L Uller

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi request reprint Lung tissue eosinophils may be cleared through luminal entry rather than apoptosis: effects of steroid treatment
    L Uller
    Department of Physiological Sciences, University Hospital, Lund, Sweden
    Am J Respir Crit Care Med 164:1948-56. 2001
  2. ncbi request reprint Occurrence of apoptosis, secondary necrosis, and cytolysis in eosinophilic nasal polyps
    Lena Uller
    Department of Physiological Sciences, BMC F10, Lund University, 221 84 Lund, Sweden
    Am J Respir Crit Care Med 170:742-7. 2004
  3. pmc Effects of steroid treatment on lung CC chemokines, apoptosis and transepithelial cell clearance during development and resolution of allergic airway inflammation
    L Uller
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Clin Exp Allergy 36:111-21. 2006
  4. pmc Role of macrophage migration inhibitory factor (MIF) in allergic and endotoxin-induced airway inflammation in mice
    M Korsgren
    Department of Physiological Sciences, Lund University Hospital, Sweden
    Mediators Inflamm 9:15-23. 2000
  5. ncbi request reprint Blockade of CTLA-4 promotes airway inflammation in naive mice exposed to aerosolized allergen but fails to prevent inhalation tolerance
    L Alenmyr
    Department of Clinical and Experimental Pharmacology, Lund University Hospital, Lund, Sweden
    Scand J Immunol 62:437-44. 2005
  6. pmc Rapid and efficient clearance of airway tissue granulocytes through transepithelial migration
    J S Erjefält
    Department of Physiological Sciences, Lund University, Lund, Sweden
    Thorax 59:136-43. 2004
  7. ncbi request reprint Allergen exposure of mouse airways evokes remodeling of both bronchi and large pulmonary vessels
    Kristina Rydell Törmänen
    Department of Physiological Sciences, BMC F10, Lund University, 221 84 Lund, Sweden
    Am J Respir Crit Care Med 171:19-25. 2005
  8. pmc Neutrophil cannibalism--a back up when the macrophage clearance system is insufficient
    Kristina Rydell-Törmänen
    Div Vascular and Airway Research, Dept Experimental Medical Science, Lund University, Lund, Sweden
    Respir Res 7:143. 2006
  9. pmc Remodeling of extra-bronchial lung vasculature following allergic airway inflammation
    Kristina Rydell-Törmänen
    Div, Vascular and Airway Research, Dept, Experimental Medical Science, Lund University, Lund, Sweden
    Respir Res 9:18. 2008
  10. pmc Anti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation
    Lena Uller
    Dept Experimental Medical Science, Lund University, BMC F10, 221 84, Lund, Sweden
    Respir Res 6:90. 2005

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Lung tissue eosinophils may be cleared through luminal entry rather than apoptosis: effects of steroid treatment
    L Uller
    Department of Physiological Sciences, University Hospital, Lund, Sweden
    Am J Respir Crit Care Med 164:1948-56. 2001
    ....
  2. ncbi request reprint Occurrence of apoptosis, secondary necrosis, and cytolysis in eosinophilic nasal polyps
    Lena Uller
    Department of Physiological Sciences, BMC F10, Lund University, 221 84 Lund, Sweden
    Am J Respir Crit Care Med 170:742-7. 2004
    ....
  3. pmc Effects of steroid treatment on lung CC chemokines, apoptosis and transepithelial cell clearance during development and resolution of allergic airway inflammation
    L Uller
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Clin Exp Allergy 36:111-21. 2006
    ..However, roles of these mechanisms in the actions of steroids in vivo have not been fully established. Also, as regards clearance of tissue eosinophils other mechanisms than apoptosis may operate in vivo...
  4. pmc Role of macrophage migration inhibitory factor (MIF) in allergic and endotoxin-induced airway inflammation in mice
    M Korsgren
    Department of Physiological Sciences, Lund University Hospital, Sweden
    Mediators Inflamm 9:15-23. 2000
    ..These findings do not support a role of MIF inhibition in the treatment of inflammatory respiratory diseases...
  5. ncbi request reprint Blockade of CTLA-4 promotes airway inflammation in naive mice exposed to aerosolized allergen but fails to prevent inhalation tolerance
    L Alenmyr
    Department of Clinical and Experimental Pharmacology, Lund University Hospital, Lund, Sweden
    Scand J Immunol 62:437-44. 2005
    ..Our findings also show that once inhalation tolerance is established it may not be disrupted by blockade of CTLA-4...
  6. pmc Rapid and efficient clearance of airway tissue granulocytes through transepithelial migration
    J S Erjefält
    Department of Physiological Sciences, Lund University, Lund, Sweden
    Thorax 59:136-43. 2004
    ..To date the focus has been on apoptotic mechanisms of cell removal and little attention has been given to alternative processes. The present study explores transepithelial migration as a mechanism of cell clearance...
  7. ncbi request reprint Allergen exposure of mouse airways evokes remodeling of both bronchi and large pulmonary vessels
    Kristina Rydell Törmänen
    Department of Physiological Sciences, BMC F10, Lund University, 221 84 Lund, Sweden
    Am J Respir Crit Care Med 171:19-25. 2005
    ..The significance of this finding with respect to occurrence in disease, pathophysiologic importance, and involved mechanisms warrants further investigation...
  8. pmc Neutrophil cannibalism--a back up when the macrophage clearance system is insufficient
    Kristina Rydell-Törmänen
    Div Vascular and Airway Research, Dept Experimental Medical Science, Lund University, Lund, Sweden
    Respir Res 7:143. 2006
    ..The aim of this study was to explore the hypothesis that neutrophils, in areas of the lung with extensive cellular infiltration, contribute to clearance by phagocytosing apoptotic cells and/or cell debris derived from secondary necrosis...
  9. pmc Remodeling of extra-bronchial lung vasculature following allergic airway inflammation
    Kristina Rydell-Törmänen
    Div, Vascular and Airway Research, Dept, Experimental Medical Science, Lund University, Lund, Sweden
    Respir Res 9:18. 2008
    ..The aim of the study was to examine whether vascular remodeling occurs also in vessels where a spill-over effect of bronchial remodeling molecules is less likely...
  10. pmc Anti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation
    Lena Uller
    Dept Experimental Medical Science, Lund University, BMC F10, 221 84, Lund, Sweden
    Respir Res 6:90. 2005
    ..We thus hypothesized that effects of anti-Fas mAb in vivo may include both apoptosis and cytolysis of eosinophils and, hence, that established eosinophilic inflammation may not resolve by this treatment...
  11. ncbi request reprint Resolution of airway disease: removal of inflammatory cells through apoptosis, egression or both?
    Lena Uller
    Department of Experimental Medical Science, Unit of Lung Biology, BMC D12, Lund University, 221 84 Lund, Sweden
    Trends Pharmacol Sci 27:461-6. 2006
    ..In this article, we propose that egression into the airway lumen is an effective mode of inflammatory cell disposal that connotes novel drug opportunities...
  12. ncbi request reprint Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits
    Trond Ulven
    7TM Pharma, Fremtidsvej 3, DK 2970 Hørsholm, Denmark
    J Med Chem 49:6638-41. 2006
    ..In addition, this selective pharmacological tool compound provides further evidence for CRTH2 as a relevant therapeutic target for treatment of Th2- and eosinophil-related inflammation...
  13. pmc Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation
    Lena Uller
    Dept Experimental Medical Science, Lund University, Sweden
    Respir Res 8:16. 2007
    ....