Olle Melander

Summary

Country: Sweden

Publications

  1. ncbi Mutations and variants of the epithelial sodium channel gene in Liddle's syndrome and primary hypertension
    O Melander
    Department of Endocrinology, Lund University, Malmo, Sweden
    Hypertension 31:1118-24. 1998
  2. ncbi Nt-proANP in plasma, a marker of salt sensitivity, is reduced in type 2 diabetes patients
    O Melander
    Department of Endocrinology, Malmo University Hospital, Lund University, Malmo, Sweden
    J Intern Med 257:281-8. 2005
  3. ncbi No evidence of a relation between 11beta-hydroxysteroid dehydrogenase type 2 activity and salt sensitivity
    Olle Melander
    Department of Endocrinology, Lund University, Malmö University Hospital MAS, S 205 02 Malmo, Sweden
    Am J Hypertens 16:729-33. 2003
  4. ncbi Plasma ProANP(1-30) reflects salt sensitivity in subjects with heredity for hypertension
    Olle Melander
    Department of Endocrinology, Lund University, Malmo, Sweden
    Hypertension 39:996-9. 2002
  5. ncbi Association between a variant in the 11 beta-hydroxysteroid dehydrogenase type 2 gene and primary hypertension
    O Melander
    Department of Endocrinology, Lund University, Malmo, Sweden
    J Hum Hypertens 14:819-23. 2000
  6. ncbi Genetic variants of thiazide-sensitive NaCl-cotransporter in Gitelman's syndrome and primary hypertension
    O Melander
    Department of Endocrinology, Lund University, Malmo, Sweden
    Hypertension 36:389-94. 2000
  7. ncbi Heredity for hypertension influences intra-uterine growth and the relation between fetal growth and adult blood pressure
    O Melander
    Department of Endocrinology, Lund University, Malmo, Sweden
    J Hypertens 17:1557-61. 1999
  8. ncbi Effect of salt on insulin sensitivity differs according to gender and degree of salt sensitivity
    O Melander
    Department of Endocrinology, Malmö University Hospital MAS, Malmo, Sweden
    Hypertension 35:827-31. 2000
  9. doi Smoking and obesity associated BDNF gene variance predicts total and cardiovascular mortality in smokers
    Sara Halldén
    Department of Clinical Sciences, Lund University, Clinical Research Center, Entrance 72, Building 91, Floor 12, Malmo University Hospital, Malmo SE 205 02, Sweden
    Heart 99:949-53. 2013
  10. doi A variant upstream of the CDH13 adiponectin receptor gene and metabolic syndrome in Swedes
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Malmo, Sweden
    Am J Cardiol 108:1432-7. 2011

Detail Information

Publications107 found, 100 shown here

  1. ncbi Mutations and variants of the epithelial sodium channel gene in Liddle's syndrome and primary hypertension
    O Melander
    Department of Endocrinology, Lund University, Malmo, Sweden
    Hypertension 31:1118-24. 1998
    ....
  2. ncbi Nt-proANP in plasma, a marker of salt sensitivity, is reduced in type 2 diabetes patients
    O Melander
    Department of Endocrinology, Malmo University Hospital, Lund University, Malmo, Sweden
    J Intern Med 257:281-8. 2005
    ....
  3. ncbi No evidence of a relation between 11beta-hydroxysteroid dehydrogenase type 2 activity and salt sensitivity
    Olle Melander
    Department of Endocrinology, Lund University, Malmö University Hospital MAS, S 205 02 Malmo, Sweden
    Am J Hypertens 16:729-33. 2003
    ..The aim of the present study was to investigate whether 11BHSD2 activity is affected by salt intake and if it is related to salt sensitivity...
  4. ncbi Plasma ProANP(1-30) reflects salt sensitivity in subjects with heredity for hypertension
    Olle Melander
    Department of Endocrinology, Lund University, Malmo, Sweden
    Hypertension 39:996-9. 2002
    ....
  5. ncbi Association between a variant in the 11 beta-hydroxysteroid dehydrogenase type 2 gene and primary hypertension
    O Melander
    Department of Endocrinology, Lund University, Malmo, Sweden
    J Hum Hypertens 14:819-23. 2000
    ..Journal of Human Hypertension (2000) 14, 819-823..
  6. ncbi Genetic variants of thiazide-sensitive NaCl-cotransporter in Gitelman's syndrome and primary hypertension
    O Melander
    Department of Endocrinology, Lund University, Malmo, Sweden
    Hypertension 36:389-94. 2000
    ..Our results further suggest that subjects homozygous for the Gln904 variant have an increased risk for development of primary hypertension...
  7. ncbi Heredity for hypertension influences intra-uterine growth and the relation between fetal growth and adult blood pressure
    O Melander
    Department of Endocrinology, Lund University, Malmo, Sweden
    J Hypertens 17:1557-61. 1999
    ..To study whether heredity for hypertension influences intra-uterine growth and the relationship between fetal growth and adult blood pressure...
  8. ncbi Effect of salt on insulin sensitivity differs according to gender and degree of salt sensitivity
    O Melander
    Department of Endocrinology, Malmö University Hospital MAS, Malmo, Sweden
    Hypertension 35:827-31. 2000
    ....
  9. doi Smoking and obesity associated BDNF gene variance predicts total and cardiovascular mortality in smokers
    Sara Halldén
    Department of Clinical Sciences, Lund University, Clinical Research Center, Entrance 72, Building 91, Floor 12, Malmo University Hospital, Malmo SE 205 02, Sweden
    Heart 99:949-53. 2013
    ..Our aim was to test whether genetic BDNF variation alters the risk of smoking related morbidity and mortality...
  10. doi A variant upstream of the CDH13 adiponectin receptor gene and metabolic syndrome in Swedes
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Malmo, Sweden
    Am J Cardiol 108:1432-7. 2011
    ..In light of the role of cadherin-13 as a vascular receptor for adiponectin, our study supports the genetic basis for the role of adiponectin in MetS pathogenesis...
  11. doi Prediction of blood pressure changes over time and incidence of hypertension by a genetic risk score in Swedes
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Sweden
    Hypertension 61:319-26. 2013
    ..Our data from a large cohort study show that a GRS is independently associated with BP increase and incidence of hypertension...
  12. pmc The Renalase Asp37Glu polymorphism is not associated with hypertension and cardiovascular events in an urban-based prospective cohort: the Malmö Diet and cancer study
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Sweden
    BMC Med Genet 13:57. 2012
    ..We tested the hypothesis that these polymorphisms could affect BP levels, hypertension prevalence, and risk of incident cardiovascular events in middle-aged Swedes...
  13. pmc Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality
    Eero Lindholm
    Department of Clinical Sciences, Clinical Research Center, University Hospital Malmö MAS, Lund University, Malmo, Sweden
    PLoS ONE 1:e64. 2006
    ..Recently, a -168A-->G polymorphism in the MHC class II transactivator gene (MHC2TA) was shown to be associated with increased susceptibility to myocardial infarction (MI)...
  14. pmc Assessment of conventional cardiovascular risk factors and multiple biomarkers for the prediction of incident heart failure and atrial fibrillation
    J Gustav Smith
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    J Am Coll Cardiol 56:1712-9. 2010
    ....
  15. ncbi Novel mutations in the SLC12A3 gene causing Gitelman's syndrome in Swedes
    Cristiano Fava
    Division of Endocrinology, Department of Clinical Sciences, University of Malmo, Malmo, Sweden
    DNA Seq 18:395-9. 2007
    ..Up to now, more than 100 mutations of the SLC12A3 gene have been described in GS patients...
  16. ncbi Determinants of kidney function in Swedish families: role of heritable factors
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Malmo, Sweden
    J Hypertens 26:1773-9. 2008
    ..The association of the circadian rhythm of blood pressure with kidney function in this sample deserves further investigation...
  17. pmc A large-sample assessment of possible association between ischaemic stroke and rs12188950 in the PDE4D gene
    Håkan Lövkvist
    Department of Clinical Sciences, Neurology, Lund University, Lund, Sweden
    Eur J Hum Genet 20:783-9. 2012
    ..042). No effect from rs12188950 on IS was found from either our pooled multi-centre data or the performed meta-analysis. We did not find any association between the examined subgroups and rs12188950 either...
  18. doi Plasma proneurotensin and incidence of diabetes, cardiovascular disease, breast cancer, and mortality
    Olle Melander
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    JAMA 308:1469-75. 2012
    ..Neurotensin regulates both satiety and breast cancer growth in the experimental setting, but little is known about its role in the development of breast cancer or cardiometabolic disease in humans...
  19. doi The common functional polymorphism -50G>T of the CYP2J2 gene is not associated with ischemic coronary and cerebrovascular events in an urban-based sample of Swedes
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Sweden
    J Hypertens 28:294-9. 2010
    ....
  20. doi A functional variant of the NEDD4L gene is associated with beneficial treatment response with β-blockers and diuretics in hypertensive patients
    Patrik Svensson-Färbom
    Department of Clinical Sciences, Lund University and Center for Emergency Medicine, Malmo University Hospital, Malmo, Sweden
    J Hypertens 29:388-95. 2011
    ....
  21. ncbi Association between adducin-1 G460W variant and blood pressure in Swedes is dependent on interaction with body mass index and gender
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Malmo, Sweden
    Am J Hypertens 20:981-9. 2007
    ..The aim of this study was to test whether the G460W variant is associated with BP levels and BP progression rate and whether G460W associations with BP are affected by sex, body mass index (BMI), or age...
  22. doi Homozygosity for the EPHX2 K55R polymorphism increases the long-term risk of ischemic stroke in men: a study in Swedes
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Sweden
    Pharmacogenet Genomics 20:94-103. 2010
    ..The aim of this study was to evaluate the effect of four polymorphisms in the EPHX2 gene on blood pressure levels, hypertension prevalence, and risk of incident cardiovascular events in a large sample of middle-aged Swedes...
  23. pmc Low plasma level of atrial natriuretic peptide predicts development of diabetes: the prospective Malmo Diet and Cancer study
    Martin Magnusson
    Departments of Clinical Sciences, Lund University, Skane University Hospital, Ent 35, Floor 2, SE 205 02 Malmo, Sweden
    J Clin Endocrinol Metab 97:638-45. 2012
    ....
  24. pmc Plasma copeptin and the risk of diabetes mellitus
    Sofia Enhörning
    Department of Clinical Sciences, Lund University, Clinical Research Center, Entrance 72, Bldg 91, Floor 12, Malmo University Hospital, SE 20502 Malmo, Sweden
    Circulation 121:2102-8. 2010
    ..Animal studies suggest that the arginine vasopressin system may play a role in glucose metabolism, but data from humans are limited...
  25. pmc A common missense variant in the ATP receptor P2X7 is associated with reduced risk of cardiovascular events
    Olof Gidlöf
    Department of Clinical Sciences, Lund University, Lund, Sweden
    PLoS ONE 7:e37491. 2012
    ..We hypothesized that polymorphisms in P2RX7 influence the risk of ischemic heart disease (IHD), ischemic stroke (IS) and cardiovascular risk factors and tested this hypothesis using genetic association studies...
  26. doi The functional variant V433M of the CYP4F2 and the metabolic syndrome in Swedes
    Cristiano Fava
    Department of Clinical Sciences, Lund University, Skane University Hospital, Malmo, Sweden
    Prostaglandins Other Lipid Mediat 98:31-6. 2012
    ..The aim of the present study was to evaluate the effect of CYP4F2 V433M, a functional polymorphism previously associated with hypertension via renal salt reabsorption, on the individual components of MetS and MetS itself...
  27. doi Orthostatic blood pressure response, carotid intima-media thickness, and plasma fibrinogen in older nondiabetic adults
    Artur Fedorowski
    Center for Emergency Medicine, Skane University Hospital, Malmo, Sweden
    J Hypertens 30:522-9. 2012
    ..Although recent studies have indicated that both orthostatic hypotension and orthostatic hypertension (OHTN) independently predict cardiovascular events, the underlying mechanisms are still debatable...
  28. doi Plasma copeptin, a unifying factor behind the metabolic syndrome
    Sofia Enhörning
    Department of Clinical Science, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    J Clin Endocrinol Metab 96:E1065-72. 2011
    ..We previously showed that high copeptin, the stable C-terminal fragment of AVP prohormone, is independently associated with hyperinsulinemia and future development of diabetes mellitus...
  29. doi Soluble urokinase plasminogen activator receptor: a risk factor for carotid plaque, stroke, and coronary artery disease
    Margaretha Persson
    From the Clinical Research Unit, Medicine, Skåne University Hospital Malmö, Malmo, Sweden M P, G O, O M and Department of Clinical Sciences Malmö, Lund University, Lund, Sweden M P, G O, G S, V H, O M, B H, G E
    Stroke 45:18-23. 2014
    ..The relationships among the soluble urokinase plasminogen activator receptor (suPAR), carotid plaque, and incidence of ischemic stroke and coronary artery disease (CAD) events were studied in a prospective cohort...
  30. doi Age and gender differences in the association between Nt-proBNP and glucometabolic disturbances
    Margret Leosdottir
    Department of Cardiology, Skane University Hospital, Malmo, Sweden
    Scand Cardiovasc J 45:294-300. 2011
    ..Brain natriuretic peptides (BNP) are used for detecting myocardial dysfunction in clinical practice. However, studies on elderly subjects and gender-specific analyses are sparse...
  31. ncbi The functional variant of the CLC-Kb channel T481S is not associated with blood pressure or hypertension in Swedes
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Sweden
    J Hypertens 25:111-6. 2007
    ..The study aim was to evaluate the association of the T481S polymorphism with blood pressure (BP) levels and the BP progression rate in Swedes...
  32. pmc Brain natriuretic peptide is related to diastolic dysfunction whereas urinary albumin excretion rate is related to left ventricular mass in asymptomatic type 2 diabetes patients
    Martin Magnusson
    Department of Cardiology, Malmo University Hospital, Lund University, Lund, Sweden
    Cardiovasc Diabetol 9:2. 2010
    ....
  33. ncbi Moderate salt restriction effectively lowers blood pressure and degree of salt sensitivity is related to baseline concentration of renin and N-terminal atrial natriuretic peptide in plasma
    Olle Melander
    Department of Clinical Sciences, Malmö University Hospital and Lund University, Malmo, Sweden
    J Hypertens 25:619-27. 2007
    ..Furthermore, we tested whether the basal plasma concentration of renin or N-terminal atrial natriuretic peptide (Nt-proANP) predict the degree of salt sensitivity...
  34. pmc Genetic polymorphisms confer risk of atrial fibrillation in patients with heart failure: a population-based study
    J Gustav Smith
    Department of Cardiology, Lund University, Lund, Sweden
    Eur J Heart Fail 15:250-7. 2013
    ..We evaluated the association of cardiovascular and genetic risk factors with AF in HF patients...
  35. doi A clinically confirmed family history for early myocardial infarction is associated with increased risk of obesity, insulin resistance and metabolic syndrome
    Martin Magnusson
    Department of Cardiology, Skane University Hospital, Malmo, Sweden
    J Hypertens 30:948-53. 2012
    ..We examined whether a parental history of clinically verified early MI may promote development of insulin resistance, obesity and the metabolic syndrome (MetS)...
  36. doi Vasoactive peptides with angiogenesis-regulating activity predict cancer risk in males
    Mattias Belting
    Department of Clinical Sciences, Lund University, Section of Oncology, Lund, Sweden
    Cancer Epidemiol Biomarkers Prev 21:513-22. 2012
    ..Here, we hypothesized that vasoactive peptides previously implicated in angiogenesis regulation predict long-term cancer risk...
  37. doi Serine/threonine kinase 39 is a candidate gene for primary hypertension especially in women: results from two cohort studies in Swedes
    Cristiano Fava
    Department of Clinical Sciences, Skane University Hospital, Lund University, Malmo, Sweden
    J Hypertens 29:484-91. 2011
    ....
  38. ncbi Dipping and variability of blood pressure and heart rate at night are heritable traits
    Cristiano Fava
    Department of Endocrinology, University Hospital MAS, Malmo, Sweden
    Am J Hypertens 18:1402-7. 2005
    ..The aim of this study was to determine whether these traits are heritable...
  39. ncbi Orthostatic hypotension in genetically related hypertensive and normotensive individuals
    Artur Fedorowski
    Department of Medicine, Malmo University Hospital, Malmo, Sweden
    J Hypertens 27:976-82. 2009
    ..Prevalence and determinants of orthostatic hypotension remain largely unexplored in younger individuals without significant burden of chronic diseases...
  40. pmc Novel and conventional biomarkers for prediction of incident cardiovascular events in the community
    Olle Melander
    Department of Clinical Sciences, Lund University, Clinical Research Center, Malmo University Hospital, SE 205 02 Malmo, Sweden
    JAMA 302:49-57. 2009
    ..Prior studies have demonstrated conflicting results regarding how much information novel biomarkers add to cardiovascular risk assessment...
  41. doi Orthostatic hypotension predicts incidence of heart failure: the Malmö preventive project
    Artur Fedorowski
    Center for Emergency Medicine, Skane University Hospital, Malmo, Sweden
    Am J Hypertens 23:1209-15. 2010
    ..The presence of orthostatic hypotension (OH) predicts all-cause mortality and incident cardiovascular disease. Whether or not OH is associated with the development of heart failure (HF) remains unknown...
  42. ncbi Functional variant in the (alpha)2B adrenoceptor gene, a positional candidate on chromosome 2, associates with hypertension
    Fredrik von Wowern
    Department of Endocrinology, Wallenberg Laboratory, Ent 46, Floor 3, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Hypertension 43:592-7. 2004
    ....
  43. doi Diabetes mellitus and elevated copeptin levels in middle age predict low cognitive speed after long-term follow-up
    Eva Tufvesson
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
    Dement Geriatr Cogn Disord 35:67-76. 2013
    ....
  44. doi Pharmacogenetic implications for eight common blood pressure-associated single-nucleotide polymorphisms
    Viktor Hamrefors
    Department of Clinical Sciences, Lund University, Malmo, Norway
    J Hypertens 30:1151-60. 2012
    ....
  45. doi Atrial fibrillation in the Malmö Diet and Cancer study: a study of occurrence, risk factors and diagnostic validity
    J Gustav Smith
    Department of Clinical Sciences, Lund University, Clinical Research Center, Malmo University Hospital, Malmo, Sweden
    Eur J Epidemiol 25:95-102. 2010
    ..Hypertension and obesity account for large portions of population risk in middle-aged individuals with low prevalence of manifest cardiac disease...
  46. doi Job strain, job demands and adrenergic beta1-receptor-polymorphism: a possible interaction affecting blood pressure in men
    Bertil Ohlin
    Department of Clinical Sciences Medicine, Lund University, Malmo University Hospital, Sweden
    J Hypertens 26:1583-9. 2008
    ..We aimed to study whether there is an interaction between the Arg389Gly polymorphism and job strain and its components (job demand and decision latitude) in relation to blood pressure...
  47. pmc Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations
    Marju Orho-Melander
    Department of Clinical Sciences, University Hospital Malmo, Clinical Research Center, Lund University, Malmo, Sweden
    Diabetes 57:3112-21. 2008
    ....
  48. doi Chromosome 2q12, the ADRA2B I/D polymorphism and metabolic syndrome
    Cristiano Fava
    Department of Clinical Sciences, University Hospital MAS, Malmo, Sweden
    J Hypertens 27:1794-803. 2009
    ....
  49. ncbi Adrenomedullin is a marker of carotid plaques and intima-media thickness as well as brachial pulse pressure
    Mikael Gottsäter
    Department of Clinical Sciences, Lund University, Skane University Hospital, Malmo, Sweden
    J Hypertens 31:1959-65. 2013
    ..The aim of this study was to investigate the association between the mid-regional part of pro-ADM (MR-proADM) and brachial pulse pressure (PP), carotid intima-media thickness (cIMT) and carotid atherosclerosis...
  50. pmc Smoking modifies the associated increased risk of future cardiovascular disease by genetic variation on chromosome 9p21
    Viktor Hamrefors
    Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmo, Sweden Clinical Physiology and Nuclear Medicine Unit, Skane University Hospital, Malmo, Sweden
    PLoS ONE 9:e85893. 2014
    ..We tested if the associated risk of CVD and CVD-mortality by the single nucleotide polymorphism rs4977574 on chromosome 9p21 is modified by life-style factors...
  51. ncbi Peroxisome proliferator-activated receptor-gammaPro12Ala polymorphism and the association with blood pressure in type 2 diabetes: skaraborg hypertension and diabetes project
    Carl J Ostgren
    Department of Community Medicine, Malmo University Hospital, Malmo, Sweden
    J Hypertens 21:1657-62. 2003
    ..This study explored whether the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPARgamma) is associated with blood pressure in subjects with type 2 diabetes...
  52. doi From circulating biomarkers to genomics and imaging in the prediction of cardiovascular events in the general population
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Sweden
    Ann Med 44:433-47. 2012
    ....
  53. ncbi Elevated plasma levels of Nt-proBNP in patients with type 2 diabetes without overt cardiovascular disease
    Martin Magnusson
    Department of Cardiology, University Hospital MAS, Lund University, Sweden
    Diabetes Care 27:1929-35. 2004
    ....
  54. doi Directionality of blood pressure response to standing may determine development of heart failure: prospective cohort study
    Artur Fedorowski
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    Eur J Heart Fail 13:496-503. 2011
    ..To study the prospective relationship of blood pressure response during orthostatic challenge with incidence of heart failure (HF)...
  55. doi Consequences of orthostatic blood pressure variability in middle-aged men (The Malmö Preventive Project)
    Artur Fedorowski
    Center for Emergency Medicine, Malmo University Hospital, Malmo, Sweden
    J Hypertens 28:551-9. 2010
    ..To investigate the determinants and consequences of orthostatic hypotension in the middle-aged segment of the general population...
  56. doi Relation between human vasopressin 1a gene variance, fat intake, and diabetes
    Sofia Enhörning
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    Am J Clin Nutr 89:400-6. 2009
    ..Male arginine vasopressin 1a receptor knockout mice (V1aR(-/-)) display a phenotype of low triglycerides and high glucose concentrations and high-fat-diet-induced obesity and diabetes...
  57. ncbi Leukocyte count and incidence of hospitalizations due to heart failure
    Gunnar Engstrom
    Department of Clinical Sciences in Malmo, Lund University, Sweden
    Circ Heart Fail 2:217-22. 2009
    ..Whether high leukocyte counts are associated with incidence of heart failure (HF) is unknown. This population-based study explored whether the leukocyte concentrations were associated with incidence of hospitalizations due to HF...
  58. doi Inflammation-sensitive proteins and risk of atrial fibrillation: a population-based cohort study
    Samuel Adamsson Eryd
    Cardiovascular epidemiology research group, Department of Clinical Sciences, Lund University, Skane University Hospital, Malmo, Sweden
    Eur J Epidemiol 26:449-55. 2011
    ..Of the individual ISPs, a significant association was observed for ceruloplasmin, a protein previously associated with copper metabolism and oxidative stress...
  59. pmc Plasma procalcitonin is associated with all-cause and cancer mortality in apparently healthy men: a prospective population-based study
    Ovidiu S Cotoi
    Department of Clinical Sciences, Lund University, Lund, Sweden
    BMC Med 11:180. 2013
    ..Our aim was to assess the relationship between plasma PCT and the risk of all-cause and cause-specific mortality in apparently healthy individuals with no previous history of cardiovascular disease or cancer...
  60. pmc A gene score of nine LDL and HDL regulating genes is associated with fluvastatin-induced cholesterol changes in women
    Viktor Hamrefors
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    J Lipid Res 51:625-34. 2010
    ..This suggests that a gene score based on variation in nine different LDL- and HDL-associated genes is of importance for the magnitude of fluvastatin HDL increase in women with asymptomatic plaque in the carotid artery...
  61. pmc Orthostatic hypotension predicts all-cause mortality and coronary events in middle-aged individuals (The Malmo Preventive Project)
    Artur Fedorowski
    Center for Emergency Medicine, Malmo University Hospital, Entrance 33, Floor 5, 20502 Malmo, Sweden
    Eur Heart J 31:85-91. 2010
    ..Orthostatic hypotension (OH) has been linked to increased mortality and incidence of cardiovascular disease in various risk groups, but determinants and consequences of OH in the general population are poorly studied...
  62. doi Population-based study of lung function and incidence of heart failure hospitalisations
    Gunnar Engstrom
    Department of Clinical Sciences, Lund University, Malmo University Hospital, Sweden
    Thorax 65:633-8. 2010
    ..However, the relationship with incidence of heart failure (HF) is incompletely known. This population-based study explored whether reduced FEV(1) or FVC is associated with the incidence of hospitalisation for HF...
  63. ncbi Heritability of ambulatory and office blood pressure phenotypes in Swedish families
    Cristiano Fava
    Department of Endocrinology, University Hospital MAS, Malmo, Sweden
    J Hypertens 22:1717-21. 2004
    ..The aim of this study was to estimate the heritability of 24-h ambulatory blood pressure and office blood pressure phenotypes in Swedish families...
  64. doi Genetic variants in serum and glucocortocoid regulated kinase 1, a regulator of the epithelial sodium channel, are associated with ischaemic stroke
    Jonas Dahlberg
    Clinical Research Center CRC, Entrance 72, Bldg 91, Floor 12, Malmo University Hospital, SE 205 02 Malmo, Sweden
    J Hypertens 29:884-9. 2011
    ..Therefore, we tested the association of these variants with ischaemic stroke...
  65. pmc Polymorphism in NEDD4L is associated with increased salt sensitivity, reduced levels of P-renin and increased levels of Nt-proANP
    Jonas Dahlberg
    Department of Clinical Sciences, Malmö University Hospital and Lund University, Malmo, Sweden
    PLoS ONE 2:e432. 2007
    ..Our aim was to test if genetic variation in NEDD4L is associated with increased salt sensitivity...
  66. ncbi A genome wide scan for early onset primary hypertension in Scandinavians
    Fredrik von Wowern
    Department of Endocrinology, Malmo University Hospital, SE 205 02, Malmo, Sweden
    Hum Mol Genet 12:2077-81. 2003
    ..Our data suggest a hypertension susceptibility locus on chromosome 14 around 41 cM. The locus on chromosome 2 is also promising as it has been implicated in hypertension and blood pressure regulation in earlier genome scans...
  67. pmc Early postural blood pressure response and cause-specific mortality among middle-aged adults
    Artur Fedorowski
    Center for Emergency Medicine, Skane University Hospital, Entrance 35, Floor 2, 205 02, Malmo, Sweden
    Eur J Epidemiol 26:537-46. 2011
    ..Moreover, both increase and pronounced decrease of SBP during early orthostasis indicate higher risk of cerebrovascular death...
  68. doi Red cell distribution width and risk for first hospitalization due to heart failure: a population-based cohort study
    Yan Borné
    Department of Clinical Sciences, Lund University, Clinical Research Center, Skane University Hospital, Malmo, Sweden
    Eur J Heart Fail 13:1355-61. 2011
    ..We investigated the association between RDW and incidence of first hospitalization due to HF in a population-based cohort...
  69. ncbi Genetic variance of SGK-1 is associated with blood pressure, blood pressure change over time and strength of the insulin-diastolic blood pressure relationship
    Fredrik von Wowern
    Department of Endocrinology, Lund University, Malmo, Sweden
    Kidney Int 68:2164-72. 2005
    ..The aim of this study was to investigate if variation in the SGK-1 gene is associated with increased blood pressure and strength of the insulin-blood pressure relationship...
  70. doi Cardiovascular and cancer mortality in very elderly post-myocardial infarction patients receiving statin treatment
    Klas Gränsbo
    Department of Clinical Sciences, Malmo University Hospital, Malmo, Sweden Lund University, Lund, Sweden
    J Am Coll Cardiol 55:1362-9. 2010
    ..The purpose of this study was to determine whether statin treatment is effective and safe in very elderly (80 years and older) acute myocardial infarction (AMI) patients...
  71. ncbi Determinants of increasing pulse pressure during 23 years' follow-up as a marker of arterial stiffness and vascular ageing
    Arash Mokhtari
    Department of Clinical Sciences, Lund University, University Hospital, Malmo, Sweden
    Blood Press 17:291-7. 2008
    ..In conclusion, several well-known cardiovascular risk factors, such as glucose, BMI, heart rate, family history of hypertension and cholesterol in particular, are long-term predictors of increased PP in both genders...
  72. ncbi Interaction between renal function and microalbuminuria for cardiovascular risk in hypertension: the nordic diltiazem study
    Patrik Färbom
    Department of Clinical Sciences, Clinical Research Center, Entrance 72, Bldg 91, Fl 12, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Hypertension 52:115-22. 2008
    ..Because estimation of the total cardiovascular risk is essential for the aggressiveness of risk factor interventions, simultaneous inclusion of GFR and microalbuminuria in global cardiovascular risk assessment is essential...
  73. doi Carotid intima-media thickness, systemic inflammation, and incidence of heart failure hospitalizations
    Gunnar Engstrom
    Department of Clinical Sciences in Malmo, Lund University, Malmo University Hospital, Sweden
    Arterioscler Thromb Vasc Biol 29:1691-5. 2009
    ..This study explored the relationships between carotid intima-media thickness (IMT), plasma levels of C-reactive protein (CRP), and incidence of heart failure hospitalizations...
  74. doi The metabolic syndrome and risk of myocardial infarction in familial hypertension (hypertension heredity in Malmö evaluation study)
    Artur Fedorowski
    Department of Medicine, Lund University, Lund, Sweden
    J Hypertens 27:109-17. 2009
    ....
  75. ncbi Beta(2)-adrenergic receptor gene variation and hypertension in subjects with type 2 diabetes
    K Bengtsson
    Department of Endocrinology, Malmo University Hospital, Lund University, Malmo, Sweden
    Hypertension 37:1303-8. 2001
    ....
  76. ncbi Uromodulin gene variant is associated with type 2 diabetic nephropathy
    Tarunveer S Ahluwalia
    Department of Endocrinology and Lund University Diabetes Centre, University Hospital, Skåne, Malmo, Sweden
    J Hypertens 29:1731-4. 2011
    ..In the present study we examined the association of the common variant of the uromodulin (UMOD) gene with type 2 diabetic nephropathy and kidney function...
  77. ncbi Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3
    Liisa Koivukoski
    Department of Endocrinology, Malmo University Hospital, Lund University, SE 205 02 Malmo, Sweden
    Hum Mol Genet 13:2325-32. 2004
    ..We conclude that modest or non-significant linkage on chromosomes 3p14.1-q12.3 and 2p12-q22.1 in each individual study translates into genome-wide significant or highly suggestive linkages to HT and DBP in our GSMA analysis...
  78. ncbi Contribution of known and unknown susceptibility genes to early-onset diabetes in scandinavia: evidence for heterogeneity
    Cecilia M Lindgren
    Department of Endocrinology, Wallenberg Laboratory, Malmo University Hospital, Malmo, Sweden
    Diabetes 51:1609-17. 2002
    ..Our data also point at putative chromosomal regions, which could harbor novel genes that contribute to EOD...
  79. ncbi Job strain, decision latitude and alpha2B-adrenergic receptor polymorphism significantly interact, and associate with higher blood pressures in men
    Bertil Ohlin
    Department of Clinical Sciences Medicine, Lund University, Malmo University Hospital, Sweden
    J Hypertens 25:1613-9. 2007
    ..We hypothesized that the I/D polymorphism interacts with external stress, such as job strain, in the development of hypertension...
  80. ncbi Subjects heterozygous for genetic loss of function of the thiazide-sensitive cotransporter have reduced blood pressure
    C Fava
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    Hum Mol Genet 17:413-8. 2008
    ....
  81. ncbi An association between Type 2 diabetes and alpha-antitrypsin deficiency
    C S Sandström
    Chronic and Degenerative Disease Research Unit, University Hospital Malmoe, Lund University, Malmo, Sweden
    Diabet Med 25:1370-3. 2008
    ..We have investigated whether plasma AAT levels are altered in Type 2 diabetes...
  82. ncbi Polymorphism in the beta(1)-adrenergic receptor gene and hypertension
    K Bengtsson
    Department of Endocrinology, Malmo University Hospital, Lund University, Sweden
    Circulation 104:187-90. 2001
    ..4+/-9.9 versus 76.0+/-10.1 mm Hg; P=0.003) and higher heart rates (68.3+/-11.0 versus 65.1+/-9.4 bpm; P=0.02) than siblings carrying 1 or 2 copies of the Gly389 allele. The Ser49Gly polymorphism was not associated with hypertension...
  83. pmc A dedicated investigation unit improves management of syncopal attacks (Syncope Study of Unselected Population in Malmo--SYSTEMA I)
    Artur Fedorowski
    Center for Emergency Medicine, Skane University Hospital, Malmo, Sweden
    Europace 12:1322-8. 2010
    ..To investigate whether a systematic approach to unexplained syncopal attacks based on the European Society of Cardiology guidelines would improve the diagnostic and therapeutic outcomes...
  84. ncbi Angiotensin converting enzyme (ACE) gene polymorphism in sarcoidosis in relation to associated autoimmune diseases
    K I Papadopoulos
    Department of Endocrinology, University of Lund, Malmo University Hospital, Malmo, Sweden
    J Intern Med 247:71-7. 2000
    ..To investigate the significance of ACE gene insertion/deletion (I/D) polymorphism in the frequency of autoimmune manifestations in sarcoidosis...
  85. ncbi 24-h ambulatory blood pressure is linked to chromosome 18q21-22 and genetic variation of NEDD4L associates with cross-sectional and longitudinal blood pressure in Swedes
    C Fava
    Department of Clinical Sciences, University Hospital MAS, Malmo, Sweden
    Kidney Int 70:562-9. 2006
    ..25 cM is explained by genetic NEDD4L variation affecting cross-sectional and longitudinal blood pressure, possibly as a consequence of altered NEDD4L interaction with ENaC...
  86. pmc Gastroparesis is associated with oxytocin deficiency, oesophageal dysmotility with hyperCCKemia, and autonomic neuropathy with hypergastrinemia
    Julia Borg
    Department of Clinical Sciences, Gastroenterology Division, Malmo University Hospital, Lund University, Lund, Sweden
    BMC Gastroenterol 9:17. 2009
    ..The aim of this study was to examine if concentrations of oxytocin, cholecystokinin (CCK), gastrin and vasopressin in plasma differ between diabetics with normal function and dysfunction in GI motility...
  87. pmc Pleiotropic effects of GIP on islet function involve osteopontin
    Valeriya Lyssenko
    Diabetes and Endocrinology, Department of Clinical Sciences, University Hospital Malmo, Lund University, Malmo, Sweden
    Diabetes 60:2424-33. 2011
    ..Here we explored mechanisms that could explain the protective effects of GIP on islet function...
  88. ncbi Weak associations between human leucocyte antigen genotype and acute myocardial infarction
    H Bjorkbacka
    Department of Clinical Sciences, Lund University, Malmo University Hospital, Malmo, Sweden
    J Intern Med 268:50-8. 2010
    ..The importance of such studies is stressed by recent experimental findings of an involvement of autoimmunity in the atherosclerotic disease process...
  89. ncbi Pro-opiomelanocortin gene is associated with serum leptin levels in lean but not in obese individuals
    E Suviolahti
    Department of Endocrinology, Lund University, Malmo, Sweden
    Int J Obes Relat Metab Disord 27:1204-11. 2003
    ..We searched for monogenic obesity due to mutations in POMC and MC4R among morbidly obese Swedes and studied the association of POMC variants with BMI and serum leptin levels...
  90. ncbi Oesophageal dysmotility, delayed gastric emptying and autonomic neuropathy correlate to disturbed glucose homeostasis
    B Ohlsson
    Department of Clinical Sciences, Gastroenterology Division, Malmo University Hospital, Lund University, Malmo, Sweden
    Diabetologia 49:2010-4. 2006
    ..This study analysed whether oesophageal dysmotility, delayed gastric emptying or autonomic neuropathy affect glucose homeostasis...
  91. doi The Pro12Ala polymorphism of the PPARG gene is not associated with the metabolic syndrome in an urban population of middle-aged Swedish individuals
    M Montagnana
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Malmo, Sweden
    Diabet Med 25:902-8. 2008
    ....
  92. ncbi Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols
    Sandosh Padmanabhan
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    J Hypertens 26:1275-81. 2008
    ..This will lead to the identification of potential targets for lifestyle and pharmacological interventions, with the ultimate goal of improving prevention, diagnosis and treatment...
  93. doi The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure
    Cristiano Fava
    Department of Biomedical and Surgical Sciences, Division of Internal Medicine C, Piazza LA Scuro 10, 37134 Verona, Italy
    Hypertension 52:373-80. 2008
    ..A common CYP4F2 V433M polymorphism might increase the risk of incident ischemic stroke in male subjects only partially through its elevating effect on BP. Additional studies are needed to confirm these data...
  94. pmc A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
    Sekar Kathiresan
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S17. 2007
    ..Genome-wide association is a promising approach to map genetic loci related to these heritable phenotypes...
  95. ncbi hTERT (-1327)T/C polymorphism is not associated with age-related telomere attrition in peripheral blood
    Katarina Nordfjäll
    Department of Medical Biosciences, Pathology, By 6M, 2nd Floor, Umea University, SE 90187 Umea, Sweden
    Biochem Biophys Res Commun 358:215-8. 2007
    ..339). Moreover, no increased age-related attrition was observed for the (-1327)C/C genotype as previously indicated, rather a telomere elongation in the control group (p=0.021) not seen in the MI group (p=0.249)...
  96. ncbi Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    Richa Saxena
    Broad Institute of Harvard and Massachusetts Institute of Technology MIT, Cambridge, MA 02142, USA
    Science 316:1331-6. 2007
    ..The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases...
  97. pmc Multilevel analysis of systolic blood pressure and ACE gene I/D polymorphism in 438 Swedish families--a public health perspective
    Juan Merlo
    Department of Health and Health Care Management Epidemiology, Region Skåne, Lund, Sweden
    BMC Med Genet 7:14. 2006
    ..We aimed to combine genetic epidemiology with public health ideas concerning life-course and multilevel epidemiology in order to understand the role of familial factors regarding individual SBP...
  98. ncbi Interaction between the angiotensin-converting enzyme gene insertion/deletion polymorphism and obstructive sleep apnoea as a mechanism for hypertension
    Kristina Bengtsson Boström
    Department of Clinical Sciences, Diabetes and Endocrinology, Skaraborg Institute, Skovde, Sweden
    J Hypertens 25:779-83. 2007
    ..The aim of this study was to explore the interaction between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and OSA in the association with hypertension...
  99. ncbi Are minor gene effects of clinical importance?
    Olle Melander
    J Hypertens 25:505-7. 2007
  100. ncbi Salt sensitivity: a consequence of the metabolic syndrome?
    Olle Melander
    J Hypertens 24:1475-7. 2006
  101. doi Genetics of cardiovascular disease: interplay between common and rare alleles
    Olle Melander
    J Hypertens 26:394-5. 2008