C Rosenblad

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. ncbi Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle
    C Rosenblad
    Department of Physiology and Neuroscience, Wallenberg Neuroscience Center, Lund University, Sweden
    Eur J Neurosci 11:1554-66. 1999
  2. ncbi In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin
    C Rosenblad
    Wallenberg Neuroscience Center, Lund University, Solvegatan 17, Lund, S 223 62, Sweden
    Mol Cell Neurosci 15:199-214. 2000
  3. ncbi Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model
    C Rosenblad
    Wallenberg Neuroscience Center, Department of Physiology, Lund University, Solvegatan 17, Lund, S 223 62, Sweden
    Exp Neurol 161:503-16. 2000
  4. ncbi Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor
    D Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Solvegatan 17, 223 62 Lund, Sweden
    Eur J Neurosci 12:3871-82. 2000
  5. ncbi Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system
    D Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Lund University, 223 62 Lund, Sweden
    J Neurosci 20:4686-700. 2000
  6. ncbi Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model
    A Bjorklund
    Wallenberg Neuroscience Center, Section of Neurobiology, Lund University, Solvegatan 17, S 22362, Lund, Sweden
    Brain Res 886:82-98. 2000
  7. ncbi Delayed infusion of GDNF promotes recovery of motor function in the partial lesion model of Parkinson's disease
    D Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, BMC A11, 221 84 Lund, Sweden
    Eur J Neurosci 13:1589-99. 2001
  8. ncbi Injury induced c-Jun expression and phosphorylation in the dopaminergic nigral neurons of the rat: correlation with neuronal death and modulation by glial-cell-line-derived neurotrophic factor
    E Vaudano
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Solvegatan 17, S 223 62 Lund, Sweden
    Eur J Neurosci 13:1-14. 2001
  9. ncbi Treatment with the spin-trap agent alpha-phenyl-N-tert-butyl nitrone does not enhance the survival of embryonic or adult dopamine neurons
    J Karlsson
    Wallenberg Neuroscience Center, Section for Neuronal Survival, Department of Physiology and Neuroscience, Lund University, Solvegatan 17, S 223 62, Lund, Sweden
    Brain Res 805:155-68. 1998
  10. ncbi Evaluation of Tet-on system to avoid transgene down-regulation in ex vivo gene transfer to the CNS
    J Johansen
    NsGene A/S, 97-Pederstrupvej, DK-2750 Ballerup, Denmark
    Gene Ther 9:1291-301. 2002

Collaborators

Detail Information

Publications11

  1. ncbi Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle
    C Rosenblad
    Department of Physiology and Neuroscience, Wallenberg Neuroscience Center, Lund University, Sweden
    Eur J Neurosci 11:1554-66. 1999
    ..The lower efficacy of NTN after IS, and particularly ICV, administration may be explained by the poor solubility and diffusion properties at neutral pH...
  2. ncbi In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin
    C Rosenblad
    Wallenberg Neuroscience Center, Lund University, Solvegatan 17, Lund, S 223 62, Sweden
    Mol Cell Neurosci 15:199-214. 2000
    ..We conclude that NBN/ART, similarly to GDNF, is a potent neuroprotective factor for the nigrostriatal DA neurons in vivo...
  3. ncbi Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model
    C Rosenblad
    Wallenberg Neuroscience Center, Department of Physiology, Lund University, Solvegatan 17, Lund, S 223 62, Sweden
    Exp Neurol 161:503-16. 2000
    ..We conclude that functional recovery in the partial lesion model depends not only on preservation of the nigral cell bodies, but more critically on the ability of GDNF to promote significant reinnervation of the denervated striatum...
  4. ncbi Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor
    D Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Solvegatan 17, 223 62 Lund, Sweden
    Eur J Neurosci 12:3871-82. 2000
    ....
  5. ncbi Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system
    D Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Lund University, 223 62 Lund, Sweden
    J Neurosci 20:4686-700. 2000
    ..GDNF transgene expression was maintained at high levels throughout this period. These results provide evidence that rAAV is a highly efficient vector system for long-term expression of therapeutic proteins in the nigrostriatal system...
  6. ncbi Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model
    A Bjorklund
    Wallenberg Neuroscience Center, Section of Neurobiology, Lund University, Solvegatan 17, S 22362, Lund, Sweden
    Brain Res 886:82-98. 2000
    ....
  7. ncbi Delayed infusion of GDNF promotes recovery of motor function in the partial lesion model of Parkinson's disease
    D Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, BMC A11, 221 84 Lund, Sweden
    Eur J Neurosci 13:1589-99. 2001
    ....
  8. ncbi Injury induced c-Jun expression and phosphorylation in the dopaminergic nigral neurons of the rat: correlation with neuronal death and modulation by glial-cell-line-derived neurotrophic factor
    E Vaudano
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Solvegatan 17, S 223 62 Lund, Sweden
    Eur J Neurosci 13:1-14. 2001
    ..We conclude that c-Jun induction and phosphorylation may be involved in the cellular events leading to death of nigral dopaminergic neurons in vivo and that this response can be modulated by glial-cell-line-derived-neurotrophic factor...
  9. ncbi Treatment with the spin-trap agent alpha-phenyl-N-tert-butyl nitrone does not enhance the survival of embryonic or adult dopamine neurons
    J Karlsson
    Wallenberg Neuroscience Center, Section for Neuronal Survival, Department of Physiology and Neuroscience, Lund University, Solvegatan 17, S 223 62, Lund, Sweden
    Brain Res 805:155-68. 1998
    ..This may be due to antioxidants and spin-trap agents interfering in different steps of free radical-induced cell damage...
  10. ncbi Evaluation of Tet-on system to avoid transgene down-regulation in ex vivo gene transfer to the CNS
    J Johansen
    NsGene A/S, 97-Pederstrupvej, DK-2750 Ballerup, Denmark
    Gene Ther 9:1291-301. 2002
    ..This emphasizes the need for alternative vector strategies for ex vivo gene transfer...
  11. ncbi Characterization of organotypic ventral mesencephalic cultures from embryonic mice and protection against MPP toxicity by GDNF
    B Jakobsen
    Anatomy and Neurobiology, Institute of Medical Biology, University of Southern Denmark, , 5000 Odense C, Denmark
    Eur J Neurosci 21:2939-48. 2005
    ..Long recovery periods after MPP(+) exposure are required to distinguish between reversible or irreversible toxic and/or trophic effects...