Valeriya Lyssenko

Summary

Country: Sweden

Publications

  1. ncbi Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes
    Valeriya Lyssenko
    Department of Endocrinology, Wallenberg Laboratory, University Hospital MAS, 20502 Malmo, Sweden
    Diabetes 54:166-74. 2005
  2. pmc Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Diabetes and Endocrinology, and Lund University Diabetes Center, Lund University, Malmo, Sweden
    J Clin Invest 117:2155-63. 2007
  3. doi Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes
    Taman Mahdi
    Lund University Diabetes Centre, Lund University, 20502 Malmo, Sweden
    Cell Metab 16:625-33. 2012
  4. doi Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes
    Johan Holmkvist
    Department of Clinical Sciences Diabetes and Endocrinology, CRC, Malmö University Hospital MAS, Lund University, Malmo, Sweden
    Diabetes 57:1738-44. 2008
  5. pmc Genetic prediction of future type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmo, Malmo, Sweden
    PLoS Med 2:e345. 2005
  6. ncbi Genes and type 2 diabetes mellitus
    Leif Groop
    Department of Clinical Sciences Diabetes and Endocrinology, Lund University, University Hospital Malmoe, 20502, Malmoe, Sweden
    Curr Diab Rep 8:192-7. 2008
  7. doi The transcription factor 7-like 2 gene and increased risk of type 2 diabetes: an update
    Valeriya Lyssenko
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmoe, Sweden
    Curr Opin Clin Nutr Metab Care 11:385-92. 2008
  8. pmc Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
    Wei Min Chen
    Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
    J Clin Invest 118:2620-8. 2008
  9. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
  10. ncbi IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies
    Cornelia Huth
    GSF Institute of Epidemiology, Neuherberg, Germany
    Diabetes 55:2915-21. 2006

Detail Information

Publications14

  1. ncbi Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes
    Valeriya Lyssenko
    Department of Endocrinology, Wallenberg Laboratory, University Hospital MAS, 20502 Malmo, Sweden
    Diabetes 54:166-74. 2005
    ..In conclusion, a marked deterioration in beta-cell function precedes the onset of type 2 diabetes. These individuals can be identified early by knowledge of FPG, BMI, and family history of diabetes...
  2. pmc Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Diabetes and Endocrinology, and Lund University Diabetes Center, Lund University, Malmo, Sweden
    J Clin Invest 117:2155-63. 2007
    ..In conclusion, the increased risk of T2D conferred by variants in TCF7L2 involves the enteroinsular axis, enhanced expression of the gene in islets, and impaired insulin secretion...
  3. doi Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes
    Taman Mahdi
    Lund University Diabetes Centre, Lund University, 20502 Malmo, Sweden
    Cell Metab 16:625-33. 2012
    ..Moreover, the protein was increased in serum from T2D patients several years before the diagnosis, suggesting that SFRP4 could be a potential biomarker for islet dysfunction in T2D...
  4. doi Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes
    Johan Holmkvist
    Department of Clinical Sciences Diabetes and Endocrinology, CRC, Malmö University Hospital MAS, Lund University, Malmo, Sweden
    Diabetes 57:1738-44. 2008
    ....
  5. pmc Genetic prediction of future type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmo, Malmo, Sweden
    PLoS Med 2:e345. 2005
    ..A number of common variants have been associated with T2D but our knowledge of their ability to predict T2D prospectively is limited...
  6. ncbi Genes and type 2 diabetes mellitus
    Leif Groop
    Department of Clinical Sciences Diabetes and Endocrinology, Lund University, University Hospital Malmoe, 20502, Malmoe, Sweden
    Curr Diab Rep 8:192-7. 2008
    ..In the future, the possibility of whole-genome DNA methylation studies may elucidate the extent of these epigenetic effects. This article reviews genes that have recently been determined to be associated with T2DM...
  7. doi The transcription factor 7-like 2 gene and increased risk of type 2 diabetes: an update
    Valeriya Lyssenko
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmoe, Sweden
    Curr Opin Clin Nutr Metab Care 11:385-92. 2008
    ..The purpose of this review is to provide a comprehensive evaluation of the most important type 2 diabetes gene to date, transcription factor 7 like-2...
  8. pmc Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
    Wei Min Chen
    Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
    J Clin Invest 118:2620-8. 2008
    ....
  9. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
  10. ncbi IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies
    Cornelia Huth
    GSF Institute of Epidemiology, Neuherberg, Germany
    Diabetes 55:2915-21. 2006
    ....
  11. ncbi Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals
    Richa Saxena
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, MA, USA
    Diabetes 55:2890-5. 2006
    ..003) but not with increased insulin resistance. These results suggest that TCF7L2 variants may act through insulin secretion to increase the risk of type 2 diabetes...
  12. pmc Variants in the FFAR1 gene are associated with beta cell function
    Martins Kalis
    Department of Clinical Sciences, Cellular Autoimmunity Unit, Lund University, Malmo University Hospital, Malmo, Sweden
    PLoS ONE 2:e1090. 2007
    ..We therefore investigated whether variations at the FFAR1 locus are associated with T2D and beta cell function...
  13. ncbi Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    Richa Saxena
    Broad Institute of Harvard and Massachusetts Institute of Technology MIT, Cambridge, MA 02142, USA
    Science 316:1331-6. 2007
    ..The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases...
  14. doi Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes
    Camilla Cervin
    Department of Clinical Sciences Diabetes and Endocrinology, Clinical Research Center, Malmo University Hospital, Lund University, S 205 02 Malmo, Sweden
    Diabetes 57:1433-7. 2008
    ..One way to improve classification is to study whether LADA shares genetic features with type 1 and/or type 2 diabetes...