Maria Sörhede Winzell


Affiliation: Lund University
Country: Sweden


  1. request reprint
    Winzell M, Ahren B. G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes. Pharmacol Ther. 2007;116:437-48 pubmed
    ..This review summarizes knowledge on islet GPCR. ..
  2. request reprint
    Winzell M, Pacini G, Ahren B. Insulin secretion after dietary supplementation with conjugated linoleic acids and n-3 polyunsaturated fatty acids in normal and insulin-resistant mice. Am J Physiol Endocrinol Metab. 2006;290:E347-54 pubmed
    ..Furthermore, the high-fat diet partly prevents the deleterious effects of CLA/PUFA, but this dietary supplementation was not able to counteract high-fat-diet-induced insulin resistance. ..
  3. request reprint
    Winzell M, Brand C, Wierup N, Sidelmann U, Sundler F, Nishimura E, et al. Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet. Diabetologia. 2007;50:1453-62 pubmed
    ..Chronic glucagon receptor antagonism in HFD-fed mice improves islet sensitivity to glucose and increases insulin secretion, suggesting improvement of key defects underlying impaired glucose tolerance and type 2 diabetes. ..
  4. Winzell M, Wulff E, Olsen G, Sauerberg P, Gotfredsen C, Ahren B. Improved insulin sensitivity and islet function after PPARdelta activation in diabetic db/db mice. Eur J Pharmacol. 2010;626:297-305 pubmed publisher
    ..This suggests that activation of PPARdelta improves glucose metabolism and may therefore potentially be target for treatment of type 2 diabetes. ..
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    Winzell M, Nogueiras R, Dieguez C, Ahren B. Dual action of adiponectin on insulin secretion in insulin-resistant mice. Biochem Biophys Res Commun. 2004;321:154-60 pubmed
    ..The results thus uncover a potential dual role for adiponectin to modify insulin secretion in insulin resistance. ..