André Struglics

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. doi request reprint MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover
    André Struglics
    Department of Orthopaedics, Clinical Sciences Lund, Lund University, Lund, Sweden
    Biochem J 446:213-23. 2012
  2. doi request reprint A comparison of different purification methods of aggrecan fragments from human articular cartilage and synovial fluid
    André Struglics
    Department of Orthopaedics, Clinical Sciences Lund, Lund University, Lund, Sweden
    Matrix Biol 29:74-83. 2010
  3. ncbi request reprint Estimation of the identity of proteolytic aggrecan fragments using PAGE migration and Western immunoblot
    A Struglics
    Department of Clinical Sciences, Orthopaedics, Lund University, Lund, Sweden
    Osteoarthritis Cartilage 14:898-905. 2006
  4. doi request reprint Western blot quantification of aggrecan fragments in human synovial fluid indicates differences in fragment patterns between joint diseases
    A Struglics
    Department of Orthopaedics, Clinical Sciences Lund, Lund University, Sweden
    Osteoarthritis Cartilage 17:497-506. 2009
  5. doi request reprint Human aggrecanase generated synovial fluid fragment levels are elevated directly after knee injuries due to proteolysis both in the inter globular and chondroitin sulfate domains
    A Struglics
    Department of Orthopaedics, Clinical Sciences Lund, Lund University, Lund, Sweden
    Osteoarthritis Cartilage 19:1047-57. 2011
  6. doi request reprint Calpain is involved in C-terminal truncation of human aggrecan
    André Struglics
    Department of Orthopaedics, Lund University, Sweden
    Biochem J 430:531-8. 2010
  7. doi request reprint Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus
    André Struglics
    Lund University, Lund, Sweden
    Arthritis Rheum 64:4151-61; author reply 4162-3. 2012
  8. ncbi request reprint Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments
    A Struglics
    Department of Orthopaedics, Lund University, Lund, Sweden
    Osteoarthritis Cartilage 14:101-13. 2006
  9. pmc Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis
    Staffan Larsson
    Department of Orthopedics, Clinical Sciences Lund, Lund University, BMC C12, Klinikgatan 28, SE 221 84 Lund, Sweden
    Arthritis Res Ther 12:R230. 2010
  10. pmc Synovial fluid level of aggrecan ARGS fragments is a more sensitive marker of joint disease than glycosaminoglycan or aggrecan levels: a cross-sectional study
    Staffan Larsson
    Department of Orthopaedics, Clinical Sciences Lund, Lund University, SE 221 85 Lund, Sweden
    Arthritis Res Ther 11:R92. 2009

Detail Information

Publications11

  1. doi request reprint MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover
    André Struglics
    Department of Orthopaedics, Clinical Sciences Lund, Lund University, Lund, Sweden
    Biochem J 446:213-23. 2012
    ..The results of the present study suggest that MMPs are mainly involved in normal aggrecan turnover and might have a less-active role in aggrecan degradation during knee injury and OA...
  2. doi request reprint A comparison of different purification methods of aggrecan fragments from human articular cartilage and synovial fluid
    André Struglics
    Department of Orthopaedics, Clinical Sciences Lund, Lund University, Lund, Sweden
    Matrix Biol 29:74-83. 2010
    ....
  3. ncbi request reprint Estimation of the identity of proteolytic aggrecan fragments using PAGE migration and Western immunoblot
    A Struglics
    Department of Clinical Sciences, Orthopaedics, Lund University, Lund, Sweden
    Osteoarthritis Cartilage 14:898-905. 2006
    ..To develop calculation models, using Western immunoblot, as a tool for the estimation of proteolytic human aggrecan fragment identity...
  4. doi request reprint Western blot quantification of aggrecan fragments in human synovial fluid indicates differences in fragment patterns between joint diseases
    A Struglics
    Department of Orthopaedics, Clinical Sciences Lund, Lund University, Sweden
    Osteoarthritis Cartilage 17:497-506. 2009
    ..To develop a Western blot method for quantification of multiple aggrecan fragments in human synovial fluids (SFs)...
  5. doi request reprint Human aggrecanase generated synovial fluid fragment levels are elevated directly after knee injuries due to proteolysis both in the inter globular and chondroitin sulfate domains
    A Struglics
    Department of Orthopaedics, Clinical Sciences Lund, Lund University, Lund, Sweden
    Osteoarthritis Cartilage 19:1047-57. 2011
    ..To examine different aggrecanase generated fragments in synovial fluid (SF) from patients with acute and chronic knee injuries and from knee healthy subjects...
  6. doi request reprint Calpain is involved in C-terminal truncation of human aggrecan
    André Struglics
    Department of Orthopaedics, Lund University, Sweden
    Biochem J 430:531-8. 2010
    ..The results of the present study indicate that calpains are involved in the C-terminal truncation of aggrecan and might have a minor role in arthritic diseases...
  7. doi request reprint Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus
    André Struglics
    Lund University, Lund, Sweden
    Arthritis Rheum 64:4151-61; author reply 4162-3. 2012
    ..To investigate aggrecan degradation in juvenile idiopathic arthritis (JIA)...
  8. ncbi request reprint Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments
    A Struglics
    Department of Orthopaedics, Lund University, Lund, Sweden
    Osteoarthritis Cartilage 14:101-13. 2006
    ..To identify the major aggrecanase- and matrix metalloproteinase (MMP)-generated aggrecan fragments in human osteoarthritis (OA) synovial fluid and in human OA joint cartilage...
  9. pmc Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis
    Staffan Larsson
    Department of Orthopedics, Clinical Sciences Lund, Lund University, BMC C12, Klinikgatan 28, SE 221 84 Lund, Sweden
    Arthritis Res Ther 12:R230. 2010
    ..We determined whether synovial fluid (SF) levels of ARGS-aggrecan distinguish subjects with progressive radiographic knee osteoarthritis (ROA) from those with stable or no ROA...
  10. pmc Synovial fluid level of aggrecan ARGS fragments is a more sensitive marker of joint disease than glycosaminoglycan or aggrecan levels: a cross-sectional study
    Staffan Larsson
    Department of Orthopaedics, Clinical Sciences Lund, Lund University, SE 221 85 Lund, Sweden
    Arthritis Res Ther 11:R92. 2009
    ....
  11. ncbi request reprint Development and characterization of a highly specific and sensitive sandwich ELISA for detection of aggrecanase-generated aggrecan fragments
    M A Pratta
    Department of Musculoskeletal Diseases, GlaxoSmithKline Pharmaceutical Company, Collegeville, PA 19426 0989, USA
    Osteoarthritis Cartilage 14:702-13. 2006
    ..To develop an enzyme linked immunosorbent assay (ELISA) to quantify the levels of specific aggrecan fragments generated by aggrecanase-mediated cleavage at the 373Glu-374 Ala bond within the aggrecan interglobular domain...