Mathias W Hornef

Summary

Affiliation: Microbiology and Tumor Biology Center
Country: Sweden

Publications

  1. ncbi request reprint DNA vaccination using coexpression of cytokine genes with a bacterial gene encoding a 60-kDa heat shock protein
    M W Hornef
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, LMU Munich, Germany
    Med Microbiol Immunol 189:97-104. 2000
  2. pmc Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells
    Mathias W Hornef
    Microbiology and Tumor Biology Center, Karolinska Institutet, 17177 Stockholm, Sweden
    J Exp Med 195:559-70. 2002
  3. ncbi request reprint Bacterial strategies for overcoming host innate and adaptive immune responses
    Mathias W Hornef
    Microbiology and Tumor Biology Center, Karolinska Institutet, Nobelsvag 16, SE 17177 Stockholm, Sweden
    Nat Immunol 3:1033-40. 2002
  4. ncbi request reprint Persistent infection with Helicobacter pylori and the development of gastric cancer
    Staffan Normark
    Microbiology and Tumor Biology Center and Smittskyddsinstitutet, Karolinska Institutet, Stockholm, Sweden
    Adv Cancer Res 90:63-89. 2003
  5. pmc Intracellular recognition of lipopolysaccharide by toll-like receptor 4 in intestinal epithelial cells
    Mathias W Hornef
    Swedish Institute for Infectious Disease Control SMI, 17182 Solna, Sweden
    J Exp Med 198:1225-35. 2003
  6. pmc Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells
    Michael Lotz
    Department for Medical Microbiology and Hygiene, University Clinic of Freiburg, 79104 Freiburg, Germany
    J Exp Med 203:973-84. 2006
  7. pmc Hormonal control of the renal immune response and antibacterial host defense by arginine vasopressin
    Cecilia Chassin
    Institut National de la Sante et de la Recherche Medicale, U773, Centre de recherche Biomedicale Bichat Beaujon, BP 416, 75018 Paris, France
    J Exp Med 204:2837-52. 2007
  8. pmc Cytokine-mediated control of lipopolysaccharide-induced activation of small intestinal epithelial cells
    Michael Lotz
    Department of Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University Clinic of Freiburg, Freiburg, Germany
    Immunology 122:306-15. 2007
  9. ncbi request reprint The role of epithelial Toll-like receptor expression in host defense and microbial tolerance
    Mathias W Hornef
    Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
    J Endotoxin Res 11:124-8. 2005
  10. ncbi request reprint Increased diversity of intestinal antimicrobial peptides by covalent dimer formation
    Mathias W Hornef
    Institute of Medical Microbiology and Hygiene, University of Freiburg, D 79104 Freiburg, Germany
    Nat Immunol 5:836-43. 2004

Collaborators

Detail Information

Publications11

  1. ncbi request reprint DNA vaccination using coexpression of cytokine genes with a bacterial gene encoding a 60-kDa heat shock protein
    M W Hornef
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, LMU Munich, Germany
    Med Microbiol Immunol 189:97-104. 2000
    ..Thus, coexpression of cytokine genes such as IFN-gamma in DNA vaccination vectors might improve immunity and help to overcome the side effects of standard adjuvants...
  2. pmc Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells
    Mathias W Hornef
    Microbiology and Tumor Biology Center, Karolinska Institutet, 17177 Stockholm, Sweden
    J Exp Med 195:559-70. 2002
    ..The cytoplasmic location of TLR4, which is identical to the final location of internalized LPS, further indicates an important role of cellular internalization and cytoplasmic traffic in the process of innate immune recognition...
  3. ncbi request reprint Bacterial strategies for overcoming host innate and adaptive immune responses
    Mathias W Hornef
    Microbiology and Tumor Biology Center, Karolinska Institutet, Nobelsvag 16, SE 17177 Stockholm, Sweden
    Nat Immunol 3:1033-40. 2002
    ....
  4. ncbi request reprint Persistent infection with Helicobacter pylori and the development of gastric cancer
    Staffan Normark
    Microbiology and Tumor Biology Center and Smittskyddsinstitutet, Karolinska Institutet, Stockholm, Sweden
    Adv Cancer Res 90:63-89. 2003
    ..This review summarizes the recent progress in the understanding of the intimate bacteria-host relationship and the mechanisms by which H. pylori may promote the process of tumor development...
  5. pmc Intracellular recognition of lipopolysaccharide by toll-like receptor 4 in intestinal epithelial cells
    Mathias W Hornef
    Swedish Institute for Infectious Disease Control SMI, 17182 Solna, Sweden
    J Exp Med 198:1225-35. 2003
    ..Thus, our data provide evidence that in contrast to the situation in macrophages, LPS recognition in intestinal epithelial cells may occur in the Golgi apparatus and require LPS internalization...
  6. pmc Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells
    Michael Lotz
    Department for Medical Microbiology and Hygiene, University Clinic of Freiburg, 79104 Freiburg, Germany
    J Exp Med 203:973-84. 2006
    ..Thus, unlike intestinal macrophages, IECs acquire TLR tolerance immediately after birth by exposure to exogenous endotoxin to facilitate microbial colonization and the development of a stable intestinal host-microbe homeostasis...
  7. pmc Hormonal control of the renal immune response and antibacterial host defense by arginine vasopressin
    Cecilia Chassin
    Institut National de la Sante et de la Recherche Medicale, U773, Centre de recherche Biomedicale Bichat Beaujon, BP 416, 75018 Paris, France
    J Exp Med 204:2837-52. 2007
    ..These findings evidenced a novel hormonal regulation of innate immune cellular activation and demonstrate that dDAVP is a potent modulator of microbial-induced inflammation in the kidney...
  8. pmc Cytokine-mediated control of lipopolysaccharide-induced activation of small intestinal epithelial cells
    Michael Lotz
    Department of Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University Clinic of Freiburg, Freiburg, Germany
    Immunology 122:306-15. 2007
    ..In conclusion, cytokines such as IL-4 and IL-13 affect intestinal epithelial cells and exhibit a modulating activity on Toll-like receptor-4-mediated epithelial cell activation...
  9. ncbi request reprint The role of epithelial Toll-like receptor expression in host defense and microbial tolerance
    Mathias W Hornef
    Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
    J Endotoxin Res 11:124-8. 2005
    ..Recent findings suggest that the role of epithelial cells in the maintenance of stable microbial colonization of host surfaces and the immediate host response to infectious challenges might have to be revised...
  10. ncbi request reprint Increased diversity of intestinal antimicrobial peptides by covalent dimer formation
    Mathias W Hornef
    Institute of Medical Microbiology and Hygiene, University of Freiburg, D 79104 Freiburg, Germany
    Nat Immunol 5:836-43. 2004
    ..CRS peptides might therefore be important in the maintenance of the microbial homeostasis within the intestinal tract...
  11. pmc Developmental switch of intestinal antimicrobial peptide expression
    Sandrine Menard
    Swedish Institute for Infectious Disease Control, Karolinska Institute, 171 77 Stockholm, Sweden
    J Exp Med 205:183-93. 2008
    ..Epithelial CRAMP expression might contribute to bacterial colonization and the establishment of gut homeostasis, and provide protection from enteric infection during the postnatal period...