Affiliation: Lund University
- Porous silicon as a potential electrode material in a nerve repair setting: Tissue reactionsFredrik Johansson
Nano Neuro Research Center, Lund University, Sweden
Acta Biomater 5:2230-7. 2009..We conclude that a pSi surface, due to its large surface area, diminished inflammatory response and firm adhesion to the tissue, should be a good material for the development of new implantable electronic nerve devices...
- Learning in sensorimotor circuitsJens Schouenborg
University of Lund, Section for Neurophysiology, Department of Physiological Sciences, BMC F10, 221 84 Lund, Sweden
Curr Opin Neurobiol 14:693-7. 2004..This experience-dependent signal adapts the circuitry in the sensorimotor module to the body anatomy and biomechanics...
- Modular organisation and spinal somatosensory imprintingJens Schouenborg
Department of Physiological Sciences, Lund University, Tornavagen 10, BMC F10, 221 84, Lund, Sweden
Brain Res Brain Res Rev 40:80-91. 2002..These findings and their implications for the understanding of higher motor functions as well as clinical aspects will be discussed...
- Action-based body maps in the spinal cord emerge from a transitory floating organizationMarcus Granmo
Neuronano Research Center, Biomedical Center F10, Lund University, S 221 84 Lund, Sweden
J Neurosci 28:5494-503. 2008..Thus, far from being inborn and stereotypic, the dorsal horn of the spinal cord now appears to be a highly adaptive brain-body interface...
- Spontaneous movements: Effect of denervation and relation to the adaptation of nociceptive withdrawal reflexes in the ratAlexandra Waldenström
Neuronano Research Center, Department of Experimental Medical Science, Lund University, BMC F12, S 221 84 Lund, Sweden
Physiol Behav 98:532-6. 2009..Moreover, the NWR adaptation appears to be related to a qualitative change in spontaneous movements caused by maturation in spinal reflex circuit connections...
- Spatial encoding in spinal sensorimotor circuits differs in different wild type mice strainsJonas Thelin
Neuronano Research Center, Department of Experimental Medical Science, Lund University, BMC F10, S 221 84, Sweden
BMC Neurosci 9:45. 2008..Receptive fields of reflexes in single hindlimb muscles were mapped with CO2 laser heat pulses...
- Developmental learning in a pain-related system: evidence for a cross-modality mechanismAlexandra Waldenström
Section of Neurophysiology, Department for Physiological Sciences, Lund University, S 221 84 Lund, Sweden
J Neurosci 23:7719-25. 2003..These findings provide a key to the puzzle of how pain-related systems can be functionally adapted through experience despite the rare occurrence of noxious input during early life...
- Properties of an adult spinal sensorimotor circuit shaped through early postnatal experiencePer Petersson
Section for Neurophysiology, Department of Physiological, University of Lund, Sweden
J Neurophysiol 92:280-8. 2004..It is suggested that after normal postnatal experience-dependent adaptation, the number of connections from a given skin site onto the reflex encoding interneurons is a major determinant of the difference in gain...
- Spinal sensorimotor transformation: relation between cutaneous somatotopy and a reflex networkAnders Levinsson
Section for Neurophysiology, Department of Physiological Sciences, Lund University, S 221 84 Lund, Sweden
J Neurosci 22:8170-82. 2002..Hence, the spinal somatotopic map may be better understood in light of the topography of such reflex systems...
- Altered nociceptive C fibre input to primary somatosensory cortex in an animal model of hyperalgesiaTanja Jensen
Neuronano Research Center, Section for Neuroscience, Lund University, BMC F10, SE 221 84 Lund, Sweden
Eur J Pain 15:368-75. 2011..Tactile evoked potentials were not affected by UV-B irradiation or tramadol. We conclude that altered sensory processing related to hyperalgesia is reflected in altered LCEPs in SI cortex...
- Implant size and fixation mode strongly influence tissue reactions in the CNSJonas Thelin
Neuronano Research Centre, Lund University, Lund, Sweden
PLoS ONE 6:e16267. 2011..Our findings therefore clearly indicate that the combined small diameter, un-tethered implants cause the smallest tissue reactions...
- Gelatine-embedded electrodes--a novel biocompatible vehicle allowing implantation of highly flexible microelectrodesGustav Lind
Department of Experimental Medical Sciences, Neuronano Research Center, Lund University, BMC F10, Lund, Sweden
J Neural Eng 7:046005. 2010..Successful electrophysiological recordings were made from very thin electrodes implanted in this fashion...
- Action-based sensory encoding in spinal sensorimotor circuitsJens Schouenborg
Group of Neurophysiology, Neuronanoscience Research Center, Department of Experimental Medical Research, BMC F10, Lund University, S 221 84 Lund, Sweden
Brain Res Rev 57:111-7. 2008..It is suggested that somatosensory imprinting plays a key role in the self-organisation of the spinal cord during development...
- What, indeed, do climbing fibers signal? Some cerebellar microcomplexes appear to monitor the activity in spinal nociceptive withdrawal reflex modulesMartin Garwicz
Section for Neurophysiology, Department of Physiological Sciences, Lund University, BMC F10, Tornav 10, S 221 84 Lund, Sweden
Ann N Y Acad Sci 978:513-4. 2002
- Heat nociception is severely reduced in a mutant mouse deficient for the L1 adhesion moleculeJonas Thelin
Section for Neurophysiology, Department of Physiological Sciences, Lund University, BMC F10, S 221 84, Lund, Sweden
Brain Res 965:75-82. 2003....
- Minimizing data transfer with sustained performance in wireless brain-machine interfacesPalmi Thor Thorbergsson
Department of Electrical and Information Technology, Lund University, Box 118, 22100 Lund, Sweden
J Neural Eng 9:036005. 2012..Such guidelines are essential during system dimensioning. Based on these findings we conclude by presenting a quantitative task-allocation scheme that can be followed to achieve optimal utilization of available resources...
- Computationally efficient simulation of extracellular recordings with multielectrode arraysPalmi Thor Thorbergsson
Department of Electrical and Information Technology, Lund University, Box 118, 22100 Lund, Sweden Neuronano Research Center, Lund University, Solvegatan 19, BMC F10, 22184 Lund, Sweden Electronic address
J Neurosci Methods 211:133-44. 2012....
- Multiple implants do not aggravate the tissue reaction in rat brainGustav Lind
Department of Experimental Medical Sciences, Neuronano Research Center, Medical Faculty, Lund University, Lund, Sweden
PLoS ONE 7:e47509. 2012..These results highlight the possibility of implanting multiple electrodes without aggravating the glial scar surrounding each implant...
- Soft tissue reactions evoked by implanted gallium phosphideCecilia E Linsmeier
Neuronano Research Center, BMC F10, Lund University, SE 221 84 Lund, Sweden
Biomaterials 29:4598-604. 2008..Taken together, our results show that the biocompatible properties of GaP are worse than those of the well-documented biomaterial Ti...
- Spinal NMDA-receptor dependent amplification of nociceptive transmission to rat primary somatosensory cortex (SI)Jarkko Kalliomäki
Section for Neurophysiology, Department of Physiological Sciences, Lund University, BMC F10, S 221 84 Lund, Sweden
Pain 104:195-200. 2003..It is concluded that spinal NMDA-receptor mechanisms amplify the acute transmission of nociceptive C fiber input to SI in a frequency-dependent way...
- Spontaneous muscle twitches during sleep guide spinal self-organizationPer Petersson
Section for Neurophysiology, Department of Physiological Sciences, BMC F10, Lund University, S 221 84 Lund, Sweden
Nature 424:72-5. 2003..The results indicate that these twitches, corresponding to human fetal movements, are important in spinal self-organization...
- Long term depression of human nociceptive skin senses induced by thin fibre stimulationHans Jörgen Nilsson
Section for Neurophysiology, Department of Physiological Sciences, University of Lund, BMC F10, Tornavagen 10, S 221 84 Lund, Sweden
Eur J Pain 7:225-33. 2003..The induction time and effective stimulation frequencies may suggest that the underlying mechanisms are similar to those of long term depression (LTD) previously described in the spinal cord in animal experiments...
- Common principles of sensory encoding in spinal reflex modules and cerebellar climbing fibresMartin Garwicz
Section for Neurophysiology, Department of Physiological Sciences, Lund University, Sweden
J Physiol 540:1061-9. 2002..This suggests that an individual climbing fibre signals cutaneous sensory events reflecting activity of a single muscle conditional upon the functional state of the muscle itself and that of functionally related muscles...
- Biocompatible multichannel electrodes for long-term neurophysiological studies and clinical therapy--novel concepts and designJens Schouenborg
Neuronano Research Center, Experimental Medical Science and The Nanometer Consortium, Lund University, Lund, Sweden
Prog Brain Res 194:61-70. 2011..In this chapter, I will briefly review the state of the art of neural interfaces and the concepts behind our recent research and development of ultrathin multichannel electrodes...
- Nanowire biocompatibility in the brain--looking for a needle in a 3D stackCecilia Eriksson Linsmeier
Neuronano Research Center, BMC F10, Lund University, SE 221 84 Lund, Sweden
Nano Lett 9:4184-90. 2009..For the nanowire-implanted animals, there is a significant astrocyte response at week 1 compared to controls. The nanowires are phagocytized by ED1 positive microglia, and some of them are degraded and/or transported away from the brain...