Anna Lundgren

Summary

Country: Sweden

Publications

  1. ncbi request reprint Parallel analysis of mucosally derived B- and T-cell responses to an oral typhoid vaccine using simplified methods
    Anna Lundgren
    Göteborg University Vaccine Research Institute GUVAX, Department of Microbiology and Immunology, University of Gothenburg, Sweden
    Vaccine 27:4529-36. 2009
  2. pmc The adjuvant double mutant Escherichia coli heat labile toxin enhances IL-17A production in human T cells specific for bacterial vaccine antigens
    Susannah Leach
    Gothenburg University Vaccine Research Institute GUVAX, Dept of Microbiology and Immunology, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 7:e51718. 2012
  3. ncbi request reprint Th1 and Th17 Responses to Helicobacter pylori in Bangladeshi Infants, Children and Adults
    Taufiqur R Bhuiyan
    International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    PLoS ONE 9:e93943. 2014
  4. doi request reprint Clinical trial to evaluate safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli prototype vaccine containing CFA/I overexpressing bacteria and recombinantly produced LTB/CTB hybrid protein
    A Lundgren
    Gothenburg University Vaccine Research Institute, Department of Microbiology and Immunology, University of Gothenburg, 405 30 Gothenburg, Sweden
    Vaccine 31:1163-70. 2013
  5. pmc Characterization of Th17 responses to Streptococcus pneumoniae in humans: comparisons between adults and children in a developed and a developing country
    Anna Lundgren
    Gothenburg University Vaccine Research Institute GUVAX, Department of Microbiology and Immunology, University of Gothenburg, Box 435, 405 30, Gothenburg, Sweden
    Vaccine 30:3897-907. 2012
  6. pmc Mucosal FOXP3-expressing CD4+ CD25high regulatory T cells in Helicobacter pylori-infected patients
    Anna Lundgren
    Dept of Medical Microbiology and Immunology, Goteborg University, Box 435, 405 30 Goteborg, Sweden
    Infect Immun 73:523-31. 2005
  7. pmc Helicobacter pylori-specific CD4+ T cells home to and accumulate in the human Helicobacter pylori-infected gastric mucosa
    Anna Lundgren
    Department of Medical Microbiology and Immunology, Goteborg University, 40530 Goteborg, Sweden
    Infect Immun 73:5612-9. 2005
  8. ncbi request reprint The local and systemic T-cell response to Helicobacter pylori in gastric cancer patients is characterised by production of interleukin-10
    B Samuel Lundin
    Department of Microbiology and Immunology, Institute of Biomedicine, Göteborg University Vaccine Research Institute, Goteborg University, Goteborg, Sweden
    Clin Immunol 125:205-13. 2007
  9. doi request reprint CD8- natural killer cells are greatly enriched in the human gastrointestinal tract and have the capacity to respond to bacteria
    Asa Lindgren
    Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden asa lindgren microbio gu se
    J Innate Immun 2:294-302. 2010
  10. doi request reprint Comparison of mucosal B- and T-cell responses in Helicobacter pylori-infected subjects in a developing and a developed country
    Taufiqur Rahman Bhuiyan
    Department of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    FEMS Immunol Med Microbiol 54:70-9. 2008

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Parallel analysis of mucosally derived B- and T-cell responses to an oral typhoid vaccine using simplified methods
    Anna Lundgren
    Göteborg University Vaccine Research Institute GUVAX, Department of Microbiology and Immunology, University of Gothenburg, Sweden
    Vaccine 27:4529-36. 2009
    ..Thus, both B- and T-cell responses could be detected using simple ELISA based assays that would be practical to use in large-scale vaccine trials...
  2. pmc The adjuvant double mutant Escherichia coli heat labile toxin enhances IL-17A production in human T cells specific for bacterial vaccine antigens
    Susannah Leach
    Gothenburg University Vaccine Research Institute GUVAX, Dept of Microbiology and Immunology, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 7:e51718. 2012
    ..Our demonstration of a potent ability of dmLT to enhance human Th17 type T cell responses to bacterial vaccine antigens encourages further evaluation of the adjuvant function of dmLT in humans...
  3. ncbi request reprint Th1 and Th17 Responses to Helicobacter pylori in Bangladeshi Infants, Children and Adults
    Taufiqur R Bhuiyan
    International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    PLoS ONE 9:e93943. 2014
    ..In conclusion, these results show that T cells can produce high levels of IL-17 and IFN-γ in response to Hp from an early age and indicate a potential role for IL-1β in promoting Th17 responses to Hp during infancy. ..
  4. doi request reprint Clinical trial to evaluate safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli prototype vaccine containing CFA/I overexpressing bacteria and recombinantly produced LTB/CTB hybrid protein
    A Lundgren
    Gothenburg University Vaccine Research Institute, Department of Microbiology and Immunology, University of Gothenburg, 405 30 Gothenburg, Sweden
    Vaccine 31:1163-70. 2013
    ....
  5. pmc Characterization of Th17 responses to Streptococcus pneumoniae in humans: comparisons between adults and children in a developed and a developing country
    Anna Lundgren
    Gothenburg University Vaccine Research Institute GUVAX, Department of Microbiology and Immunology, University of Gothenburg, Box 435, 405 30, Gothenburg, Sweden
    Vaccine 30:3897-907. 2012
    ....
  6. pmc Mucosal FOXP3-expressing CD4+ CD25high regulatory T cells in Helicobacter pylori-infected patients
    Anna Lundgren
    Dept of Medical Microbiology and Immunology, Goteborg University, Box 435, 405 30 Goteborg, Sweden
    Infect Immun 73:523-31. 2005
    ..These findings suggest that regulatory T cells may suppress mucosal immune responses and thereby contribute to the persistence of H. pylori infections...
  7. pmc Helicobacter pylori-specific CD4+ T cells home to and accumulate in the human Helicobacter pylori-infected gastric mucosa
    Anna Lundgren
    Department of Medical Microbiology and Immunology, Goteborg University, 40530 Goteborg, Sweden
    Infect Immun 73:5612-9. 2005
    ..In conclusion, these results suggest that H. pylori-specific CD4(+) T cells preferentially home to and accumulate in the infected stomach and that L-selectin and CCR4/MDC are important for this recruitment...
  8. ncbi request reprint The local and systemic T-cell response to Helicobacter pylori in gastric cancer patients is characterised by production of interleukin-10
    B Samuel Lundin
    Department of Microbiology and Immunology, Institute of Biomedicine, Göteborg University Vaccine Research Institute, Goteborg University, Goteborg, Sweden
    Clin Immunol 125:205-13. 2007
    ..pylori-infected GC patients leads to a diminished cytotoxic anti-tumour T-cell response in the stomach, which may contribute to tumour progression in subjects suffering from GC...
  9. doi request reprint CD8- natural killer cells are greatly enriched in the human gastrointestinal tract and have the capacity to respond to bacteria
    Asa Lindgren
    Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden asa lindgren microbio gu se
    J Innate Immun 2:294-302. 2010
    ..These findings may have important implications for the understanding of NK cell subsets and the innate defense against gastrointestinal bacterial infections...
  10. doi request reprint Comparison of mucosal B- and T-cell responses in Helicobacter pylori-infected subjects in a developing and a developed country
    Taufiqur Rahman Bhuiyan
    Department of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    FEMS Immunol Med Microbiol 54:70-9. 2008
    ..pylori, compared with Swedish volunteers. Increased inflammation is present in the duodenum of Bangladeshi volunteers, maybe as a result of frequent exposure to enteric infections in these individuals...
  11. pmc Helicobacter pylori-specific CD4+ CD25high regulatory T cells suppress memory T-cell responses to H. pylori in infected individuals
    Anna Lundgren
    Department of Medical Microbiology and Immunology, Göteborg University Vaccine Research Institute GUVAX, Goteborg University, 405 30 Goteborg, Sweden
    Infect Immun 71:1755-62. 2003
    ..In conclusion, we have shown that H. pylori-infected individuals have impaired memory CD4+ T-cell responses to H. pylori that are linked to the presence of H. pylori-specific regulatory T cells that actively suppress the responses...
  12. doi request reprint Different kinetics of circulating antibody-secreting cell responses after primary and booster oral immunizations: a tool for assessing immunological memory
    Susannah Leach
    Gothenburg University Vaccine Research Institute GUVAX, Department of Microbiology and Immunology, University of Gothenburg, Sweden
    Vaccine 31:3035-8. 2013
    ..The results also suggest that detection of peak ASC responses at an early time point after booster immunization can be used as a simple tool to assess immunological memory...
  13. pmc Natural killer cells and Helicobacter pylori infection: bacterial antigens and interleukin-12 act synergistically to induce gamma interferon production
    Cheol H Yun
    Department of Medical Microbiology and Immunology and Göteborg University Vaccine Institute GUVAX, Goteborg University, Box 435, 40530 Goteborg, Sweden
    Infect Immun 73:1482-90. 2005
    ..pylori antigen and IL-12. We propose that NK cells play an active role in the local immune response to H. pylori infection...
  14. ncbi request reprint BAFF, stimulatory DNA and IL-15 stimulates IgA(+) memory B cells and provides a novel approach for analysis of memory responses to mucosal vaccines
    Sara Tengvall
    Department of Microbiology and Immunology and Göteborg University Vaccine Research Institute GUVAX, University of Gothenburg, Medicinaregatan 7A, Box 435, 405 30 Gothenburg, Sweden
    Vaccine 28:5445-50. 2010
    ..We also show that stimulated IgA memory B cells do not secrete IgA unless they reencounter the specific antigen...
  15. doi request reprint Presence of high numbers of transcriptionally active Helicobacter pylori in vomitus from Bangladeshi patients suffering from acute gastroenteritis
    Anders Janzon
    Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Helicobacter 14:237-47. 2009
    ..pylori was quantified in vomitus and diarrheal stool of patients suffering from acute gastroenteritis in Dhaka, Bangladesh...
  16. ncbi request reprint Dendritic cells express CCR7 and migrate in response to CCL19 (MIP-3beta) after exposure to Helicobacter pylori
    Malin Hansson
    Department of Medical Microbiology and Immunology and Göteborg University Vaccine Research Institute GUVAX, Goteborg University, Box 435, 405 30 Goteborg, Sweden
    Microbes Infect 8:841-50. 2006
    ..pylori stimulated DC in vitro that may contribute to chronic gastritis in vivo, and our results suggest that H. pylori induces maturation and migration of DC to lymph nodes where they promote T cell responses...
  17. ncbi request reprint Progress in vaccine development against Helicobacter pylori
    Ann Mari Svennerholm
    Department of Microbiology and Immunology, Institute of Biomedicine, Goteborg University, Goteborg, Sweden
    FEMS Immunol Med Microbiol 50:146-56. 2007
    ..pylori as well as to identify a cocktail of strong protective antigens, or recombinant bacterial strains that express such antigens, that could be administered by a regimen that gives rise to effective immune responses in humans...
  18. doi request reprint Two cases of hemolytic uremic syndrome caused by Streptococcus pneumoniae serotype 3, one being a vaccine failure
    Daniel Novak
    Department of Pediatrics, Queen Silvia Children s Hospital Gothenburg, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Scand J Infect Dis 45:411-4. 2013
    ..SP-HUS must be considered in children, and conjugate vaccines may be less effective against serotype 3 than other serotypes...
  19. doi request reprint Decreased IgA antibody production in the stomach of gastric adenocarcinoma patients
    Marianne Quiding-Jarbrink
    Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute GUVAX, Institute of Biomedicine, the Sahlgrenska Academy at University of Gothenburg, Sweden
    Clin Immunol 131:463-71. 2009
    ..We conclude that patients suffering from gastric adenocarcinoma have a dramatically decreased local IgA production in the stomach compared to asymptomatic H. pylori infected individuals...
  20. ncbi request reprint A controlled study of colonic immune activity and beta7+ blood T lymphocytes in patients with irritable bowel syndrome
    Lena Ohman
    Department of Internal Medicine, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Clin Gastroenterol Hepatol 3:980-6. 2005
    ..The aim of this study was to characterize the phenotype and homing properties of colonic and peripheral blood lymphocytes in patients with IBS...
  21. ncbi request reprint Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity
    Nathalie Holmén
    Department of Internal Medicine, Sahlgrenka Academy, Goteborg University, Goteborg, Sweden
    Inflamm Bowel Dis 12:447-56. 2006
    ..Therefore, the aims of this study were to determine whether colonic Tregs have suppressive effects on colonic effector T cells in UC and to analyze the association between segmental colonic Treg distribution and disease activity...
  22. doi request reprint Recent progress toward an enterotoxigenic Escherichia coli vaccine
    Ann Mari Svennerholm
    Gothenburg University Vaccine Research Institute and Department of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Sweden
    Expert Rev Vaccines 11:495-507. 2012
    ..They also discuss possibilities of enhancing immune responses to candidate ETEC vaccines, particularly in children...
  23. ncbi request reprint Function and recruitment of mucosal regulatory T cells in human chronic Helicobacter pylori infection and gastric adenocarcinoma
    Karin Enarsson
    Inst of Biomedicine, Dept of Microbiology and Immunology and Göteborg University Vaccine Research Institute GUVAX, Goteborg, Sweden
    Clin Immunol 121:358-68. 2006
    ..pylori-infected gastric mucosa supports an important role for these cells in suppression of mucosal effector T cell responses, which probably contribute to bacterial persistence and possibly also to gastric tumor progression...
  24. ncbi request reprint CD4 T cell activation by myelin oligodendrocyte glycoprotein is suppressed by adult but not cord blood CD25+ T cells
    Kajsa Wing
    Department of Rheumatology and Inflammation Research, University of Goteborg, Guldhedsgatan 10A, S 41346 Goteborg, Sweden
    Eur J Immunol 33:579-87. 2003
    ..We conclude that activation of self-reactive T cells in normal healthy individuals is prevented by the presence of self-antigen-specific CD25+ regulatory T cells and that the majority of these cells mature after birth...
  25. pmc Interleukin-17A mediates acquired immunity to pneumococcal colonization
    Ying Jie Lu
    Department of Medicine, Division of Infectious Diseases, Children s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 4:e1000159. 2008
    ..We conclude that IL-17A mediates pneumococcal immunity in mice and probably in humans; its elicitation in vitro could help in the development of candidate pneumococcal vaccines...
  26. ncbi request reprint Antigenic variation of Anaplasma marginale msp2 occurs by combinatorial gene conversion
    Kelly A Brayton
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Mol Microbiol 43:1151-9. 2002
    ..marginale provides for a combinatorial number of possible expressed MSP2 variants sufficient for lifelong persistence...