Lucia Mincheva-Nilsson

Summary

Country: Sweden

Publications

  1. doi request reprint Cancer exosomes and NKG2D receptor-ligand interactions: impairing NKG2D-mediated cytotoxicity and anti-tumour immune surveillance
    Lucia Mincheva-Nilsson
    Department of Clinical Microbiology, Division of Clinical Immunology, Umea University, S 90187 Umea, Sweden Electronic address
    Semin Cancer Biol 28:24-30. 2014
  2. doi request reprint The role of placental exosomes in reproduction
    Lucia Mincheva-Nilsson
    Department of Clinical Immunology, Umea University, Umea, Sweden
    Am J Reprod Immunol 63:520-33. 2010
  3. pmc Pregnancy and gamma/delta T cells: taking on the hard questions
    Lucia Mincheva-Nilsson
    Dept of Clinical Immunology, Umea University, S 90185 Umea, Sweden
    Reprod Biol Endocrinol 1:120. 2003
  4. ncbi request reprint Immune cells and molecules in pregnancy: friends or foes to the fetus?
    Lucia Mincheva-Nilsson
    Department of Clinical Immunology, Umea University, S 90185, Umea, Sweden
    Expert Rev Clin Immunol 2:457-70. 2006
  5. ncbi request reprint Placenta-derived soluble MHC class I chain-related molecules down-regulate NKG2D receptor on peripheral blood mononuclear cells during human pregnancy: a possible novel immune escape mechanism for fetal survival
    Lucia Mincheva-Nilsson
    Department of Clinical Immunology, Umea University, S 90185 Umea, Sweden
    J Immunol 176:3585-92. 2006
  6. doi request reprint Exosomes secreted by human placenta carry functional Fas ligand and TRAIL molecules and convey apoptosis in activated immune cells, suggesting exosome-mediated immune privilege of the fetus
    Ann Christin Stenqvist
    Division of Clinical Immunology, Department of Clinical Microbiology, Umea University, S 90185 Umea, Sweden
    J Immunol 191:5515-23. 2013
  7. ncbi request reprint An optimized technique for separation of human decidual leukocytes for cellular and molecular analyses
    Olga Nagaeva
    Department of Clinical Immunology, Umea University, Sweden
    Am J Reprod Immunol 47:203-12. 2002
  8. pmc Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells
    Malin Hedlund
    Division of Clinical Immunology, Department of Clinical Microbiology, Umea University, Umea, Sweden
    PLoS ONE 6:e16899. 2011
  9. doi request reprint An efficient optimized method for isolation of villous trophoblast cells from human early pregnancy placenta suitable for functional and molecular studies
    Ann Christin Stenqvist
    Department of Clinical Immunology, Umea University, Umea, Sweden
    Am J Reprod Immunol 60:33-42. 2008
  10. doi request reprint Maternal Foxp3 expressing CD4+ CD25+ and CD4+ CD25- regulatory T-cell populations are enriched in human early normal pregnancy decidua: a phenotypic study of paired decidual and peripheral blood samples
    Tanya Dimova
    Department of Clinical Microbiology Clinical Immunology, Umea University, Umea, Sweden
    Am J Reprod Immunol 66:44-56. 2011

Collaborators

  • Tanya Dimova
  • Solbritt Rantapaa-Dahlqvist
  • F Dieli
  • Ting Chen
  • Olga Nagaeva
  • Ann Christin Stenqvist
  • Malin Hedlund
  • Vladimir Baranov
  • Marie Lundholm
  • Lennart Kjellberg
  • Salah E Farouk
  • Anders Widmark
  • Pernilla Wikstrom
  • Grethe Neumann Andersen
  • Mona Schröder
  • Dominic Kargl
  • Marianne Wulff
  • Eva Innala
  • Alan M Krensky
  • Marita Troye-Blomberg
  • Ann Sofi Petersson
  • Elsadig Kazzam
  • Jan Olofsson
  • Anders Waldenstrom
  • Karin Bondestam
  • Gunnar Nyberg
  • Lena Jonsson
  • Mats Göran Damber
  • Natalia Klintland
  • Kenneth Caidahl

Detail Information

Publications16

  1. doi request reprint Cancer exosomes and NKG2D receptor-ligand interactions: impairing NKG2D-mediated cytotoxicity and anti-tumour immune surveillance
    Lucia Mincheva-Nilsson
    Department of Clinical Microbiology, Division of Clinical Immunology, Umea University, S 90187 Umea, Sweden Electronic address
    Semin Cancer Biol 28:24-30. 2014
    ..This review summarizes recent findings concerning the role of NKG2D receptor-ligand system in cancer with emphasis on regulation of NKG2D ligand expression and the immunosuppressive role of exosomally expressed NKG2D ligands. ..
  2. doi request reprint The role of placental exosomes in reproduction
    Lucia Mincheva-Nilsson
    Department of Clinical Immunology, Umea University, Umea, Sweden
    Am J Reprod Immunol 63:520-33. 2010
    ..In this review, we summarize the current knowledge on the nature of placenta-derived exosomes and discuss their role in pregnancy...
  3. pmc Pregnancy and gamma/delta T cells: taking on the hard questions
    Lucia Mincheva-Nilsson
    Dept of Clinical Immunology, Umea University, S 90185 Umea, Sweden
    Reprod Biol Endocrinol 1:120. 2003
  4. ncbi request reprint Immune cells and molecules in pregnancy: friends or foes to the fetus?
    Lucia Mincheva-Nilsson
    Department of Clinical Immunology, Umea University, S 90185, Umea, Sweden
    Expert Rev Clin Immunol 2:457-70. 2006
    ..The goal of this review is to discuss the major cellular and molecular components of the immune system that control and promote fetal survival...
  5. ncbi request reprint Placenta-derived soluble MHC class I chain-related molecules down-regulate NKG2D receptor on peripheral blood mononuclear cells during human pregnancy: a possible novel immune escape mechanism for fetal survival
    Lucia Mincheva-Nilsson
    Department of Clinical Immunology, Umea University, S 90185 Umea, Sweden
    J Immunol 176:3585-92. 2006
    ..These findings suggest a new physiological mechanism of silencing the maternal immune system that promotes fetal allograft immune escape and supports the view of the placenta as an immunoregulatory organ...
  6. doi request reprint Exosomes secreted by human placenta carry functional Fas ligand and TRAIL molecules and convey apoptosis in activated immune cells, suggesting exosome-mediated immune privilege of the fetus
    Ann Christin Stenqvist
    Division of Clinical Immunology, Department of Clinical Microbiology, Umea University, S 90185 Umea, Sweden
    J Immunol 191:5515-23. 2013
    ..Our results suggest that bioactive FasL- and TRAIL-carrying exosomes, able to convey apoptosis, are secreted by the placenta and tie up the immunomodulatory and protective role of human placenta to its exosome-secreting ability. ..
  7. ncbi request reprint An optimized technique for separation of human decidual leukocytes for cellular and molecular analyses
    Olga Nagaeva
    Department of Clinical Immunology, Umea University, Sweden
    Am J Reprod Immunol 47:203-12. 2002
    ..In vitro studies of decidual leukocytes require constant improvement of cell isolation technique in order to obtain highly purified viable and functionally active cells...
  8. pmc Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells
    Malin Hedlund
    Division of Clinical Immunology, Department of Clinical Microbiology, Umea University, Umea, Sweden
    PLoS ONE 6:e16899. 2011
    ..The adverse effect of thermal and oxidative stress, enhancing the release of immunosuppressive exosomes, should be considered when cytostatic and hyperthermal anti-cancer therapies are designed...
  9. doi request reprint An efficient optimized method for isolation of villous trophoblast cells from human early pregnancy placenta suitable for functional and molecular studies
    Ann Christin Stenqvist
    Department of Clinical Immunology, Umea University, Umea, Sweden
    Am J Reprod Immunol 60:33-42. 2008
    ..Constant improvement in the isolation technique is required to obtain a high yield of pure trophoblast cells with high viability and well preserved morphology...
  10. doi request reprint Maternal Foxp3 expressing CD4+ CD25+ and CD4+ CD25- regulatory T-cell populations are enriched in human early normal pregnancy decidua: a phenotypic study of paired decidual and peripheral blood samples
    Tanya Dimova
    Department of Clinical Microbiology Clinical Immunology, Umea University, Umea, Sweden
    Am J Reprod Immunol 66:44-56. 2011
    ..We investigated Treg cells in paired decidual and peripheral blood (PB) samples from healthy women in early pregnancy and PB samples from non-pregnant women...
  11. doi request reprint Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function
    Malin Hedlund
    Department of Clinical Immunology, Umea University, Sweden
    J Immunol 183:340-51. 2009
    ..These findings highlight a role for NKG2D ligand-bearing placental exosomes in the fetal immune escape and support the view of placenta as a unique immunosuppressive organ...
  12. pmc Prostate tumor-derived exosomes down-regulate NKG2D expression on natural killer cells and CD8+ T cells: mechanism of immune evasion
    Marie Lundholm
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    PLoS ONE 9:e108925. 2014
    ..These data suggest prostate tumor-derived exosomes as down-regulators of the NKG2D-mediated cytotoxic response in PC patients, thus promoting immune suppression and tumor escape. ..
  13. doi request reprint Placenta-derived exosomes and syncytiotrophoblast microparticles and their role in human reproduction: immune modulation for pregnancy success
    Lucia Mincheva-Nilsson
    Department of Clinical Microbiology, Division of Clinical Immunology, Umea University, Umea, Sweden
    Am J Reprod Immunol 72:440-57. 2014
    ..In a concluding remark, a hypothetical proposal on how STBM and exosomes might interact in pregnancy is discussed and a way to evaluate this interaction is suggested...
  14. ncbi request reprint Dominant IL-10 and TGF-beta mRNA expression in gammadeltaT cells of human early pregnancy decidua suggests immunoregulatory potential
    Olga Nagaeva
    Department of Clinical Immunology, Umea University, Sweden
    Am J Reprod Immunol 48:9-17. 2002
    ..To examine the cytokine gene expression in gammadeltaT-cells from human early pregnancy decidua...
  15. ncbi request reprint Assessment of vascular function in systemic sclerosis: indications of the development of nitrate tolerance as a result of enhanced endothelial nitric oxide production
    Grethe Neumann Andersen
    Department of Rheumatology, University Hospital of Umea, Umea, Sweden
    Arthritis Rheum 46:1324-32. 2002
    ..To investigate the relationship between endothelium-dependent and endothelium-independent functions and the stiffness of conduit arteries as well as levels of endothelial activation markers in patients with systemic sclerosis (SSc)...
  16. ncbi request reprint Gamma delta T cells inhibit in vitro growth of the asexual blood stages of Plasmodium falciparum by a granule exocytosis-dependent cytotoxic pathway that requires granulysin
    Salah E Farouk
    Department of Immunology, Stockholm University, Svante Arrheniusvägen 16, S 10691 Stockholm, Sweden
    Eur J Immunol 34:2248-56. 2004
    ..falciparum is based on the granule exocytosis-dependent cytotoxic pathway and that the presence of granulysin is essential to maintain efficient killing...