Julien Ochala

Summary

Affiliation: Muscle Cell Physiology Laboratory
Country: Sweden

Publications

  1. ncbi request reprint Changes in mechanical properties of human plantar flexor muscles in ageing
    Julien Ochala
    Equipe INSERM ERIT M 0207 Motricité Plasticité, Faculte des Sciences du Sport, Universite de Bourgogne, BP 27877, 21078 Dijon Cedex, France
    Exp Gerontol 39:349-58. 2004
  2. ncbi request reprint Gender differences in human muscle and joint mechanical properties during plantar flexion in old age
    Julien Ochala
    Equipe Motricité Plasticité, Faculte des Sciences du Sport, Universite de Bourgogne, Dijon, France
    J Gerontol A Biol Sci Med Sci 59:441-8. 2004
  3. ncbi request reprint Effect of strength training on musculotendinous stiffness in elderly individuals
    Julien Ochala
    Equipe INSERM ERM 207 Motricité Plasticité, Faculte des Sciences du Sport, Universite de Bourgogne, Dijon, France
    Eur J Appl Physiol 94:126-33. 2005
  4. ncbi request reprint Single skeletal muscle fiber behavior after a quick stretch in young and older men: a possible explanation of the relative preservation of eccentric force in old age
    Julien Ochala
    Muscle Cell Physiology Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, MA, USA
    Pflugers Arch 452:464-70. 2006
  5. ncbi request reprint Changes in muscle and joint elasticity following long-term strength training in old age
    Julien Ochala
    Equipe INSERM ERM 207 Motricité Plasticité, Faculte des Sciences du Sport, Universite de Bourgogne, BP 27 877, 21 078 Dijon Cedex, France
    Eur J Appl Physiol 100:491-8. 2007
  6. doi request reprint Ca2+ sensitizers: An emerging class of agents for counterbalancing weakness in skeletal muscle diseases?
    Julien Ochala
    Department of Clinical Neurophysiology, Uppsala University Hospital, Sweden
    Neuromuscul Disord 20:98-101. 2010
  7. doi request reprint Thin filament proteins mutations associated with skeletal myopathies: defective regulation of muscle contraction
    Julien Ochala
    Department of Neuroscience, Clinical Neurophysiology, University Hospital, Entrance 85, SE 751 85, Uppsala, Sweden
    J Mol Med (Berl) 86:1197-204. 2008
  8. pmc Defective regulation of contractile function in muscle fibres carrying an E41K beta-tropomyosin mutation
    Julien Ochala
    Department of Neuroscience, Clinical Neurophysiology, University Hospital, Entrance 85, 3rd Floor, SE 751 85 Uppsala, Sweden
    J Physiol 586:2993-3004. 2008
  9. doi request reprint Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres
    Julien Ochala
    Department of Neuroscience, Clinical Neurophysiology, University Hospital, Uppsala, Sweden
    Exp Physiol 93:486-95. 2008
  10. ncbi request reprint Single skeletal muscle fiber elastic and contractile characteristics in young and older men
    Julien Ochala
    Muscle Cell Physiology Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    J Gerontol A Biol Sci Med Sci 62:375-81. 2007

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Changes in mechanical properties of human plantar flexor muscles in ageing
    Julien Ochala
    Equipe INSERM ERIT M 0207 Motricité Plasticité, Faculte des Sciences du Sport, Universite de Bourgogne, BP 27877, 21078 Dijon Cedex, France
    Exp Gerontol 39:349-58. 2004
    ..Invariance of SI(MA) and Kp would suggest an adaptive mechanism in articular structures to avoid the continuous integration of the ankle joint stiffness by the central nervous system, what may simplify most daily motor tasks...
  2. ncbi request reprint Gender differences in human muscle and joint mechanical properties during plantar flexion in old age
    Julien Ochala
    Equipe Motricité Plasticité, Faculte des Sciences du Sport, Universite de Bourgogne, Dijon, France
    J Gerontol A Biol Sci Med Sci 59:441-8. 2004
    ..05). These results are interpreted in terms of possible differences in the muscle mass, fiber-type distribution, and tendons. They may also have implications for daily motor behavior...
  3. ncbi request reprint Effect of strength training on musculotendinous stiffness in elderly individuals
    Julien Ochala
    Equipe INSERM ERM 207 Motricité Plasticité, Faculte des Sciences du Sport, Universite de Bourgogne, Dijon, France
    Eur J Appl Physiol 94:126-33. 2005
    ..05). The present results underlined that MT stiffness decreases following training in elderly individuals, counterbalancing the effect of ageing. These changes seem not only to be due to peripheral but also to neural adaptations...
  4. ncbi request reprint Single skeletal muscle fiber behavior after a quick stretch in young and older men: a possible explanation of the relative preservation of eccentric force in old age
    Julien Ochala
    Muscle Cell Physiology Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, MA, USA
    Pflugers Arch 452:464-70. 2006
    ....
  5. ncbi request reprint Changes in muscle and joint elasticity following long-term strength training in old age
    Julien Ochala
    Equipe INSERM ERM 207 Motricité Plasticité, Faculte des Sciences du Sport, Universite de Bourgogne, BP 27 877, 21 078 Dijon Cedex, France
    Eur J Appl Physiol 100:491-8. 2007
    ..Gender-related differences in MA stiffness response may originate from passive MA elastic structures...
  6. doi request reprint Ca2+ sensitizers: An emerging class of agents for counterbalancing weakness in skeletal muscle diseases?
    Julien Ochala
    Department of Clinical Neurophysiology, Uppsala University Hospital, Sweden
    Neuromuscul Disord 20:98-101. 2010
    ..Therefore, in the future, under certain conditions, these agents may represent an emerging class of agents to enhance the quality of life of patients suffering from skeletal muscle weakness...
  7. doi request reprint Thin filament proteins mutations associated with skeletal myopathies: defective regulation of muscle contraction
    Julien Ochala
    Department of Neuroscience, Clinical Neurophysiology, University Hospital, Entrance 85, SE 751 85, Uppsala, Sweden
    J Mol Med (Berl) 86:1197-204. 2008
    ..With an enhanced understanding of the cellular and molecular mechanisms underlying muscle weakness in patients carrying such mutations, better therapy strategies can be developed to improve the quality of life...
  8. pmc Defective regulation of contractile function in muscle fibres carrying an E41K beta-tropomyosin mutation
    Julien Ochala
    Department of Neuroscience, Clinical Neurophysiology, University Hospital, Entrance 85, 3rd Floor, SE 751 85 Uppsala, Sweden
    J Physiol 586:2993-3004. 2008
    ....
  9. doi request reprint Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres
    Julien Ochala
    Department of Neuroscience, Clinical Neurophysiology, University Hospital, Uppsala, Sweden
    Exp Physiol 93:486-95. 2008
    ..Thus, a change in Ca(2+) activation of the contractile apparatus in patients with preferential myosin loss is proposed as an additional factor contributing to the muscle function impairment in these patients...
  10. ncbi request reprint Single skeletal muscle fiber elastic and contractile characteristics in young and older men
    Julien Ochala
    Muscle Cell Physiology Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    J Gerontol A Biol Sci Med Sci 62:375-81. 2007
    ..e., reduced specific force and unloaded shortening velocity) in type I and IIa fibers. However, the changes in fiber stiffness may not directly influence contractile characteristics alterations...
  11. pmc Effects of a R133W beta-tropomyosin mutation on regulation of muscle contraction in single human muscle fibres
    Julien Ochala
    Department of Clinical Neurophysiology, Uppsala University Hospital, Entrance 85, 3rd Floor, SE 751 85 Uppsala, Sweden
    J Physiol 581:1283-92. 2007
    ....
  12. pmc Sparing of muscle mass and function by passive loading in an experimental intensive care unit model
    Guillaume Renaud
    Department of Neuroscience, Clinical Neurophysiology, University Hospital, Entrance 85, 3rd Floor, SE 751 85 Uppsala, Sweden
    J Physiol 591:1385-402. 2013
    ....
  13. pmc Diaphragm muscle weakness in an experimental porcine intensive care unit model
    Julien Ochala
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e20558. 2011
    ..Unexpectedly, sepsis, CS or NMBA have no significant additive effects, suggesting that mechanical ventilation and sedation are the triggering factors leading to diaphragm weakness in the intensive care unit...
  14. pmc Factors underlying the early limb muscle weakness in acute quadriplegic myopathy using an experimental ICU porcine model
    Julien Ochala
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e20876. 2011
    ..These results suggest that the rapid declines in CMAP amplitude and in force generation capacity are triggered by independent mechanisms with significant clinical and therapeutic implications...
  15. doi request reprint Mechanisms underlying the sparing of masticatory versus limb muscle function in an experimental critical illness model
    Sudhakar Aare
    Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden
    Physiol Genomics 43:1334-50. 2011
    ..spinal nerve innervated muscles during exposure to the ICU intervention...
  16. doi request reprint A myopathy-related actin mutation increases contractile function
    Johan Lindqvist
    Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Sweden
    Acta Neuropathol 123:739-46. 2012
    ..Overall, at the cell level, these divergent mechanisms conduct to an improved steady-state force production. Such results provide new surprising scientific insights and crucial information for future therapeutic strategies...
  17. doi request reprint EMD 57033 partially reverses ventilator-induced diaphragm muscle fibre calcium desensitisation
    Julien Ochala
    Department of Clinical Neurophysiology, Uppsala University Hospital, Uppsala, Sweden
    Pflugers Arch 459:475-83. 2010
    ..Thus, EMD 57033 partly restored the Ca(2+) activation of cells, reducing VIDD. This finding offers a strong basis for evaluating the effect of Ca(2+) sensitisers on diaphragm function in vivo...
  18. pmc Disrupted myosin cross-bridge cycling kinetics triggers muscle weakness in nebulin-related myopathy
    Julien Ochala
    Department of Neuroscience, Clinical Neurophysiology, Uppsala University Hospital, Entrance 85, 3rd Floor, SE 751 85 Uppsala, Sweden
    FASEB J 25:1903-13. 2011
    ..To reverse such a negative cascade of events, future potential therapeutic interventions should, therefore, focus on the triggering component, the altered myosin cross-bridge cycling kinetics...
  19. doi request reprint Distinct underlying mechanisms of limb and respiratory muscle fiber weaknesses in nemaline myopathy
    Johan Lindqvist
    Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden
    J Neuropathol Exp Neurol 72:472-81. 2013
    ..These divergent muscle-specific results provide new important insights into the pathophysiology of severe nemaline myopathy and crucial information for future development of therapeutic strategies...
  20. pmc Congenital myopathy-causing tropomyosin mutations induce thin filament dysfunction via distinct physiological mechanisms
    Julien Ochala
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Hum Mol Genet 21:4473-85. 2012
    ..Therefore, administration of troponin activators may constitute a promising therapeutic approach in the future...
  21. pmc The fraction of strongly bound cross-bridges is increased in mice that carry the myopathy-linked myosin heavy chain mutation MYH4L342Q
    Johan Lindqvist
    Department of Neuroscience, Uppsala University, Uppsala 751 85, Sweden
    Dis Model Mech 6:834-40. 2013
    ..Overall, these findings provide important insights into the molecular pathogenesis of skeletal myosinopathies...
  22. pmc A myopathy-linked tropomyosin mutation severely alters thin filament conformational changes during activation
    Julien Ochala
    Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden
    Proc Natl Acad Sci U S A 107:9807-12. 2010
    ....
  23. doi request reprint Relationship between force and size in human single muscle fibres
    Lisa S Krivickas
    Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, MA, USA
    Exp Physiol 96:539-47. 2011
    ..e. specific force versus 'normalized force')...
  24. pmc Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms
    Julien Ochala
    Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden
    J Physiol 589:2007-26. 2011
    ....
  25. pmc Maintenance of muscle mass, fiber size, and contractile function in mice lacking the Z-disc protein myotilin
    Julien Ochala
    Department of Clinical Neurophysiology, Uppsala University Hospital, Sweden
    Ups J Med Sci 114:235-41. 2009
    ..Myotilin location and interactions with other Z-disc proteins are clearly defined, but its role in the regulation of muscle structure and function remains unknown. The present study aims at investigating this specific role of myotilin...
  26. pmc Nemaline myopathy-related skeletal muscle α-actin (ACTA1) mutation, Asp286Gly, prevents proper strong myosin binding and triggers muscle weakness
    Julien Ochala
    Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Sweden
    PLoS ONE 7:e45923. 2012
    ..To counterbalance such negative events, future potential therapeutic strategies may focus on the inappropriate actin-actin interface or myosin binding...
  27. doi request reprint Gene expression and muscle fiber function in a porcine ICU model
    Varuna C Banduseela
    Department of Clinical Neurophysiology, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Physiol Genomics 39:141-59. 2009
    ..To our knowledge, this is the first study that isolates the effect of immobilization and mechanical ventilation in an ICU condition from various other cofactors...