Yihai Cao

Summary

Affiliation: Microbiology and Tumor Biology Center
Country: Sweden

Publications

  1. pmc Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases
    Y Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77, Stockholm, Sweden
    J Clin Invest 101:1055-63. 1998
  2. ncbi request reprint Update on therapeutic neovascularization
    Yihai Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Cardiovasc Res 65:639-48. 2005
  3. ncbi request reprint Direct role of PDGF-BB in lymphangiogenesis and lymphatic metastasis
    Yihai Cao
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Cell Cycle 4:228-30. 2005
  4. ncbi request reprint Angiostatin
    Yihai Cao
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Semin Thromb Hemost 30:83-93. 2004
  5. ncbi request reprint Antiangiogenic cancer therapy
    Yihai Cao
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm S 171 77, Sweden
    Semin Cancer Biol 14:139-45. 2004
  6. ncbi request reprint Tumor angiogenesis and therapy
    Y Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Biomed Pharmacother 59:S340-3. 2005
  7. ncbi request reprint Angiogenesis inhibitors and their therapeutic potentials
    Cao Yihai
    Microbiology and Tumor Biology Center, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Adv Exp Med Biol 532:109-20. 2003
  8. ncbi request reprint Kringle structures and antiangiogenesis
    Yihai Cao
    Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
    Curr Med Chem Anticancer Agents 2:667-81. 2002
  9. ncbi request reprint Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis
    Yihai Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumour Biology Center, Karolinska Institute, 171 77 Stockholm, Sweden
    Nat Rev Cancer 5:735-43. 2005
  10. ncbi request reprint Endogenous angiogenesis inhibitors and their therapeutic implications
    Y Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77, Stockholm, Sweden
    Int J Biochem Cell Biol 33:357-69. 2001

Collaborators

Detail Information

Publications73

  1. pmc Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases
    Y Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77, Stockholm, Sweden
    J Clin Invest 101:1055-63. 1998
    ..Our data may also provide a novel approach for cancer therapy by antiangiogenic gene therapy with a specific angiogenesis inhibitor...
  2. ncbi request reprint Update on therapeutic neovascularization
    Yihai Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Cardiovasc Res 65:639-48. 2005
    ..With the increasing complexity of therapeutic strategies, it remains imperative that these approaches are rationally based on fundamental and preclinical data...
  3. ncbi request reprint Direct role of PDGF-BB in lymphangiogenesis and lymphatic metastasis
    Yihai Cao
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Cell Cycle 4:228-30. 2005
    ..In this review, multiple roles of PDGFs in control of tumor growth and metastasis are discussed...
  4. ncbi request reprint Angiostatin
    Yihai Cao
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Semin Thromb Hemost 30:83-93. 2004
    ..We hope that the information will be useful for further development of angiostatin and its related inhibitors as therapeutic agents...
  5. ncbi request reprint Antiangiogenic cancer therapy
    Yihai Cao
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm S 171 77, Sweden
    Semin Cancer Biol 14:139-45. 2004
    ....
  6. ncbi request reprint Tumor angiogenesis and therapy
    Y Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Biomed Pharmacother 59:S340-3. 2005
    ..In this review, I will discuss current development of antiangiogenic therapy in the treatment of cancer. I present data obtained from our own research laboratory to demonstrate antiangiogenic cancer therapy...
  7. ncbi request reprint Angiogenesis inhibitors and their therapeutic potentials
    Cao Yihai
    Microbiology and Tumor Biology Center, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Adv Exp Med Biol 532:109-20. 2003
  8. ncbi request reprint Kringle structures and antiangiogenesis
    Yihai Cao
    Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
    Curr Med Chem Anticancer Agents 2:667-81. 2002
    ..This review will focus on the structural and functional relationships of kringle domains in regulation of angiogenesis and tumor growth...
  9. ncbi request reprint Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis
    Yihai Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumour Biology Center, Karolinska Institute, 171 77 Stockholm, Sweden
    Nat Rev Cancer 5:735-43. 2005
    ..Understanding the underlying mechanisms by which tumours induce lymphangiogenesis might provide important information for the therapeutic intervention of metastatic spread...
  10. ncbi request reprint Endogenous angiogenesis inhibitors and their therapeutic implications
    Y Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77, Stockholm, Sweden
    Int J Biochem Cell Biol 33:357-69. 2001
    ..Despite the above-mentioned disadvantages, a few inhibitors have entered into the early stages of clinical trials and they may bring new hopes for the treatment of cancer and other angiogenesis dependent diseases...
  11. pmc Vascular endothelial growth factor C induces angiogenesis in vivo
    Y Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 95:14389-94. 1998
    ..Thus, VEGF-C may regulate physiological angiogenesis and participate in the development and progression of angiogenic diseases in addition to lymphangiogenesis...
  12. ncbi request reprint Therapeutic potentials of angiostatin in the treatment of cancer
    Y Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77, Stockholm, Sweden
    Haematologica 84:643-50. 1999
    ..In particular, I will emphasize the therapeutic potentials of angiostatin gene therapy and more potent angiogenesis inhibitors that are related to angiostatin...
  13. pmc VEGFR1-mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathy
    Renhai Cao
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 107:856-61. 2010
    ..Our findings link VEGF and PlGF to cancer-associated retinopathy, reveal the molecular mechanisms of VEGFR1 ligand-mediated retinopathy, and define VEGFR1 as an important target of antiangiogenic therapy for treatment of retinopathy...
  14. doi request reprint Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis
    Kayoko Hosaka
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm 171 77, Sweden
    Nat Commun 4:2129. 2013
    ..Our data suggest that tumour PDGF-BB levels may serve as a biomarker for selection of tumour-bearing hosts for anti-PDGF therapy and unsupervised use of anti-PDGF drugs could potentially promote tumour invasion and metastasis. ..
  15. pmc Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis
    Ebba Brakenhielm
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 101:2476-81. 2004
    ..Adiponectin, as a direct endogenous angiogenesis inhibitor, may have therapeutic implications in the treatment of angiogenesis-dependent diseases...
  16. ncbi request reprint Blockage of VEGF-induced angiogenesis by preventing VEGF secretion
    Meit Bjorndahl
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    Circ Res 94:1443-50. 2004
    ..Gene transfer of a hVEGF-KDEL construct into tumor cells likewise produced a dramatic antitumor effect. Thus, our study provides a novel antiangiogenic approach by preventing the secretion of VEGF...
  17. ncbi request reprint Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis
    Meit A Björndahl
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, David Geffen School of Medicine at University of California, Los Angeles, CA, USA
    Cancer Res 65:9261-8. 2005
    ..Our data show that VEGF-A contributes to lymphatic mestastasis. Thus, blockage of VEGF-A-induced lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic metastasis...
  18. ncbi request reprint Small GTP-binding protein Rac is an essential mediator of vascular endothelial growth factor-induced endothelial fenestrations and vascular permeability
    Anna Eriksson
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    Circulation 107:1532-8. 2003
    ..Although its angiogenic activity has been well characterized, the signaling pathways of VEGF-induced permeability remain poorly understood...
  19. ncbi request reprint Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for k1-5-induced antiangiogenesis
    Niina Veitonmaki
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 64:3679-86. 2004
    ..Thus, our findings provide a mechanistic insight with respect to the angiostatic action and signaling pathway of K1-5 and angiostatin...
  20. pmc Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugs
    Eva Maria Eleonora Hedlund
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 110:654-9. 2013
    ..These findings demonstrate that tumor-derived PlGF negatively modulates tumor angiogenesis and tumor growth and may potentially serve as a predictive marker of anti-VEGF cancer therapy...
  21. pmc Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis
    Renhai Cao
    Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, Stockholm, Sweden
    Proc Natl Acad Sci U S A 109:15894-9. 2012
    ..Thus, intervention and targeting of the FGF-2- and VEGF-C-induced angiogenic and lymphangiogenic synergism could be potentially important approaches for cancer therapy and prevention of metastasis...
  22. ncbi request reprint Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action
    Renhai Cao
    Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
    Blood 107:3531-6. 2006
    ..Our findings indicate that HGF may play a critical role in lymphangiogenesis and potentially contribute to lymphatic metastasis...
  23. ncbi request reprint PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis
    Renhai Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
    Cancer Cell 6:333-45. 2004
    ..These data demonstrate that PDGF-BB is an important growth factor contributing to lymphatic metastasis. Thus, blockage of PDGF-induced lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic metastasis...
  24. ncbi request reprint Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers
    Anna Eriksson
    Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77, Stockholm, Sweden
    Cancer Cell 1:99-108. 2002
    ..The underlying mechanism is due to the formation of functionally inactive heterodimers...
  25. ncbi request reprint Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability
    Renhai Cao
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Circ Res 94:664-70. 2004
    ..Such information is important to consider in development of novel therapeutic strategies using these angiogenic factors...
  26. pmc Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth
    Xiaojuan Yang
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 110:13932-7. 2013
    ..Our data uncover molecular mechanisms underlying the complex interplay between PlGF and VEGF in modulation of tumor growth and angiogenesis, and have conceptual implication for antiangiogenic cancer therapy. ..
  27. pmc Anti-VEGF- and anti-VEGF receptor-induced vascular alteration in mouse healthy tissues
    Yunlong Yang
    Department of Microbiology, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 110:12018-23. 2013
    ..Understanding anti-VEGF drug-induced vascular alterations in healthy tissues is crucial to minimize and even to avoid adverse effects produced by currently used anti-VEGF-specific drugs. ..
  28. ncbi request reprint Therapeutic targets of multiple angiogenic factors for the treatment of cancer and metastasis
    Yihai Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
    Adv Cancer Res 97:203-24. 2007
    ..Understanding the roles of individual and combined angiogenic factors in promoting tumor angiogenesis is crucial for defining therapeutic targets and antiangiogenic drug development for the treatment of cancer...
  29. pmc Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature
    Eva Maria Hedlund
    Department of Microbiology and Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:17505-10. 2009
    ..Our findings shed light on functions of PlGF as a vascular remodeling factor that normalizes the tumor vasculature and thus may have conceptual implications of cancer therapy...
  30. doi request reprint PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells
    Yuan Xue
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
    Nat Med 18:100-10. 2012
    ....
  31. pmc Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model
    Samantha Lin Chiou Lee
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:19485-90. 2009
    ..Our findings also shed light on molecular mechanisms of beneficial effects of clinically available anti-VEGF drugs for cancer therapy...
  32. pmc Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndrome
    Yuan Xue
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:18513-8. 2008
    ..These findings define novel therapeutic targets of anti-VEGF agents and provide mechanistic insights into the action of this new class of clinically available anti-VEGF cancer drugs...
  33. pmc Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis
    Lars Johan Nissen
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
    J Clin Invest 117:2766-77. 2007
    ..Our data suggest that intervention of this non-VEGF reciprocal interaction loop for the tumor vasculature could be an important therapeutic target for the treatment of cancer and metastasis...
  34. doi request reprint Differential roles of PDGFR-alpha and PDGFR-beta in angiogenesis and vessel stability
    Junhang Zhang
    Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 17176, Stockholm, Sweden
    FASEB J 23:153-63. 2009
    ..A combination of PDGF-AB and FGF-2 would be optimal proangiogenic agents for the treatment of ischemic diseases...
  35. ncbi request reprint Tumor-derived lymphangiogenic factors and lymphatic metastasis
    Yihai Cao
    Laboratory of Angiogenesis Research, Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden
    Biomed Pharmacother 61:534-9. 2007
    ..Understanding regulatory mechanisms of lymphangiogenesis is pivotal for development of lymphangiogenesis antagonists that might therapeutically be used for intervention of lymphatic metastasis...
  36. ncbi request reprint Opposing effects of circadian clock genes bmal1 and period2 in regulation of VEGF-dependent angiogenesis in developing zebrafish
    Lasse Dahl Jensen
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
    Cell Rep 2:231-41. 2012
    ..These results shed mechanistic insight on the role of the circadian clock in regulation of developmental angiogenesis, and our findings may be reasonably extended to other types of physiological or pathological angiogenesis...
  37. ncbi request reprint Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2
    Renhai Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Nat Med 9:604-13. 2003
    ..Our data show that a specific combination of angiogenic factors establishes functional and stable vascular networks, and provides guidance for the ongoing clinical trials of angiogenic factors for the treatment of ischemic diseases...
  38. ncbi request reprint Pathological angiogenesis facilitates tumor cell dissemination and metastasis
    Pegah Rouhi
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
    Cell Cycle 9:913-7. 2010
    ....
  39. doi request reprint Why and how do tumors stimulate lymphangiogenesis?
    Yihai Cao
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 17177 Stockholm, Sweden
    Lymphat Res Biol 6:145-8. 2008
    ....
  40. doi request reprint Hypoxia-induced metastasis model in embryonic zebrafish
    Pegah Rouhi
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Nat Protoc 5:1911-8. 2010
    ..The average experimental time for this model is 7 d. Our protocol offers a remarkable opportunity to study molecular mechanisms of hypoxia-induced cancer metastasis...
  41. doi request reprint Zebrafish models to study hypoxia-induced pathological angiogenesis in malignant and nonmalignant diseases
    Lasse Dahl Jensen
    Deparment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Birth Defects Res C Embryo Today 93:182-93. 2011
    ..These zebrafish disease models offer exciting opportunities to understand the mechanisms of disease development, progression, and development of more effective drugs for therapeutic intervention...
  42. pmc FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue
    Yuan Xue
    Department of Microbiology, Laboratory of Angiogenesis Research, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:10167-72. 2008
    ..Thus, the FOXC2-Ang-2 signaling system is crucial for controlling adipose vascular function, which is part of an adaptation to increased adipose tissue metabolism...
  43. ncbi request reprint Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice
    Ebba Brakenhielm
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Circ Res 94:1579-88. 2004
    ..Our findings suggest that similarly to growth and organogenesis in other tissues, adipose tissue growth is dependent on angiogenesis. Our observations may have conceptual implications for the prevention of obesity and related disorders...
  44. pmc Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo
    Meit Bjorndahl
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:15593-8. 2005
    ..Because members of the IGF ligand and receptor families are widely expressed in various types of solid tumors, our findings suggest that these factors are likely to contribute to lymphatic metastasis...
  45. doi request reprint Mouse corneal lymphangiogenesis model
    Renhai Cao
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Nat Protoc 6:817-26. 2011
    ..This protocol offers a unique opportunity to study the mechanisms underlying lymphatic vessel formation, remodeling and function...
  46. doi request reprint Hypoxia-independent angiogenesis in adipose tissues during cold acclimation
    Yuan Xue
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Cell Metab 9:99-109. 2009
    ..Our findings have conceptual implications concerning application of angiogenesis modulators for treatment of obesity and metabolic disorders...
  47. doi request reprint Angiogenesis and vascular functions in modulation of obesity, adipose metabolism, and insulin sensitivity
    Yihai Cao
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden Department of Medicine and Health Sciences, Linkoping University, 581 85 Linkoping, Sweden Electronic address
    Cell Metab 18:478-89. 2013
    ..Understanding fundamental mechanisms by which angiogenesis and vasculatures modulate adipocyte functions may provide new therapeutic options for treatment of obesity and metabolic disorders by targeting the adipose vasculature. ..
  48. doi request reprint Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice
    Sharon Lim
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
    Nat Protoc 7:606-15. 2012
    ..BAT and the increased metabolic rate result in a lean phenotype. This protocol provides an outstanding opportunity to study the molecular mechanisms that control adipose mass...
  49. pmc Nitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lymphatic conduits in zebrafish and glass catfish
    Lasse Dahl Ejby Jensen
    Department of Microbiology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:18408-13. 2009
    ..Our results might also imply that the hypoxia-induced NO pathway contributes to development of progression of pathologies, including promotion of lymphatic metastasis by modulating arterial-lymphatic conduits, in the mammalian system...
  50. doi request reprint Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases
    Yihai Cao
    Yihai Cao is at the Department of Microbiology, Tumour and Cell Biology, Karolinska Institute, 171 77 Stockholm
    Nat Rev Drug Discov 9:107-15. 2010
    ..This Perspective discusses recent progress in understanding the molecular mechanisms that control adipose tissue angiogenesis and in defining potential new vascular targets and approaches for the treatment of this group of diseases...
  51. doi request reprint R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways
    Yihai Cao
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77, Stockholm, Sweden
    J Mol Med (Berl) 86:785-9. 2008
    ..Thus, therapeutic development of antiangiogenic agents for the treatment of cancer should be aimed to block multiple angiogenic signaling pathways and their interactive loops...
  52. pmc Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response
    Xiaowei Zheng
    Department of Cell and Molecular Biology and Microbiology and Tumor Biology Center, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 111:2560-5. 2014
    ..These results unravel an important mechanism that selectively regulates the nuclear accumulation and function of HIF-1α and potentiates angiogenesis and tumor progression. ..
  53. ncbi request reprint Presence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vessels
    Piotr Religa
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, Nobelsvag 16, 171 77 Stockholm, Sweden
    Blood 106:4184-90. 2005
    ..EGFP+/CEPCs were also present in peritumoral lymphatic vessels of a fibrosarcoma. These data suggest that BM-derived CEPCs may play a role in "lymphvasculogenesis."..
  54. pmc Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization
    Xiaowei Zheng
    Department of Cell and Molecular Biology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Mol Cell Biol 26:4628-41. 2006
    ....
  55. doi request reprint Adipose angiogenesis: quantitative methods to study microvessel growth, regression and remodeling in vivo
    Yuan Xue
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Nat Protoc 5:912-20. 2010
    ....
  56. doi request reprint Off-tumor target--beneficial site for antiangiogenic cancer therapy?
    Yihai Cao
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Nobelsvag 16, Solna Campus, Box 280, 171 77 Stockholm, Sweden
    Nat Rev Clin Oncol 7:604-8. 2010
    ..This new concept has been validated in preclinical tumor models, and responses in patients have positively correlated with clinical benefits...
  57. pmc Antiangiogenic agents significantly improve survival in tumor-bearing mice by increasing tolerance to chemotherapy-induced toxicity
    Danfang Zhang
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 108:4117-22. 2011
    ....
  58. doi request reprint Improvement of antiangiogenic cancer therapy by understanding the mechanisms of angiogenic factor interplay and drug resistance
    Yihai Cao
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
    Semin Cancer Biol 19:338-43. 2009
    ....
  59. pmc Clock controls angiogenesis
    Lasse Dahl Jensen
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
    Cell Cycle 12:405-8. 2013
    ..Thus, our findings, for the first time, shed new light on mechanisms that underlie circadian clock-regulated angiogenesis...
  60. doi request reprint Forty-year journey of angiogenesis translational research
    Yihai Cao
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
    Sci Transl Med 3:114rv3. 2011
    ..Today, antiangiogenic drugs are used to treat human cancers and retinal vascular diseases. Here, we guide readers through 40 years of angiogenesis research and discuss challenges of antiangiogenic therapy...
  61. pmc Hypoxia-induced retinal angiogenesis in zebrafish as a model to study retinopathy
    Renhai Cao
    Department of Microbiology, Tumor and Cell Biology, The Karolinska Institute, Stockholm, Sweden
    PLoS ONE 3:e2748. 2008
    ....
  62. doi request reprint Molecular mechanisms and therapeutic development of angiogenesis inhibitors
    Yihai Cao
    Laboratory of Angiogenesis Research, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Adv Cancer Res 100:113-31. 2008
    ..Thus, deeper understanding the mechanisms of tumor angiogenesis and actions of these therapeutic molecules is crucial for designing more potent anticancer drugs...
  63. ncbi request reprint Cancer-associated retinopathy: a new mechanistic insight on vascular remodeling
    Renhai Cao
    Department of Microbiology, Karolinska Institute, Stockholm, Sweden
    Cell Cycle 9:1882-5. 2010
    ..These results demonstrate that tumor-derived angiogenic factors significantly confer the development of CAR and anti-VEGF agents might be potentially used for the treatment of CAR...
  64. doi request reprint Optimizing the delivery of cancer drugs that block angiogenesis
    Yihai Cao
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
    Sci Transl Med 2:15ps3. 2010
    ..In this Perspective, we discuss these drug-related issues and propose ways to optimize antiangiogenic therapy by the development of new drug delivery systems...
  65. ncbi request reprint Positive and negative modulation of angiogenesis by VEGFR1 ligands
    Yihai Cao
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
    Sci Signal 2:re1. 2009
    ..This Review discusses the distinctive roles of VEGFR1 and its ligands PlGF and VEGF-B in the mediation of angiogenic signaling and considers the therapeutic potential of targeting these particular vascular factors...
  66. pmc Angiogenesis modulates adipogenesis and obesity
    Yihai Cao
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
    J Clin Invest 117:2362-8. 2007
    ..Thus antiangiogenic agents provide a novel therapeutic option for prevention and treatment of human obesity and its related disorders...
  67. doi request reprint Antiangiogenic cancer therapy: why do mouse and human patients respond in a different way to the same drug?
    Yihai Cao
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
    Int J Dev Biol 55:557-62. 2011
    ....
  68. pmc A review of Judah Folkman's remarkable achievements in biomedicine
    Yihai Cao
    Department of Microbiology and Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:13203-5. 2008
  69. doi request reprint Angiogenesis: What can it offer for future medicine?
    Yihai Cao
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
    Exp Cell Res 316:1304-8. 2010
    ..In this mini-review, I discuss current available antiangiogenic drugs and future therapeutic options based on the angiogenesis principle...
  70. ncbi request reprint Tumor angiogenesis and molecular targets for therapy
    Yihai Cao
    Laboratory of Angiogenesis Research, Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
    Front Biosci (Landmark Ed) 14:3962-73. 2009
    ....
  71. ncbi request reprint Immortalization of bovine capillary endothelial cells by hTERT alone involves inactivation of endogenous p16INK4A/pRb
    Niina Veitonmaki
    Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
    FASEB J 17:764-6. 2003
    ..In agreement with this finding, the expression levels of the prototypic DNA methyltransferase DNMT1 were elevated in the hTERT-positive cells...
  72. pmc Deletion of the laminin alpha4 chain leads to impaired microvessel maturation
    Jill Thyboll
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 17 177 Stockholm, Sweden
    Mol Cell Biol 22:1194-202. 2002
    ..The results demonstrate a central role for the laminin alpha4 chain in microvessel growth and, in the absence of other laminin alpha chains, in the composition of endothelial basement membranes...
  73. ncbi request reprint Therapeutic angiogenesis for ischemic disorders: what is missing for clinical benefits?
    Yihai Cao
    Department of Microbiology and Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Discov Med 9:179-84. 2010
    ....