Mathias W Hornef
Affiliation: Microbiology and Tumor Biology Center
- DNA vaccination using coexpression of cytokine genes with a bacterial gene encoding a 60-kDa heat shock proteinM W Hornef
Max von Pettenkofer Institute for Hygiene and Medical Microbiology, LMU Munich, Germany
Med Microbiol Immunol 189:97-104. 2000..Thus, coexpression of cytokine genes such as IFN-gamma in DNA vaccination vectors might improve immunity and help to overcome the side effects of standard adjuvants...
- Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cellsMathias W Hornef
Microbiology and Tumor Biology Center, Karolinska Institutet, 17177 Stockholm, Sweden
J Exp Med 195:559-70. 2002..The cytoplasmic location of TLR4, which is identical to the final location of internalized LPS, further indicates an important role of cellular internalization and cytoplasmic traffic in the process of innate immune recognition...
- Bacterial strategies for overcoming host innate and adaptive immune responsesMathias W Hornef
Microbiology and Tumor Biology Center, Karolinska Institutet, , SE-17177 Stockholm, Sweden
Nat Immunol 3:1033-40. 2002....
- Persistent infection with Helicobacter pylori and the development of gastric cancerStaffan Normark
Microbiology and Tumor Biology Center and Smittskyddsinstitutet, Karolinska Institutet, Stockholm, Sweden
Adv Cancer Res 90:63-89. 2003..This review summarizes the recent progress in the understanding of the intimate bacteria-host relationship and the mechanisms by which H. pylori may promote the process of tumor development...
- Intracellular recognition of lipopolysaccharide by toll-like receptor 4 in intestinal epithelial cellsMathias W Hornef
Swedish Institute for Infectious Disease Control SMI, 17182 Solna, Sweden
J Exp Med 198:1225-35. 2003..Thus, our data provide evidence that in contrast to the situation in macrophages, LPS recognition in intestinal epithelial cells may occur in the Golgi apparatus and require LPS internalization...
- Postnatal acquisition of endotoxin tolerance in intestinal epithelial cellsMichael Lotz
Department for Medical Microbiology and Hygiene, University Clinic of Freiburg, 79104 Freiburg, Germany
J Exp Med 203:973-84. 2006..Thus, unlike intestinal macrophages, IECs acquire TLR tolerance immediately after birth by exposure to exogenous endotoxin to facilitate microbial colonization and the development of a stable intestinal host-microbe homeostasis...
- Hormonal control of the renal immune response and antibacterial host defense by arginine vasopressinCecilia Chassin
Institut National de la Sante et de la Recherche Medicale, U773, Centre de recherche Biomedicale Bichat Beaujon, BP 416, 75018 Paris, France
J Exp Med 204:2837-52. 2007..These findings evidenced a novel hormonal regulation of innate immune cellular activation and demonstrate that dDAVP is a potent modulator of microbial-induced inflammation in the kidney...
- Cytokine-mediated control of lipopolysaccharide-induced activation of small intestinal epithelial cellsMichael Lotz
Department of Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University Clinic of Freiburg, Freiburg, Germany
Immunology 122:306-15. 2007..In conclusion, cytokines such as IL-4 and IL-13 affect intestinal epithelial cells and exhibit a modulating activity on Toll-like receptor-4-mediated epithelial cell activation...
- The role of epithelial Toll-like receptor expression in host defense and microbial toleranceMathias W Hornef
Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
J Endotoxin Res 11:124-8. 2005..Recent findings suggest that the role of epithelial cells in the maintenance of stable microbial colonization of host surfaces and the immediate host response to infectious challenges might have to be revised...
- Increased diversity of intestinal antimicrobial peptides by covalent dimer formationMathias W Hornef
Institute of Medical Microbiology and Hygiene, University of Freiburg, D 79104 Freiburg, Germany
Nat Immunol 5:836-43. 2004..CRS peptides might therefore be important in the maintenance of the microbial homeostasis within the intestinal tract...
- Developmental switch of intestinal antimicrobial peptide expressionSandrine Menard
Swedish Institute for Infectious Disease Control, Karolinska Institute, 171 77 Stockholm, Sweden
J Exp Med 205:183-93. 2008..Epithelial CRAMP expression might contribute to bacterial colonization and the establishment of gut homeostasis, and provide protection from enteric infection during the postnatal period...