Yezhou Sheng

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa
    Y Sheng
    Department of Cell and Molecular Biology, University of Lund, Sweden
    Anticancer Res 18:3363-8. 1998
  2. ncbi Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa
    Y Sheng
    Department of Cell and Molecular Biology, University of Lund, Sweden
    J Ethnopharmacol 69:115-26. 2000
  3. ncbi Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa
    Y Sheng
    Department of Cell and Molecular Biology, University of Lund, Sweden
    Phytomedicine 7:137-43. 2000
  4. ncbi DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study
    Y Sheng
    Department of Cell and Molecular Biology, Section of Tumor and Immune Biology, University of Lund, Sweden
    Phytomedicine 8:275-82. 2001
  5. ncbi Combretastatin family member OXI4503 induces tumor vascular collapse through the induction of endothelial apoptosis
    Yezhou Sheng
    Department of Cell and Molecular Biology, Section for Tumor Immunology, University of Lund, Lund, Sweden
    Int J Cancer 111:604-10. 2004
  6. ncbi Oxi4503, a novel vascular targeting agent: effects on blood flow and antitumor activity in comparison to combretastatin A-4 phosphate
    Jianyi Hua
    Department of Cell and Molecular Biology, Section for Tumor Immunology, University of Lund, BMC 112, 22184 Lund, Sweden
    Anticancer Res 23:1433-40. 2003
  7. ncbi Pharmacokinetics and splenic accumulation of N-acetylamino-3-chloro-N-(2-diethylamino-ethyl) benzamide after a single administration to rats
    Jianyi Hua
    Department of Cell and Molecular Biology, Section for Tumor Immunology, University of Lund, 221 84, Sweden
    Biopharm Drug Dispos 25:313-22. 2004
  8. ncbi Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4
    Mallinath B Hadimani
    Department of Chemistry and Biochemistry, Center for Drug Discovery, Baylor University, Waco, TX 76798-7348, USA
    Bioorg Med Chem Lett 13:1505-8. 2003

Collaborators

Detail Information

Publications8

  1. ncbi Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa
    Y Sheng
    Department of Cell and Molecular Biology, University of Lund, Sweden
    Anticancer Res 18:3363-8. 1998
    ..These results provide the first direct evidence for the antitumor properties of Uncaria tomentosa extracts to be via a mechanism of selective induction of apoptosis...
  2. ncbi Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa
    Y Sheng
    Department of Cell and Molecular Biology, University of Lund, Sweden
    J Ethnopharmacol 69:115-26. 2000
    ..In addition, no body weight, food consumption, organ weight and kidney, liver, spleen, and heart pathological changes were found to be associated with C-MED-100 treatment...
  3. ncbi Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa
    Y Sheng
    Department of Cell and Molecular Biology, University of Lund, Sweden
    Phytomedicine 7:137-43. 2000
    ..The mechanism of the C-Med-100 effect on WBC is not known but other data showing enhanced effects on DNA repair and immune cell proliferative response support a general immune enhancement...
  4. ncbi DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study
    Y Sheng
    Department of Cell and Molecular Biology, Section of Tumor and Immune Biology, University of Lund, Sweden
    Phytomedicine 8:275-82. 2001
    ..Taken together, this trial has confirmed the earlier results obtained in the rat model when estimating DNA repair enhancement by C-Med-100...
  5. ncbi Combretastatin family member OXI4503 induces tumor vascular collapse through the induction of endothelial apoptosis
    Yezhou Sheng
    Department of Cell and Molecular Biology, Section for Tumor Immunology, University of Lund, Lund, Sweden
    Int J Cancer 111:604-10. 2004
    ..The time course of the tumor vascular response observed with OXI4503 treatment supports this drug for development as a stand alone therapy, and also lends support for the use of the drug in combination with other cancer therapies...
  6. ncbi Oxi4503, a novel vascular targeting agent: effects on blood flow and antitumor activity in comparison to combretastatin A-4 phosphate
    Jianyi Hua
    Department of Cell and Molecular Biology, Section for Tumor Immunology, University of Lund, BMC 112, 22184 Lund, Sweden
    Anticancer Res 23:1433-40. 2003
    ..These results are promising for the use of Oxi4503 as a tumor vascular targeting agent. Moreover the potent antitumor effect when administered as a single agent suggests a different activity profile than CA4P...
  7. ncbi Pharmacokinetics and splenic accumulation of N-acetylamino-3-chloro-N-(2-diethylamino-ethyl) benzamide after a single administration to rats
    Jianyi Hua
    Department of Cell and Molecular Biology, Section for Tumor Immunology, University of Lund, 221 84, Sweden
    Biopharm Drug Dispos 25:313-22. 2004
    ..All these results suggest that NACPA may be a good candidate drug for oral administration for immune modulation...
  8. ncbi Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4
    Mallinath B Hadimani
    Department of Chemistry and Biochemistry, Center for Drug Discovery, Baylor University, Waco, TX 76798-7348, USA
    Bioorg Med Chem Lett 13:1505-8. 2003
    ..A variety of alkyl and aryl di- and triesters of CA4P have been synthesized and evaluated as potential CA4 prodrugs and/or stable CA4P analogues...