Research Topics
Genomes and Genes
| Yihai CaoSummaryAffiliation: Microbiology and Tumor Biology Center Country: Sweden Publications
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Detail Information
Publications
Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastasesY Cao
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77, Stockholm, Sweden
J Clin Invest 101:1055-63. 1998..Our data may also provide a novel approach for cancer therapy by antiangiogenic gene therapy with a specific angiogenesis inhibitor...
Direct role of PDGF-BB in lymphangiogenesis and lymphatic metastasisYihai Cao
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Cell Cycle 4:228-30. 2005..In this review, multiple roles of PDGFs in control of tumor growth and metastasis are discussed...- Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasisYihai Cao
Laboratory of Angiogenesis Research, Microbiology and Tumour Biology Center, Karolinska Institute, 171 77 Stockholm, Sweden
Nat Rev Cancer 5:735-43. 2005..Understanding the underlying mechanisms by which tumours induce lymphangiogenesis might provide important information for the therapeutic intervention of metastatic spread... - AngiostatinYihai Cao
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Semin Thromb Hemost 30:83-93. 2004..We hope that the information will be useful for further development of angiostatin and its related inhibitors as therapeutic agents... - Antiangiogenic cancer therapyYihai Cao
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm S 171 77, Sweden
Semin Cancer Biol 14:139-45. 2004.... - Update on therapeutic neovascularizationYihai Cao
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, S 171 77 Stockholm, Sweden
Cardiovasc Res 65:639-48. 2005..With the increasing complexity of therapeutic strategies, it remains imperative that these approaches are rationally based on fundamental and preclinical data... - Kringle structures and antiangiogenesisYihai Cao
Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
Curr Med Chem Anticancer Agents 2:667-81. 2002..This review will focus on the structural and functional relationships of kringle domains in regulation of angiogenesis and tumor growth... - Tumor angiogenesis and therapyY Cao
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Biomed Pharmacother 59:S340-3. 2005..In this review, I will discuss current development of antiangiogenic therapy in the treatment of cancer. I present data obtained from our own research laboratory to demonstrate antiangiogenic cancer therapy... - Endogenous angiogenesis inhibitors and their therapeutic implicationsY Cao
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77, Stockholm, Sweden
Int J Biochem Cell Biol 33:357-69. 2001..Despite the above-mentioned disadvantages, a few inhibitors have entered into the early stages of clinical trials and they may bring new hopes for the treatment of cancer and other angiogenesis dependent diseases... - Angiogenesis inhibitors and their therapeutic potentialsCao Yihai
Microbiology and Tumor Biology Center, Karolinska Institutet, S-171 77 Stockholm, Sweden
Adv Exp Med Biol 532:109-20. 2003 - Vascular endothelial growth factor C induces angiogenesis in vivoY Cao
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, S 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 95:14389-94. 1998..Thus, VEGF-C may regulate physiological angiogenesis and participate in the development and progression of angiogenic diseases in addition to lymphangiogenesis... - Therapeutic potentials of angiostatin in the treatment of cancerY Cao
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77, Stockholm, Sweden
Haematologica 84:643-50. 1999..In particular, I will emphasize the therapeutic potentials of angiostatin gene therapy and more potent angiogenesis inhibitors that are related to angiostatin... - VEGFR1-mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathyRenhai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 107:856-61. 2010..Our findings link VEGF and PlGF to cancer-associated retinopathy, reveal the molecular mechanisms of VEGFR1 ligand-mediated retinopathy, and define VEGFR1 as an important target of antiangiogenic therapy for treatment of retinopathy... - Blockage of VEGF-induced angiogenesis by preventing VEGF secretionMeit Bjorndahl
Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
Circ Res 94:1443-50. 2004..Gene transfer of a hVEGF-KDEL construct into tumor cells likewise produced a dramatic antitumor effect. Thus, our study provides a novel antiangiogenic approach by preventing the secretion of VEGF... - Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for k1-5-induced antiangiogenesisNiina Veitonmaki
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Cancer Res 64:3679-86. 2004..Thus, our findings provide a mechanistic insight with respect to the angiostatic action and signaling pathway of K1-5 and angiostatin... - Small GTP-binding protein Rac is an essential mediator of vascular endothelial growth factor-induced endothelial fenestrations and vascular permeabilityAnna Eriksson
Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
Circulation 107:1532-8. 2003..This may have conceptual implications for applying Rac antagonists in treatment and prevention of VEGF-induced vascular leakage and edema in connection with ischemic disorders... - Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosisEbba Brakenhielm
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 101:2476-81. 2004..Adiponectin, as a direct endogenous angiogenesis inhibitor, may have therapeutic implications in the treatment of angiogenesis-dependent diseases... - Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasisMeit A Björndahl
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, David Geffen School of Medicine at University of California, Los Angeles, CA, USA
Cancer Res 65:9261-8. 2005..Our data show that VEGF-A contributes to lymphatic mestastasis. Thus, blockage of VEGF-A-induced lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic metastasis... - Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasisRenhai Cao
Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, Stockholm, Sweden
Proc Natl Acad Sci U S A 109:15894-9. 2012..Thus, intervention and targeting of the FGF-2- and VEGF-C-induced angiogenic and lymphangiogenic synergism could be potentially important approaches for cancer therapy and prevention of metastasis... - Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of actionRenhai Cao
Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
Blood 107:3531-6. 2006..Our findings indicate that HGF may play a critical role in lymphangiogenesis and potentially contribute to lymphatic metastasis... - PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasisRenhai Cao
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
Cancer Cell 6:333-45. 2004..These data demonstrate that PDGF-BB is an important growth factor contributing to lymphatic metastasis. Thus, blockage of PDGF-induced lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic metastasis... - Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeabilityRenhai Cao
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Circ Res 94:664-70. 2004..Such information is important to consider in development of novel therapeutic strategies using these angiogenic factors... - Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimersAnna Eriksson
Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77, Stockholm, Sweden
Cancer Cell 1:99-108. 2002..The underlying mechanism is due to the formation of functionally inactive heterodimers... - Therapeutic targets of multiple angiogenic factors for the treatment of cancer and metastasisYihai Cao
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
Adv Cancer Res 97:203-24. 2007..Understanding the roles of individual and combined angiogenic factors in promoting tumor angiogenesis is crucial for defining therapeutic targets and antiangiogenic drug development for the treatment of cancer... - Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculatureEva Maria Hedlund
Department of Microbiology and Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 106:17505-10. 2009..Our findings shed light on functions of PlGF as a vascular remodeling factor that normalizes the tumor vasculature and thus may have conceptual implications of cancer therapy... 
PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cellsYuan Xue
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
Nat Med 18:100-10. 2012....- Tumor-derived lymphangiogenic factors and lymphatic metastasisYihai Cao
Laboratory of Angiogenesis Research, Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden
Biomed Pharmacother 61:534-9. 2007..Understanding regulatory mechanisms of lymphangiogenesis is pivotal for development of lymphangiogenesis antagonists that might therapeutically be used for intervention of lymphatic metastasis... - Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndromeYuan Xue
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 105:18513-8. 2008..These findings define novel therapeutic targets of anti-VEGF agents and provide mechanistic insights into the action of this new class of clinically available anti-VEGF cancer drugs... - Differential roles of PDGFR-alpha and PDGFR-beta in angiogenesis and vessel stabilityJunhang Zhang
Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 17176, Stockholm, Sweden
FASEB J 23:153-63. 2009..A combination of PDGF-AB and FGF-2 would be optimal proangiogenic agents for the treatment of ischemic diseases... - Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasisLars Johan Nissen
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
J Clin Invest 117:2766-77. 2007..Our data suggest that intervention of this non-VEGF reciprocal interaction loop for the tumor vasculature could be an important therapeutic target for the treatment of cancer and metastasis... - Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor modelSamantha Lin Chiou Lee
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 106:19485-90. 2009..Our findings also shed light on molecular mechanisms of beneficial effects of clinically available anti-VEGF drugs for cancer therapy... - Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in miceEbba Brakenhielm
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Circ Res 94:1579-88. 2004..Our findings suggest that similarly to growth and organogenesis in other tissues, adipose tissue growth is dependent on angiogenesis. Our observations may have conceptual implications for the prevention of obesity and related disorders... - Why and how do tumors stimulate lymphangiogenesis?Yihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 17177 Stockholm, Sweden
Lymphat Res Biol 6:145-8. 2008.... - Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2Renhai Cao
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Nat Med 9:604-13. 2003..Our data show that a specific combination of angiogenic factors establishes functional and stable vascular networks, and provides guidance for the ongoing clinical trials of angiogenic factors for the treatment of ischemic diseases... - Pathological angiogenesis facilitates tumor cell dissemination and metastasisPegah Rouhi
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
Cell Cycle 9:913-7. 2010.... - FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissueYuan Xue
Department of Microbiology, Laboratory of Angiogenesis Research, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
Proc Natl Acad Sci U S A 105:10167-72. 2008..Thus, the FOXC2-Ang-2 signaling system is crucial for controlling adipose vascular function, which is part of an adaptation to increased adipose tissue metabolism... - Hypoxia-induced metastasis model in embryonic zebrafishPegah Rouhi
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Nat Protoc 5:1911-8. 2010..The average experimental time for this model is 7 d. Our protocol offers a remarkable opportunity to study molecular mechanisms of hypoxia-induced cancer metastasis... - Zebrafish models to study hypoxia-induced pathological angiogenesis in malignant and nonmalignant diseasesLasse Dahl Jensen
Deparment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Birth Defects Res C Embryo Today 93:182-93. 2011..These zebrafish disease models offer exciting opportunities to understand the mechanisms of disease development, progression, and development of more effective drugs for therapeutic intervention... - Mouse corneal lymphangiogenesis modelRenhai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Nat Protoc 6:817-26. 2011..This protocol offers a unique opportunity to study the mechanisms underlying lymphatic vessel formation, remodeling and function... - Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivoMeit Bjorndahl
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 102:15593-8. 2005..Because members of the IGF ligand and receptor families are widely expressed in various types of solid tumors, our findings suggest that these factors are likely to contribute to lymphatic metastasis... - Hypoxia-independent angiogenesis in adipose tissues during cold acclimationYuan Xue
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, SE 171 77 Stockholm, Sweden
Cell Metab 9:99-109. 2009..Our findings have conceptual implications concerning application of angiogenesis modulators for treatment of obesity and metabolic disorders... - Opposing effects of circadian clock genes bmal1 and period2 in regulation of VEGF-dependent angiogenesis in developing zebrafishLasse Dahl Jensen
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
Cell Rep 2:231-41. 2012..These results shed mechanistic insight on the role of the circadian clock in regulation of developmental angiogenesis, and our findings may be reasonably extended to other types of physiological or pathological angiogenesis... - Cold-induced activation of brown adipose tissue and adipose angiogenesis in miceSharon Lim
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
Nat Protoc 7:606-15. 2012..BAT and the increased metabolic rate result in a lean phenotype. This protocol provides an outstanding opportunity to study the molecular mechanisms that control adipose mass... - Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseasesYihai Cao
Yihai Cao is at the Department of Microbiology, Tumour and Cell Biology, Karolinska Institute, 171 77 Stockholm
Nat Rev Drug Discov 9:107-15. 2010..This Perspective discusses recent progress in understanding the molecular mechanisms that control adipose tissue angiogenesis and in defining potential new vascular targets and approaches for the treatment of this group of diseases... - R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathwaysYihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77, Stockholm, Sweden
J Mol Med (Berl) 86:785-9. 2008..Thus, therapeutic development of antiangiogenic agents for the treatment of cancer should be aimed to block multiple angiogenic signaling pathways and their interactive loops... - Nitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lymphatic conduits in zebrafish and glass catfishLasse Dahl Ejby Jensen
Department of Microbiology, Karolinska Institute, SE 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 106:18408-13. 2009..Our results might also imply that the hypoxia-induced NO pathway contributes to development of progression of pathologies, including promotion of lymphatic metastasis by modulating arterial-lymphatic conduits, in the mammalian system... - Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugsEva Maria Eleonora Hedlund
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 110:654-9. 2013..These findings demonstrate that tumor-derived PlGF negatively modulates tumor angiogenesis and tumor growth and may potentially serve as a predictive marker of anti-VEGF cancer therapy... - Presence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vesselsPiotr Religa
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, Nobelsvag 16, 171 77 Stockholm, Sweden
Blood 106:4184-90. 2005..EGFP+/CEPCs were also present in peritumoral lymphatic vessels of a fibrosarcoma. These data suggest that BM-derived CEPCs may play a role in "lymphvasculogenesis.".. - Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalizationXiaowei Zheng
Department of Cell and Molecular Biology, Karolinska Institutet, S 171 77 Stockholm, Sweden
Mol Cell Biol 26:4628-41. 2006.... - Antiangiogenic agents significantly improve survival in tumor-bearing mice by increasing tolerance to chemotherapy-induced toxicityDanfang Zhang
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 108:4117-22. 2011.... - Improvement of antiangiogenic cancer therapy by understanding the mechanisms of angiogenic factor interplay and drug resistanceYihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Semin Cancer Biol 19:338-43. 2009.... - Off-tumor target--beneficial site for antiangiogenic cancer therapy?Yihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Nobelsvag 16, Solna Campus, Box 280, 171 77 Stockholm, Sweden
Nat Rev Clin Oncol 7:604-8. 2010..This new concept has been validated in preclinical tumor models, and responses in patients have positively correlated with clinical benefits... - Adipose angiogenesis: quantitative methods to study microvessel growth, regression and remodeling in vivoYuan Xue
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Nat Protoc 5:912-20. 2010.... - Forty-year journey of angiogenesis translational researchYihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Sci Transl Med 3:114rv3. 2011..Today, antiangiogenic drugs are used to treat human cancers and retinal vascular diseases. Here, we guide readers through 40 years of angiogenesis research and discuss challenges of antiangiogenic therapy... - Optimizing the delivery of cancer drugs that block angiogenesisYihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Sci Transl Med 2:15ps3. 2010..In this Perspective, we discuss these drug-related issues and propose ways to optimize antiangiogenic therapy by the development of new drug delivery systems... - Cancer-associated retinopathy: a new mechanistic insight on vascular remodelingRenhai Cao
Department of Microbiology, Karolinska Institute, Stockholm, Sweden
Cell Cycle 9:1882-5. 2010..These results demonstrate that tumor-derived angiogenic factors significantly confer the development of CAR and anti-VEGF agents might be potentially used for the treatment of CAR... - Hypoxia-induced retinal angiogenesis in zebrafish as a model to study retinopathyRenhai Cao
Department of Microbiology, Tumor and Cell Biology, The Karolinska Institute, Stockholm, Sweden
PLoS ONE 3:e2748. 2008.... - Molecular mechanisms and therapeutic development of angiogenesis inhibitorsYihai Cao
Laboratory of Angiogenesis Research, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Adv Cancer Res 100:113-31. 2008..Thus, deeper understanding the mechanisms of tumor angiogenesis and actions of these therapeutic molecules is crucial for designing more potent anticancer drugs... - Positive and negative modulation of angiogenesis by VEGFR1 ligandsYihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Sci Signal 2:re1. 2009..This Review discusses the distinctive roles of VEGFR1 and its ligands PlGF and VEGF-B in the mediation of angiogenic signaling and considers the therapeutic potential of targeting these particular vascular factors... - Antiangiogenic cancer therapy: why do mouse and human patients respond in a different way to the same drug?Yihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
Int J Dev Biol 55:557-62. 2011.... - Angiogenesis modulates adipogenesis and obesityYihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
J Clin Invest 117:2362-8. 2007..Thus antiangiogenic agents provide a novel therapeutic option for prevention and treatment of human obesity and its related disorders... - A review of Judah Folkman's remarkable achievements in biomedicineYihai Cao
Department of Microbiology and Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 105:13203-5. 2008 - Tumor angiogenesis and molecular targets for therapyYihai Cao
Laboratory of Angiogenesis Research, Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Front Biosci 14:3962-73. 2009.... - Angiogenesis: What can it offer for future medicine?Yihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Exp Cell Res 316:1304-8. 2010..In this mini-review, I discuss current available antiangiogenic drugs and future therapeutic options based on the angiogenesis principle... - Therapeutic angiogenesis for ischemic disorders: what is missing for clinical benefits?Yihai Cao
Department of Microbiology and Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Discov Med 9:179-84. 2010.... - Immortalization of bovine capillary endothelial cells by hTERT alone involves inactivation of endogenous p16INK4A/pRbNiina Veitonmaki
Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
FASEB J 17:764-6. 2003..In agreement with this finding, the expression levels of the prototypic DNA methyltransferase DNMT1 were elevated in the hTERT-positive cells... - Deletion of the laminin alpha4 chain leads to impaired microvessel maturationJill Thyboll
Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 17 177 Stockholm, Sweden
Mol Cell Biol 22:1194-202. 2002..The results demonstrate a central role for the laminin alpha4 chain in microvessel growth and, in the absence of other laminin alpha chains, in the composition of endothelial basement membranes...