Research Topics
| Asa MelhusSummaryAffiliation: Malmö University Hospital Country: Sweden Publications The treatment of Haemophilus influenzae acute otitis media with amoxicillin protects against reinfection but not against structural changesEva Westman Department of Oto-Rhino-Laryngology, Umeå University Hospital, Ume, Sweden J Antimicrob Chemother 49:141-7 Jun N-terminal protein kinase enhances middle ear mucosal proliferation during bacterial otitis mediaMasayuki Furukawa Department of Surgery, UCSD School of Medicine, Fir Bldg, Rm 106, 9500 Gilman Dr 0666, La Jolla, CA 92037, USA Infect Immun 75:2562-71 In vitro activities of three carbapenems against recent bacterial isolates from severely ill patients at Swedish hospitalsCarl Johan Fraenkel Department of Clinical Microbiology, Blekinge Hospital, Karlskrona, Sweden Scand J Infect Dis 38:853-9 Nontypeable Haemophilus influenzae strains with the capsule-associated insertion element IS1016 may mimic encapsulated strainsEva Karlsson Department of Medical Microbiology, Malmö University Hospital, Lund University, Malm, Sweden APMIS 114:633-40 Fluoroquinolones and tendon disordersAsa Melhus Lund University, Department of Medical Microbiology, Malmö University Hospital, S 205 02 Malmö, Sweden Expert Opin Drug Saf 4:299-309 Beta-lactamase-producing nontypeable Haemophilus influenzae fails to protect Streptococcus pneumoniae from amoxicillin during experimental acute otitis mediaEva Westman Department of Oto Rhino Laryngology, Umeå University Hospital, Umeå, Sweden Antimicrob Agents Chemother 48:3536-42 Role of p38 mitogen-activated protein kinase in middle ear mucosa hyperplasia during bacterial otitis mediaSean D Palacios Department of Surgery Otolaryngology, University of California San Diego, La Jolla, 92037, USA Infect Immun 72:4662-7 Effects of amoxicillin on cytokine and osteocalcin expression in bone tissue during experimental acute otitis mediaAsa Melhus Department of Medical Microbiology, Lund University, Malmö University Hospital, S 205 02 Malmö, Sweden Cytokine 25:254-9 A mouse model for acute otitis mediaAsa Melhus Department of Medical Microbiology, Lund University, Malmö University Hospital, Malmö, Sweden APMIS 111:989-94 Levofloxacin-associated Achilles tendon rupture and tendinopathyAsa Melhus Department of Medical Microbiology, Malmö University Hospital, Malmö, Sweden Scand J Infect Dis 35:768-70 | Collaborators
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Detail Information
Publications
The treatment of Haemophilus influenzae acute otitis media with amoxicillin protects against reinfection but not against structural changesEva Westman
Department of Oto-Rhino-Laryngology, Umeå University Hospital, Ume, Sweden
J Antimicrob Chemother 49:141-7
Department of Oto-Rhino-Laryngology, Umeå University Hospital, Ume, Sweden
J Antimicrob Chemother 49:141-7
..These experimental findings constitute support for further studies of antimicrobial drugs and recurrent AOM...
Jun N-terminal protein kinase enhances middle ear mucosal proliferation during bacterial otitis mediaMasayuki Furukawa
Department of Surgery, UCSD School of Medicine, Fir Bldg, Rm 106, 9500 Gilman Dr 0666, La Jolla, CA 92037, USA
Infect Immun 75:2562-71
Department of Surgery, UCSD School of Medicine, Fir Bldg, Rm 106, 9500 Gilman Dr 0666, La Jolla, CA 92037, USA
Infect Immun 75:2562-71
..We conclude that activation of JNK is a critical pathway for bacterially induced mucosal hyperplasia during otitis media, influencing tissue proliferation...
In vitro activities of three carbapenems against recent bacterial isolates from severely ill patients at Swedish hospitalsCarl Johan Fraenkel
Department of Clinical Microbiology, Blekinge Hospital, Karlskrona, Sweden
Scand J Infect Dis 38:853-9
Department of Clinical Microbiology, Blekinge Hospital, Karlskrona, Sweden
Scand J Infect Dis 38:853-9
..aeruginosa, Enterobacter and Proteus spp...
Nontypeable Haemophilus influenzae strains with the capsule-associated insertion element IS1016 may mimic encapsulated strainsEva Karlsson
Department of Medical Microbiology, Malmö University Hospital, Lund University, Malm, Sweden
APMIS 114:633-40
Department of Medical Microbiology, Malmö University Hospital, Lund University, Malm, Sweden
APMIS 114:633-40
..Although this subset of strains mimicked traits usually exhibited by encapsulated strains, the isolation frequency did not seem to have been affected by vaccination...
Fluoroquinolones and tendon disordersAsa Melhus
Lund University, Department of Medical Microbiology, Malmö University Hospital, S 205 02 Malmö, Sweden
Expert Opin Drug Saf 4:299-309
Lund University, Department of Medical Microbiology, Malmö University Hospital, S 205 02 Malmö, Sweden
Expert Opin Drug Saf 4:299-309
....
Beta-lactamase-producing nontypeable Haemophilus influenzae fails to protect Streptococcus pneumoniae from amoxicillin during experimental acute otitis mediaEva Westman
Department of Oto Rhino Laryngology, Umeå University Hospital, Umeå, Sweden
Antimicrob Agents Chemother 48:3536-42
Department of Oto Rhino Laryngology, Umeå University Hospital, Umeå, Sweden
Antimicrob Agents Chemother 48:3536-42
..These experimental findings constitute support for further studies of antimicrobial drugs and AOM caused by bacteria with and without mechanisms of antibiotic resistance...
Role of p38 mitogen-activated protein kinase in middle ear mucosa hyperplasia during bacterial otitis mediaSean D Palacios
Department of Surgery Otolaryngology, University of California San Diego, La Jolla, 92037, USA
Infect Immun 72:4662-7
Department of Surgery Otolaryngology, University of California San Diego, La Jolla, 92037, USA
Infect Immun 72:4662-7
..The results of this study suggest that intracellular signaling via p38 MAPK influences the hyperplastic response of the middle ear mucosa during bacterial otitis media...
Effects of amoxicillin on cytokine and osteocalcin expression in bone tissue during experimental acute otitis mediaAsa Melhus
Department of Medical Microbiology, Lund University, Malmö University Hospital, S 205 02 Malmö, Sweden
Cytokine 25:254-9
Department of Medical Microbiology, Lund University, Malmö University Hospital, S 205 02 Malmö, Sweden
Cytokine 25:254-9
..By comparing the host responses on the molecular level in different tissues during treated and untreated AOM, new approaches to how to minimize the risks of severe AOM complications may evolve...
A mouse model for acute otitis mediaAsa Melhus
Department of Medical Microbiology, Lund University, Malmö University Hospital, Malmö, Sweden
APMIS 111:989-94
Department of Medical Microbiology, Lund University, Malmö University Hospital, Malmö, Sweden
APMIS 111:989-94
..The mouse model can become a useful tool in studies of pneumococcal and H. influenzae-induced otitis media, but the bacterial dose has to be carefully titrated and adjusted to the chosen mouse strain...
Levofloxacin-associated Achilles tendon rupture and tendinopathyAsa Melhus
Department of Medical Microbiology, Malmö University Hospital, Malmö, Sweden
Scand J Infect Dis 35:768-70
Department of Medical Microbiology, Malmö University Hospital, Malmö, Sweden
Scand J Infect Dis 35:768-70
..This article reports 5 cases of Achilles tendon disorders, including 3 complicated by rupture of the tendon, during levofloxacin treatment of patients with chronic obstructive pulmonary disease...
Participation of Ras and extracellular regulated kinase in the hyperplastic response of middle-ear mucosa during bacterial otitis mediaSean D Palacios
Department of Head and Neck Surgery, University of California, San Diego, School of Medicine, La Jolla, California, USA
J Infect Dis 186:1761-9
Department of Head and Neck Surgery, University of California, San Diego, School of Medicine, La Jolla, California, USA
J Infect Dis 186:1761-9
..MEM explants treated with either inhibitor demonstrated significant suppression of bacterially induced growth. These data support a role for Ras and Erk signaling in MEM hyperplasia during bacterial OM...
First documented case of Aeromonas veronii biovar sobria infection in northern EuropeAsa Melhus
Department of Medical Microbiology, Malmö University Hospital, Sweden
Scand J Infect Dis 34:218-9
Department of Medical Microbiology, Malmö University Hospital, Sweden
Scand J Infect Dis 34:218-9
..The first Scandinavian case of Aeromonas veronii biovar sobria infection, an episode of peritonitis in a patient suffering from a cirrhotic liver and an earlier unrecognized appendiceal cancer, is described...
Mouse models of induced otitis mediaAllen F Ryan
Department of Surgery, Division of Otolaryngology, UCSD School of Medicine and VA Medical Center, La Jolla, CA 92093 0666, USA
Brain Res 1091:3-8
Department of Surgery, Division of Otolaryngology, UCSD School of Medicine and VA Medical Center, La Jolla, CA 92093 0666, USA
Brain Res 1091:3-8
..They further suggest that the considerable genetic resources of this species can be harnessed to increase our understanding of this disease...
The first major extended-spectrum beta-lactamase outbreak in Scandinavia was caused by clonal spread of a multiresistant Klebsiella pneumoniae producing CTX-M-15Birgitta Lytsy
Department of Clinical Microbiology, Uppsala University Hospital, Uppsala, Sweden
APMIS 116:302-8
Department of Clinical Microbiology, Uppsala University Hospital, Uppsala, Sweden
APMIS 116:302-8
..pneumoniae in Scandinavia. The outbreak demonstrates the epidemic potential of enterobacteria containing ESBLs of the CTX-M type, even in a country with a relatively low selective pressure and a low prevalence of multiresistant bacteria...