Angelo De Milito

Summary

Affiliation: Microbiology and Tumor Biology Center
Country: Sweden

Publications

  1. ncbi Antiretroviral therapy with protease inhibitors in human immunodeficiency virus type 1- and human herpesvirus 8-coinfected patients
    A De Milito
    Department of Molecular Biology, University of Siena, Italy
    J Med Virol 57:140-4. 1999
  2. pmc Plasma levels of soluble CD27: a simple marker to monitor immune activation during potent antiretroviral therapy in HIV-1-infected subjects
    A De Milito
    Microbiology and Tumourbiology Centre, Karolinska Institutet, Stockholm, Sweden
    Clin Exp Immunol 127:486-94. 2002
  3. ncbi Surrogate markers as a guide to evaluate response to antiretroviral therapy
    A De Milito
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Curr Med Chem 10:349-65. 2003
  4. ncbi B lymphocyte dysfunctions in HIV infection
    Angelo De Milito
    Microbiology and Tumor Biology Center, Karolinska Institutet, S 17177 Stockholm, Sweden
    Curr HIV Res 2:11-21. 2004
  5. ncbi Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection
    Angelo De Milito
    Microbiology and Tumor Biology Center, Karolinska Institute, and Gay Men s Health Clinic, The Soder Hospital, Stockholm, Sweden
    Blood 103:2180-6. 2004
  6. ncbi Primary HIV-1 infection sets the stage for important B lymphocyte dysfunctions
    Kehmia Titanji
    Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm, Sweden
    AIDS 19:1947-55. 2005
  7. ncbi Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection
    Kehmia Titanji
    Microbiology and Tumor Biology Center, Karolinska Institutet, S 17177 Stockholm, Sweden
    Blood 108:1580-7. 2006
  8. doi B cell immunopathology during HIV-1 infection: lessons to learn for HIV-1 vaccine design
    Alberto Cagigi
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels vag 16, S 17177 Stockholm, Sweden
    Vaccine 26:3016-25. 2008
  9. ncbi Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection
    Caroline Fluur
    Department of Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    J Immunol 178:5340-50. 2007
  10. pmc Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection
    Kehmia Titanji
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Immunology 123:164-70. 2008

Collaborators

Detail Information

Publications18

  1. ncbi Antiretroviral therapy with protease inhibitors in human immunodeficiency virus type 1- and human herpesvirus 8-coinfected patients
    A De Milito
    Department of Molecular Biology, University of Siena, Italy
    J Med Virol 57:140-4. 1999
    ..Nevertheless, our data support the hypothesis that KS patients may significantly benefit from PI therapy as an indirect consequence of partial restoration of immune functions following effective anti-HIV-1 combination therapy...
  2. pmc Plasma levels of soluble CD27: a simple marker to monitor immune activation during potent antiretroviral therapy in HIV-1-infected subjects
    A De Milito
    Microbiology and Tumourbiology Centre, Karolinska Institutet, Stockholm, Sweden
    Clin Exp Immunol 127:486-94. 2002
    ..HIV-1-induced immune activation can be normalized by HAART in successfully treated patients where the disease is not advanced...
  3. ncbi Surrogate markers as a guide to evaluate response to antiretroviral therapy
    A De Milito
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Curr Med Chem 10:349-65. 2003
    ..This review summarizes the benefits and limits of reference and candidate surrogate markers and their integration for optimal antiretroviral therapy...
  4. ncbi B lymphocyte dysfunctions in HIV infection
    Angelo De Milito
    Microbiology and Tumor Biology Center, Karolinska Institutet, S 17177 Stockholm, Sweden
    Curr HIV Res 2:11-21. 2004
    ..The current knowledge on B cell damage is also discussed in the context of anti-HIV therapeutic treatment...
  5. ncbi Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection
    Angelo De Milito
    Microbiology and Tumor Biology Center, Karolinska Institute, and Gay Men s Health Clinic, The Soder Hospital, Stockholm, Sweden
    Blood 103:2180-6. 2004
    ..Our results may be relevant to the design of HIV-1 therapeutical vaccines and to the clinical management of HIV-1-infected patients...
  6. ncbi Primary HIV-1 infection sets the stage for important B lymphocyte dysfunctions
    Kehmia Titanji
    Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm, Sweden
    AIDS 19:1947-55. 2005
    ..To investigate the effects of primary HIV-1 infection (PHI) and of two antiretroviral therapies [highly active antiretroviral therapy (HAART) or reverse transcriptase inhibitors (RTI)] on activation, differentiation and survival of B cells...
  7. ncbi Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection
    Kehmia Titanji
    Microbiology and Tumor Biology Center, Karolinska Institutet, S 17177 Stockholm, Sweden
    Blood 108:1580-7. 2006
    ..This may have important consequences for the response of HIV-infected patients to immunizations...
  8. doi B cell immunopathology during HIV-1 infection: lessons to learn for HIV-1 vaccine design
    Alberto Cagigi
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels vag 16, S 17177 Stockholm, Sweden
    Vaccine 26:3016-25. 2008
    ..In addition novel data indicate that B cell activation may be at the basis of impaired immune responses...
  9. ncbi Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection
    Caroline Fluur
    Department of Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    J Immunol 178:5340-50. 2007
    ..Elevated IL-7 levels associated with lymphopenic conditions, including HIV-infection, might participate in the increased sensitivity of T cells for activation-induced apoptosis...
  10. pmc Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection
    Kehmia Titanji
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Immunology 123:164-70. 2008
    ..Imbalance of NK cell subsets and up-regulated expression of CD27 and CD70 initiated early in HIV-1 infection may indicate NK cell activation and intrinsic defects initiated by HIV-1 to disarm the innate immune response to the virus...
  11. ncbi Effects of potent antiretroviral therapy on the immune activation marker soluble CD27 in patients infected with HIV-1 subtypes A-D
    Ann Atlas
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    J Med Virol 72:345-51. 2004
    ..Intriguingly, subtype C infection seems to be associated with higher levels of plasma sCD27, suggesting that HIV-1 genetic subtype C may have a different impact on disease outcome and response to therapy...
  12. ncbi Expression of CD27-CD70 on early B cell progenitors in the bone marrow: implication for diagnosis and therapy of childhood ALL
    Anna Nilsson
    Pediatric Cancer Research Unit, Astrid Lindgren Children Hospital, Stockholm, Sweden
    Exp Hematol 33:1500-7. 2005
    ..This study addresses the expression of CD27 and its ligand, CD70, in children with acute lymphoblastic leukemia (ALL) and the possible role of this receptor-ligand pair in the pathogenesis of ALL...
  13. ncbi Loss of IL-7Ralpha is associated with CD4 T-cell depletion, high interleukin-7 levels and CD28 down-regulation in HIV infected patients
    Bence Rethi
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    AIDS 19:2077-86. 2005
    ..The subset(s) of T cells with low IL-7Ralpha and the consequence of low IL-7Ralpha expression for T-cell survival are poorly characterized...
  14. ncbi Current chemotherapy protocols for childhood acute lymphoblastic leukemia induce loss of humoral immunity to viral vaccination antigens
    Anna Nilsson
    Pediatric Cancer Research Unit, Astrid Lindgren Children Hospital, Stockholm, Sweden
    Pediatrics 109:e91. 2002
    ....
  15. ncbi Astrocyte activation and apoptosis: their roles in the neuropathology of HIV infection
    Farideh Sabri
    Microbiology and Tumor Biology Center, Karolinska Institute, Nobels vag 16, S 17177 Stockholm, Sweden
    Brain Pathol 13:84-94. 2003
    ....
  16. doi The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy
    Emma Hernlund
    Department of Oncology and Pathology, Karolinska Institute, 171 76 Stockholm, Sweden
    Eur J Cancer 48:396-406. 2012
    ..Treatment strategies where antiproliferative agents are used to inhibit tumour regrowth between chemotherapy cycles are attractive, but such strategies are difficult to test using conventional monolayer culture systems...
  17. pmc FasL and TRAIL induce epidermal apoptosis and skin ulceration upon exposure to Leishmania major
    Liv Eidsmo
    Department of Microbiology, Karolinska Institutet, MTC, 171 77 Stockholm, Sweden
    Am J Pathol 170:227-39. 2007
    ..We propose that activation of Fas and TRAIL apoptosis pathways, in the presence of inflammatory mediators at the site of infection, leads to tissue destruction and ulceration during CL...
  18. ncbi A rationale for the use of proton pump inhibitors as antineoplastic agents
    Angelo De Milito
    Cancer Center Karolinska, Dep Oncology Pathology, Karolinska Institute, Stockholm, Sweden
    Curr Pharm Des 18:1395-406. 2012
    ..This review will update the current knowledge on the antitumor activities of PPI and their potential applications...