Maria Sörhede Winzell
Affiliation: Lund University
Winzell M, Ahren B. G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes. Pharmacol Ther. 2007;116:437-48 pubmed
..This review summarizes knowledge on islet GPCR. ..
Winzell M, Pacini G, Ahren B. Insulin secretion after dietary supplementation with conjugated linoleic acids and n-3 polyunsaturated fatty acids in normal and insulin-resistant mice. Am J Physiol Endocrinol Metab. 2006;290:E347-54 pubmed
..Furthermore, the high-fat diet partly prevents the deleterious effects of CLA/PUFA, but this dietary supplementation was not able to counteract high-fat-diet-induced insulin resistance. ..
Winzell M, Brand C, Wierup N, Sidelmann U, Sundler F, Nishimura E, et al
. Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet. Diabetologia. 2007;50:1453-62 pubmed
..Chronic glucagon receptor antagonism in HFD-fed mice improves islet sensitivity to glucose and increases insulin secretion, suggesting improvement of key defects underlying impaired glucose tolerance and type 2 diabetes. ..
Winzell M, Wulff E, Olsen G, Sauerberg P, Gotfredsen C, Ahren B. Improved insulin sensitivity and islet function after PPARdelta activation in diabetic db/db mice. Eur J Pharmacol. 2010;626:297-305 pubmed publisher
..This suggests that activation of PPARdelta improves glucose metabolism and may therefore potentially be target for treatment of type 2 diabetes. ..
Winzell M, Nogueiras R, Dieguez C, Ahren B. Dual action of adiponectin on insulin secretion in insulin-resistant mice. Biochem Biophys Res Commun. 2004;321:154-60 pubmed
..The results thus uncover a potential dual role for adiponectin to modify insulin secretion in insulin resistance. ..