Research Topics
| Alan W JonesSummaryAffiliation: National Board of Forensic Medicine Country: Sweden Publications
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Detail Information
Publications
Concentrations of unconjugated morphine, codeine and 6-acetylmorphine in urine specimens from suspected drugged driversGunnel Ceder
Department of Forensic Chemistry, University Hospital, , Sweden
J Forensic Sci 47:366-8. 2002..These results give a clear picture of the concentrations of unconjugated morphine, codeine and 6-acetylmorphine that can be expected in opiate-positive urine specimens from individuals apprehended for DUID after taking heroin...- Relation between blood- and urine-amphetamine concentrations in impaired drivers as influenced by urinary pH and creatinineA W Jones
Department of Forensic Toxicology, University Hospital, 581 85 Linkoping, Sweden
Hum Exp Toxicol 24:615-22. 2005..6, t= -3.12, P < 0.005). Other factors could impact on the urine-blood amphetamine relationship, such as route of administration, pattern of voiding and time elapsed after use of the drug... 
High re-arrest rates among drug-impaired drivers despite zero-tolerance legislationAnita Holmgren
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Artillerigatan 12, SE 581 33 Linköping, Sweden
Accid Anal Prev 40:534-40. 2008..The statutory blood-alcohol concentration (BAC) limit for driving is 0.2 mg/g ( approximately 0.02 g%)...- Are changes in blood-ethanol concentration during storage analytically significant? Importance of method imprecisionA Wayne Jones
Department of Forensic Genetics and Forensic Chemistry, National Board of Forensic Medicine, Linkoping, Sweden
Clin Chem Lab Med 45:1299-304. 2007..This study examines changes in blood-ethanol concentration (BEC) during the storage of specimens for up to 12 months at 4 degrees C... - Concentrations of scheduled prescription drugs in blood of impaired drivers: considerations for interpreting the resultsA W Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Artillerigatan 12, Linkoping, Sweden
Ther Drug Monit 29:248-60. 2007..In blood samples from DUID suspects, the concentrations of many commonly used sedatives and hypnotics exceeded the accepted therapeutic limits, which gives an indication of the abuse potential of these types of medications... - Concentrations of zolpidem and zopiclone in venous blood samples from impaired drivers compared with femoral blood from forensic autopsiesAlan Wayne Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linkoping, Sweden
Forensic Sci Int 222:118-23. 2012..This large compilation of forensic cases should prove useful when toxicologists are required to interpret concentrations of z-hypnotics in blood samples in relation to cause of death... - Blood methadone concentrations in living and deceased persons: variations over time, subject demographics, and relevance of coingested drugsA W Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linkoping, Sweden
J Anal Toxicol 36:12-8. 2012..Adverse drug-drug interactions and varying degrees of tolerance to opiates complicate the interpretation... - Concentrations of free-morphine in peripheral blood after recent use of heroin in overdose deaths and in apprehended driversA W Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Artillerigatan 12, SE 587 58 Linköping, Sweden
Forensic Sci Int 215:18-24. 2012.... - Five-year update on the occurrence of alcohol and other drugs in blood samples from drivers killed in road-traffic crashes in SwedenAlan Wayne Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Artillerigatan 12, SE 587 58 Linköping, Sweden
Forensic Sci Int 186:56-62. 2009.... - Occurrence of ethanol and other drugs in blood and urine specimens from female victims of alleged sexual assaultAlan Wayne Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Artillerigatan 12, SE 587 58 Linköping, Sweden
Forensic Sci Int 181:40-6. 2008..surreptitious administration of drugs and the degree of incapacitation in the victim as well as ability to give informed consent for sexual activity is fraught with difficulties... - Driving under the influence of opiates: concentration relationships between morphine, codeine, 6-acetyl morphine, and ethyl morphine in bloodA Wayne Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Artillerigatan 12, SE 581 33 Linköping, Sweden
J Anal Toxicol 32:265-72. 2008..5 (median 6.7), and this important ratio was less than unity in only two cases. This study finds compelling evidence that approximately 90% of apprehended drivers in Sweden with morphine and codeine in their blood had used heroin... - [Hospital alcohol tests not completely easy to use for legal purposes. Conversion of ethanol levels in plasma or serum to permillage level in blood]Alan Wayne Jones
Lakartidningen 105:367-8. 2008 - Driving under the influence of central stimulant amines: age and gender differences in concentrations of amphetamine, methamphetamine, and ecstasy in bloodAlan Wayne Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Artillerigatan 12, SE 581 33 Linköping, Sweden
J Stud Alcohol Drugs 69:202-8. 2008..Here we report the age and gender of offenders, along with the concentrations of amphetamine, methamphetamine, and ecstasy (3,4-methylenedioxymeth-amphetamine) in blood samples analyzed since the institution of the new legislation... - Ultra-rapid rate of ethanol elimination from blood in drunken drivers with extremely high blood-alcohol concentrationsAlan Wayne Jones
Department of Forensic Chemistry, National Board of Forensic Medicine, Artillerigatan 12, 581 85 Linkoping, Sweden
Int J Legal Med 122:129-34. 2008..However, the dose of alcohol and the duration of drinking necessary to boost the activity of CYP2E1 enzymes in humans have not been established... - Driving under the influence of cannabis: a 10-year study of age and gender differences in the concentrations of tetrahydrocannabinol in bloodAlan W Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Sweden
Addiction 103:452-61. 2008..This paper compares age, gender and the concentrations of THC in blood of individuals apprehended for driving under the influence of drugs (DUID) in Sweden, where a zero-tolerance law operates... - Concentrations of cocaine and its major metabolite benzoylecgonine in blood samples from apprehended drivers in SwedenA W Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Artillerigatan 12, SE 581 33 Linköping, Sweden
Forensic Sci Int 177:133-9. 2008..07) and 0.5mg/L for cocaine and 1.01 (0.70) and 3.1mg/L for BZE. Typical signs of drug influence noted by the arresting police officers included bloodshot and glossy eyes, agitation, difficulty in sitting still and incoherent speech... - Gamma-hydroxybutyrate concentrations in the blood of impaired drivers, users of illicit drugs, and medical examiner casesA Wayne Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Artillerigatan 12, SE 581 33 Linköping, Sweden
J Anal Toxicol 31:566-72. 2007..The short elimination half-life of GHB means that the concentrations in blood decrease rapidly and are probably a lot lower than at the time of driving, which was 30-90 min earlier... - Driving under the influence of gamma-hydroxybutyrate (GHB)Alan Wayne Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Artillerigatan 12, 58133 Linköping, Sweden
Forensic Sci Med Pathol 4:205-11. 2008..The blood concentrations reported here are probably appreciably less than at time of driving (30-90 min earlier) owing to the short elimination half-life of GHB (t ((1/2)) = 30-40 min)... - Age and gender differences in blood-alcohol concentration in apprehended drivers in relation to the amounts of alcohol consumedAlan Wayne Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Artillerigatan 12, SE 587 58 Linköping, Sweden
Forensic Sci Int 188:40-5. 2009.... - Quantitative analysis of amphetamine in femoral blood from drug-poisoning deaths compared with venous blood from impaired driversAlan Wayne Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linkoping, Sweden
Bioanalysis 3:2195-204. 2011..3 mg/l in multidrug users (n = 8250). Conclusion: Fatal amphetamine poisonings cannot be identified on the basis of the concentration in blood alone, owing to the development of tolerance and the toxicity of co-ingested substances... - Early drug discovery and the rise of pharmaceutical chemistryAlan Wayne Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Artillerigatan, Linkoping, Sweden
Drug Test Anal 3:337-44. 2011..This was acetylsalicylic acid, better known as Aspirin®, the first blockbuster drug. At the start of the twentieth century, the first of the barbiturate family of drugs entered the pharmacopoeia and the rest, as they say, is history... - Biomarkers of recent drinking, retrograde extrapolation of blood-alcohol concentration and plasma-to-blood distribution ratio in a case of driving under the influence of alcoholAlan Wayne Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Artillerigatan 12, SE 587 58 Linköping, Sweden
J Forensic Leg Med 18:213-6. 2011..The risk of contaminating a blood sample by swabbing the skin with isopropanol is discussed along with the use of alcohol biomarkers (ethyl glucuronide and ethyl sulphate) as evidence of recent drinking... - Fatality from drinking denatured alcohol and hypothermiaAlan Wayne Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linkoping, Sweden
J Anal Toxicol 35:316-8. 2011.... - Concentration ratios of free-morphine to free-codeine in femoral blood in heroin-related poisoning deathsA Wayne Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Artillerigatan 12, SE 587 58 Linköping, Sweden
Leg Med (Tokyo) 13:171-3. 2011..However, finding a low Mo/Co ratio (<1.0 or <2.0) does not preclude use of heroin because such low ratios are possible if a person had co-ingested heroin along with use or abuse of codeine medication... - Drug poisoning deaths in Sweden show a predominance of ethanol in mono-intoxications, adverse drug-alcohol interactions and poly-drug useA W Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, 587 58 Linköping, Sweden
Forensic Sci Int 206:43-51. 2011..The autopsy report, the police investigation, the findings at the scene and eye-witness statements should all be carefully considered when the cause and manner of death are determined... - Evidence-based survey of the elimination rates of ethanol from blood with applications in forensic caseworkAlan Wayne Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, 587 58 Linköping, Sweden
Forensic Sci Int 200:1-20. 2010..The results presented can hopefully serve as best-practice guidelines when questions arise in criminal and civil litigation about the elimination rate of ethanol from blood in humans... - Concentration distributions of the drugs most frequently identified in post-mortem femoral blood representing all causes of deathAlan Wayne Jones
Department of Forensic Toxicology, Artillerigatan 12, 58758 Linköping, Sweden
Med Sci Law 49:257-73. 2009..The drug concentration together with the findings at autopsy and the police report can then be used to reach a conclusion about the cause and manner of death... - Relationship between blood and urine alcohol concentrations in apprehended drivers who claimed consumption of alcohol after driving with and without supporting evidenceAlan Wayne Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linkoping, Sweden
Forensic Sci Int 194:97-102. 2010..Unless supporting evidence exists (eye witness, police reports, etc.) of post-offence drinking the courts are encouraged to ignore this defence argument... - Concentration-time profiles of gamma-hydroxybutyrate in blood after recreational doses are best described by zero-order rather than first-order kineticsA W Jones
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Artillerigatan 12, 587 58 Linköping, Sweden
J Anal Toxicol 33:332-5. 2009..Toxicologists should not arbitrarily apply the principles of first-order kinetics after abuse doses of drugs, when zero-order or saturation kinetics (Michaelis-Menten) are more appropriate... - Age- and gender-related differences in blood amphetamine concentrations in apprehended drivers: lack of association with clinical evidence of impairmentAlan Wayne Jones
Department of Forensic Genetics and Forensic Chemistry, National Board of Forensic, Medicine and University Hospital, Linkoping, Sweden
Addiction 102:1085-91. 2007..In a smaller retrospective sample (n = 70) the relationship between clinical tests of impairment were compared with the concentration of amphetamine in blood... - Does consumption of ethanol distort measurements of exhaled nitric oxide?A Wayne Jones
Department of Forensic Toxicology, University Hospital, SE 581 85 Linkoping, Sweden
Respir Med 99:196-9. 2005..Measuring FE(NO) is a novel and non-invasive way to monitor airway inflammation (e.g. asthma). This clinical study was designed to investigate whether drinking ethanol might distort FE(NO) measurements... - Crème de la crème in forensic science and legal medicine. The most highly cited articles, authors and journals 1981-2003Alan Wayne Jones
Department of Forensic Toxicology, University Hospital, 581 85 Linkoping, Sweden
Int J Legal Med 119:59-65. 2005..This in-depth bibliometric analysis has identified the creme de la creme in forensic science and legal medicine in a quantitative and objective way by citation analysis with focus on articles, authors and journals... - Magnitude and time-course of arterio-venous differences in blood-alcohol concentration in healthy menAlan Wayne Jones
Department of Forensic Toxicology, University Hospital, Linkoping, Sweden
Clin Pharmacokinet 43:1157-66. 2004..We therefore investigated the intravenous and intra-arterial concentrations of alcohol (ethanol) during the absorption, distribution and elimination stages of alcohol metabolism in healthy men... - How good are clinical chemistry laboratories at analysing ethylene glycol?A W Jones
Department of Forensic Chemistry, University Hospital, SE 581 85 Linkoping, Sweden
Scand J Clin Lab Invest 64:629-34. 2004..Efforts should be made to standardize the analytical methods used for toxicological analysis... - High concentrations of diazepam and nordiazepam in blood of impaired drivers: association with age, gender and spectrum of other drugs presentA W Jones
Department of Forensic Toxicology, University Hospital, 58185 Linkoping, Sweden
Forensic Sci Int 146:1-7. 2004..Furthermore, Swedish traffic delinquents frequently overdose with prescription drugs as exemplified here by unusually high concentrations of D and its active metabolite ND... - Distribution of diazepam and nordiazepam between plasma and whole blood and the influence of hematocritAlan Wayne Jones
Department of Forensic Toxicology, University Hospital, Linkoping, Sweden
Ther Drug Monit 26:380-5. 2004.... - Urine/blood ratios of ethanol in deaths attributed to acute alcohol poisoning and chronic alcoholismA W Jones
Department of Forensic Toxicology, National Laboratory of Forensic Chemistry, University Hospital, 581 85 Linkoping, Sweden
Forensic Sci Int 135:206-12. 2003..The higher UAC/BAC ratio in chronic alcoholism (median 1.30:1) is closer to the value expected for complete absorption and distribution of ethanol in all body fluids... - Blood analysis by headspace gas chromatography: does a deficient sample volume distort ethanol concentration?A W Jones
Department of Forensic Toxicology, University Hospital, 581 85 Linkoping, Sweden
Med Sci Law 43:241-7. 2003..In a separate study, we showed that the concentration of ethanol was lowered even more when a 4-carbon alcohol (t-butanol) was used as the internal standard... - Impact factors of forensic science and toxicology journals: what do the numbers really mean?A W Jones
Department of Forensic Toxicology, University Hospital, 581 85 Linkoping, Sweden
Forensic Sci Int 133:1-8. 2003..For example, one might consider whether the articles contained new ideas or innovations that proved useful in routine forensic casework or are widely relied upon in courts of law as proof source... - Comparison of ethanol concentrations in venous blood and end-expired breath during a controlled drinking studyA W Jones
Department of Alcohol Toxicology, National Laboratory of Forensic Chemistry, Linköping 581 85, Sweden
Forensic Sci Int 132:18-25. 2003.... 
Uncertainty in estimating blood ethanol concentrations by analysis of vitreous humourA W Jones
Department of Forensic Toxicology, University Hospital, SE 581 85 Linkoping, Sweden
J Clin Pathol 54:699-702. 2001....- Time course and reproducibility of urinary excretion profiles of ethanol, methanol, and the ratio of serotonin metabolites after intravenous infusion of ethanolA W Jones
Department of Forensic Toxicology, University Hospital, Linkoping, Sweden
Alcohol Clin Exp Res 23:1921-6. 1999.... - Driving under the influence of chlormethiazoleAlan Wayne Jones
Department of Forensic Toxicology, University Hospital, 581 85 Linkoping, Sweden
Forensic Sci Int 153:213-7. 2005..6 mg/L (1.6 mg/L) and 0.3-3.3 mg/L. This case report underscores the need to consider clinical observations and the person's behaviour in relation to the toxicology report when interpreting and testifying in drug-impaired driving cases... - False-positive breath-alcohol test after a ketogenic dietA W Jones
Department of Forensic Chemistry, National Board of Forensic Medicine and University Hospital, Linkoping, Sweden
Int J Obes (Lond) 31:559-61. 2007..This 'side effect' of ketogenic diets needs further discussion by authorities when people engaged in safety-sensitive work (e.g. bus drivers and airline pilots) submit to random breath-alcohol tests... - Urine as a biological specimen for forensic analysis of alcohol and variability in the urine-to-blood relationshipAlan W Jones
Department of Forensic Chemistry and Genetics, National Board of Forensic Medicine, and University Hospital, Linkoping, Sweden
Toxicol Rev 25:15-35. 2006..This information is useful to support or challenge allegations of drinking alcohol after driving, which has become known as the hip-flask defence... - The distribution of forensic journals, reflections on authorship practices, peer-review and role of the impact factorAlan Wayne Jones
Department of Forensic Chemistry and Genetics, National Board of Forensic Medicine, Artillerigatan 12, SE 581 33 Linköping and University Hospital, SE 581 85 Linkoping, Sweden
Forensic Sci Int 165:115-28. 2007..The information, conclusions and opinions published in forensic science journals might one day be proffered as evidence in criminal or civil litigation... - Which articles and which topics in the forensic sciences are most highly cited?A W Jones
Department of Forensic Toxicology, University Hospital, Linkoping, Sweden
Sci Justice 45:175-82. 2005..The Thompson ISI citation databases provide unique tools for tracking citations to individual articles and impact and citation records of scholarly journals... - Driving under the influence of drugs in Sweden with zero concentration limits in blood for controlled substancesAlan Wayne Jones
Department of Forensic Toxicology, University Hospital, Linkoping, Sweden
Traffic Inj Prev 6:317-22. 2005.... - Abnormally high concentrations of amphetamine in blood of impaired driversA W Jones
Department of Forensic Toxicology, University Hospital, 581 85 Linkoping, Sweden
J Forensic Sci 50:1215-20. 2005..Anecdotal information indicated that those with the very highest concentrations of amphetamine in blood had swallowed the drug to prevent being apprehended in possession of an illicit substance... - Toxicological analysis of blood and urine samples from female victims of alleged sexual assaultAlan W Jones
Department of Forensic Toxicology, National Board of Forensic Medicine, Linkoping, Sweden
Clin Toxicol (Phila) 50:555-61. 2012..The toxicological analysis of blood and urine samples from victims of alleged sexual assault represents a crucial part of the forensic evidence when this crime is investigated... - Predominance of illicit drugs and poly-drug use among drug-impaired drivers in SwedenAnita Holmgren
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Artillerigatan 12, Linkoping, Sweden
Traffic Inj Prev 8:361-7. 2007..This prompted an in-depth investigation into the kinds of drugs used by DUID offenders, whether licit or illicit, and the frequency of their occurrence... - Enhanced rate of ethanol elimination from blood after intravenous administration of amino acids compared with equicaloric glucoseBjorn Lisander
Department of Anaesthesiology, University Hospital, 581 85 Linkoping, Sweden
Alcohol Alcohol 41:39-43. 2006..To investigate the effect of an amino acid mixture given intravenously (i.v.) on the rate of ethanol elimination from blood compared with equicaloric glucose and Ringer's acetate as control treatments... - [A teetotaller rejected by alcohol ignition interlock]Alan Wayne Jones
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Lakartidningen 103:2487-8. 2006 - Impact of JAT publications 1981-2003: the most prolific authors and the most highly cited articlesAlan Wayne Jones
Department of Forensic Toxicology, University Hospital, , Sweden
J Anal Toxicol 28:541-5. 2004..g., impact factors). This article has identified JAT's scientific elite as evidenced by the most prolific authors and the most highly cited papers... - Interpreting results of ethanol analysis in postmortem specimens: a review of the literatureFredrik C Kugelberg
Department of Forensic Medicine, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Forensic Sci Int 165:10-29. 2007..This literature review will hopefully be a good starting point for those who are contemplating a fresh investigation into some aspect of postmortem alcohol analysis and toxicology...