Goran Stenman

Summary

Affiliation: Lundberg Laboratory for Cancer Research
Country: Sweden

Publications

  1. pmc New tricks from an old oncogene: gene fusion and copy number alterations of MYB in human cancer
    Goran Stenman
    Lundberg Laboratory for Cancer Research, Department of Pathology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Cell Cycle 9:2986-95. 2010
  2. ncbi request reprint Fusion oncogenes and tumor type specificity--insights from salivary gland tumors
    Goran Stenman
    Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
    Semin Cancer Biol 15:224-35. 2005
  3. doi request reprint High-resolution genomic profiling of adenomas and carcinomas of the salivary glands reveals amplification, rearrangement, and fusion of HMGA2
    Fredrik Persson
    Department of Pathology, Lundberg Laboratory for Cancer Research, tSahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Genes Chromosomes Cancer 48:69-82. 2009
  4. ncbi request reprint Molecular analyses of the candidate tumor suppressor gene, PLAGL1, in benign and malignant salivary gland tumors
    Fredrik Enlund
    Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Eur J Oral Sci 112:545-7. 2004
  5. ncbi request reprint Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene
    Afrouz Behboudi
    Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
    Genes Chromosomes Cancer 45:470-81. 2006
  6. ncbi request reprint Cytogenetic and spectral karyotype analyses of benign and malignant cartilage tumours
    Helene Sjögren
    Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Int J Oncol 24:1385-91. 2004
  7. ncbi request reprint Abnormal expression of cell cycle regulators in FUS-CHOP carrying liposarcomas
    Anita Olofsson
    Lundberg Laboratory for Cancer Research, Department of Pathology, Sahlgrenska University Hospital, Gula straket 8, SE 413 45 Gothenburg, Sweden
    Int J Oncol 25:1349-55. 2004
  8. ncbi request reprint Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas
    Marta Winnes
    The Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
    Genes Chromosomes Cancer 46:559-63. 2007
  9. doi request reprint Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma
    Marta Persson
    Sahlgrenska Cancer Center, Department of Pathology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Genes Chromosomes Cancer 51:805-17. 2012
  10. doi request reprint Germline mutation screening of the Saethre-Chotzen-associated genes TWIST1 and FGFR3 in families with BRCA1/2-negative breast cancer
    Annika Bergman
    Lundberg Laboratory for Cancer Research, Department of Pathology, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Goteborg, Sweden
    Scand J Plast Reconstr Surg Hand Surg 43:251-5. 2009

Collaborators

Detail Information

Publications28

  1. pmc New tricks from an old oncogene: gene fusion and copy number alterations of MYB in human cancer
    Goran Stenman
    Lundberg Laboratory for Cancer Research, Department of Pathology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Cell Cycle 9:2986-95. 2010
    ..This study, together with previous and recent data showing rearrangements and copy number alterations of the MYB locus in T-cell leukemia and certain solid tumors, will be the main focus of this review...
  2. ncbi request reprint Fusion oncogenes and tumor type specificity--insights from salivary gland tumors
    Goran Stenman
    Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
    Semin Cancer Biol 15:224-35. 2005
    ..The downstream gene products of these fusions will be important targets for development of new intracellular therapeutic strategies...
  3. doi request reprint High-resolution genomic profiling of adenomas and carcinomas of the salivary glands reveals amplification, rearrangement, and fusion of HMGA2
    Fredrik Persson
    Department of Pathology, Lundberg Laboratory for Cancer Research, tSahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Genes Chromosomes Cancer 48:69-82. 2009
    ..2-q31.2, gains of 8q12.1 (PLAG1) and 8q22.1-q24.1 (MYC), and amplification of ERBB2 may be of importance for malignant transformation of benign PA...
  4. ncbi request reprint Molecular analyses of the candidate tumor suppressor gene, PLAGL1, in benign and malignant salivary gland tumors
    Fredrik Enlund
    Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Eur J Oral Sci 112:545-7. 2004
    ..Collectively, these results indicate that PLAGL1 is not likely to be the major target gene of the 6q rearrangements in salivary gland tumors...
  5. ncbi request reprint Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene
    Afrouz Behboudi
    Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
    Genes Chromosomes Cancer 45:470-81. 2006
    ..These findings suggest that molecularly classifying MECs on the basis of an MECT1-MAML2 fusion is histopathologically and clinically relevant and that the fusion is a useful marker in predicting the biological behavior of MECs...
  6. ncbi request reprint Cytogenetic and spectral karyotype analyses of benign and malignant cartilage tumours
    Helene Sjögren
    Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Int J Oncol 24:1385-91. 2004
    ....
  7. ncbi request reprint Abnormal expression of cell cycle regulators in FUS-CHOP carrying liposarcomas
    Anita Olofsson
    Lundberg Laboratory for Cancer Research, Department of Pathology, Sahlgrenska University Hospital, Gula straket 8, SE 413 45 Gothenburg, Sweden
    Int J Oncol 25:1349-55. 2004
    ..We conclude that deregulation of G1 controlling proteins is common in MLS/RCLS and that aberrant expression of these proteins is of importance in the pathogenesis of this tumor type...
  8. ncbi request reprint Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas
    Marta Winnes
    The Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
    Genes Chromosomes Cancer 46:559-63. 2007
    ....
  9. doi request reprint Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma
    Marta Persson
    Sahlgrenska Cancer Center, Department of Pathology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Genes Chromosomes Cancer 51:805-17. 2012
    ..33-p35.3 that may be of clinical significance in high-grade tumors. Further, studies of these and other potential target genes may lead to the identification of novel driver genes in ACC...
  10. doi request reprint Germline mutation screening of the Saethre-Chotzen-associated genes TWIST1 and FGFR3 in families with BRCA1/2-negative breast cancer
    Annika Bergman
    Lundberg Laboratory for Cancer Research, Department of Pathology, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Goteborg, Sweden
    Scand J Plast Reconstr Surg Hand Surg 43:251-5. 2009
    ..Taken together, our findings indicate that mutations in Saethre-Chotzen-associated genes are uncommon or absent in BRCA1/2-negative patients with hereditary breast cancer...
  11. pmc Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck
    Marta Persson
    Department of Pathology, Lundberg Laboratory for Cancer Research, the Sahlgrenska Academy at University of Gothenburg, SE 413 45 Gothenburg, Sweden
    Proc Natl Acad Sci U S A 106:18740-4. 2009
    ..Our findings also suggest that the gain-of-function activity resulting from the MYB-NFIB fusion is a candidate therapeutic target...
  12. doi request reprint Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck
    Fredrik Persson
    Sahlgrenska Cancer Center, Department of Pathology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Int J Oncol 40:80-4. 2012
    ....
  13. ncbi request reprint Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion
    Afrouz Behboudi
    Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
    Genes Chromosomes Cancer 43:202-5. 2005
    ....
  14. ncbi request reprint CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas
    Julia Asp
    Lundberg Laboratory for Cancer Research, Department of Pathology, The Sahlgrenska Academy at Goteborg University, SE 413 45 Goteborg, Sweden
    Genes Chromosomes Cancer 45:820-8. 2006
    ..Our findings further emphasize the significance of PLAG1 activation in pleomorphic adenomas and demonstrate that the gene is more frequently activated than previously anticipated...
  15. ncbi request reprint Characterization of the 12q amplicons by high-resolution, oligonucleotide array CGH and expression analyses of a novel liposarcoma cell line
    Fredrik Persson
    Lundberg Laboratory for Cancer Research, Department of Pathology, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Cancer Lett 260:37-47. 2008
    ..Our results also identify several novel candidate genes of potential pathogenetic and therapeutic importance for WDLS...
  16. ncbi request reprint Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancer
    Marta Winnes
    Lundberg Laboratory for Cancer Research, Department of Pathology, SE 413 45 Goteborg, Sweden
    Oncol Rep 17:1033-6. 2007
    ..Our findings suggest that ERG gene fusions might be of prognostic significance in prostate cancer...
  17. doi request reprint High-resolution genomic profiling reveals gain of chromosome 14 as a predictor of poor outcome in ileal carcinoids
    Ellinor Andersson
    Lundberg Laboratory for Cancer Research, Department of Pathology, Sahlgrenska University Hospital, Gula straket 8, SE 413 45 Goteborg, Sweden
    Endocr Relat Cancer 16:953-66. 2009
    ..Predictive fluorescence in situ hybridization analysis of chromosome 14 status in patients with ileal carcinoids is suggested...
  18. ncbi request reprint Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors
    Fredrik Enlund
    Department of Pathology, Goteborg University, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Exp Cell Res 292:21-8. 2004
    ..These findings suggest that altered Notch signaling plays an important role in the genesis of benign and malignant neoplasms of salivary and bronchial gland origin...
  19. doi request reprint Adenoid cystic carcinoma of the lacrimal gland: MYB gene activation, genomic imbalances, and clinical characteristics
    Sarah L von Holstein
    Eye Pathology Section, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Denmark Sahlgrenska Cancer Center, Department of Pathology, University of Gothenburg, Sweden
    Ophthalmology 120:2130-8. 2013
    ....
  20. ncbi request reprint Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomas
    Frederik Enlund
    The Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Goteborg, Sweden
    Int J Oncol 20:713-6. 2002
    ..Cytogenetically polyclonal adenomas are thus most likely also of monoclonal origin...
  21. doi request reprint HER2-testing in 538 consecutive breast cancer cases using FISH and immunohistochemistry
    Anikó Kovács
    Department of Pathology, Sahlgrenska University Hospital, Gothenburg SE 41345, Sweden
    Pathol Res Pract 206:39-42. 2010
    ....
  22. pmc Studies on the molecular pathogenesis of extraskeletal myxoid chondrosarcoma-cytogenetic, molecular genetic, and cDNA microarray analyses
    Helene Sjögren
    Department of Pathology, Lundberg Laboratory for Cancer Research, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Am J Pathol 162:781-92. 2003
    ....
  23. pmc The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response
    Mattias K Andersson
    Lundberg Laboratory for Cancer Research, Department of Pathology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    BMC Cell Biol 9:37. 2008
    ..In the present study, we investigated the expression and cellular localization of FET proteins in multiple human tissues and cell types...
  24. ncbi request reprint A transplantable human medullary thyroid carcinoma as a model for RET tyrosine kinase-driven tumorigenesis
    Viktor Johanson
    Lundberg Laboratory for Cancer Research, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Endocr Relat Cancer 14:433-44. 2007
    ..Our results show that this transplantable MTC, designated GOT2, represents a novel and useful model for studies of MTC and RET tyrosine kinase-dependent tumor growth...
  25. ncbi request reprint Women with Saethre-Chotzen syndrome are at increased risk of breast cancer
    Pelle Sahlin
    Department of Plastic Surgery, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
    Genes Chromosomes Cancer 46:656-60. 2007
    ..Additional studies are, however, necessary to reveal the mechanism by which TWIST1 may predispose to early onset breast cancer in Saethre-Chotzen patients...
  26. doi request reprint Salivary gland cancer: an update on present and emerging therapies
    Julie Carlson
    From the Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO Head and Neck Unit, Medical Oncology Department, Fondazione, IRCCS Istituto Tumori, Milan, Italy Departments of Pathology and Oncology, Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden
    Am Soc Clin Oncol Educ Book 33:257-63. 2013
    ..Future trials investigating concurrent chemotherapy and radiation, as well as the use of targeted agents based on evolving molecular discoveries, will elucidate optimal personalized approaches for this challenging disease. ..
  27. pmc Translocation, deletion/amplification, and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenoma
    Eva Roijer
    Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Am J Pathol 160:433-40. 2002
    ..These findings suggest that amplification and overexpression of HMGIC and possibly MDM2 might be important genetic events that may contribute to malignant transformation of benign PA...
  28. pmc The complexity of KIT gene mutations and chromosome rearrangements and their clinical correlation in gastrointestinal stromal (pacemaker cell) tumors
    Johanna Andersson
    Department of Pathology, Lundberg Laboratory for Cancer Research, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Am J Pathol 160:15-22. 2002
    ..Collectively, these findings indicate that the role of KIT mutations and chromosomal rearrangements in the pathogenesis of GIST/GIPACTs are more complex than previously recognized...