Research Topics
Genomes and Genes | Goran StenmanSummaryAffiliation: Lundberg Laboratory for Cancer Research Country: Sweden Publications
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Detail Information
Publications
Fusion oncogenes and tumor type specificity--insights from salivary gland tumorsGoran Stenman
Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
Semin Cancer Biol 15:224-35. 2005..The downstream gene products of these fusions will be important targets for development of new intracellular therapeutic strategies...
New tricks from an old oncogene: gene fusion and copy number alterations of MYB in human cancerGoran Stenman
Lundberg Laboratory for Cancer Research, Department of Pathology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Cell Cycle 9:2986-95. 2010..This study, together with previous and recent data showing rearrangements and copy number alterations of the MYB locus in T-cell leukemia and certain solid tumors, will be the main focus of this review...
High-resolution genomic profiling of adenomas and carcinomas of the salivary glands reveals amplification, rearrangement, and fusion of HMGA2Fredrik Persson
Department of Pathology, Lundberg Laboratory for Cancer Research, tSahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Genes Chromosomes Cancer 48:69-82. 2009..2-q31.2, gains of 8q12.1 (PLAG1) and 8q22.1-q24.1 (MYC), and amplification of ERBB2 may be of importance for malignant transformation of benign PA...- Cytogenetic and spectral karyotype analyses of benign and malignant cartilage tumoursHelene Sjögren
Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
Int J Oncol 24:1385-91. 2004.... - Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomasMarta Winnes
The Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
Genes Chromosomes Cancer 46:559-63. 2007.... - Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinomaMarta Persson
Sahlgrenska Cancer Center, Department of Pathology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Genes Chromosomes Cancer 51:805-17. 2012..33-p35.3 that may be of clinical significance in high-grade tumors. Further, studies of these and other potential target genes may lead to the identification of novel driver genes in ACC... - Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neckMarta Persson
Department of Pathology, Lundberg Laboratory for Cancer Research, the Sahlgrenska Academy at University of Gothenburg, SE 413 45 Gothenburg, Sweden
Proc Natl Acad Sci U S A 106:18740-4. 2009..Our findings also suggest that the gain-of-function activity resulting from the MYB-NFIB fusion is a candidate therapeutic target... - Germline mutation screening of the Saethre-Chotzen-associated genes TWIST1 and FGFR3 in families with BRCA1/2-negative breast cancerAnnika Bergman
Lundberg Laboratory for Cancer Research, Department of Pathology, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Goteborg, Sweden
Scand J Plast Reconstr Surg Hand Surg 43:251-5. 2009..Taken together, our findings indicate that mutations in Saethre-Chotzen-associated genes are uncommon or absent in BRCA1/2-negative patients with hereditary breast cancer... - Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neckFredrik Persson
Sahlgrenska Cancer Center, Department of Pathology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Int J Oncol 40:80-4. 2012.... - Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusionAfrouz Behboudi
Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
Genes Chromosomes Cancer 43:202-5. 2005.... - CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomasJulia Asp
Lundberg Laboratory for Cancer Research, Department of Pathology, The Sahlgrenska Academy at Goteborg University, SE 413 45 Goteborg, Sweden
Genes Chromosomes Cancer 45:820-8. 2006..Our findings further emphasize the significance of PLAG1 activation in pleomorphic adenomas and demonstrate that the gene is more frequently activated than previously anticipated... - Characterization of the 12q amplicons by high-resolution, oligonucleotide array CGH and expression analyses of a novel liposarcoma cell lineFredrik Persson
Lundberg Laboratory for Cancer Research, Department of Pathology, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Cancer Lett 260:37-47. 2008..Our results also identify several novel candidate genes of potential pathogenetic and therapeutic importance for WDLS... - High-resolution genomic profiling reveals gain of chromosome 14 as a predictor of poor outcome in ileal carcinoidsEllinor Andersson
Lundberg Laboratory for Cancer Research, Department of Pathology, Sahlgrenska University Hospital, Gula straket 8, SE 413 45 Goteborg, Sweden
Endocr Relat Cancer 16:953-66. 2009..Predictive fluorescence in situ hybridization analysis of chromosome 14 status in patients with ileal carcinoids is suggested... - Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancerMarta Winnes
Lundberg Laboratory for Cancer Research, Department of Pathology, SE 413 45 Goteborg, Sweden
Oncol Rep 17:1033-6. 2007..Our findings suggest that ERG gene fusions might be of prognostic significance in prostate cancer... - Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumorsFredrik Enlund
Department of Pathology, Goteborg University, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
Exp Cell Res 292:21-8. 2004..These findings suggest that altered Notch signaling plays an important role in the genesis of benign and malignant neoplasms of salivary and bronchial gland origin... - HER2-testing in 538 consecutive breast cancer cases using FISH and immunohistochemistryAnikó Kovács
Department of Pathology, Sahlgrenska University Hospital, Gothenburg SE 41345, Sweden
Pathol Res Pract 206:39-42. 2010.... - Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomasFrederik Enlund
The Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Goteborg, Sweden
Int J Oncol 20:713-6. 2002..Cytogenetically polyclonal adenomas are thus most likely also of monoclonal origin... - The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress responseMattias K Andersson
Lundberg Laboratory for Cancer Research, Department of Pathology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
BMC Cell Biol 9:37. 2008..In the present study, we investigated the expression and cellular localization of FET proteins in multiple human tissues and cell types... - A transplantable human medullary thyroid carcinoma as a model for RET tyrosine kinase-driven tumorigenesisViktor Johanson
Lundberg Laboratory for Cancer Research, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
Endocr Relat Cancer 14:433-44. 2007..Our results show that this transplantable MTC, designated GOT2, represents a novel and useful model for studies of MTC and RET tyrosine kinase-dependent tumor growth... - Studies on the molecular pathogenesis of extraskeletal myxoid chondrosarcoma-cytogenetic, molecular genetic, and cDNA microarray analysesHelene Sjögren
Department of Pathology, Lundberg Laboratory for Cancer Research, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
Am J Pathol 162:781-92. 2003.... - Women with Saethre-Chotzen syndrome are at increased risk of breast cancerPelle Sahlin
Department of Plastic Surgery, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
Genes Chromosomes Cancer 46:656-60. 2007..Additional studies are, however, necessary to reveal the mechanism by which TWIST1 may predispose to early onset breast cancer in Saethre-Chotzen patients... - Abnormal expression of cell cycle regulators in FUS-CHOP carrying liposarcomasAnita Olofsson
Lundberg Laboratory for Cancer Research, Department of Pathology, Sahlgrenska University Hospital, , SE-413 45 Gothenburg, Sweden
Int J Oncol 25:1349-55. 2004..We conclude that deregulation of G1 controlling proteins is common in MLS/RCLS and that aberrant expression of these proteins is of importance in the pathogenesis of this tumor type... - Molecular analyses of the candidate tumor suppressor gene, PLAGL1, in benign and malignant salivary gland tumorsFredrik Enlund
Lundberg Laboratory for Cancer Research, Department of Pathology, , Sahlgrenska University Hospital, , Sweden
Eur J Oral Sci 112:545-7. 2004..Collectively, these results indicate that PLAGL1 is not likely to be the major target gene of the 6q rearrangements in salivary gland tumors... - Translocation, deletion/amplification, and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenomaEva Roijer
Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
Am J Pathol 160:433-40. 2002..These findings suggest that amplification and overexpression of HMGIC and possibly MDM2 might be important genetic events that may contribute to malignant transformation of benign PA... - The complexity of KIT gene mutations and chromosome rearrangements and their clinical correlation in gastrointestinal stromal (pacemaker cell) tumorsJohanna Andersson
Department of Pathology, Lundberg Laboratory for Cancer Research, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
Am J Pathol 160:15-22. 2002..Collectively, these findings indicate that the role of KIT mutations and chromosomal rearrangements in the pathogenesis of GIST/GIPACTs are more complex than previously recognized... - Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogeneAfrouz Behboudi
Lundberg Laboratory for Cancer Research, Department of Pathology, , Sahlgrenska University Hospital, , Sweden
Genes Chromosomes Cancer 45:470-81. 2006..These findings suggest that molecularly classifying MECs on the basis of an MECT1-MAML2 fusion is histopathologically and clinically relevant and that the fusion is a useful marker in predicting the biological behavior of MECs...