Karl Eric Magnusson

Summary

Country: Sweden

Publications

  1. pmc Fluxes of water through aquaporin 9 weaken membrane-cytoskeleton anchorage and promote formation of membrane protrusions
    Thommie Karlsson
    Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    PLoS ONE 8:e59901. 2013
  2. pmc Characterization of human alpha-dystrobrevin isoforms in HL-60 human promyelocytic leukemia cells undergoing granulocytic differentiation
    Agné Kulyté
    Division of Medical Microbiology, Linkopings Universitet, SE 581 85 Linkoping, Sweden
    Mol Biol Cell 13:4195-205. 2002
  3. ncbi request reprint Role of calcium signalling and phosphorylations in disruption of the epithelial junctions by Pseudomonas aeruginosa quorum sensing molecule
    Elena Vikström
    Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Linkoping University, SE 58185 Linkoping, Sweden
    Eur J Cell Biol 89:584-97. 2010
  4. doi request reprint Aquaporin 9 phosphorylation mediates membrane localization and neutrophil polarization
    Thommie Karlsson
    Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    J Leukoc Biol 90:963-73. 2011
  5. pmc Protein kinase C activation has distinct effects on the localization, phosphorylation and detergent solubility of the claudin protein family in tight and leaky epithelial cells
    Anita Sjö
    Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    J Membr Biol 236:181-9. 2010
  6. doi request reprint Water fluxes through aquaporin-9 prime epithelial cells for rapid wound healing
    Thommie Karlsson
    Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, SE 58185 Linkoping, Sweden
    Biochem Biophys Res Commun 430:993-8. 2013
  7. ncbi request reprint Distinct effects of protein kinase C on the barrier function at different developmental stages
    Anita Sjö
    Division of Medical Microbiology, Department of Molecular and Clinical Medicine, Linkoping University, SE 581 85 Linkoping, Sweden
    Biosci Rep 23:87-102. 2003
  8. ncbi request reprint Phagocytosis and phagosome maturation are regulated by calcium in J774 macrophages interacting with unopsonized prey
    Katarina Tejle
    Division of Medical Microbiology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, S 58185 Linkoping, Sweden
    Biosci Rep 22:529-40. 2002
  9. pmc The Pseudomonas aeruginosa N-acylhomoserine lactone quorum sensing molecules target IQGAP1 and modulate epithelial cell migration
    Thommie Karlsson
    Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    PLoS Pathog 8:e1002953. 2012
  10. ncbi request reprint Neutrophil leukocyte motility requires directed water influx
    Vesa Matti Loitto
    Division of Medical Microbiology, Department of Health and Environment, Faculty of Health Sciences, Linkoping University, Sweden
    J Leukoc Biol 71:212-22. 2002

Collaborators

Detail Information

Publications24

  1. pmc Fluxes of water through aquaporin 9 weaken membrane-cytoskeleton anchorage and promote formation of membrane protrusions
    Thommie Karlsson
    Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    PLoS ONE 8:e59901. 2013
    ..Based on this, we present a model for AQP9-induced membrane protrusion, where the interplay of water fluxes through AQP9 and actin dynamics regulate the cellular protrusive and motile activity of cells...
  2. pmc Characterization of human alpha-dystrobrevin isoforms in HL-60 human promyelocytic leukemia cells undergoing granulocytic differentiation
    Agné Kulyté
    Division of Medical Microbiology, Linkopings Universitet, SE 581 85 Linkoping, Sweden
    Mol Biol Cell 13:4195-205. 2002
    ....
  3. ncbi request reprint Role of calcium signalling and phosphorylations in disruption of the epithelial junctions by Pseudomonas aeruginosa quorum sensing molecule
    Elena Vikström
    Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Linkoping University, SE 58185 Linkoping, Sweden
    Eur J Cell Biol 89:584-97. 2010
    ....
  4. doi request reprint Aquaporin 9 phosphorylation mediates membrane localization and neutrophil polarization
    Thommie Karlsson
    Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    J Leukoc Biol 90:963-73. 2011
    ..Our results show that AQP9 plays an active role in neutrophil volume regulation and migration. The display of AQP9 at the plasma membrane depends on AQP9 phosphorylation, which appeared to be regulated through a Rac1-dependent pathway...
  5. pmc Protein kinase C activation has distinct effects on the localization, phosphorylation and detergent solubility of the claudin protein family in tight and leaky epithelial cells
    Anita Sjö
    Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    J Membr Biol 236:181-9. 2010
    ....
  6. doi request reprint Water fluxes through aquaporin-9 prime epithelial cells for rapid wound healing
    Thommie Karlsson
    Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, SE 58185 Linkoping, Sweden
    Biochem Biophys Res Commun 430:993-8. 2013
    ..We suggest a novel mechanism for epithelial wound healing based on AQP-induced swelling and expansion of the monolayer...
  7. ncbi request reprint Distinct effects of protein kinase C on the barrier function at different developmental stages
    Anita Sjö
    Division of Medical Microbiology, Department of Molecular and Clinical Medicine, Linkoping University, SE 581 85 Linkoping, Sweden
    Biosci Rep 23:87-102. 2003
    ..We conclude that protein kinase C regulation of the epithelial barrier involves specific molecular mechanisms and achieves distinct effects at different developmental stages...
  8. ncbi request reprint Phagocytosis and phagosome maturation are regulated by calcium in J774 macrophages interacting with unopsonized prey
    Katarina Tejle
    Division of Medical Microbiology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, S 58185 Linkoping, Sweden
    Biosci Rep 22:529-40. 2002
    ..We conclude that calcium is essential for phagocytosis, depolymerization of periphagosomal F-actin, and phagosomal maturation in J774 macrophages interacting with unopsonized prey, as well as for proper functioning of LPG...
  9. pmc The Pseudomonas aeruginosa N-acylhomoserine lactone quorum sensing molecules target IQGAP1 and modulate epithelial cell migration
    Thommie Karlsson
    Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    PLoS Pathog 8:e1002953. 2012
    ..We propose that the targeting of IQGAP1 by 3O-C(12)-HSL can trigger essential changes in the cytoskeleton network and be an essential component in bacterial--human cell communication...
  10. ncbi request reprint Neutrophil leukocyte motility requires directed water influx
    Vesa Matti Loitto
    Division of Medical Microbiology, Department of Health and Environment, Faculty of Health Sciences, Linkoping University, Sweden
    J Leukoc Biol 71:212-22. 2002
    ..Our observations provide the first experimental support for motility models where water fluxes play a pivotal role in cell-volume increases accompanying membrane extensions...
  11. doi request reprint N-Acylhomoserine lactones are potent neutrophil chemoattractants that act via calcium mobilization and actin remodeling
    Thommie Karlsson
    Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    J Leukoc Biol 91:15-26. 2012
    ..Indeed, recognition of HSL QS signals by neutrophils may play a critical role in their recruitment during infections...
  12. doi request reprint Water flux in cell motility: expanding the mechanisms of membrane protrusion
    Vesa M Loitto
    Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Linkoping University, Sweden
    Cell Motil Cytoskeleton 66:237-47. 2009
    ....
  13. ncbi request reprint Assessing the interaction between Helicobacter pylori and human neutrophils by freeze-fracture replica labeling
    Christoffer Petersson
    Division of Medical Microbiology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Sweden
    Micron 36:558-62. 2005
    ..The here launched methodology can be used as a tool to investigate the events taking place between pathogenic microbes and phagocytes, as well as for pinpoint targeting of other cell-cell communications in the field of cell biology...
  14. ncbi request reprint The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone stimulates phagocytic activity in human macrophages through the p38 MAPK pathway
    Elena Vikström
    Division of Medical Microbiology, Department of Molecular and Clinical Medicine, Linkoping University, SE 58185, Sweden
    Microbes Infect 7:1512-8. 2005
    ..These findings demonstrate that the bacterial quorum-sensing can play a significant role also in regulation of macrophage activity during infections caused by P. aeruginosa...
  15. pmc Disruption of epithelial barrier integrity by Salmonella enterica serovar typhimurium requires geranylgeranylated proteins
    Farideh Tafazoli
    Division of Medical Microbiology, Department of Molecular and Clinical Medicine, Linkoping University, Sweden
    Infect Immun 71:872-81. 2003
    ..These results suggest that activation of geranylgeranylated proteins, including Rac1 and Cdc42, is critical for disruption of barrier integrity by serovar Typhimurium in polarized MDCK-1 cells...
  16. ncbi request reprint Hg2+ and small-sized polyethylene glycols have inverse effects on membrane permeability, while both impair neutrophil cell motility
    Vesa Matti Loitto
    Division of Medical Microbiology, Department of Molecular and Clinical, Medicine, Linkoping University, SE 581 85 Linkoping, Sweden
    Biochem Biophys Res Commun 316:370-8. 2004
    ..The local additions of Hg(2+) or PEG probably force other cell regions to take over from those with blocked AQPs. Hence, the cells turn direction of motility away from the micromanipulator needle...
  17. pmc Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting
    Marie Hagbom
    Division of Molecular Virology, Medical Faculty, University of Linkoping, Linkoping, Sweden
    PLoS Pathog 7:e1002115. 2011
    ..This hypothesis is supported by treating vomiting in children with acute gastroenteritis with 5-HT₃ receptor antagonists...
  18. ncbi request reprint Pseudomonas aeruginosa quorum sensing molecule N-(3 oxododecanoyl)-l-homoserine lactone disrupts epithelial barrier integrity of Caco-2 cells
    Elena Vikström
    Division of Medical Microbiology, Department of Molecular and Clinical Medicine, Linkoping University, SE 58185 Linkoping, Sweden
    FEBS Lett 580:6921-8. 2006
    ..These findings demonstrate that P. aeruginosa 3O-C(12)-HSL can modulate tight junction integrity of Caco-2 cells...
  19. ncbi request reprint Height changes associated with pigment aggregation in Xenopus laevis melanophores
    Charlotte Immerstrand
    Division of Medical Microbiology, Department of Molecular and Clinical Medicine, Linkopings Universitet, SE 581 85, Linkoping, Sweden
    Biosci Rep 24:203-14. 2004
    ..Moreover, the elevation of the plasma membrane did not correlate with influx of water through aquaporins or formation of new microtubules, Rather, the accumulation of granules seemed to drive the change in cell height...
  20. doi request reprint Immobilized chemoattractant peptides mediate adhesion and distinct calcium-dependent cell signaling in human neutrophils
    Jonas Wetterö
    Rheumatology AIR, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Langmuir 24:6803-11. 2008
    ..This is a crucial step in designing surfaces with specific effects on cellular behavior...
  21. pmc Pancreatic adenocarcinoma exerts systemic effects on the peripheral blood myeloid and plasmacytoid dendritic cells: an indicator of disease severity?
    Vegard Tjomsland
    Division of Molecular Virology, Department of Clinical and Experimental Medicine, Linkoping University, Sweden
    BMC Cancer 10:87. 2010
    ..Ductal pancreatic adenocarcinoma (PDAC), the most common pancreatic cancer, is recognized as a very aggressive cancer type with a mortality that almost matches the rate of incidence...
  22. ncbi request reprint Helicobacter pylori SabA adhesin evokes a strong inflammatory response in human neutrophils which is down-regulated by the neutrophil-activating protein
    Christoffer Petersson
    Division of Medical Microbiology, Faculty of Health Sciences, Linkoping University, 581 85 Linkoping, Sweden
    Med Microbiol Immunol 195:195-206. 2006
    ..Interestingly, HP-NAP modulates the oxidative burst, which could tune the impact of the H. pylori infection for establishment of balanced and chronic inflammation of the gastric mucosa...
  23. doi request reprint Wild-type Leishmania donovani promastigotes block maturation, increase integrin expression and inhibit detachment of human monocyte-derived dendritic cells--the influence of phosphoglycans
    Katarina Tejle
    Department of Molecular and Clinical Medicine, Division of Medical Microbiology, Linkoping University, Linkoping, Sweden
    FEMS Microbiol Lett 279:92-102. 2008
    ..These findings demonstrate that phosphoglycans of WT L. donovani might also inhibit human DC migration to lymphoid organs...
  24. ncbi request reprint Functional compartmentalisation of NF-κB-associated proteins in A431 cells
    Anastasia Bolshakova
    Department of Cell Cultures, Institute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave 4, St Petersburg 194064, Russian Federation Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Link ping University, SE 581 85, Link ping, Sweden
    Cell Biol Int . 2013
    ..Moreover, we discovered the existence of a dynamic, IκB-α-free pool of RelA/p65 associated with cytoskeletal fraction, what argues for a special regulatory role of the cytoskeleton in NF-κB stimulation...