George Klein

Summary

Affiliation: Microbiology and Tumor Biology Center
Country: Sweden

Publications

  1. ncbi request reprint Surveillance against tumors--is it mainly immunological?
    George Klein
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    Immunol Lett 100:29-33. 2005
  2. ncbi request reprint Perspectives in studies of human tumor viruses
    George Klein
    Microbiology and Tumor Biology Center MTC, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Front Biosci 7:d268-74. 2002
  3. ncbi request reprint Nasopharyngeal carcinoma (NPC) is an enigmatic tumor
    George Klein
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Semin Cancer Biol 12:415-8. 2002
  4. ncbi request reprint Introduction: genetic and epigenetic contributions to tumor evolution
    George Klein
    Microbiology and Tumor Biology Center, Karolinska Institute, Box 280, 17177 Stockholm, Sweden
    Semin Cancer Biol 12:327-30. 2002
  5. ncbi request reprint EBV-encoded EBNA-5 associates with P14ARF in extranucleolar inclusions and prolongs the survival of P14ARF-expressing cells
    Elena Kashuba
    Microbiology and Tumor Biology Center MTC, Karolinska Institute, Nobels vag 16, Box 280, S 171 77 Stockholm, Sweden
    Int J Cancer 105:644-53. 2003
  6. ncbi request reprint Concomitant increase of LMP1 and CD25 (IL-2-receptor alpha) expression induced by IL-10 in the EBV-positive NK lines SNK6 and KAI3
    Miki Takahara
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 119:2775-83. 2006
  7. pmc High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer
    Vladimir I Kashuba
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 4:e5231. 2009
  8. ncbi request reprint Discovery of frequent homozygous deletions in chromosome 3p21.3 LUCA and AP20 regions in renal, lung and breast carcinomas
    Vera N Senchenko
    Microbiology and Tumor Biology Center, Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm 17177 Sweden
    Oncogene 23:5719-28. 2004
  9. ncbi request reprint Upregulation of the truncated basic hair keratin 1(hHb1-DeltaN) in carcinoma cells by Epstein-Barr virus (EBV)
    Jun Nishikawa
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 107:597-602. 2003
  10. ncbi request reprint An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies
    Alexei Protopopov
    Microbiology and Tumor Biology Center, Karolinska Institute, 171 77 Stockholm, Sweden
    Cancer Res 63:404-12. 2003

Detail Information

Publications88

  1. ncbi request reprint Surveillance against tumors--is it mainly immunological?
    George Klein
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    Immunol Lett 100:29-33. 2005
    ..4) Intercellular surveillance. The tissue microenvironment influences the probability of disseminated tumor cell growth. Moreover, appropriate differentiation inducing signals may revert the tumor cell phenotype...
  2. ncbi request reprint Perspectives in studies of human tumor viruses
    George Klein
    Microbiology and Tumor Biology Center MTC, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Front Biosci 7:d268-74. 2002
    ....
  3. ncbi request reprint Nasopharyngeal carcinoma (NPC) is an enigmatic tumor
    George Klein
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Semin Cancer Biol 12:415-8. 2002
  4. ncbi request reprint Introduction: genetic and epigenetic contributions to tumor evolution
    George Klein
    Microbiology and Tumor Biology Center, Karolinska Institute, Box 280, 17177 Stockholm, Sweden
    Semin Cancer Biol 12:327-30. 2002
  5. ncbi request reprint EBV-encoded EBNA-5 associates with P14ARF in extranucleolar inclusions and prolongs the survival of P14ARF-expressing cells
    Elena Kashuba
    Microbiology and Tumor Biology Center MTC, Karolinska Institute, Nobels vag 16, Box 280, S 171 77 Stockholm, Sweden
    Int J Cancer 105:644-53. 2003
    ..The inclusions also contained p53 and HDM2, and were surrounded by PML bodies and proteasomes, which suggests that these inclusions could be targets for proteasome dependent protein degradation...
  6. ncbi request reprint Concomitant increase of LMP1 and CD25 (IL-2-receptor alpha) expression induced by IL-10 in the EBV-positive NK lines SNK6 and KAI3
    Miki Takahara
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 119:2775-83. 2006
    ..By this mechanism EBV could have an important role in the development of NK lymphoma since the inflammatory component in the tumor tissue can provide these cytokines...
  7. pmc High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer
    Vladimir I Kashuba
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 4:e5231. 2009
    ..Somatic hypermutation is a powerful mechanism for generation of different mutations. It was shown previously that somatic hypermutability of proto-oncogenes can induce development of lymphomas...
  8. ncbi request reprint Discovery of frequent homozygous deletions in chromosome 3p21.3 LUCA and AP20 regions in renal, lung and breast carcinomas
    Vera N Senchenko
    Microbiology and Tumor Biology Center, Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm 17177 Sweden
    Oncogene 23:5719-28. 2004
    ..Mapping of 19 HDs in the AP20 region resulted in the localization of the minimal region to the interval flanked by D3S1298 and D3S3623 markers. Only four genes were discovered in this interval, namely, APRG1, ITGA9, HYA22 and VILL...
  9. ncbi request reprint Upregulation of the truncated basic hair keratin 1(hHb1-DeltaN) in carcinoma cells by Epstein-Barr virus (EBV)
    Jun Nishikawa
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 107:597-602. 2003
    ..It also may establish a link between EBV and the low differentiated or anaplastic status of the carcinomas that carry the virus...
  10. ncbi request reprint An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies
    Alexei Protopopov
    Microbiology and Tumor Biology Center, Karolinska Institute, 171 77 Stockholm, Sweden
    Cancer Res 63:404-12. 2003
    ..NotI digestion revealed that the AP20 region was frequently and extensively methylated in renal carcinoma cell lines and tumor biopsies...
  11. ncbi request reprint EBV infection induces expression of the transcription factors ATF-2/c-Jun in B lymphocytes but not in B-CLL cells
    Kentaro Bandobashi
    Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77, Stockholm, Sweden
    Virus Genes 30:323-30. 2005
    ..Treatment with phorbol-12, 13-dibutyrate (PDB) induced LMP-1 expression in three of four clones. Neither the HDACi nor the PDB treated cells survived...
  12. ncbi request reprint Consistent downregulation of human lactoferrin gene, in the common eliminated region 1 on 3p21.3, following tumor growth in severe combined immunodeficient (SCID) mice
    Ying Yang
    Microbiology and Tumor Biology Center, Karolinska Institute, Nobelsvägen 16, 171 77 Stockholm, Sweden
    Cancer Lett 191:155-64. 2003
    ..Promoter methylation and/or rearrangement of the insertion site may be responsible for human LF downregulation in mouse fibrosarcoma derived tumors...
  13. pmc Mandatory chromosomal segment balance in aneuploid tumor cells
    Maria Kost-Alimova
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institute, Box 280, 171 77 Stockholm, Sweden
    BMC Cancer 7:21. 2007
    ..According to the alternative quantitative model, the tumor cell would not tolerate an increased dosage of the relevant gene or segment. If so, either a normal cell derived, or, a tumor derived endogenous segment could be lost...
  14. ncbi request reprint IL-10 can induce the expression of EBV-encoded latent membrane protein-1 (LMP-1) in the absence of EBNA-2 in B lymphocytes and in Burkitt lymphoma- and NK lymphoma-derived cell lines
    Lorand L Kis
    Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
    Blood 107:2928-35. 2006
    ....
  15. ncbi request reprint Leukotriene B4 activates T cells that inhibit B-cell proliferation in EBV-infected cord blood-derived mononuclear cell cultures
    Anquan Liu
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels vag 16, Stockholm, Sweden
    Blood 111:2693-703. 2008
    ..Importantly, the results indicate that endogenous LTB(4) can induce T-cell activation that inhibits the EBV-induced proliferation of B lymphocytes...
  16. ncbi request reprint Functional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C
    Jingfeng Li
    Microbiology and Tumor Biology Center, Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
    Cancer Res 64:6438-43. 2004
    ..This study, together with previously obtained results, indicates that NPRL2 is a multiple tumor suppressor gene...
  17. ncbi request reprint Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice
    Irina D Kholodnyuk
    Microbiology and Tumour Biology Center, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 119:99-107. 2006
    ..Our data indicate these genes as putative tumour suppressor genes...
  18. pmc IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoter
    Lorand L Kis
    Department of Microbiology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 107:872-7. 2010
    ..In light of the fact that IL-21 is already in clinical trials for the treatment of multiple malignancies, the in vivo modulation of EBV gene expression by IL-21 might have therapeutic benefits for the EBV-carrying malignancies...
  19. ncbi request reprint Upregulation of LMP1 expression by histone deacetylase inhibitors in an EBV carrying NPC cell line
    Jun Nishikawa
    Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
    Virus Genes 28:121-8. 2004
    ..With this cell line it was thus possible to study the regulation of LMP1 expression by modification of chromatin acetylation state...
  20. pmc The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative disease
    Noemi Nagy
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:11966-71. 2009
    ..We have shown that the anti-apoptotic protein VCP (valosin-containing protein) binds to SAP, suggesting that it could be instrumental in the enhanced apoptotic response modulated by SAP...
  21. ncbi request reprint Inactivation of RASSF1C during in vivo tumor growth identifies it as a tumor suppressor gene
    Jingfeng Li
    Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm 171 77, Sweden
    Oncogene 23:5941-9. 2004
    ..In addition, RASSF1C was shown to induce cell cycle arrest in KRC/Y cells. These results strongly imply that like RASSF1A the RASSF1C gene could serve a tumor suppressor function...
  22. doi request reprint Simultaneous detection of the two main proliferation driving EBV encoded proteins, EBNA-2 and LMP-1 in single B cells
    Abu E Rasul
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels vag 16, S 171 77 Stockholm, Sweden
    J Immunol Methods 385:60-70. 2012
    ..Consequently, Type IIa lines could not be established from Hodgkin's lymphoma in vitro. We propose that these experimental cultures can be exploited for study of the Type IIa cells...
  23. ncbi request reprint In vitro EBV-infected subline of KMH2, derived from Hodgkin lymphoma, expresses only EBNA-1, while CD40 ligand and IL-4 induce LMP-1 but not EBNA-2
    Lorand L Kis
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 113:937-45. 2005
    ..The KMH2 EBV cells expressed LMP-2A, but not LMP-2B mRNAs. This result is highly relevant for the type II expression pattern of H/RS cells in vivo, since these stimuli can be provided by the surrounding activated T lymphocytes...
  24. pmc HYAL1 and HYAL2 inhibit tumour growth in vivo but not in vitro
    Fuli Wang
    Microbiology and Tumour Biology Center, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 3:e3031. 2008
    ..Until now TSGs which were isolated from AP20 and LUCA regions (e.g.G21/NPRL2, RASSF1A, RASSF1C, SEMA3B, SEMA3F, RBSP3) were shown to inhibit tumour cell growth both in vitro and in vivo...
  25. ncbi request reprint Regulation of transactivation function of the aryl hydrocarbon receptor by the Epstein-Barr virus-encoded EBNA-3 protein
    Elena V Kashuba
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    J Biol Chem 281:1215-23. 2006
    ..Taken together, our studies revealed a novel interaction between EBV- and AhR-dependent cellular pathways that control cell proliferation and survival...
  26. pmc RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies
    Vladimir I Kashuba
    Microbiology and Tumor Biology Center and Center for Genomics and Bioinformatics, Karolinska Institute, 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 101:4906-11. 2004
    ....
  27. pmc T cell leukemia I oncogene expression depends on the presence of Epstein-Barr virus in the virus-carrying Burkitt lymphoma lines
    Csaba Kiss
    Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 100:4813-8. 2003
    ..In the originally EBV-positive BLs, the ability of the virus to switch on TCL-1 expression would obviate this need...
  28. doi request reprint Genetic and epigenetic analysis of non-small cell lung cancer with NotI-microarrays
    Alexey A Dmitriev
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
    Epigenetics 7:502-13. 2012
    ....
  29. pmc Segmental duplications and evolutionary plasticity at tumor chromosome break-prone regions
    Eva Darai-Ramqvist
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm SE 171 77, Sweden
    Genome Res 18:370-9. 2008
    ....
  30. ncbi request reprint SH2D1A expression in Burkitt lymphoma cells is restricted to EBV positive group I lines and is downregulated in parallel with immunoblastic transformation
    Noemi Nagy
    Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 100:433-40. 2002
    ..It is possible that SH2D1A is expressed in a narrow window of B cell development represented by germinal center cells...
  31. ncbi request reprint Microcell-mediated chromosome transfer provides evidence that polysomy promotes structural instability in tumor cell chromosomes through asynchronous replication and breakage within late-replicating regions
    Maria Kost-Alimova
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    Genes Chromosomes Cancer 40:316-24. 2004
    ..This may explain the increased structural chromosome instability and preferential pericentromeric localization of breakpoints in hyperploid tumors...
  32. doi request reprint The architecture of fibroblast monolayers of different origin differentially influences tumor cell growth
    Emilie Flaberg
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 131:2274-83. 2012
    ..This suggests that our model system may reveal molecular mechanisms involved in contact-mediated microenvironmental surveillance that may protect the organism from the outgrowth of disseminated tumor cells...
  33. pmc Latency type-dependent modulation of Epstein-Barr virus-encoded latent membrane protein 1 expression by type I interferons in B cells
    Daniel Salamon
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    J Virol 86:4701-7. 2012
    ..Furthermore, our results may explain the expression of LMP-1 in memory B cells of systemic lupus erythematosus patients...
  34. doi request reprint To the genesis of Burkitt lymphoma: regulation of apoptosis by EBNA-1 and SAP may determine the fate of Ig-myc translocation carrying B lymphocytes
    Noemi Nagy
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institute, Nobelsv 16, SE 171 77 Stockholm, Sweden
    Semin Cancer Biol 19:407-10. 2009
    ..However, their EBV positive counterparts are permissive for SAP expression, due to the anti-apoptotic function of EBNA-1...
  35. pmc MRPS18-2 protein immortalizes primary rat embryonic fibroblasts and endows them with stem cell-like properties
    Elena Kashuba
    Department of Microbiology, Karolinska Institutet, Box 280, S 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:19866-71. 2009
    ..In immunodeficient mice, 18IM cells formed small transiently growing tumors that have down-regulated SSEA-1 and showed pan-keratin staining. We conclude that S18-2 can immortalize REFs and induces them to express stem cell traits...
  36. doi request reprint STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma
    Lorand L Kis
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Blood 117:165-74. 2011
    ....
  37. pmc Epstein-Barr virus infection negatively impacts the CXCR4-dependent migration of tonsillar B cells
    Barbro Ehlin-Henriksson
    Microbiology and Tumour Biology Centre, Karolinska Institute, Stockholm, Sweden
    Immunology 117:379-85. 2006
    ..Our finding suggests that changing the SDF-1alpha response of the EBV-infected B cells may serve the viral strategy by directing the infected cells into the extrafollicular areas, rather than retaining them in the lymphoepithelium...
  38. pmc EBV-encoded EBNA-6 binds and targets MRS18-2 to the nucleus, resulting in the disruption of pRb-E2F1 complexes
    Elena Kashuba
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institute, Box 280, Stockholm, S 17177 Sweden
    Proc Natl Acad Sci U S A 105:5489-94. 2008
    ..This would inhibit pRb binding to E2F1 competitively and lift the block preventing S-phase entry...
  39. ncbi request reprint Expression of SH2D1A in five classical Hodgkin's disease-derived cell lines
    Lorand L Kis
    Microbiology and Tumor Biology Center MTC, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 104:658-61. 2003
    ..It is likely therefore that in addition to the demonstrated functional defect of T and NK cells imposed by the SH2D1A mutation, the behavior of certain EBV-infected B lymphocytes is also modified...
  40. doi request reprint Epstein-Barr virus-encoded EBNA-5 forms trimolecular protein complexes with MDM2 and p53 and inhibits the transactivating function of p53
    Elena Kashuba
    Department of Microbiology, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 128:817-25. 2011
    ..The p53-dependent genes P21 and VDR were not induced in EBV-infected, in contrast to mitogen-activated cells. This may explain the tolerance of established LCLs to high levels of p53 without undergoing apoptosis...
  41. pmc Soluble factors produced by activated CD4+ T cells modulate EBV latency
    Noemi Nagy
    Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 109:1512-7. 2012
    ..We detected similar regulatory functions of T cells in in vitro-infected lymphocyte populations. In conclusion, our results revealed an additional mechanism by which CD4(+) T cells can control the EBV-induced B-cell proliferation...
  42. doi request reprint Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and blocks activation of its target genes
    Surya Pavan Yenamandra
    Department of Microbiology, Tumor, and Cell Biology MTC, Karolinska Institute, 171 77, Stockholm, Sweden
    Cell Mol Life Sci 67:4249-56. 2010
    ..The presented data shed some light on the anti-apoptotic EBV program and the role of the EBNA-3-VDR interaction in the viral strategy...
  43. pmc Changes in chemokines and chemokine receptor expression on tonsillar B cells upon Epstein-Barr virus infection
    Barbro Ehlin-Henriksson
    Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Immunology 127:549-57. 2009
    ..Both receptors mediate homing to mucosal tissue. The alterations of the expression of these molecules may lead to retention of EBV-infected tonsillar B cells in the interfollicular region of the tonsil...
  44. ncbi request reprint Cytokine mediated induction of the major Epstein-Barr virus (EBV)-encoded transforming protein, LMP-1
    Lorand L Kis
    Microbiology and Tumor Biology Center, Karolinska Institute, S 17177 Stockholm, Sweden
    Immunol Lett 104:83-8. 2006
    ..Cytokine mediated induction of LMP-1 may also explain the heterogeneous expression of this viral gene seen in normal and malignant cells...
  45. ncbi request reprint The apoptosis modulating role of SAP (SLAM associated protein) contributes to the symptomatology of the X linked lymphoproliferative disease
    Noemi Nagy
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institute, Stockholm, Sweden
    Cell Cycle 8:3086-90. 2009
    ..This mechanism is inefficient in XLP patients. In addition, in the absence of SAP, lymphoma development may be promoted by the illegitimate survival of lymphocytes with damaged DNA that would be normally eliminated by apoptosis...
  46. pmc PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein
    Gyorgy Stuber
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institute, Stockholm, Sweden
    Mol Cancer 8:23. 2009
    ..We propose that PRIMA-1MET may reversibly inhibit cellular chaperons that prevent the aggregation of misfolded proteins, and that EBNA-5 may serve as a surrogate drug target for elucidating the precise molecular action of PRIMA-1MET...
  47. ncbi request reprint Improved subtractive suppression hybridization combined with high density cDNA array screening identifies differentially expressed viral and cellular genes
    Csaba Kiss
    Microbiology and Tumor Biology Center MTC, Karolinska Institute, Nobels vag 16, S 17177, Stockholm, Sweden
    J Virol Methods 107:195-203. 2003
    ..Statistical analysis of the data revealed that the spotting of the arrayer is exceptionally reproducible, which makes the comparison of the hybridization of parallel filters possible...
  48. doi request reprint Interaction of Epstein-Barr virus (EBV) with human B-lymphocytes
    George Klein
    Karolinska Institutet, Department of Microbiology, Tumor and Cell Biology MTC, Box 280, S17177 Stockholm, Sweden
    Biochem Biophys Res Commun 396:67-73. 2010
    ..We describe a possible growth promoting mechanism in the genesis of Burkitt lymphoma that depends on the presence of EBV...
  49. ncbi request reprint Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3
    Hajnalka Kiss
    Microbiology and Tumor Biology Center MTC, Karolinska Institutet, Nobelsvag 16, S 171 77 Stockholm, Sweden
    Mamm Genome 13:646-55. 2002
    ..We also recognized a large number of conserved elements that were neither exons, CpG islands, nor repeats. We further identified and characterized five novel orthologous mouse genes (Kiaa0028, Xtrp3s1, Fyco1, Tmem7, and Lrrc2)...
  50. ncbi request reprint CD40 ligation downregulates EBNA-2 and LMP-1 expression in EBV-transformed lymphoblastoid cell lines
    Katja Pokrovskaja
    Microbiology and Tumorbiology Center, Karolinska Institute, S 17177, Stockholm, Sweden
    Int J Cancer 99:705-12. 2002
    ..This would permit virus persistence in the B-cell memory compartment...
  51. ncbi request reprint Deletion mapping using quantitative real-time PCR identifies two distinct 3p21.3 regions affected in most cervical carcinomas
    Vera Senchenko
    Microbiology and Tumor Biology Center, Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, 17177 Sweden
    Oncogene 22:2984-92. 2003
    ..The results strongly suggest that 3p21.3T and 3p21.3C regions harbor genes involved in the origin and/or development of CCs and imply that those genes might be multiple TSG(s)...
  52. ncbi request reprint Epstein-Barr virus-encoded EBNA-5 binds to Epstein-Barr virus-induced Fte1/S3a protein
    Elena Kashuba
    Microbiology and Tumor Biology Center MTC, S 171 77 Stockholm, Sweden
    Exp Cell Res 303:47-55. 2005
    ..We suggest that EBNA-5 through binding may influence the growth promoting, differentiation inhibiting, or apoptosis regulating functions of Fte-1/S3a...
  53. ncbi request reprint Rearrangements of the telomeric region of mouse chromosome 11 in Pre-B ABL/MYC cells revealed by mBANDing, spectral karyotyping, and fluorescence in-situ hybridization with a subtelomeric probe
    Katalin Benedek
    Microbiology and Tumorbiology Centre, Karolinska Institute, Stockholm, Sweden
    Chromosome Res 12:777-85. 2004
    ..Our findings suggest that the Pre-B ABL/MYC cells may be used to analyse the genetic changes affecting chromosome 11 that are associated with v-abl/myc-dependent tumorigenesis in mouse B cells...
  54. pmc Coincidence of synteny breakpoints with malignancy-related deletions on human chromosome 3
    Maria Kost-Alimova
    Microbiology and Tumor Biology Center, Karolinska Institute, Box 280, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 100:6622-7. 2003
    ..This repeat is nonrandomly localized within the other tumor-associated deletions and in the vicinity of 3p12-22 CBRs...
  55. pmc HHV-8 encoded LANA-1 alters the higher organization of the cell nucleus
    Gyorgy Stuber
    Department of Microbiology, Tumor and Cell Biology MTC and Center for Integrative Recognition in the Immune System, Karolinska Institute, Stockholm, Sweden
    Mol Cancer 6:28. 2007
    ..The induction of histone modification in adjacent host genes may lead to altered gene expression, thereby contributing to the viral oncogenesis...
  56. pmc p53 contributes to T cell homeostasis through the induction of pro-apoptotic SAP
    Harsha S Madapura
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Stockholm, Sweden
    Cell Cycle 11:4563-9. 2012
    ..Our result suggests that p53 contributes to T cell homeostasis through the induction of the pro-apoptotic SAP. A high level of SAP is necessary for the activation-induced cell death that is pivotal in termination of the T cell response...
  57. doi request reprint Type I interferons directly down-regulate BCL-6 in primary and transformed germinal center B cells: differential regulation in B cell lines derived from endemic or sporadic Burkitt's lymphoma
    Daniel Salamon
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels vag 16, SE 171 77 Stockholm, Sweden
    Cytokine 57:360-71. 2012
    ..Our results identify type I IFNs as the first group of cytokines that can down-regulate BCL-6 expression directly in GC B cells...
  58. pmc p14ARF induces the relocation of HDM2 and p53 to extranucleolar sites that are targeted by PML bodies and proteasomes
    Elena Kashuba
    Microbiology and Tumor Biology Center MTC, Karolinska Institute, S 171 77, Stockholm, Sweden
    Mol Cancer 2:18. 2003
    ..p14ARF is a protein product of the alternative reading frame of the human INK4a locus. It functions as a tumor suppressor protein. p14ARF suppresses growth through p53-dependent and p53-independent pathways...
  59. doi request reprint High-throughput live-cell imaging reveals differential inhibition of tumor cell proliferation by human fibroblasts
    Emilie Flaberg
    Department of Microbiology, Tumor and Cell Biology and Center for Integrative Recognition in the Immune System, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 128:2793-802. 2011
    ..Our high-throughput system allows the quantitative analysis of the inhibitory effect of fibroblasts on the population level and the exploration of differences depending on the source of the normal cells...
  60. ncbi request reprint PSK and Trx80 inhibit B-cell growth in EBV-infected cord blood mononuclear cells through T cells activated by the monocyte products IL-15 and IL-12
    Anquan Liu
    Microbiology and Tumor Biology Center, Karolinska Institute, Box 280, 171 77 Stockholm, Sweden
    Blood 105:1606-13. 2005
    ..Phosphatidylinositol 3-(PI 3)-kinase and reactive oxygen species (ROSs) were involved in the PSK-induced activation of monocytes. Restimulation of the cultures with EBV-transformed B cells generated specific cytotoxic activity...
  61. doi request reprint Comparative analysis of the Epstein-Barr virus encoded nuclear proteins of EBNA-3 family
    Surya Pavan Yenamandra
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, S 17177 Stockholm, Sweden
    Comput Biol Med 39:1036-42. 2009
    ..Charged clusters are believed to play an important role in interactions with DNA or signaling proteins. Additionally, unique primary sequence repeats were found in all three proteins...
  62. pmc Array-CGH and multipoint FISH to decode complex chromosomal rearrangements
    Eva Darai-Ramqvist
    Department of Microbiology, Tumour and Cell Biology MTC, Karolinska Institutet, S 17177, Stockholm, Sweden
    BMC Genomics 7:330. 2006
    ..We have used 179 BAC/PAC clones covering chr3 with an approximately 1 Mb resolution to analyze nine carcinoma lines. Chr3 was chosen for analysis, because of its frequent rearrangements in human solid tumours...
  63. ncbi request reprint Multipoint interphase FISH in childhood T-acute lymphoblastic leukemia detects subpopulations that carry different chromosome 3 aberrations
    Irén Haltrich
    Microbiology and Tumor Biology Center, Karolinska Institute, Nobelsvägen 16, Stockholm 17177, Sweden
    Cancer Genet Cytogenet 172:54-60. 2007
    ....
  64. ncbi request reprint Human cell lines engineered for tetracycline-regulated expression of tumor suppressor candidate genes from a frequently affected chromosomal region, 3p21
    Alexei I Protopopov
    Microbiology and Tumor Biology Center, Karolinska Institute, 17177 Stockholm, Sweden
    J Gene Med 4:397-406. 2002
    ..This study describes in detail new vectors and a unifying strategy to generate tTA-expressing cell lines...
  65. pmc Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase
    Elena Kashuba
    Microbiology and Tumor Biology Centre, Karolinska Institute, S 171 77, Stockholm, Sweden
    BMC Cell Biol 3:23. 2002
    ..The transformed immunoblasts may grow up as immunoblastic lymphomas in immuno-suppressed hosts...
  66. doi request reprint Burkitt lymphoma--a stalking horse for cancer research?
    George Klein
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Box 280, SE 171 77 Stockholm, Sweden
    Semin Cancer Biol 19:347-50. 2009
    ....
  67. pmc Toward a genetics of cancer resistance
    George Klein
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:859-63. 2009
    ..e., to stop them at their inception. It is further suggested that resistance genes may act at the level of tissue organization in a dominant fashion...
  68. ncbi request reprint Search for unknown tumor-antagonizing genes
    Stephan Imreh
    Karolinska Institutet, Microbiology and Tumor Biology Center, Stockholm, Sweden
    Genes Chromosomes Cancer 38:307-21. 2003
    ..quot; These findings raise the question whether the number and variety of genes that may contribute to the defense against uncontrolled proliferation may have been underestimated...
  69. ncbi request reprint SH2D1A expression reflects activation of T and NK cells in cord blood lymphocytes infected with EBV and treated with the immunomodulator PSK
    Anquan Liu
    Microbiology and Tumorbiology Center MTC, Karolinska Institute, Box 280, 171 77 Stockholm, Sweden
    Immunol Lett 80:181-8. 2002
    ..Its potentiation by immunomodulators may have practical significance...
  70. ncbi request reprint The transcriptional map of the common eliminated region 1 (C3CER1) in 3p21.3
    Hajnalka Kiss
    Microbiology and Tumor Biology Center MTC, Karolinska Institutet, S 17177, Stockholm, Sweden
    Eur J Hum Genet 10:52-61. 2002
    ..The detailed knowledge of gene content in C3CER1 is a prerequisite for functional analysis of these genes and understanding of their possible role in tumorigenesis...
  71. ncbi request reprint The microcell hybrid-based "elimination test" identifies a 1-Mb putative tumor-suppressor region at 3p22.2-p22.1 centromeric to the homozygous deletion region detected in lung cancer
    Irina D Kholodnyuk
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    Genes Chromosomes Cancer 34:341-4. 2002
    ..5 Mb centromeric to the known homozygous deletion region, identified in lung cancer. Remarkably, two chemokine-receptor genes (CCRs), CCR8 and CX3CR1, are located within CER2, whereas seven CCRs were found within CER1...
  72. ncbi request reprint Optimisation of the degenerate oligonucleotide primed PCR (DOP-PCR) for capillary thermocycler
    Csaba Kiss
    Microbiology and Tumor Biology Center MTC, Karolinska Institute, Nobels vag 16, S 17177 Stockholm, Sweden
    Biomol Eng 19:31-4. 2002
    ..The efficiency of the amplification was confirmed by gel electrophoresis and fluorescence in situ hybridisation on metaphase chromosomes...
  73. ncbi request reprint Latent nuclear antigen of Kaposi's sarcoma herpesvirus/human herpesvirus-8 induces and relocates RING3 to nuclear heterochromatin regions
    Karin Mattsson
    Microbiology and Tumor Biology Center, Karolinska Institute, PO Box 280, S 171 77, Stockholm, Sweden
    J Gen Virol 83:179-88. 2002
    ..We suggest that LANA and RING3 may create a local euchromatic microenvironment around the viral episomes that are anchored to the heterochromatin...
  74. pmc NotI subtraction and NotI-specific microarrays to detect copy number and methylation changes in whole genomes
    Jingfeng Li
    Microbiology and Tumor Biology Center, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 99:10724-9. 2002
    ..These microarrays, when probed with NRs, can simultaneously detect copy number changes and methylation. NotI microarrays offer a powerful tool with which to study carcinogenesis...
  75. pmc B-lymphocyte subpopulations are equally susceptible to Epstein-Barr virus infection, irrespective of immunoglobulin isotype expression
    Barbro Ehlin-Henriksson
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Immunology 108:427-30. 2003
    ..These data indicate that recirculating B cells have both the potential for, and susceptibility to, initial infection by EBV, irrespective of the immunoglobulin isotype expressed...
  76. ncbi request reprint hUNC93B1: a novel human gene representing a new gene family and encoding an unc-93-like protein
    Vladimir I Kashuba
    Center for Genomics Research, Karolinska Institute, 171 77, Stockholm, Sweden
    Gene 283:209-17. 2002
    ..The gene was mapped to chromosomal band 11q13 by fluorescence in situ hybridization. We suggest that this gene is a member of a novel hUNC93B-related gene family...
  77. pmc The interferon-alpha responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma
    Xiaoling Zhou
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Building 37, Room 4128, 37 Convent Drive, MSC 4264, Bethesda, MD 20892 4255, USA
    Cancer Genet Cytogenet 177:6-15. 2007
    ..These findings implicate loss of TMEM7 expression in hepatocarcinogenesis and suggest that modification of TMEM7 expression by IFN-alpha may have therapeutic relevance in a subset of HCC...
  78. ncbi request reprint SPR-based immunocapture approach to creating an interfacial sensing architecture: Mapping of the MRS18-2 binding site on retinoblastoma protein
    Boris Snopok
    V Lashkaryov Institute of Semiconductor Physics, NASU, Prospekt Nauki 41, 03028 Kiev 28, Ukraine
    Anal Bioanal Chem 386:2063-73. 2006
    ..We have also shown that MRS18-2, which was detected as the Epstein-Barr virus-encoded EBNA-6 binding partner using the yeast two-hybrid system, binds to pRb in GST pull-down assays...
  79. ncbi request reprint Jumping translocation of 17q11 approximately qter and 3q25 approximately q28 duplication in a variant Philadelphia t(9;14;22)(q34;q32;q11) in a childhood chronic myelogenous leukemia
    Irén Haltrich
    Semmelweis University, Faculty of Medicine, II Department of Pediatrics, Budapest, Hungary
    Cancer Genet Cytogenet 164:74-80. 2006
    ..Gain of this region is known in adult hematological malignancies and solid tumors, suggesting its general involvement in tumor initiation or progression (or both), regardless of tissue origin...
  80. ncbi request reprint EBV-expressing AGS gastric carcinoma cell sublines present increased motility and invasiveness
    Jareer Kassis
    Department of Pathology, Pittsburgh VAMC and University of Pittsburgh, Pittsburgh, PA, USA
    Int J Cancer 99:644-51. 2002
    ..Instead, we found that the EBV-infected cells presented increased focal adhesion kinase (FAK) phosphorylation. These findings suggest a role for integrin-mediated signaling in promoting EBV-associated invasiveness...
  81. ncbi request reprint Critical tumor-suppressor gene regions on chromosome 3P in major human epithelial malignancies: allelotyping and quantitative real-time PCR
    Eleonora Braga
    Russian State Genetics Center, Moscow, Russia
    Int J Cancer 100:534-41. 2002
    ..The D3S1286 and D3S3047 markers (3p25.2-p24.3) were deleted nonrandomly in NSCLC. High-frequency LOH was detected in a segment mapped closely distal to the LUCA site (3p21.3), around the D3S2409 and D3S2456 markers...
  82. pmc LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription
    Tyson V Sharp
    Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, University College London, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 101:16531-6. 2004
    ..Our data indicate that LIMD1 is a tumor-suppressor gene, the protein product of which functionally interacts with pRB and the loss of which promotes lung carcinogenesis...
  83. ncbi request reprint Experimental appraisal of the lack of antitumor natural killer cell-mediated immunosurveillance in response to lymphomas growing in the mouse brain
    Toshiki Yamasaki
    Department of Neurosurgery, Shimane Medical University, Izumo, Japan
    J Neurosurg 98:599-606. 2003
    ..The goal of this study, in which a controlled tumor model was used, was to investigate a relationship between NK cells and major histocompatibility complex (MHC) Class I gene expression in intracerebral tumor-bearing hosts...
  84. ncbi request reprint Signal transduction pathways in Burkitt's lymphoma cell lines BL41 and DG75 with different sensitivity to doxorubicin
    Larysa M Shlapatska
    R E Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology NAS of Ukraine, Kyiv, Ukraine
    Exp Oncol 26:210-6. 2004
    ....
  85. ncbi request reprint Epstein-Barr virus nuclear antigen-1 and Myc cooperate in lymphomagenesis
    Mark E Drotar
    Division of Molecular Genetics, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 6NU, Scotland, UK
    Int J Cancer 106:388-95. 2003
    ..Expression of EBNA-1 by EBV may provide a selection pressure in addition to translocation of the c-myc locus in the genesis of endemic Burkitt's lymphoma (BL)...
  86. ncbi request reprint Epigenetics: surveillance team against cancer
    George Klein
    Nature 434:150. 2005
  87. ncbi request reprint Multipoint interphase FISH analysis of chromosome 3 abnormalities in 28 childhood AML patients
    Irén Haltrich
    Department of Pediatrics, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Eur J Haematol 76:124-33. 2006
    ..The poor outcome in pediatric patients with 3q rearrangements appears to be quite uniform...
  88. ncbi request reprint Modern criteria to establish human cancer etiology
    Michele Carbone
    Cardinal Bernardin Cancer Center, Department of Pathology, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60302, USA
    Cancer Res 64:5518-24. 2004
    ....