0F1-ATPase mRNA
    Tatiana V Kramarova
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochim Biophys Acta 1777:747-57. 2008
    ....
  37. ncbi A novel pathway for adrenergic stimulation of cAMP-response-element-binding protein (CREB) phosphorylation: mediation via alpha1-adrenoceptors and protein kinase C activation
    Håkan Thonberg
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 10691 Stockholm, Sweden
    Biochem J 364:73-9. 2002
    ....
  38. ncbi Uncoupling proteins: current status and therapeutic prospects
    Jan Nedergaard
    The Wenner-Gren Institute, Stockholm University, Stockholm SE-106 91, Sweden
    EMBO Rep 6:917-21. 2005
  39. ncbi Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice
    Daniel Edgar
    Division of Metabolic Diseases, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
    Cell Metab 10:131-8. 2009
    ....
  40. ncbi Differential signalling pathways for EGF versus PDGF activation of Erk1/2 MAP kinase and cell proliferation in brown pre-adipocytes
    Therese E Holmström
    Department of Physiology, The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Exp Cell Res 314:3581-92. 2008
    ....
  41. ncbi Adrenergic receptor density in brown adipose tissue of active and hibernating hamsters and ground squirrels
    Ludmila I Kramarova
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Comp Biochem Physiol A Mol Integr Physiol 146:408-14. 2007
    ..The balance between the various adrenoceptor subtypes may be important for the final effect of catecholamines in BAT in different physiological states...
  42. ncbi Studies of thermogenesis and mitochondrial function in adipose tissues
    Barbara Cannon
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
    Methods Mol Biol 456:109-21. 2008
    ..Questions concerning thermogenic capacity of the tissues, their potential influence on whole body metabolism, and specific properties of the mitochondria and their mode of function may be addressed using these methods...
  43. ncbi Ultraendurance exercise increases the production of reactive oxygen species in isolated mitochondria from human skeletal muscle
    Kent Sahlin
    The Swedish School of Sport and Health Sciences GIH, Astrand Laboratory of Work Physiology, Stockholm, Sweden
    J Appl Physiol 108:780-7. 2010
    ..Mitochondrial ROS production was not correlated with oxidative damage of mitochondrial proteins, which was increased at recovery but not immediately after exercise...
  44. ncbi Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages
    James A Timmons
    Wenner Gren Institute, Arrhenius Laboratories, Stockholm University, SE 106 91 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:4401-6. 2007
    ....
  45. ncbi Thermogenesis challenges the adipostat hypothesis for body-weight control
    Barbara Cannon
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Proc Nutr Soc 68:401-7. 2009
    ..Thus, increased thermogenesis may counteract obesity, without dietary intervention...
  46. ncbi Thermogenesis inhibition in brown adipocytes is a specific property of volatile anesthetics
    Kerstin B E Ohlson
    The Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Sweden
    Anesthesiology 98:437-48. 2003
    ..As the distinction between thermogenesis inhibitors and thermogenesis noninhibitors corresponds to the distinction between volatile and nonvolatile anesthetics, it may be related to the mode of action of the volatile anesthetics...
  47. ncbi Nonshivering thermogenesis and its adequate measurement in metabolic studies
    Barbara Cannon
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm SE 106 91, Sweden
    J Exp Biol 214:242-53. 2011
    ..Thus, experiments with animals kept and examined at thermoneutrality are likely to yield an improved possibility of identifying agents and genes important for human energy balance...
  48. ncbi Yes, even human brown fat is on fire!
    Barbara Cannon
    The Wenner Gren Institute, Stockholm University, Stockholm, Sweden
    J Clin Invest 122:486-9. 2012
    ....
  49. ncbi Brown adipose tissue: function and physiological significance
    Barbara Cannon
    The Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
    Physiol Rev 84:277-359. 2004
    ....
  50. ncbi Norepinephrine specifically stimulates ribonucleotide reductase subunit R2 gene expression in proliferating brown adipocytes: mediation via a cAMP/PKA pathway involving Src and Erk1/2 kinases
    J Magnus Fredriksson
    The Wenner Gren Institute, Stockholm University, Stockholm, SE 106 91, Sweden
    Exp Cell Res 274:207-15. 2002
    ....
  51. ncbi New powers of brown fat: fighting the metabolic syndrome
    Jan Nedergaard
    The Wenner Gren Institute, Stockholm University, Stockholm 106 91, Sweden
    Cell Metab 13:238-40. 2011
    ..2011) add further impressive aspects to the potential powers of BAT in the combat against the metabolic syndrome by demonstrating its vast capacity for triglyceride clearance and glucose disposal...
  52. ncbi Differential role of Presenilin-1 and -2 on mitochondrial membrane potential and oxygen consumption in mouse embryonic fibroblasts
    Homira Behbahani
    Department of Neurobiology, Karolinska Institutet Dainippon Sumitomo Pharmaceuticals Alzheimer Center, Caring Sciences and Society, Novum, Huddinge, Sweden
    J Neurosci Res 84:891-902. 2006
    ..These data point toward a specific role of PS2/gamma-secretase activity for proper mitochondrial function and indicate interplay between PS1 and PS2 in mitochondrial functionality...
  53. ncbi Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation
    Jacob B Hansen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark
    Proc Natl Acad Sci U S A 101:4112-7. 2004
    ..We propose that pRB acts as a molecular switch determining white vs. brown adipogenesis, suggesting a previously uncharacterized function of this key cell cycle regulator in adipocyte lineage commitment and differentiation...
  54. ncbi Nonshivering thermogenesis protects against defective calcium handling in muscle
    Jan Aydin
    Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden
    FASEB J 22:3919-24. 2008
    ..These results indicate that activation of UCP1-mediated heat production in brown adipose tissue during cold exposure reduces the necessity for shivering and thus prevents the development of severe dysfunction in shivering muscles...
  55. ncbi Effect of transforming growth factor-beta on calcium homeostasis in prostate carcinoma cells
    Zemfira Z Gizatullina
    Biomedical Center, The Ludwig Institute for Cancer Research, Box 595, SE-751 24 Uppsala, Sweden
    Biochem Biophys Res Commun 304:643-9. 2003
    ..The results implicate that TGF-beta1 affects the function of the mitochondria and may be of significance for the understanding of the proapoptotic effect of TGF-beta1 in these cells...
  56. ncbi A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity
    Elisabet Arvidsson Nordström
    Professor, Karolinska Institutet, Karolinska University Hospital Huddinge, M63 SE 141 86 Stockholm, Sweden
    Diabetes 54:1726-34. 2005
    ..We propose an important and human-specific role for CIDEA in lipolysis regulation and metabolic complications of obesity, which is at least in part mediated by cross-talk between CIDEA and TNF-alpha...
  57. ncbi Cold-induced alterations of phospholipid fatty acyl composition in brown adipose tissue mitochondria are independent of uncoupling protein-1
    Augustine Ocloo
    Medical Research Council, Dunn Human Nutrition Unit, Hills Road, Cambridge, U K
    Am J Physiol Regul Integr Comp Physiol 293:R1086-93. 2007
    ..Thus, the alterations in brown adipose tissue phospholipid acyl composition are revealed to be an independent part of the recruitment process, and their functional significance for thermogenesis should be elucidated...
  58. ncbi Developmental biology: Neither fat nor flesh
    Barbara Cannon
    Nature 454:947-8. 2008