L Uller

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi Resolution of cell-mediated airways diseases
    Carl G Persson
    Department of Clinical Pharmacology, Lund University Hospital, S 22185 Lund, Sweden
    Respir Res 11:75. 2010
  2. ncbi Remodeling of extra-bronchial lung vasculature following allergic airway inflammation
    Kristina Rydell-Törmänen
    Div, Vascular and Airway Research, Dept, Experimental Medical Science, Lund University, Lund, Sweden
    Respir Res 9:18. 2008
  3. ncbi Neutrophil cannibalism--a back up when the macrophage clearance system is insufficient
    Kristina Rydell-Törmänen
    Div Vascular and Airway Research, Dept Experimental Medical Science, Lund University, Lund, Sweden
    Respir Res 7:143. 2006
  4. ncbi Early phase resolution of mucosal eosinophilic inflammation in allergic rhinitis
    Lena Uller
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Respir Res 11:54. 2010
  5. ncbi Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation
    Lena Uller
    Dept Experimental Medical Science, Lund University, Sweden
    Respir Res 8:16. 2007
  6. ncbi Anti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation
    Lena Uller
    Dept Experimental Medical Science, Lund University, BMC F10, 221 84, Lund, Sweden
    Respir Res 6:90. 2005
  7. ncbi Effects of steroid treatment on lung CC chemokines, apoptosis and transepithelial cell clearance during development and resolution of allergic airway inflammation
    L Uller
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Clin Exp Allergy 36:111-21. 2006
  8. ncbi Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-beta in bronchial epithelial cells from donors with asthma
    Lena Uller
    The Brooke Laboratories, Sir Henry Wellcome Laboratories, South Block, Southampton General Hospital, Southampton SO16 6YD, UK
    Thorax 65:626-32. 2010
  9. ncbi Blockade of CTLA-4 promotes airway inflammation in naive mice exposed to aerosolized allergen but fails to prevent inhalation tolerance
    L Alenmyr
    Department of Clinical and Experimental Pharmacology, Lund University Hospital, Lund, Sweden
    Scand J Immunol 62:437-44. 2005
  10. ncbi Lung tissue eosinophils may be cleared through luminal entry rather than apoptosis: effects of steroid treatment
    L Uller
    Department of Physiological Sciences, University Hospital, Lund, Sweden
    Am J Respir Crit Care Med 164:1948-56. 2001

Detail Information

Publications18

  1. ncbi Resolution of cell-mediated airways diseases
    Carl G Persson
    Department of Clinical Pharmacology, Lund University Hospital, S 22185 Lund, Sweden
    Respir Res 11:75. 2010
    ..It helps interpretation of common airway lumen data, and suggests approaches to treat cell-mediated airway inflammation...
  2. ncbi Remodeling of extra-bronchial lung vasculature following allergic airway inflammation
    Kristina Rydell-Törmänen
    Div, Vascular and Airway Research, Dept, Experimental Medical Science, Lund University, Lund, Sweden
    Respir Res 9:18. 2008
    ..The aim of the study was to examine whether vascular remodeling occurs also in vessels where a spill-over effect of bronchial remodeling molecules is less likely...
  3. ncbi Neutrophil cannibalism--a back up when the macrophage clearance system is insufficient
    Kristina Rydell-Törmänen
    Div Vascular and Airway Research, Dept Experimental Medical Science, Lund University, Lund, Sweden
    Respir Res 7:143. 2006
    ..The aim of this study was to explore the hypothesis that neutrophils, in areas of the lung with extensive cellular infiltration, contribute to clearance by phagocytosing apoptotic cells and/or cell debris derived from secondary necrosis...
  4. ncbi Early phase resolution of mucosal eosinophilic inflammation in allergic rhinitis
    Lena Uller
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Respir Res 11:54. 2010
    ....
  5. ncbi Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation
    Lena Uller
    Dept Experimental Medical Science, Lund University, Sweden
    Respir Res 8:16. 2007
    ....
  6. ncbi Anti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation
    Lena Uller
    Dept Experimental Medical Science, Lund University, BMC F10, 221 84, Lund, Sweden
    Respir Res 6:90. 2005
    ..We thus hypothesized that effects of anti-Fas mAb in vivo may include both apoptosis and cytolysis of eosinophils and, hence, that established eosinophilic inflammation may not resolve by this treatment...
  7. ncbi Effects of steroid treatment on lung CC chemokines, apoptosis and transepithelial cell clearance during development and resolution of allergic airway inflammation
    L Uller
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Clin Exp Allergy 36:111-21. 2006
    ..However, roles of these mechanisms in the actions of steroids in vivo have not been fully established. Also, as regards clearance of tissue eosinophils other mechanisms than apoptosis may operate in vivo...
  8. ncbi Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-beta in bronchial epithelial cells from donors with asthma
    Lena Uller
    The Brooke Laboratories, Sir Henry Wellcome Laboratories, South Block, Southampton General Hospital, Southampton SO16 6YD, UK
    Thorax 65:626-32. 2010
    ....
  9. ncbi Blockade of CTLA-4 promotes airway inflammation in naive mice exposed to aerosolized allergen but fails to prevent inhalation tolerance
    L Alenmyr
    Department of Clinical and Experimental Pharmacology, Lund University Hospital, Lund, Sweden
    Scand J Immunol 62:437-44. 2005
    ..Our findings also show that once inhalation tolerance is established it may not be disrupted by blockade of CTLA-4...
  10. ncbi Lung tissue eosinophils may be cleared through luminal entry rather than apoptosis: effects of steroid treatment
    L Uller
    Department of Physiological Sciences, University Hospital, Lund, Sweden
    Am J Respir Crit Care Med 164:1948-56. 2001
    ....
  11. ncbi Occurrence of apoptosis, secondary necrosis, and cytolysis in eosinophilic nasal polyps
    Lena Uller
    Department of Physiological Sciences, BMC F10, Lund University, 221 84 Lund, Sweden
    Am J Respir Crit Care Med 170:742-7. 2004
    ....
  12. ncbi Allergen exposure of mouse airways evokes remodeling of both bronchi and large pulmonary vessels
    Kristina Rydell Törmänen
    Department of Physiological Sciences, BMC F10, Lund University, 221 84 Lund, Sweden
    Am J Respir Crit Care Med 171:19-25. 2005
    ..The significance of this finding with respect to occurrence in disease, pathophysiologic importance, and involved mechanisms warrants further investigation...
  13. ncbi Rapid and efficient clearance of airway tissue granulocytes through transepithelial migration
    J S Erjefält
    Department of Physiological Sciences, Lund University, Lund, Sweden
    Thorax 59:136-43. 2004
    ..To date the focus has been on apoptotic mechanisms of cell removal and little attention has been given to alternative processes. The present study explores transepithelial migration as a mechanism of cell clearance...
  14. ncbi Direct evidence of secondary necrosis of neutrophils during intense lung inflammation
    K Rydell-Törmänen
    Dept of Experimental Medical Science, Division of Vascular and Airway Research, BMC D12, S 221 84 Lund, Sweden
    Eur Respir J 28:268-74. 2006
    ..In summary, this study provides direct evidence that secondary necrosis of neutrophils is a common process during intense lung inflammation. This implies that neutrophil apoptosis may cause rather than resolve airway inflammation...
  15. ncbi Allergic airway inflammation initiates long-term vascular remodeling of the pulmonary circulation
    Kristina Rydell-Törmänen
    Division of Vascular and Airway Research, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Int Arch Allergy Immunol 149:251-8. 2009
    ..The aim of this study is to investigate the reversibility and resolution of vascular remodeling, induced by allergic airway inflammation...
  16. ncbi Transepithelial exit of leucocytes: inflicting, reflecting or resolving airway inflammation?
    Carl Persson
    Department of Clinical Pharmacology, Lund University Hospital, Lund S 22185, Sweden
    Thorax 65:1111-5. 2010
    ....
  17. ncbi Resolution of airway disease: removal of inflammatory cells through apoptosis, egression or both?
    Lena Uller
    Department of Experimental Medical Science, Unit of Lung Biology, BMC D12, Lund University, 221 84 Lund, Sweden
    Trends Pharmacol Sci 27:461-6. 2006
    ..In this article, we propose that egression into the airway lumen is an effective mode of inflammatory cell disposal that connotes novel drug opportunities...
  18. ncbi Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits
    Trond Ulven
    7TM Pharma, Fremtidsvej 3, DK 2970 Hørsholm, Denmark
    J Med Chem 49:6638-41. 2006
    ..In addition, this selective pharmacological tool compound provides further evidence for CRTH2 as a relevant therapeutic target for treatment of Th2- and eosinophil-related inflammation...